HPLC-MS Determination of Acrolein and Acetone Generated from ¹³C₃ -Labeled Glycerol Added to Cigarette Tobacco Using Two Machine-Smoking Regimes

1. Stein, Y. S., M. J. Antal Jr, and M. Jones Jr: A Study of the Gas-Phase Pyrolysis of Glycerol; J. Anal. Appl. Pyrol.: 4 (1983) 283–296.10.1016/0165-2370(83)80003-5Search in Google Scholar

2. Canada Government Tobacco Act: Tobacco Reporting Regulations, SOR/2000-273. Registration June 26, 2000. Part 3 - Emissions from Designated Tobacco Products. Available from (Accessed July 2010): http://www.hc-sc.gc.ca/hl-vs/pubs/tobac-tabac/tir-rft/emissions-eng.php or through Health Canada, Tobacco Control Programme, P. L. 3507A1, Ottawa, Canada, K1A 0K9.Search in Google Scholar

3. Canada Government Tobacco Act: Tobacco Reporting Regulations, SOR/2000-273. Registration June 26, 2000. Schedule 2: Official Methods for Collection of Emission Data on Mainstream Smoke. Available from (accessed July 2010): http://www.hc-sc.gc.ca/hl-vs/pubs/tobac-tabac/tir-rft/repeal-abrogation-eng.php#a2 or through Health Canada, Tobacco Control Programme, P. L. 3507A1, Ottawa, Canada, K1A 0K9.Search in Google Scholar

4. Counts, M. E., M. J. Morton, S. W. Laffoon, R. H. Cox, and P. J. Lipowicz: Smoke composition and predicting relationships for international commercial cigarettes smoked with three machine-smoking conditions; Regul. Toxicol. Pharmacol. 41 (2005) 185–227.Search in Google Scholar

5. Chung, H. L., D. S. Moore, and J. C. Aldridge: Pyrolyzates of glycerin; February, 1987, see www.rjrtdocs. com 512077486Search in Google Scholar

6. Baker, R. R. and L. J. Bishop: The pyrolysis of tobacco ingredients; J. Anal. Appl. Pyrolysis 71 (2004) 223–311.10.1016/S0165-2370(03)00090-1Search in Google Scholar

7. Gori, G. B. (Editor): Report No. 3. Toward less hazardous cigarettes. The third set of experimental cigarettes; DHEW Publ. No. (NIH) 77-1280 (1977).Search in Google Scholar

8. Blake, C.: The effect of the humectants glycerol and propylene glycol on mainstream and sidestream smoke deliveries of acrolein, formaldehyde, acetaldehyde, acetone and propionaldehyde; February, 1987, see (Accessed July 2010): http://legacy.library.ucsf.edu/tid/jvl37e00/pdf?searc h=%222029135129%22.Search in Google Scholar

9. Baker, R. R., J. R. Pereira da Silva, and G. Smith: The effect of tobacco ingredients on smoke chemistry. Part II: Casing ingredients; Food Chem. Toxicol. 42S (2004) S39–S52.10.1016/j.fct.2003.08.00915072837Search in Google Scholar

10. Pillsbury, H. C., C. C. Bright, K. J. O'Connor, and F. W. Irish: Tar and nicotine in cigarette smoke; J. Assoc. Off. Anal. Chem. 52 (1969) 458–462.Search in Google Scholar

11. Stevens, N. A. and M. F. Borgerding: GC-AED studies of nicotine fate in a burning cigarette; Anal. Chem. 71 (1999) 2179–2185.Search in Google Scholar

12. Rodgman, A. and T. A. Perfetti: The Chemical Components of Tobacco and Tobacco Smoke; CRC Press. Boca Raton, FL, 2009.10.1201/9781420078848Search in Google Scholar

13. Green, C. R. and A. Rodgman: The Tobacco Chemists’ Research Conference: A half century forum for advances in analytical methodology of tobacco and its products; Rec. Adv. Tob. Sci. 22 (1996) 131–304.Search in Google Scholar

14. Borgerding, M. and H. Klus: Analysis of complex mixtures – Cigarette smoke; Exp. Toxicol. Pathol. 57 (2005) 43–73.Search in Google Scholar

15. Dong, J. Z. and S. C. Moldoveanu: Gas chromatography-mass spectrometry of carbonyl compounds in cigarette mainstream smoke after derivatization with 2, 4-dinitrophenylhydrazine; J. Chromatogr. A 1027 (2003) 25–35.Search in Google Scholar

16. Wang, T. L., H. W. Tong, X. Y. Yan, L. Q. Sheng, J. Yang and S. M. Liu: Determination of volatile carbonyl compounds in cigarette smoke by LC-DAD; Chromatographia 62 (2005) 631–636.Search in Google Scholar

17. Stotesbury, S. J., L. J. Willoughby, and A. Couch: Pyrolysis of Cigarette Ingredients Labeled with Stable Isotopes; Beitr. Tabakforsch. Int. 19 (2000) 55–64.Search in Google Scholar