This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
Uganda Ministry of Health. National Health Policy: Reducing poverty through promoting people’s health. Knowledge Management Portal; 2009.Search in Google Scholar
Ssenyange CW, Namulindwa A, Oyik B, Ssebuliba J. Plants used to manage type II diabetes mellitus in selected districts of central Uganda. Afr Health Sci. 2015;15:496-502.Search in Google Scholar
Fatoumata B, MamadouSaïdou B, Mohamet S, Joseph KS, Modou MG, El HB. Antidiabetic properties of Moringa oleifera: A review of the literature. J Diabetes Endocrinol. 2020;11:18-29.Search in Google Scholar
Davis NS. Insulin, oral hypoglycemic agents and the pharmacology of the endocrine pancrease: Goodman and Gilman’s “Pharmacological Basis of Therapeutics.” 11th ed. New York: McGraw Hill MedicalPublishing Division; 2006Search in Google Scholar
International Diabetes Federation. Recommendations for managing type 2 diabetes in primary care; 2017.Search in Google Scholar
Pastakia SD, Pekny CR, Manyara SM, Fischer L. Diabetes in sub-Saharan Africa – from policy to practice to progress: Targeting the existing gaps for future care for diabetes. Diabetes Metab Syndr Obes Targets Ther. 2017;10:247-63.Search in Google Scholar
Alebel A, Wondemagegn AT, Tesema C, Kibret GD, Wagnew F, Petrucka P, et al. Prevalence of diabetes mellitus among tuberculosis patients in Sub-Saharan Africa: A systematic review and meta-analysis of observational studies. BMC Infect Dis. 2019;19:254.Search in Google Scholar
Chamberlain JJ, Rhinehart AS, Shaefer CF, Neuman A. Diagnosis and management of diabetes: Synopsis of the 2016 American diabetes association standards of medical care in diabetes. Ann Intern Med. 2016;164:542-52.Search in Google Scholar
Shaw JE, Sicree RA, Zimmet PZ. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract. 2010;87:4-14.Search in Google Scholar
Groenewald AJ, Van Wyk HJ, Walsh CM, Van Zyl S, Van Der Merwe LJ. Prevalence of diabetes mellitus in the rural southern Free State. SAFP. 2009;51:502-5.Search in Google Scholar
Sicree R, Shaw J. Type 2 diabetes: An epidemic or not, and why it is happening. Diabetes Metab Syndr Clin Res Rev. 2007;1:75-81.Search in Google Scholar
Erasmus RT, Soita DJ, Hassan MS, Blanco-Blanco E, Vergotine Z, Kengne AP, et al. High prevalence of diabetes mellitus and metabolic syndrome in a South African coloured population: Baseline data of a study in Bellville, Cape Town. SAMJ. 2012;102:841-4.Search in Google Scholar
Aboua Y, Meyer S, Oguntibeju O. Diabetes mellitus: economic and health burden, treatment and the therapeutical effects of Hypoxis hemerrocallidea plant. Med Technol SA. 2016;30:39-46.Search in Google Scholar
World Health Organization. Traditional medicine strategy 2002-2005. WHO/EDM/TRM/2002.1: Geneva, Switzerland; 2002.Search in Google Scholar
Hall V, Thomsen R, Henriksen O, Lohse N. Diabetes in Sub Saharan Africa 1999-2011: Epidemiology and public health implications. A systematic review. BMC Public Health. 2011;11:564.Search in Google Scholar
Sobngwi E, Mauvais-Jarvis F, Vexiau P, Mbanya JC GJ. Diabetes in Africans. Part 1: epidemiology and clinical specificities. Diabetes Metab J. 2001;27:628-34.Search in Google Scholar
Mbanya JCN, Motala AA, Sobngwi E, Assah FK, Enoru ST. Diabetes in sub-Saharan Africa. Lancet. 2010;375:2254-66.Search in Google Scholar
Kiawi E, Edwards R, Shu J, Unwin N, Kamadjeu R, Mbanya JC. Knowledge, attitudes, and behavior relating to diabetes and its main risk factors among urban residents in Cameroon: A qualitative survey. Ethn Dis. 2006;16:503-9.Search in Google Scholar
Renzaho AMN. Fat, rich and beautiful: Changing socio-cultural paradigms associated with obesity risk, nutritional status and refugee children from sub-Saharan Africa. Heal Place. 2004;10:105-13.Search in Google Scholar
Shirey K, Manyara SM, Atwoli L, Tomlin R, Gakinya B, Cheng S, et al. Symptoms of depression among patients attending a diabetes care clinic in rural western Kenya. J Clin Transl Endocrinol. 2015;2:51-4.Search in Google Scholar
Saxena S, Thornicroft G, Knapp M, Whiteford H. Resources for mental health: scarcity, inequity, and inefficiency. Lancet. 2007;370:878-89.Search in Google Scholar
Lund C, De Silva M, Plagerson S, Cooper S, Chisholm D, Das J, et al. Poverty and mental disorders: Breaking the cycle in low-income and middle-income countries. Lancet. 2011;378:1502-14.Search in Google Scholar
Gill GV, Mbanya JC, Ramaiya KL, Tesfaye S. A sub-Saharan African perspective of diabetes. Diabetologia. 2009;52:8-16.Search in Google Scholar
Chen R, Corona E, Sikora M, Dudley JT, Morgan AA, Moreno-Estrada A, et al. Type 2 diabetes risk alleles demonstrate extreme directional differentiation among human populations, compared to other diseases. PLoS Genet. 2012;8:e1002621.Search in Google Scholar
Corona E, Chen R, Sikora M, Morgan AA, Patel CJ, Ramesh A, et al. Analysis of the genetic basis of disease in the context of worldwide human relationships and migration. PLoS Genet. 2013;9:e1003447.Search in Google Scholar
Osei K, Schuster DP, Amoah AGB, Owusu SK. Pathogenesis of type 1 and type 2 diabetes mellitus in sub-saharan Africa: Implications for transitional populations. J Cardiovasc Risk. 2003;10:85-96.Search in Google Scholar
International Diabetes Federation. Data from: IFD Diabetes Altas Globally; 2017.Search in Google Scholar
Rena G, Hardie DG, Pearson ER. The mechanisms of action of metformin. Diabetologia. 2017;60:1577-85.Search in Google Scholar
Ashcroft F. Mechanisms of the glycaemic effects of sulfonylureas. Horm Metab Res. 1996;28:456-63.Search in Google Scholar
Lee Y, Jun H. Anti-diabetic actions of glucagon-like peptide-1 on pancreatic beta-cells. Metabolism. 2014;63:9-19.Search in Google Scholar
Züger D, Forster K, Lutz TA, Riediger T. Amylin and GLP-1 target different populations of area postrema neurons that are both modulated by nutrient stimuli. Physiol Behav. 2013;112-113:61-9.Search in Google Scholar
Galderisi A, Sherr J, VanName M, Carria L, Zgorski M, Tichy E, et al. Pramlintide but Not Liraglutide Suppresses Meal-Stimulated Glucagon Responses in Type 1 Diabetes. J Clin Endocrinol Metab. 2018;103:1088-94.Search in Google Scholar
Li X, Liu ZQ. Pharmacogenetic factors that affect drug metabolism and efficacy in Type 2 diabetes mellitus. Drug Metab Dis. 2017:157-79.Search in Google Scholar
Omar B, Ahrén B. Pleiotropic mechanisms for the glucose-lowering action of DPP-4 inhibitors. Diabetes. 2014;63:2196-202.Search in Google Scholar
Hsia DS, Grove O, Cefalu WT. An Update on SGLT2 Inhibitors for the treatment of diabetes mellitus. Curr Opin Endocrinol Diabetes Obes. 2017;24:73.Search in Google Scholar
Akmal M, Wadhwa R. Alpha glucosidase inhibitors. Treasure Island (FL): StatPearls Publishing; 2021.Search in Google Scholar
Hauner H. The mode of action of thiazolidinediones. Diabetes Metab Res Rev. 2002;18(Suppl 2).Search in Google Scholar
Ün M, Erbaş O. Pancreatic islet cell transplantation. Demiroglu Sci Univ Florence Nightingale J Transplant. 2019;4:016-22.Search in Google Scholar
Pareek H, Sharma S, Khajja BS, Jain K, Jain GC. Evaluation of hypoglycemic and anti-hyperglycemic potential of Tridax procumbens (Linn). BMC Complement Altern Med. 2009;9:2-8.Search in Google Scholar
Meenakshi P, Bhuvaneshwari R, Rathi MA, Thirumoorthi L, Guravaiah DC, Jiji MJ, et al. Antidiabetic activity of ethanolic extract of Zaleya decandra in alloxan-induced diabetic rats. Appl Biochem Biotechnol. 2010;162:1153-9.Search in Google Scholar
Aba PE, Asuzu IU. Mechanisms of actions of some bioactive anti-diabetic principles from phytochemicals of medicinal plants : A review. Indian J Nat Prod Resour. 2018;9:85-96.Search in Google Scholar
Hui H, Tang G, Go VLW. Hypoglycemic herbs and their action mechanisms. Chin Med. 2009;4:1-11.Search in Google Scholar
Farzaei F, Morovati MR, Farjadmand F, Farzaei MH. A mechanistic review on medicinal plants used for diabetes mellitus in traditional Persian medicine. J Evidence-Based Complement Altern Med. 2017;22:944-55.Search in Google Scholar
Choudhury H, Pandey M, Hua CK, Mun CS, Jing JK, Kong L, et al. An update on natural compounds in the remedy of diabetes mellitus: A systematic review. J Tradit Complement Med. 2018;8:361-76.Search in Google Scholar
WHO. Traditional Medicine; 2008. [http://www.who.int/mediacentre/factsheets/fs134/en/]Search in Google Scholar
WHO. WHO Traditional Medicine Strategy2014-2023. Geneva, Switzerland: WHO Press; 2013.Search in Google Scholar
Thomson M, Al-Qattan KK, Divya JS, Ali M. Anti-diabetic and anti-oxidant potential of aged garlic extract (AGE) in streptozotocin-induced diabetic rats. BMC Complement Altern Med. 2016;16:17.Search in Google Scholar
Tjeck OP, Souza A, Mickala P, Lepengue AN, M’Batchi B. Bio-efficacy of medicinal plants used for the management of diabetes mellitus in gabon: An ethnopharmacological approach. J Intercult Ethnopharmacol. 2017;6:206-17.Search in Google Scholar
Hammeso WW, Emiru YK, Getahun KA, Kahaliw W. Antidiabetic and antihyperlipidemic activities of the Leaf Latex Extract of Aloe megalacantha Baker (Aloaceae) in streptozotocin-induced diabetic model. Evidence-Based Complement Altern Med. 2019;2019. https://doi.org/10.1155/2019/8263786.Search in Google Scholar
Jaiswal YS, Tatke PA, Gabhe SY, Vaidya AB. Antidiabetic activity of extracts of Anacardium occidentale Linn. leaves on n-streptozotocin diabetic rats. J Tradit Complement Med. 2017;7:421-7.Search in Google Scholar
Sunmonu TO, Lewu FB. Phytochemical analysis, in vitro antioxidant activity and inhibition of key diabetic enzymes by selected Nigerian medicinal plants with antidiabetic potential. Indian J Pharm Educ Res. 2019;53:250-60.Search in Google Scholar
Nwauzoma AB, Dappa MS. Ethnobotanical studies of Port Harcourt Metropolis, Nigeria. ISRN Bot. 2013;2013. https://doi.org/10.1155/2013/829424.Search in Google Scholar
Septembre-Malaterre A, Rakoto ML, Marodon C, Bedoui Y, Nakab J, Simon E, et al. Artemisia annua, a traditional plant brought to light. Int J Mol Sci. 2020;21:4986.Search in Google Scholar
Lutgen P, Munyangi J, Idumbo M, Mupenda B. Five case reports on treatment of diabetes by Artemisia annua and Artemisia afra herbal tea. Pharm Pharmacol Int J. 2020;8:79-85.Search in Google Scholar
Issa TO, Mohamed YS, Yagi S, Ahmed RH, Najeeb TM, Makhawi AM, et al. Ethnobotanical investigation on medicinal plants in Algoz area (South Kordofan), Sudan. J Ethnobiol Ethnomed. 2018;14:31.Search in Google Scholar
Umar MB, Kabiru AY, Mann A OE. In vivo antihyperglycaemic activity of crude and partitioned fractions of selected medicinal plants. BIOMED Nat Appl Sci. 2021;01:43-56.Search in Google Scholar
Xuan TD, Khanh TD. Chemistry and pharmacology of Bidens pilosa: an overview. J Pharm Investig. 2016;46:91-132.Search in Google Scholar
Ajagun-Ogunleye MO, Tirwomwe M, Mitaki RN, Ejekwumadu JN, Kasozi KI, Pantoglou J, et al. Hypoglycemic and high dosage effects of Bidens pilosa in Type-1 diabetes mellitus. J Diabetes Mellit. 2015;05:146-54.Search in Google Scholar
Ebenezer AM, Folasade OA, Senga KP. Antidiabetic effect of aqueous extract of ripe Carica papaya Linnaeus seed in alloxan-induced diabetic albino rats. J Diabetes Endocrinol. 2019;10:13-7.Search in Google Scholar
Tsai TH, Wang GJ, Lin LC. Vasorelaxing alkaloids and flavonoids from Cassytha filiformis. J Nat Prod. 2008;71:289-91.Search in Google Scholar
Adamu AA, Garba FN, Ahmed TM, Abubakar A. Pharmacognostic studies and elemental analysis of Cassytha filiformis Linn. J Pharmacogn Phyther. 2017;9:131-7.Search in Google Scholar
Goboza M, Meyer M, Aboua YG, Oguntibeju OO. In vitro antidiabetic and antioxidant effects of different extracts of Catharanthus roseus and its indole alkaloid, vindoline. Molecules. 2020;25. https://doi.org/10.3390/molecules25235546.Search in Google Scholar
Aloke C, Ibiam UA, Obasi NA, Orji OU, Ezeani NN, Aja PM, et al. Effect of ethanol and aqueous extracts of seed pod of Copaifera salikounda (Heckel) on complete Freund’s adjuvant-induced rheumatoid arthritis in rats. J Food Biochem. 2019;43:1-13.Search in Google Scholar
Aloke C, Igwe ES, Obasi NA, Amu PA, Ogbonnia EC. Anti-diabetic effect of ethanol extract of Copaifera salikounda (HECKEL) against alloxan-induced diabetes in rats. Slov Vet Res. 2021;58:63-75.Search in Google Scholar
Merchaoui M, Kthiri Z, Ben Jabeur M, Hamada W. Ethnobotanical and phytopharmacological notes on Cymbopogon citratus (DC.) Stapf. J New Sci. 2018;55:3642-52.Search in Google Scholar
Garba HA, Mohammed A, Ibrahim MA, Shuaibu MN. Effect of lemongrass (Cymbopogon citratus Stapf) tea in a type 2 diabetes rat model. Clin Phytoscience. 2020;6:19.Search in Google Scholar
Boye A, Amoateng P, Koffuor GA, Atsu Barku VY, Bawa EM, Anto OE. Antinociceptive and antioxidant activity of an aqueous root bark extract of Daniellia oliveri (Rolfe) Hutch. & Dalziel (Fam: Leguminosae (Fabaceae)) in ICR mice. J Appl Pharm Sci. 2013;3:36-45.Search in Google Scholar
Temitope O, Fasusi O, Ogunmodede A, Thonda A, Oladejo B, Yusuf-Babatunde A, et al. Phytochemical composition and antimicrobial activity of Daniella oliveri extracts on selected clinical microorganisms. Int J Biochem Res Rev. 2016;14:1-13.Search in Google Scholar
Fasina KA, Adesetan TO, Oseghale F, Egberongbe HO, Aghughu OO, Akpobome FA. Bacteriological and phytochemical assessment of Ficus asperifolia Linn. infusion. Biomed Res Int. 2020;2020.Search in Google Scholar
Nwankwo IU, Ukaegbu-Obi KM. Preliminary phytochemical screening and antibacterial activity of two Nigerian medicinal plants (Ficus asperifolia and Terminalis catappa). J Med Plant Herb Ther Res. 2014;2:1-5.Search in Google Scholar
Kifle ZD, Belayneh YM. Antidiabetic and anti-hyperlipidemic effects of the crude hydromethanol extract of Hagenia abyssinica (Rosaceae) leaves in streptozotocin-induced diabetic mice. Diabetes Metab Syndr Obes Targets Ther. 2020;13:4085-94.Search in Google Scholar
Lee HJ, Wang SC, Lee SF, Wang CJ, Lee CH, Lee WC. Aqueous extract from Hibiscus sabdariffa linnaeus ameliorate diabetic nephropathy via regulating oxidative status and Akt/Bad/14-3-3γ in an experimental animal model. Evid Based Complement Altern Med. 2011;2011. https://doi.org/10.1093/ecam/nep181.Search in Google Scholar
Jabeur I, Pereira E, Barros L, Calhelha RC, Soković M, Oliveira MBPP, et al. Hibiscus sabdariffa L. as a source of nutrients, bioactive compounds and colouring agents. Food Res Int. 2017;100:717-23.Search in Google Scholar
Komoreng L, Thekisoe O, Lehasa S, Tiwani T, Mzizi N, Mokoena N, et al. An ethnobotanical survey of traditional medicinal plants used against lymphatic filariasis in South Africa. South African J Bot. 2017;111:12-6.Search in Google Scholar
Polori KL, Mashele SS, Aremu AO. In vitro anti-diabetic effect and cytotoxicity of South African Ipomoea oblongata. South African J Bot. 2021;142:96-9.Search in Google Scholar
Muhammad I, Alhassan A, Sule M, Idi A, Mohammed A, El-taalu A, et al. Anti-hyperglycemic activity of solvents extract of Khaya senegalensis stem bark in alloxan induced diabetic rats. J Adv Biol Biotechnol. 2016;6:1-8.Search in Google Scholar
Celestine UA, Christopher GB, Innocent OO. Phytochemical profile of stem bark extracts of Khaya senegalensis by Gas Chromatography-Mass Spectrometry (GC-MS) analysis. J Pharmacogn Phyther. 2017;9:35-43.Search in Google Scholar
Mahmoud MF, El Ashry FEZZ, El Maraghy NN, Fahmy A. Studies on the antidiabetic activities of Momordica charantia fruit juice in streptozotocin-induced diabetic rats. Pharm Biol. 2017;55:758-65.Search in Google Scholar
Mbikay M. Therapeutic potential of Moringa oleifera leaves in chronic hyperglycemia and dyslipidemia: A review. Front Pharmacol. 2012;3.Search in Google Scholar
Agnaniet H, Mbot EJ, Keita O, Fehrentz JA, Ankli A, Gallud A, et al. Antidiabetic potential of two medicinal plants used in Gabonese folk medicine. BMC Complement Altern Med. 2016;16:71.Search in Google Scholar
Ibibia ET, Olabisi KN, Oluwagbemiga OS. Gas chromatography-mass spectrometric analysis of methanolic leaf extracts of Lannea kerstingii and Nauclea diderrichii, two medicinal plants used for the treatment of gastrointestinal tract infections. Asian J Pharm Clin Res. 2016;9:179-82.Search in Google Scholar
Casanova LM, Da Silva D, Sola-Penna M, De Magalhães Camargo LM, De Moura Celestrini D, Tinoco LW, et al. Identification of chicoric acid as a hypoglycemic agent from Ocimum gratissimum leaf extract in a biomonitoring in vivo study. Fitoterapia. 2014;93:132-41.Search in Google Scholar
Chinedu OG, Ngozi AK, Naomi AU, Daniel NA, Edith OC, Ekeleme-Egedigwe CA. Preliminary biochemical investigation of bioactive compounds and antibiofilm activity of Ocimum Gratissimum against food-borne microorganisms. Carpathian J Food Sci Technol. 2018;10:19-34.Search in Google Scholar
Ibrahim MA, Habila JD, Koorbanally NA, Islam MS. Butanol fraction of Parkia biglobosa (Jacq.) G. Don leaves enhance pancreatic β-cell functions, stimulates insulin secretion and ameliorates other type 2 diabetes-associated complications in rats. J Ethnopharmacol. 2016;183:103-11.Search in Google Scholar
Abioye EO, Akinpelu DA, Aiyegoro OA, Adegboye MF, Oni MO, Okoh AI. Preliminary phytochemical screening and antibacterial properties of crude stem bark extracts and fractions of Parkia biglobosa (Jacq.). Molecules. 2013;18:8485-99.Search in Google Scholar
Oyedemi SO, Eze K, Aiyegoro OA, Ibeh RC, Ikechukwu GC, Swain SS, et al. Computational, chemical profiling and biochemical evaluation of antidiabetic potential of Parkia biglobosa stem bark extract in type 2 model of rats. J Biomol Struct Dyn. 2021:1-14.Search in Google Scholar
Ezeani NN, Ibiam UA, Orji OU, Igwenyi IO, Aloke C, Alum E, et al. Effects of aqueous and ethanol root extracts of Olax subscopioidea on inflammatory parameters in complete freund’s adjuvant-collagen type II induced arthritic albino rats. Pharmacogn J. 2019;11:16-25.Search in Google Scholar
Akpojotor P, Ebomoyi MI. Effect of hydromethanolic extract of Rauvolfia vomitoria leaf on blood glucose, plasma insulin and histomorphology of the pancreas of streptozotocin-induced diabetic male wistar rats. J African Assoc Physiol Sci. 2021;9:40-7.Search in Google Scholar
Okereke SC, Ijeh II, Arunsi UO. Determination of bioactive constituents of Rauwolfia vomitoria Afzel (Asofeyeje) roots using gas chromatography-mass spectrometry (GC-MS) and Fourier transform infrared spectrometry (FT-IR). African J Pharm Pharmacol. 2017;11:25-31.Search in Google Scholar
Yüce I, Agnaniet H, Morlock GE. New Antidiabetic and Free-Radical Scavenging Potential of Strictosamide in Sarcocephalus pobeguinii Ground Bark Extract via Effect-Directed Analysis. ACS Omega. 2019;4:5038-43.Search in Google Scholar
Farombi EO, Owoeye O. Antioxidative and chemopreventive properties of Vernonia amygdalina and Garcinia biflavonoid. Int J Environ Res Public Health. 2011;8:2533-55.Search in Google Scholar
Hannan JMA, Marenah L, Ali L, Rokeya B, Flatt PR, Abdel-Wahab YHA. Ocimum sanctum leaf extracts stimulate insulin secretion from perfused pancreas, isolated islets and clonal pancreatic β-cells. J Endocrinol. 2006;189:127-36.Search in Google Scholar
Kumar Bharti, Supriya Krishnan AK and AK. Antidiabetic phytoconstituents and their mode of action on metabolic pathways. Ther Adv Endocrinol Metab. 2018;9:81-100.Search in Google Scholar
Zunjar V, Dash RP, Jivrajani M, Trivedi B, Nivsarkar M. Antithrombocytopenic activity of carpaine and alkaloidal extract of Carica papaya Linn. leaves in busulfan induced thrombocytopenic Wistar rats. J Ethnopharmacol. 2016;181:20-5.Search in Google Scholar
Putta S, Sastry Yarla N, Kumar Kilari E, Surekha C, Aliev G, Basavaraju Divakara M, et al. Therapeutic potentials of triterpenes in diabetes and its associated complications. Curr Top Med Chem. 2016;16:2532-42.Search in Google Scholar
Aparna V, Dileep K V., Mandal PK, Karthe P, Sadasivan C, Haridas M. Anti-inflammatory property of n-hexadecanoic acid: Structural evidence and kinetic assessment. Chem Biol Drug Des. 2012;80:434-9.Search in Google Scholar
Ding L, Jin D, Chen X. Luteolin enhances insulin sensitivity via activation of PPARΓ transcriptional activity in adipocytes. J Nutr Biochem. 2010;21:941-7.Search in Google Scholar
Liu Y, Fu X, Lan N, Li S, Zhang J, Wang S, et al. Luteolin protects against high fat diet-induced cognitive deficits in obesity mice. Behav Brain Res. 2014;267:178-88.Search in Google Scholar
McAnuff-Harding MA, Omoruyi FO, Asemota HN. Intestinal disaccharidases and some renal enzymes in streptozotocin-induced diabetic rats fed sapogenin extract from bitter yam (Dioscorea polygonoides). Life Sci. 2006;78:2595-600.Search in Google Scholar
Hao HH, Shao ZM, Tang DQ, Lu Q, Chen X, Yin XX, et al. Preventive effects of rutin on the development of experimental diabetic nephropathy in rats. Life Sci. 2012;91:959-67.Search in Google Scholar
Niture NT, Ansari AA, Naik SR. Anti-hyperglycemic activity of Rutin in streptozotocin-induced diabetic rats: An effect mediated through cytokines, antioxidants and lipid biomarkers. Indian J Exp Biol. 2014;52:720-7.Search in Google Scholar
Coskun O, Kanter M, Korkmaz A, Oter S. Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and β-cell damage in rat pancreas. Pharmacol Res. 2005;51:117-23.Search in Google Scholar
Stewart LK, Wang Z, Ribnicky D, Soileau JL, Cefalu WT, Gettys TW. Failure of dietary quercetin to alter the temporal progression of insulin resistance among tissues of C57BL/6J mice during the development of diet-induced obesity. Diabetologia. 2009;52:514-23.Search in Google Scholar
Abo-Salem OM. Kaempferol attenuates the development of diabetic neuropathic pain in mice: possible anti-inflammatory and anti-oxidant mechanisms. Open Access Maced J Med Sci. 2014;2:424-30.Search in Google Scholar
Al-Numair KS, Chandramohan G, Veeramani C, Alsaif MA. Ameliorative effect of kaempferol, a flavonoid, on oxidative stress in streptozotocin-induced diabetic rats. Redox Rep. 2015;20:198-209.Search in Google Scholar
Vinayagam R, Xiao J, Xu B. An insight into anti-diabetic properties of dietary phytochemicals. Phytochem Rev. 2017;16:535-53.Search in Google Scholar
Vinayagam R, Xu B. Antidiabetic properties of dietary flavonoids: A cellular mechanism review. Nutr Metab. 2015;12:60.Search in Google Scholar
Häkkinen SH, Kärenlampi SO, Heinonen IM, Mykkänen HM, Törronen AR. Content of the flavonols quercetin, myricetin, and kaempferol in 25 edible berries. J Agric Food Chem. 1999;47:2274-9.Search in Google Scholar
Nirmala P, Ramanathan M. Effect of kaempferol on lipid peroxidation and antioxidant status in 1,2-dimethyl hydrazine induced colorectal carcinoma in rats. Eur J Pharmacol. 2011;654:75-9.Search in Google Scholar
An G, Gallegos J, Morris ME. The bioflavonoid kaempferol is an Abcg2 substrate and inhibits Abcg2-mediated quercetin efflux. Drug Metab Dispos. 2011;39:426-32.Search in Google Scholar
Zhang Y, Liu D. Flavonol kaempferol improves chronic hyperglycemia-impaired pancreatic beta-cell viability and insulin secretory function. Eur J Pharmacol. 2011;670:325-32.Search in Google Scholar
Kreft S, Knapp M, Kreft I. Extraction of rutin from buckwheat (Fagopyrum esculentum moench) seeds and determination by capillary electrophoresis. J Agric Food Chem. 1999;47:4649-52.Search in Google Scholar
Huang WY, Zhang HC, Liu WX, Li CY. Survey of antioxidant capacity and phenolic composition of blueberry, blackberry, and strawberry in Nanjing. J Zhejiang Univ Sci B. 2012;13:94-102.Search in Google Scholar
Neuhouser ML. Dietary flavonoids and cancer risk: Evidence from human population studies. Nutr Cancer. 2004;50:1-7.Search in Google Scholar
Miean KH, Mohamed S. Flavonoid (myricetin, quercetin, kaempferol, luteolin, and apigenin) content of edible tropical plants. J Agric Food Chem. 2001;49:3106-12.Search in Google Scholar
Gates MA, Tworoger SS, Hecht JL, De Vivo I, Rosner B, Hankinson SE. A prospective study of dietary flavonoid intake and incidence of epithelial ovarian cancer. Int J Cancer. 2007;121:2225-32.Search in Google Scholar
Alinezhad H, Azimi R, Zare M, Ebrahimzadeh MA, Eslami S, Nabavi SF, et al. Antioxidant and antihemolytic activities of ethanolic extract of flowers, leaves, and stems of Hyssopus officinalis L. Var. angustifolius. Int J Food Prop. 2013;16:1169-78.Search in Google Scholar
Sharma B, Salunke R, Balomajumder C, Daniel S, Roy P. Anti-diabetic potential of alkaloid rich fraction from Capparis decidua on diabetic mice. J Ethnopharmacol. 2010;127:457-62.Search in Google Scholar
Patel OPS, Mishra A, Maurya R, Saini D, Pandey J, Taneja I, et al. Naturally Occurring Carbazole Alkaloids from Murraya koenigii as Potential Antidiabetic Agents. J Nat Prod. 2016;79:1276-84.Search in Google Scholar
Tiong SH, Looi CY, Hazni H, Arya A, Paydar M, Wong WF, et al. Antidiabetic and antioxidant properties of alkaloids from Catharanthus roseus (L.) G. Don. Molecules. 2013;18:9770-84.Search in Google Scholar
Kunyanga CN, Imungi JK, Okoth M, Momanyi C, Biesalski HK, Vadivel V. Antioxidant and Antidiabetic Properties of Condensed Tannins in Acetonic Extract of Selected Raw and Processed Indigenous Food Ingredients from Kenya. J Food Sci. 2011;76:560-7.Search in Google Scholar
Liu X, Kim JK, Li Y, Li J, Liu F, Chen X. Tannic acid stimulates glucose transport and inhibits adipocyte differentiation in 3T3-L1 cells. J Nutr. 2005;135:165-71.Search in Google Scholar
Metwally NS, Mohamed AM, El Sharabasy FS. Chemical constituents of the Egyptian plant Anabasis articulata (Forssk) moq and its antidiabetic effects on rats with streptozotocininduced diabetic hepatopathy. J Appl Pharm Sci. 2012;2:54-65.Search in Google Scholar
Zheng T, Shu G, Yang Z, Mo S, Zhao Y, Mei Z. Antidiabetic effect of total saponins from Entada phaseoloides (L.) Merr. in type 2 diabetic rats. J Ethnopharmacol. 2012;139:814-21.Search in Google Scholar
Shaw D, Graeme L, Pierre D, Elizabeth W, Kelvin C. Pharmacovigi-lance of herbal medicine. J Ethnopharmacol. 2012;140:513-8.Search in Google Scholar
, 