Comparative analysis of surgical treatments for GERD in patients with hiatal hernia: Nissen fundoplication, Toupet fundoplication, LINX, and RefluxStop™
This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License.
Granderath, F. A., Schweiger, U. M., Kamolz, T., Asche, K. U., & Pointner, R. (2005). Laparoscopic Nissen fundoplication with prosthetic hiatal closure reduces postoperative intrathoracic wrap herniation: Preliminary results of a prospective randomized functional and clinical study. Archives of Surgery, 140(1), 40–48. https://doi.org/10.1001/archsurg.140.1.40GranderathF. A.SchweigerU. M.KamolzT.AscheK. U.PointnerR. (2005). Laparoscopic Nissen fundoplication with prosthetic hiatal closure reduces postoperative intrathoracic wrap herniation: Preliminary results of a prospective randomized functional and clinical study.Archives of Surgery,140(1), 40–48. https://doi.org/10.1001/archsurg.140.1.40Search in Google Scholar
Watson, D. I., Jamieson, G. G., Pike, G. K., Davies, N., Richardson, M., & Devitt, P. G. (1999). Prospective randomized double-blind trial between laparoscopic Nissen fundoplication and anterior partial fundoplication. British Journal of Surgery, 86(2), 123–130. https://doi.org/10.1046/j.1365-2168.1999.00969.xWatsonD. I.JamiesonG. G.PikeG. K.DaviesN.RichardsonM.DevittP. G. (1999). Prospective randomized double-blind trial between laparoscopic Nissen fundoplication and anterior partial fundo-plication.British Journal of Surgery,86(2), 123–130. https://doi.org/10.1046/j.1365-2168.1999.00969.xSearch in Google Scholar
Qin, M., Ding, G., & Yang, H. (2013). A clinical comparison of laparoscopic Nissen and Toupet fundo-plication for gastroesophageal reflux disease. Journal of Laparoendoscopic & Advanced Surgical Techniques, 23(4), 324–327. https://doi.org/10.1089/lap.2012.0485QinM.DingG.YangH. (2013). A clinical comparison of laparoscopic Nissen and Toupet fundo-plication for gastroesophageal reflux disease.Journal of Laparoendoscopic & Advanced Surgical Techniques,23(4), 324–327. https://doi.org/10.1089/lap.2012.0485Search in Google Scholar
Schwameis, K., Schwameis, M., Zörner, B., Lenglinger, J., Asari, R., Riegler, F. M., & Schoppmann, S. F. (2014). Modern GERD treatment: Feasibility of minimally invasive esophageal sphincter augmentation. Surgical Endoscopy, 28(3), 988–994. https://doi.org/10.1007/s00464-013-3232-3SchwameisK.SchwameisM.ZörnerB.LenglingerJ.AsariR.RieglerF. M.SchoppmannS. F. (2014). Modern GERD treatment: Feasibility of minimally invasive esophageal sphincter augmentation.Surgical Endoscopy,28(3), 988–994. https://doi.org/10.1007/s00464-013-3232-3Search in Google Scholar
Lipham, J. C., DeMeester, T. R., Ganz, R. A., Bonavina, L., Saino, G., Dunn, D. H., Fockens, P., & Bemelman, W. (2012). The LINX reflux management system: Confirmed safety and efficacy now at 4 years. Surgical Endoscopy, 26(10), 2944–2949. https://doi.org/10.1007/s00464-012-2289-1LiphamJ. C.DeMeesterT. R.GanzR. A.BonavinaL.SainoG.DunnD. H.FockensP.BemelmanW. (2012). The LINX reflux management system: Confirmed safety and efficacy now at 4 years.Surgical Endoscopy,26(10), 2944–2949. https://doi.org/10.1007/s00464-012-2289-1Search in Google Scholar
Bjelović, M., Harsányi, L., Altorjay, Á., Kincses, Z., Forsell, P., & Investigators of the RefluxStop™ Clinical Investigation Study Group. (2020). Non-active implantable device treating acid reflux with a new dynamic treatment approach: 1-year results. RefluxStop™ device; a new method in acid reflux surgery obtaining CE mark. BMC Surgery, 20, Article 179. https://doi.org/10.1186/s12893-020-00794-9BjelovićM.HarsányiL.AltorjayÁ.KincsesZ.ForsellP.Investigators of the RefluxStop™ Clinical Investigation Study Group. (2020). Non-active implantable device treating acid reflux with a new dynamic treatment approach: 1-year results. RefluxStop™ device; a new method in acid reflux surgery obtaining CE mark.BMC Surgery,20, Article 179. https://doi.org/10.1186/s12893-020-00794-9Search in Google Scholar
Harsányi, L., Kincses, Z., Zehetner, J., & Altorjay, Á. (2024). Treating acid reflux without compressing the food passageway: 4-year safety and clinical outcomes with the RefluxStop device in a prospective multicenter study. Surgical Endoscopy. https://doi.org/10.1007/s00464-024-11114-0HarsányiL.KincsesZ.ZehetnerJ.AltorjayÁ. (2024). Treating acid reflux without compressing the food passageway: 4-year safety and clinical outcomes with the RefluxStop device in a prospective multicenter study.Surgical Endoscopy. https://doi.org/10.1007/s00464-024-11114-0Search in Google Scholar
Fringeli, Y., Linas, I., Kessler, U., & Zehetner, J. (2024). Laparoscopic large hiatal hernia repair with RefluxStop: Outcomes of six months follow-up in thirty patients. Surgical Laparoscopy, Endoscopy & Percutaneous Techniques, 34(1), e27–e31. https://doi.org/10.1097/SLE.0000000000001256FringeliY.LinasI.KesslerU.ZehetnerJ. (2024). Laparoscopic large hiatal hernia repair with RefluxStop: Outcomes of six months follow-up in thirty patients.Surgical Laparoscopy, Endoscopy & Percutaneous Techniques,34(1), e27–e31. https://doi.org/10.1097/SLE.0000000000001256Search in Google Scholar
Bonavina, L., Saino, G., Lipham, J. C., & DeMeester, T. R. (2013). LINX® Reflux Management System in chronic gastroesophageal reflux: A novel effective technology for restoring the natural barrier to reflux. Therapeutic Advances in Gastroenterology, 6(4), 261–268. https://doi.org/10.1177/1756283X13486311BonavinaL.SainoG.LiphamJ. C.DeMeesterT. R. (2013). LINX® Reflux Management System in chronic gastroesophageal reflux: A novel effective technology for restoring the natural barrier to reflux.Therapeutic Advances in Gastroenterology, 6(4), 261–268. https://doi.org/10.1177/1756283X13486311Search in Google Scholar
Fringeli, Y., Linas, I., Kessler, U., & Zehetner, J. (2024). Short-term results of laparoscopic anti-reflux surgery with the RefluxStop device in patients with gastro-esophageal reflux disease and ineffective esophageal motility. Langenbeck’s Archives of Surgery. https://doi.org/10.1007/s00423-024-03264-5FringeliY.LinasI.KesslerU.ZehetnerJ. (2024). Short-term results of laparoscopic anti-reflux surgery with the RefluxStop device in patients with gastro-esophageal reflux disease and ineffective esophageal motility.Langenbeck’s Archives of Surgery. https://doi.org/10.1007/s00423-024-03264-5Search in Google Scholar
Feka, J., Saad, M., Boyle, N., Paireder, M., Kristo, I., Rieder, E., Asari, R., & Schoppmann, S. F. (2024). Multicentric short term and safety study of ineffective esophageal motility patients treated with Reflux-Stop device. Scientific Reports. https://doi.org/10.1038/s41598-024-67801-wFekaJ.SaadM.BoyleN.PairederM.KristoI.RiederE.AsariR.SchoppmannS. F. (2024). Multicentric short term and safety study of ineffective esophageal motility patients treated with Reflux-Stop device.Scientific Reports. https://doi.org/10.1038/s41598-024-67801-wSearch in Google Scholar
Lehmann, T., Šimkus, M., & Oehler, C. (2024). A retrospective study assessing RefluxStop surgery for gastroesophageal reflux disease: Clinical outcomes in 79 patients from Germany. Surgery Open Science, 12, 100533. https://doi.org/10.1016/j.sopen.2024.12.003LehmannT.ŠimkusM.OehlerC. (2024). A retrospective study assessing RefluxStop surgery for gastroesophageal reflux disease: Clinical outcomes in 79 patients from Germany.Surgery Open Science, 12, 100533. https://doi.org/10.1016/j.sopen.2024.12.003Search in Google Scholar
Dallemagne B, Weerts J, Markiewicz S, Dewandre J-M, Wahlen C, Monami B, Jehaes C. Clinical results of laparoscopic fundoplication at ten years after surgery. Surg Endosc. 2006;20(1):159–165. doi:10.1007/s00464-005-0174-xDallemagneB.WeertsJ.MarkiewiczS.DewandreJ-MWahlenC.MonamiB.JehaesC.Clinical results of laparoscopic fundoplication at ten years after surgery.Surg Endosc. 2006;20(1):159–165. 10.1007/s00464-005-0174-xOpen DOISearch in Google Scholar
Asti E, Bonitta G, Lovece A, Lazzari V, Bonavina L. Longitudinal comparison of quality of life in patients undergoing laparoscopic Toupet fundoplication versus magnetic sphincter augmentation. Medicine (Baltimore). 2016;95(30):e4366. doi:10.1097/MD.0000000000004366AstiE.BonittaG.LoveceA.LazzariV.BonavinaL.Longitudinal comparison of quality of life in patients undergoing laparoscopic Toupet fundoplication versus magnetic sphincter augmentation.Medicine (Baltimore). 2016;95(30):e4366. 10.1097/MD.0000000000004366Open DOISearch in Google Scholar
Louie BE, Farivar AS, Shultz D, Brennan C, Vallieres E, Aye RW. Short-term outcomes using magnetic sphincter augmentation versus Nissen fundoplication for medically resistant gastroesophageal reflux disease. Ann Thorac Surg. 2014;98(2):498–505. doi:10.1016/j.athoracsur.2014.04.074LouieBE.FarivarAS.ShultzD.BrennanC.VallieresE.AyeRW.Short-term outcomes using magnetic sphincter augmentation versus Nissen fundoplication for medically resistant gastroesophageal reflux disease.Ann Thorac Surg. 2014;98(2):498–505. 10.1016/j.athoracsur.2014.04.074Open DOISearch in Google Scholar
Bonavina, L., DeMeester, T., Fockens, P., Dunn, D., Saino, G., Bona, D., Lipham, J., Bemelman, W., & Ganz, R. A. (2010). Laparoscopic sphincter augmentation device eliminates reflux symptoms and normalizes esophageal acid exposure: One-and 2-year results of a feasibility trial. Annals of Surgery, 252(5), 857–862. https://doi.org/10.1097/SLA.0b013e3181fd879bBonavinaL.DeMeesterT.FockensP.DunnD.SainoG.BonaD.LiphamJ.BemelmanW.GanzR. A. (2010). Laparoscopic sphincter augmentation device eliminates reflux symptoms and normalizes esophageal acid exposure: One-and 2-year results of a feasibility trial.Annals of Surgery,252(5), 857–862. https://doi.org/10.1097/SLA.0b013e3181fd879bSearch in Google Scholar
Gray JP. Nissen fundoplication.png [ilustracja]. Public domain. Wikimedia Commons; 2007 [cyt. 2025-06-08]. Dostępny na: https://commons.wikimedia.org/wiki/File:Nissen_fundoplication.pngGrayJP.Nissen fundoplication.png [ilustracja]. Public domain. Wikimedia Commons; 2007 [cyt. 2025-06-08]. Dostępny na: https://commons.wikimedia.org/wiki/File:Nissen_fundoplication.pngSearch in Google Scholar
Tzortzis N, Eleftheriadis E. Evaluation of the efficacy of partial posterior fundoplication (Toupet) in the treatment of GERD. BMC Surg. 2025;25:124. doi:10.1186/s12893-025-02760-9.TzortzisN.EleftheriadisE.Evaluation of the efficacy of partial posterior fundoplication (Toupet) in the treatment of GERD. BMC Surg. 2025;25:124. 10.1186/s12893-025-02760-9.Open DOISearch in Google Scholar
Chen Y, Liu Y, Zhang R, Li X. Long-term outcomes of Toupet fundoplication in GERD patients: a retrospective cohort study. BMC Surg. 2025;25:139. doi:10.1186/s12893-025-02900-1.ChenY.LiuY.ZhangR.LiX.Long-term outcomes of Toupet fundoplication in GERD patients: a retrospective cohort study. BMC Surg. 2025;25:139. 10.1186/s12893-025-02900-1.Open DOISearch in Google Scholar
Zornig, C., Strate, U., Fibbe, C., Emmermann, A., & Layer, P. (2002). Nissen vs Toupet laparoscopic fundoplication: A prospective randomized study of 200 patients with and without preoperative esophageal motility disorders. Surgical Endoscopy, 16(5), 758–766. https://doi.org/10.1007/s00464-001-9092-8ZornigC.StrateU.FibbeC.EmmermannA.LayerP. (2002). Nissen vs Toupet laparoscopic fundoplication: A prospective randomized study of 200 patients with and without preoperative esophageal motility disorders.Surgical Endoscopy, 16(5), 758–766. https://doi.org/10.1007/s00464-001-9092-8Search in Google Scholar