Antibiotic Sensitivity of Staphilococcus Aureus Strains in the Clinical Hospital for Infectious Diseaseas Constanta

Introduction: Staphylococcus are gram-positive bacteria that inhabit both the skin and mucous membranes of both humans and animals.

Antimicrobial susceptibility testing is one of the most important laboratory procedures for infectious disease management.

Material and method: Between January 2017 and June 2019, in the Clinical Infectious Diseases Hospital (CIDH) of Constanta, 331 strains of staphylococcus isolated from various pathological products were identified and tested for antibiotic sensitivity: urine culture, stool culture, pharyngeal / nasal discharge, blood culture, sputum, vomiting fluid and various secretions.

Results: During 2017, 95 strains were isolated from patients hospitalized in CIDH, in 2018: 118, and in the first half of 2019: 124 staphylococcal strains.

An analysis by age groups shows that staphylococcus infection predominates in adults with a total of 196 (59.21%), and in children, less than 18 years: 135 (40.78%). Of the 196 adults, there are immunocompetent patients: 115 (58.67%), immunocompromised by HIV 40 (20.50%), and 19 were hospitalized in the intensive care unit (9.69%).

Regarding the predominant sex in staph infections, the most strains were registered in males: 179 (54.07%) and 152 in females (45.92%).

Out of the total strains of isolated Staphylococcus, 160 (48.33%) of Staphylococcus aureus were identified, of which methycillin resistant staphylococcus aureus (MRSA) 43 (26.87%).

Testing for Staphylococcus aureus strains with Oxacillin showed that 45 (28.12%) were resistant, Rifampicin 26 (16.25%) was resistant, Fluoroquinolones 29 (18.12%), and Cotrimoxazole / Sulfamethoxazole 27 (16.87%) of the strains were resistant.

Conclusions: There is a relatively high resistance to Oxacillin of Staphylococcus aureus strains and a relatively low resistance to fluoroquinolones, Rifampicin and Cotrimoxazole / Sulfamethoxazole, over the years studied.