<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Allergenicity of proteins is a subtle property encoded in their structures. The prediction of allergenicity of novel proteins saves time and resources for subsequent experimental work. In the host antigen-presenting cells, the allergens are processed as antigens by the means of Human Leukocyte Antigens (HLA) class II proteins. Sometimes, people allergic to a given protein show allergic reaction to a different protein, even when the two proteins have different routes of exposure. This phenomenon is termed cross-reactivity. Here, we describe a server for allergenicity and cross-reactivity prediction based on the abilities of allergenic proteins to generate binders to HLA class II proteins. The generated peptides are compared to HLA binders originating from known allergens. As a result, the server returns a list of common binders, origin proteins, and species. Different species generate common HLA binders and this determines their cross-reactivity. The server is named AllerScreener and is freely accessible at: <bold><ext-link ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://www.ddg-pharmfac.net/AllerScreener">http://www.ddg-pharmfac.net/AllerScreener</ext-link></bold>.</p></abstract>

Allergenicity of proteins is a subtle property encoded in their structures. The prediction of allergenicity of novel proteins saves time and resources for subsequent experimental work. In the host antigen-presenting cells, the allergens are processed as antigens by the means of Human Leukocyte Antigens (HLA) class II proteins. Sometimes, people allergic to a given protein show allergic reaction to a different protein, even when the two proteins have different routes of exposure. This phenomenon is termed cross-reactivity. Here, we describe a server for allergenicity and cross-reactivity prediction based on the abilities of allergenic proteins to generate binders to HLA class II proteins. The generated peptides are compared to HLA binders originating from known allergens. As a result, the server returns a list of common binders, origin proteins, and species. Different species generate common HLA binders and this determines their cross-reactivity. The server is named AllerScreener and is freely accessible at: http://www.ddg-pharmfac.net/AllerScreener.

AllerScreener – A Server for Allergenicity and Cross-Reactivity Prediction

Cybernetics and Information Technologies

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"AllerScreener \u2013 A Server for Allergenicity and Cross-Reactivity Prediction"}

Allergenicity of proteins is a subtle property encoded in their structures. The prediction of allergenicity of novel proteins saves time and resources for...

AllerScreener – A Server for Allergenicity and Cross-Reactivity Prediction

Online veröffentlicht: 31. Dez. 2020

Seitenbereich: 175 - 184

Eingereicht: 15. Sept. 2020

Akzeptiert: 04. Nov. 2020

DOI: https://doi.org/10.2478/cait-2020-0071

Schlüsselwörter
AllerScreener, allergenicity, cross-reactivity, EpiTOP, EpiDOCK, HLA class II

© 2020 Ivan Dimitrov et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

AllerScreener – A Server for Allergenicity and Cross-Reactivity Prediction

Online veröffentlicht: 31. Dez. 2020

Seitenbereich: 175 - 184

Eingereicht: 15. Sept. 2020

Akzeptiert: 04. Nov. 2020

DOI: https://doi.org/10.2478/cait-2020-0071

SchlüsselwörterAllerScreener, allergenicity, cross-reactivity, EpiTOP, EpiDOCK, HLA class II

© 2020 Ivan Dimitrov et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Schlüsselwörter
AllerScreener, allergenicity, cross-reactivity, EpiTOP, EpiDOCK, HLA class II