Scutellaria baicalensis – a small plant with large pro-health biological activities

1. Brezniak N, Wasserstein A. Orthodontically induced inflammatory root resorption. Part I: The basic science aspects. Angle Orthod. 2002; 72:175-9.Search in Google Scholar

2. Suh MG, Choi HS, Cho K, Park SS, Kim WJ, Suh HJ, et al. Anti-inflammatory action of herbal medicine comprised of Scutellaria baicalensis and Chrysanthemum morifolium. Biosci Biotechnol Biochem. 2020;84:1799-09.10.1080/09168451.2020.1769464Search in Google Scholar

3. Xia YT, Chana GKL, Wanga HY, Donga TTX, Duan R, Hua WH, et al. The anti-bacterial effects of aerial parts of Scutellaria baicalensis: Potential application as an additive in aquaculture feedings. Aquaculture. 2020;526:735418.10.1016/j.aquaculture.2020.735418Search in Google Scholar

4. Wang ZL, Wang S, Kuang Y, Hu ZM, Qiao X, Ye M. A comprehensive review on phytochemistry, pharmacology, and flavonoid biosynthesis of Scutellaria baicalensis. Pharm Biol. 2018;56:465-86.10.1080/13880209.2018.1492620Search in Google Scholar

5. Gong GW, Wang HY, Kong XP, Duan R, Dong TX, Tsim WK. Flavonoids are identified from the extract of Scutellariae Radix to suppress inflammatory-induced angiogenic responses in cultured RAW 264.7 macrophages. Sci Report. 2018;8:17412.10.1038/s41598-018-35817-2Search in Google Scholar

6. Chan FL, Choi HL, Chen ZY, Chan PS, Huang Y. Induction of apoptosis in prostate cancer cell lines by a flavonoid, baicalin. Cancer Lett. 2000;160:219-28.10.1016/S0304-3835(00)00591-7Search in Google Scholar

7. Cheng F, Lu Y, Zhong X, Song W, Wang X, Sun X, Qin J, et al. Baicalin’s therapeutic time window of neuroprotection during transient focal cerebral ischemia and its antioxidative effects in vitro and in vivo. Evid Complement Alternat Med. 2013, 120261.10.1155/2013/120261370844523878589Search in Google Scholar

8. Cheng CS, Chen J, Tan HY, Wang N, Chen Z, et al. Scutellaria baicalensis and Cancer treatment: recent progress and perspectives in biomedical and clinical studies. Am J Chin Med. 2018;46:25-54.10.1142/S0192415X1850002729316796Search in Google Scholar

9. Song J, Zhou YZ, Panga YY, Gao L, Du GH, Qin XM. The anti-aging effect of Scutellaria baicalensis Georgi flowers extract by regulating the glutamine-glutamate metabolic pathway in D-galactose induced aging rats. Rev Aquac. 2020;134:110843.10.1016/j.exger.2020.11084332045633Search in Google Scholar

10. Ma JL. Study on chemical constituents from stems and leaves of Scutellaria baicalensis. Chin J Exp Trad Med Formulae. 2013;19:147-9.Search in Google Scholar

11. Popova TP, Litvinenko VI, Kovalev IP. Flavones of the roots of Scutellaria baicalensis. Chem Nat Compound. 1973;9:699-702.10.1007/BF00565789Search in Google Scholar

12. Ji S, Li ZW, Song W, Wang YR, Liang WF, Li K, et al. Bioactive constituents of Glycyrrhiza uralensis (licorice): Discovery of the effective components of a traditional herbal medicine. J Nat Product. 2016;79:281-92.10.1021/acs.jnatprod.5b0087726841168Search in Google Scholar

13. Tomimori T, Miyaichi Y, Imoto Y, Kizu HA, Tanabe Y. Studies on the constituents of Scutellaria species II. On the flavonoid constituents of the roots of Scutellaria baicalensis Georgi. Yakugaku Zasshi. 1983;103:607-11.10.1248/yakushi1947.103.6_607Search in Google Scholar

14. Wang HY. Studies on anxiolytic constituents of Scutellaria baicalensis Georgi [dissertation]. Liaoning (Shenyang): Shenyang Pharmaceutical University. 2002. Chinese.Search in Google Scholar

15. Takagi S, Yamaki M, Inoue K. Studies on the water-soluble constituents of the roots of Scutellaria baicalensis Georgi (wogon). Yakugaku Zasshi. 1980;100:1220-4.10.1248/yakushi1947.100.12_1220Search in Google Scholar

16. Tomimori T, Miyaichi Y, Imoto Y, Kizu H, Suzuki C. Studies on the constituents of Scutellaria species. IV. On the flavonoid constituents of the root of Scutellaria baicalensis Georgi. Yakugaku Zasshi. 1984;104:529-34.10.1248/yakushi1947.104.5_529Search in Google Scholar

17. Long HL, Xu GY, Deng AJ, Li ZH, Ma L, Lu Y, et al. Two new flavonoids from the roots of Scutellaria baicalensis. J Asian Nat Product Res. 2015;17:756-60.10.1080/10286020.2014.999048Search in Google Scholar

18. Wang HW, Yin ZF, Li HB, Yuan XX, Yang MM, Zhao GQ. Chemical constituents from stems and leaves of Scutellaria baicalensis. Chin J Exp Trad Med Formulae. 2016;22:41-4.Search in Google Scholar

19. Miyaichi Y, Tomimori T. Studies on the constituents of Scutellaria Species XVII: phenol glycosides of the root of Scutellaria baicalensis Georgi (2). J Nat Med. 1995;49:350-3.Search in Google Scholar

20. Takagi S, Yamaki M, Inoue K. Flavone di-C-glycosides from Scutellaria baicalensis. Phytochemistry. 1981;20:2443-44.10.1016/S0031-9422(00)82692-8Search in Google Scholar

21. Cha JH, Kim HW, Kim S, Jung SH, Whang WK. Antioxidant and antiallergic activity of compounds from the aerial parts of Scutellaria baicalensis Georgi. Yakhak Hoeji. 2006;50:136-43.Search in Google Scholar

22. Ishimaru K, Nishikawa K, Omoto T, Asai I, Yoshihira K, Shimomura K. Two flavone 2’-glucosides from Scutellaria baicalensis. Phytochemistry. 1995;40:279-81.10.1016/0031-9422(95)00200-QSearch in Google Scholar

23. Zhou Y, Hirotani M, Yoshikawa T, Furuya T. Flavonoids and phenylethanoids from hairy root cultures of Scutellaria baicalensis. Phytochemistry. 1997;44:83-7.10.1016/S0031-9422(96)00443-8Search in Google Scholar

24. Miyaichi Y, Tomimori T. Studies on the constituents of Scutellaria species XVI phenol glycosides of the root of Scutellaria baicaleinsis Georgi. J Nat Med. 1994;48:215-8.Search in Google Scholar

25. Ji S, Li R, Wang Q, Miao WJ, Li ZW, Si LL, Qiao X, Yu SW, Zhou DM, Ye M. Anti-H1N1 virus, cytotoxic and Nrf2 activation activities of chemical constituents from Scutellaria baicalensis. J Ethnopharmacol. 2015;176:475-84.10.1016/j.jep.2015.11.01826578185Search in Google Scholar

26. Xu DY, Chen PD, Zhang L, Cao YD, Ding AW. Study on chemical constituents of Scutellaria baicalensis. Chin J Exp Trad Med Formulae. 2011;17:78-80.Search in Google Scholar

27. Xu JX, Ding LQ, Jiang MM, Qiu F. Non-flavonoid constituents from the roots of Scutellaria baicalensis Georgi. Chin J Med Chem. 2016;26:480-3.Search in Google Scholar

28. Liu YX, Liu ZG, Su L, Yang RP, Hao DF, Pei YH. Chemical constituents from Scutellaria baicalensis Georgi. Chin J Med Chem. 2009;19:59-62.Search in Google Scholar

29. Zhu C, Zhao Y, Wu X, Qiang C, Liu J, Shi J, Gou J, et al. The therapeutic role of baicalein in combating experimental periodontitis with diabetes via Nrf2 antioxidant signaling pathway. J Periodont Res. 2020;55:381-91.10.1111/jre.1272231854466Search in Google Scholar

30. Chao J, Xu M, Wang X, Guo, Z. Baicalein-p-sulfonatocalix[n] arenes inclusion complexes: characterization, antioxidant ability and stability. Polym Bull. 2019;76:989-1006.10.1007/s00289-018-2415-xSearch in Google Scholar

31. Sarkar P, Nath K, Banu S. Modulatory effect of baicalein on gene expression and activity of antioxidant enzymes in streptozotocinnicotinamide induced diabetic rats. Braz J Pharm Sci. 2019;55:e18201.10.1590/s2175-97902019000118201Search in Google Scholar

32. Tian Y, Li X, Xie H, Wang X, Xie Y, Chen C, Chen D. Protective mechanism of the antioxidant baicalein toward hydroxyl radical-treated bone marrow-derived mesenchymal stem cells. Molecules. 2018;23:223.10.3390/molecules23010223601729329361712Search in Google Scholar

33. Paudel KR, Kim D.W. Microparticles-mediated vascular inflammation and its amelioration by antioxidant activity of baicalin. Antioxidants. 2020;9:890.10.3390/antiox9090890755560032962240Search in Google Scholar

34. Chao J, Wang X, Xu M, Zuo Y. Characterization and enhanced antioxidant activity of the inclusion complexes of baicalin with p-sulfonatocalix[n]arenes. J Incl Phenom Macrocycl Chem. 2019;93:361-70.10.1007/s10847-019-00887-wSearch in Google Scholar

35. Martínez Medina JJ, Nasob LG, Pérez AL, Rizzi A, Ferrer EG, Williams PAM. Antioxidant and anticancer effects and bioavail-ability studies of the flavonoid baicalin and its oxidovanadium (IV) complex. J Inorg Biochem. 2017;166:150-61.10.1016/j.jinorgbio.2016.11.00527863301Search in Google Scholar

36. Liu Q, Li X, Ouyang X, Chen D. Dual effect of glucuronidation of a pyrogallol-type phytophenol antioxidant: A comparison between scutellarein and scutellarin. Molecules. 2018;23:3225.10.3390/molecules23123225632156530563286Search in Google Scholar

37. Gao L, Tang H, Zeng, Tang T, Chen M, Pu P. The anti-insulin resistance effect of scutellarin may be related to antioxidant stress and AMPKα activation in diabetic mice. Obes Res Clin Pract. 2020;14:368-74.10.1016/j.orcp.2020.06.00532631803Search in Google Scholar

38. Mo J,Yang R, Li F, Zhang X, He B, Zhang Y, Chen P, Shen Z. Scutellarin protects against vascular endothelial dysfunction and prevents atherosclerosis via antioxidation. Phytomedicine. 2018;42:66-74.10.1016/j.phymed.2018.03.02129655699Search in Google Scholar

39. Han YK, Kim H, Shin H, Song J, Lee MK, Park B, Lee KY. Characterization of anti-inflammatory and antioxidant constituents from Scutellaria baicalensis using LC-MS coupled with a bioassay method. Molecules. 2020;25:3617.10.3390/molecules25163617746494232784835Search in Google Scholar

40. Vergun O, Svydenko L, Grygorieva O, Shymanska O, Rakhmetov D, Brindza J, Ivanišová E, Antioxidant capacity of plant raw material of Scutellaria baicalensis Georgi. Potr Slovac J Food Sci. 2019;13:614-21.10.5219/1090Search in Google Scholar

41. Li K, Fan H,Yin P, Yang L, Xue Q, Li X, et al. Structure-activity relationship of eight high content flavonoids analyzed with a preliminary assign-score method and their contribution to antioxidant ability of flavonoids-rich extract from Scutellaria baicalensis shoots. Arab J Chem. 2018;11:159-70.10.1016/j.arabjc.2017.08.002Search in Google Scholar

42. Seo ON, Kim GS, Kim YH, Sung SP, Soo WJ, Jong JL, et al. Determination of polyphenol components of Korean Scutellaria baicalensis Georgi using liquid chromatography – tandem mass spectrometry: Contribution to overall antioxidant activity. J Funct Foods. 2013;5:1741-50.10.1016/j.jff.2013.07.020Search in Google Scholar

43. Peng Y, Guo CS, Li PX, Fu ZZ, Gao LM, Di Y, et al. Immune and Anti-oxidant Functions of Ethanol Extracts of Scutellaria baicalensis Georgi in Mice Bearing U14 Cervical Cancers. Asian Pac J Cancer Prev. 2014;15:4129-33.10.7314/APJCP.2014.15.10.412924935358Search in Google Scholar

44. Jeong K, Shin YC, Park S, Park JS, Kim N, Um JY, et al. Ethanol extract of Scutellaria baicalensis Georgi prevents oxidative damage and neuroinflammation and memorial impairments in artificial senescense mice. J Biomed Sci. 2011;18:14.10.1186/1423-0127-18-14304173421299906Search in Google Scholar

45. Ming J, Zhuoneng L, Guangxun Z. Protective role of flavonoid baicalin from Scutellaria baicalensis in periodontal disease pathogenesis: A literature review. Complement Ther Med. 2018;38:11-8.10.1016/j.ctim.2018.03.01029857875Search in Google Scholar

46. Leung KC, Seneviratne CJ, Li X, Leung PC, Lau CBS, Wong CH, et al. Synergistic antibacterial effects of nanoparticles encapsulated with Scutellaria baicalensis and pure chlorhexidine on oral bacterial biofilms. Nanomaterials (Basel). 2016;6:61.10.3390/nano6040061530255628335189Search in Google Scholar

47. Cao Z, Li C, Zhu G. Inhibitory effects of baicalin on IL-1beta-induced MMP-1/TIMP-1 and its stimulated effect on collagen-1 production in human periodontal ligament cells. Eur J Pharmacol. 2010;641:1-6.10.1016/j.ejphar.2010.04.04220471972Search in Google Scholar

48. Li H, Li G, Liu X, Qiao Y, Cui J, Liu Z. The histological observation of the inhibitory effects of baicalin in lipopolysaccharide-induced periodontitis in rats. J Pract Stomatol. 2016;32:133-4.Search in Google Scholar

49. Chung CP, Park JB, Bae KH. Pharmacological effects of methanolic extract from the root of scutellaria baicalensis and its flavonoids on human gingival fibroblast. Planta Med. 1995;61:150-310.1055/s-2006-9580367753922Search in Google Scholar

50. Doyle SL, O’Neill LA. Toll-like receptors: from the discovery of NF-κB to new insights into transcriptional regulations in innate immunity. Biochem Pharmacol. 2006;72:1102-13.10.1016/j.bcp.2006.07.01016930560Search in Google Scholar

51. Cai X, Li C, Du G, Cao Z. Protective effects of baicalin on ligature-induced periodontitis in rats. J Periodontal Res. 2008;43:14-21.Search in Google Scholar

52. Li Q, Yu Z, Xiao D, Wang Y, Zhao L, An Y, et al. Baicalein inhibits mitochondrial apoptosis induced by oxidative stress in cardiomyocytes by stabilizing MARCH5 expression. J Cell Mol Med. 2020;24:2040-51.10.1111/jcmm.14903699170131880404Search in Google Scholar

53. Jian X, Liu Y, Zhao Z, Zhao L, Wang D, Liu Q. The role of traditional Chinese medicine in the treatment of atherosclerosis through the regulation of macrophage activity. Biomed Pharmacother. 2019;118:109375.10.1016/j.biopha.2019.10937531548175Search in Google Scholar

54. Kim OS, Seo CS, Kim Y, Shin HK, Ha H. Extracts of Scutellariae Radix inhibit low-density lipoprotein oxidation and the lipopolysaccharide-induced macrophage inflammatory response. Mol Med Rep. 2015;12:1335-41.10.3892/mmr.2015.350225815437Search in Google Scholar

55. Wu YH, Chuang LP, Yu CL, Wang SW, Chen HY, Chang YL. Anticoagulant effect of wogonin against tissue factor expression. Eur J Pharmacol. 2019;859:172517.10.1016/j.ejphar.2019.17251731265843Search in Google Scholar

56. Khan S, Kamal M. Can wogonin be used in controlling diabetic cardiomyopathy? Curr Pharm Des. 2019;25:2171-7.10.2174/1381612825666190708173108Search in Google Scholar

57. Wang G, Liang J, Gao LR, Si ZP, Zhang XT, Liang G. et al. Baicalin administration attenuates hyperglycemia-induced malformation of cardiovascular system. Cell Death Dis. 2018;9:1-17.10.1038/s41419-018-0318-2583340529445081Search in Google Scholar

58. Dinda B, Dinda S, DasSharma S, Banik R, Chakraborty A, Dinda M. Therapeutic potentials of baicalin and its aglycone, baicalein against inflammatory disorders. Eur J Med Chem. 2017;131:68-80.10.1016/j.ejmech.2017.03.00428288320Search in Google Scholar