<abstract xmlns="http://www.w3.org/1999/xhtml"><p> For the estimation of the different methods used for obtaining and fractioning tobacco tars, it is necessary to consider the reactivity of the For the estimation of the different methods used for obtaining and fractioning tobacco tars, it is necessary to consider the reactivity of the individual components and the characteristic action of the entire product. For analytical and biological tests a product is required which has not undergone any important chemical or biochemical changes. It is shown that this important condition has mostly been neglected. The changes likely to occur in the tar during the different smoking and preparation procedures are discussed. It is pointed out that a great number of compounds have been described, in particular in the more recent literature, which are eager to react with other substances and which, being constituents of tobacco smoke, might be responsible for such chemical changes.Several tars were submitted to a limited ageing under different physical conditions. Such simple tests demonstrate the important changes taking place in the original tar when submitted to temperature, light and air and if concentrations in the solvent are too high. On the basis of such general reflections it is concluded that the biological tests described until now require reexamination and that it is necessary to develop and apply such procedures, both for the production and the preparation of tobacco tars, which prevent the formation of artefacts</p></abstract>

For the estimation of the different methods used for obtaining and fractioning tobacco tars, it is necessary to consider the reactivity of the For the estimation of the different methods used for obtaining and fractioning tobacco tars, it is necessary to consider the reactivity of the individual components and the characteristic action of the entire product. For analytical and biological tests a product is required which has not undergone any important chemical or biochemical changes. It is shown that this important condition has mostly been neglected. The changes likely to occur in the tar during the different smoking and preparation procedures are discussed. It is pointed out that a great number of compounds have been described, in particular in the more recent literature, which are eager to react with other substances and which, being constituents of tobacco smoke, might be responsible for such chemical changes.Several tars were submitted to a limited ageing under different physical conditions. Such simple tests demonstrate the important changes taking place in the original tar when submitted to temperature, light and air and if concentrations in the solvent are too high. On the basis of such general reflections it is concluded that the biological tests described until now require reexamination and that it is necessary to develop and apply such procedures, both for the production and the preparation of tobacco tars, which prevent the formation of artefacts

Fundamental Reflections on the Chemical Composition of Tobacco Smoke and its Reactivity Products / Grundsätzliche Überlegungen zur chemischen Zusammensetzung des Tabakrauches und seiner Abscheidungsprodukte

Medizinische Forschungsanstalt der Max-Planck-Gesellschaft, Göttingen, Germany

Contributions to Tobacco & Nicotine Research

This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

For the estimation of the different methods used for obtaining and fractioning tobacco tars, it is necessary to consider the reactivity of the For the...

Fundamental Reflections on the Chemical Composition of Tobacco Smoke and its Reactivity Products / Grundsätzliche Überlegungen zur chemischen Zusammensetzung des Tabakrauches und seiner Abscheidungsprodukte

Online veröffentlicht: 28. Mai 2014

Seitenbereich: 155 - 164

DOI: https://doi.org/10.2478/cttr-2013-0024

© Beiträge zur Tabakforschung International

This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.