Association Between the Polymorphism of Angiotensin-Converting Enzyme Gene and Interleukin-1 Beta Gene and the Response to Erythropoietin Therapy in Dialysis Patients with Anemia
, , , , , , , und | 12. März 2024
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Article Category: Original Article
Online veröffentlicht: 12. März 2024
Seitenbereich: 27 - 34
DOI: https://doi.org/10.2478/bjmg-2023-0022
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© 2023 P Dzekova-Vidimliski et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
The frequency of genotypes of the IL-1B 511 C/T (rs1143627) in all patients and the mean value of ERI in patients with different genotypes of IL-1B 511 C/T.
| Number of patients | % | X ± SD | |
|---|---|---|---|
| 7 | 10.1 | 8.34 ± 3.64 |
|
| 35 | 50.7 | 9.83 ± 6.75 |
|
| 27 | 39.1 | 9.56 ± 5.68 |
|
The frequency of the ACE I/D genotypes (rs1799752) in all patients, and the mean value of ERI in the patients with different genotypes of ACE I/D.
| Number of patients | % | X ± SD | |
|---|---|---|---|
| 10 | 14.5 | 11.87 ± 6.56 |
|
| 41 | 59.4 | 8.42 ± 5.84 |
|
| 18 | 26.1 | 10.92 ± 6.56 |
|
Comparison of demographic characteristics, dialysis vintage, laboratory parameters, and erythropoietin resistance index (ERI) between patients with hemoglobin value <110 g/l and ≥ 110 g/l.
| Age (years) | 58.6 ± 18.3 | 65.1 ± 138 | 0.099 |
| Weight (kg) | 70.8 ± 16.9 | 73.5 ± 15.3 | 0.486 |
| Dialysis vintage (months) | 84.0 ± 79.7 | 104.1 ± 95.9 | 0.351 |
| Hemoglobin (g/l) | 99.9 ± 9.2 | 116.9 ± 4.8 | 0.000 |
| Red blood cell count (1012/l) | 3.3 ± 0.4 | 38. ± 0.2 | 0.000 |
| Hematocrit (rv) | 0.31 ± 0.03 | 0.36 ± 0.02 | 0.000 |
| Alkaline phosphatase (U/L) | 114.4 ± 96.5 | 103.1 ± 53.1 | 0.539 |
| Total protein (g/l) | 68.1 ± 6.5 | 70.3 ± 3.8 | 0.086 |
| Albumin (g/l) | 38.6 ± 5.9 | 40.8 ± 2.7 | 0.044 |
| Calcium (mmol/l) | 2.3 ± 0.2 | 2.4 ± 0.3 | 0.282 |
| Phosphates (mmol/l) | 1.6 ± 0.5 | 1.6 ± 0.5 | 0.494 |
| Cholesterol (mg/dl) | 3.5 ± 0.8 | 4.1 |
0.005 |
| Iron (µmol/l) | 9.7 ± 3.0 | 11.7 ± 2.6 | 0.005 |
| TIBC (µmol/l) |
35.6 ± 9.4 | 38.1± 7.6 | 0.229 |
| TSAI (%) |
27.8 ± 7.9 | 31.4 ± 7.2 | 0.051 |
| Ferritin (ng/ml) | 566.6 ± 529.5 | 437.0 ± 299.7 | 0.210 |
| iPTH (pg/ml) |
560.7 ± 550.5 | 442.9 ± 410.8 | 0.317 |
| CRP(mg/l) |
21.8 ± 34.3 | 8.3 ± 9.9 | 0.025 |
| Erythropoietin (IU/per week) | 8714.6 ± 2982.4 | 5234.6 ± 2836.1 | 0.000 |
| ERI (IU kg/week/g/dl) |
13.5 ± 6.1 | 6.2 ± 3.4 | 0.000 |
Demographic characteristics, dialysis vintage, laboratory parameters, and erythropoietin resistance index (ERI) of all study patients.
| Age (years) | 62.1 | 16.3 |
| Weight (kg) | 72.3 | 16.0 |
| Dialysis vintage (months) | 94.8 | 88.7 |
| Hemoglobin (g/l) | 109.4 | 11.1 |
| Red blood cell count (1012/l) | 3.6 | 0.4 |
| Hematocrit (rv) | 0.34 | 0.04 |
| Alkaline phosphatase (U/L) | 102.3 | 58.3 |
| Total protein (g/l) | 69.5 | 5.2 |
| Albumin (g/l) | 40.2 | 4.2 |
| Calcium (mmol/l) | 2.3 | 0.2 |
| Phosphates (mmol/l) | 1.6 | 0.5 |
| Iron (µmol/l) | 10.9 | 2.9 |
| TIBC (µmol/l) |
37.6 | 8.2 |
| TSAI (%) |
29.4 | 7.6 |
| CRP (mg/l) |
12.1 | 14.2 |
| Ferritin (ng/ml) | 468.8 | 343.1 |
| iPTH (pg/ml) |
499.3 | 490.3 |
| Erythropoietin (IU/per week) | 6909.6 | 3465.7 |
| ERI (IU kg/week/g/dl) |
9.6 | 6.2 |
Comparison of demographic characteristics, dialysis vintage, and laboratory parameters between patients with ERI ≥ 10 and ERI < 10 IU/kg/week/g/dl.
| Age (years) | 59.1 ± 19.7 | 63.9 ± 13.5 | 0.234 |
| Weight (kg) | 68.6 ± 14.1 | 74.6 ± 16.9 | 0.131 |
| Dialysis vintage (months) | 70.6 ± 56.4 | 110.3 ± 102.0 | 0.070 |
| Hemoglobin (g/l) | 100.6 ± 11.4 | 114.4 ± 6.9 | 0.000 |
| Red blood cell count (1012/l) | 3.4 ± 0.4 | 3.7 ± 0.3 | 0.000 |
| Hematocrit (rv) | 0.32 ± 0.04 | 0.35 ± 0.03 | 0.000 |
| Alkaline phosphatase (U/L) | 106.6 ± 66.2 | 109.5 ± 82.4 | 0.879 |
| Total protein (g/l) | 69.1 ± 5.8 | 69.5 ± 4.9 | 0.762 |
| Albumin (g/l) | 39.5 ± 4.9 | 40.0 ±4.37 | 0.639 |
| Calcium (mmol/l) | 2.3 ± 0.3 | 2.3 ± 0.2 | 0.672 |
| Phosphates (mmol/l) | 1.6 ± 0.5 | 1.6 ± 0.5 | 0.940 |
| Cholesterol (mg/dl) | 3.5 ± 0.7 | 3.9 ± 0.9 | 0.045 |
| Iron (µmol/l) | 9.2 ± 2.7 | 11.8 ± 2.6 | 0.000 |
| TIBC (µmol/l) |
36.3 ± 9.3 | 37.4 ± 8.0 | 0.609 |
| TSAI (%) |
26.4 ± 7.5 | 31.8 ± 7.1 | 0.003 |
| Ferritin (ng/ml) | 630.4 ± 555.4 | 412.3 ± 290.4 | 0.038 |
| CRP(mg/l) |
24.2 ± 36.8 | 8.5 ± 9.9 | 0.010 |
| iPTH (pg/ml) |
518.5 ± 511.6 | 483.1 ± 464.3 | 0.770 |
| Erythropoietin (IU/per week) | 9392.1 ± 2496.0 | 5213.4 ± 2811.9 | 0.000 |