25 Nov 2011
4 Hefte pro Jahr
Open Access

The efficacy of applying some plants and herbs in cancer therapy for humans and animals – a comperhensive review

25 Nov 2011
4 Hefte pro Jahr

Abd El-Hack M.E., Alagawany M., Arif M., Emam M., Saeed M., Arain M.A., Khan R.U. (2018). The uses of microbial phytase as a feed additive in poultry nutrition – a review. Ann. Anim. Sci., 18: 639-658. Search in Google Scholar

Abd El-Hack M.E., Alagawany M., Farag M.R., Tiwari R., Karthik K., Dhama K. (2016). Nutritional, healthical and therapeutic efficacy of black cumin (Nigella sativa) in animals, poultry and humans. Int. J. Pharmacol, 12: 232-248. Search in Google Scholar

Abd El-Hack M.E., Shafi M.E., Alghamdi W.Y., Abdelnour S.A., Shehata A.M., Ragni M. (2020). Black soldier fly (Hermetia illucens) meal as a promising feed ingredient for poultry: A comprehensive review. Agriculture, 10: 339. Search in Google Scholar

Abd El-Hack M.E., El-Saadony M.T., Shehata A.M., Arif M., Paswan V.K., Elbestawy A.R. (2021). Approaches to prevent and control Campylobacter spp. colonization in broiler chickens: a review. Environ. Sci. Poll. Res., 28: 4989-5004. Search in Google Scholar

Abdel-Moneim A.M.E., Shehata A.M., Alzahrani S.O., Shafi M.E., Mesalam N.M., Taha A. E., Abd El-Hack M.E. (2020). The role of polyphenols in poultry nutrition. J. Anim. Physiol. Anim. Nutr., 104: 1851-1866. Search in Google Scholar

Alagawany M., Abd El-Hack M.E., El-Kholy M.S. (2016). Productive performance, egg quality, blood constituents, immune functions, and antioxidant parameters in laying hens fed diets with different levels of Yucca schidigera extract. Environ. Sci. Poll. Res., 23: 6774-6782. Search in Google Scholar

Alagawany M., Abd El-Hack M.E., Laudadio V., Tufarelli V. (2014). Effect of low-protein diets with crystalline amino acid supplementation on egg production, blood parameters and nitrogen balance in laying Japanese quails. Avian Biol. Res., 7: 235-243. Search in Google Scholar

Al-Dalaen S. (2014). Carcinogen metabolizing enzymes: modulation of their activities in liver, lung and stomach by thymoquinone. European J. Med. Plants., 4(4): 383–393. Search in Google Scholar

Alesiani D., Canini A., D’Abrosca B., DellaGreca M., Fiorentino A., Mastellone C., Pacifico, S. (2010). Antioxidant and antiproliferative activities of phytochemicals from Quince (Cydonia vulgaris) peels. Food Chem., Elsevier, 118(2).10.1016/j.foodchem.2009.04.098 Search in Google Scholar

Al-Oqail M.M., Al-Sheddi E.S., Al-Massarani S.M., Siddiqui M.A., Ahmad J., Musarrat J., Farshori N. (2017) Nigella sativa seed oil suppresses cell proliferation and induces ROS dependent mitochondrial apoptosis through p53 pathway in hepatocellular carcinoma cells. South African J. Botany., 112: 70–78.10.1016/j.sajb.2017.05.019 Search in Google Scholar

AlRawi S.N., Fetters M.D. (2012). Traditional Arabic & Islamic Medicine: A Conceptual Model for Clinicians and Researchers. Glob. J. Health Sci., 4(3). doi: 10.5539/gjhs.v4n3p164. DOI öffnenSearch in Google Scholar

Arshad Qamar K., Dar A., Siddiqui B., Kabir N., Aslam H., Ahmed S., Begum, S. (2010). Anticancer activity of Ocimum basilicum and the effect of ursolic acid on the cytoskeleton of MCF-7 human breast cancer cells. Lett. Drug Des. Dis., 7(10): 726–736. Search in Google Scholar

Ashour A.E., Abd-Allah A.R., Korashy H.M., Attia S.M., Alzahrani A.Z., Saquib Q., Rishi A.K. (2014). Thymoquinone suppression of the human hepatocellular carcinoma cell growth involves inhibition of IL-8 expression, elevated levels of TRAIL receptors, oxidative stress and apoptosis. Mol. Cell. Biochem. 389(1–2): 85–98. Search in Google Scholar

Awad E.M. (2005). In vitro decreases of the fibrinolytic potential of cultured human fibrosarcoma cell line, HT1080, by Nigella sativa oil. Phytomed. 12(1–2): 100–107. doi: 10.1016/j.phymed.2003.09.003. DOI öffnenSearch in Google Scholar

Bassiri-Jahromi S. (2018). Punica granatum (Pomegranate) activity in health promotion and cancer prevention. Oncology Rev.,12(1). doi: 10.4081/oncol.2018.345. DOI öffnenSearch in Google Scholar

Behbahan M. (2014). Evaluation of in vitro anticancer activity of Ocimum basilicum, Alhagi Maurorum, Calendula Officinalis and their parasite cuscuta campestris. PLoSOne., 9(12): e116049. doi: 10.1371/journal.pone.0116049. DOI öffnenSearch in Google Scholar

Caliskan O. (2015). Mediterranean figs (Ficus carica L.) functional food properties. The Mediterranean Diet. Academic Press, 629–637. doi: 10.1016/B978-0-12-407849-9.00056-7. DOI öffnenSearch in Google Scholar

Capasso A. (2013). Antioxidant action and therapeutic efficacy of Allium sativum L. Molecules., 18(1): 690–700. Search in Google Scholar

Carvalho M., Silva B.M., Silva R., Valentao P., Andrade P.B., Bastos M.L. (2010). First Report on Cydonia oblonga miller anticancer potential: differential antiproliferative effect against human kidney and colon cancer cells. J. Agric. Food Chem. 58(6): 3366–3370. Search in Google Scholar

Chan J.M. (2005). Vegetable and fruit intake and pancreatic cancer in a population-based case-control study in the San Francisco Bay area. Cancer Epidemiol. Biomar. Preven., 14(9): 2093–2097. Search in Google Scholar

Chawla A., Kaur R., Sharma A. (2012). Ficus carica Linn: A review on its pharmacognostic, phytochemical and pharmacological aspects. Inter. J. Pharm. Phytopharmacol. Res., 1: 215–232. Search in Google Scholar

Chehl N., Chipitsyna G., Gong Q., Yeo C.J., Arafat H.A. (2009). Anti-inflammatory effects of the Nigella sativa seed extract, thymoquinone, in pancreatic cancer cells. Hpb, 11(5): 373–381. Search in Google Scholar

Chen Y.K., Lee C.H., Wu I.C., Liu J.S., Wu D.C., Lee J.M., Wu M.T. (2009). Food intake and the occurrence of squamous cell carcinoma in different sections of the esophagus in Taiwanese men. Nutrition, 25(7–8): 753–761. Search in Google Scholar

Colín-González A.L., Santana R.A., Silva-Islas C.A., Chánez-Cárdenas M.E., Santamaría A., Maldonado P.D. (2012). The antioxidant mechanisms underlying the aged garlic extract- and S-Allylcysteine-Induced protection. Oxidative Med. Cell. Long.1–16.10.1155/2012/907162 Search in Google Scholar

Conforti F., Menichini G., Zanfini L., Tundis R., Statti G.A., Provenzano E., Alfano C. (2012). Evaluation of phototoxic potential of aerial components of the fig tree against human melanoma. Cell Prolifer. 45(3): 279–285. doi:10.1111/j.1365-2184.2012.00816.x Search in Google Scholar

Cooksey C. (2012). An annotated bibliography of recent significant publications on indigo and related compounds. Biotech. Histochem. 87(7): 439–463. Search in Google Scholar

Costa R.M., Magalhães A.S., Pereira J.A., Andrade P.B., Valentão P., Carvalho M., Silva B. M. (2009). Evaluation of free radical-scavenging and antihemolytic activities of quince (Cydonia oblonga) leaf: a comparative study with green tea (Camellia sinensis). Food Chem. Toxicol. 47: 860-865. Search in Google Scholar

da Silva J.A.T., Hussain A.I. (2017). Citrullus colocynthis (L.) Schrad. (colocynth): Biotechnological perspectives. Emir. J. Food Agric., 83-90. Search in Google Scholar

Dahlaw H., Jordan-Mahy N., Clench M., McDougall G.J., Le Maitre C.L. (2013). Polyphenols are responsible for the proapoptotic properties of pomegranate juice on leukemia cell lines. Food Sci Nutr., 1(2): 196-208. Search in Google Scholar

Deering K., Nethery W., Averill C., Esposito E. (2017). Effects of Thyme essential oil chemotypes on breast and cervical cancer cell lineages. Ann. Pharmacol. Pharmacother: 2: 1-3. Search in Google Scholar

Dhanjal D.S., Chopra C., Singh R. (2021). Himalayan Herbal Medicine for Cancer. Modern Cancer Therapies and Traditional Medicine: An Integrative Approach to Combat Cancers, 268. Search in Google Scholar

Dilshad A., Abulkhair O., Nemenqani D., Tamimi W. (2012). Antiproliferative properties of methanolic extract of Nigella sativa against the MDA-MB-231 cancer cell line. Asian. Pac. J. Cancer Prev., 13(11): 5839-5842. Search in Google Scholar

Dosoky W.M., Zeweil H.S., Ahmed M.H., Zahran S.M., Shaalan M.M., Abdelsalam N.R., Abdel-Moneim E.A., Taha A.E., El-Tarabily K.A., Abd El-Hack M.E. (2021). Impacts of onion and cinnamon supplementation as natural additives on the performance, egg quality, and immunity in laying Japanese quail. Poult. Sci., 100(12): 101482. Search in Google Scholar

Effenberger K., Breyer S., Schobert R. (2010). Terpene conjugates of the Nigella sativa seed-oil constituent thymoquinone with enhanced efficacy in cancer cells. Chem. Biodivers., 7(1): 129-139. Search in Google Scholar

Eja, M. E., Asikong, B. E., Abriba, C., Arikpo, G. E., Anwan, E. E., Enyi-Idoh, K. H. (2007). A comparative assessment of the antimicrobial effects of garlic (Allium sativum) and antibiotics on diarrheagenic organisms. Southeast Asian J. Trop. Med. Public Health., 38(2): 343. Search in Google Scholar

Elbarbry F., Ragheb A., Marfleet T., Shoker A. (2012). Modulation of hepatic drug metabolizing enzymes by dietary doses of thymoquinone in female New Zealand White rabbits. Phytother. Res., 26(11): 1726-1730. Search in Google Scholar

El-Far A.H., Korshom M.A., Mandour A.A., El-Bessoumy A.A., El-Sayed Y.S. (2017). Hepatoprotective efficacy of Nigella sativa seeds dietary supplementation against lead acetate-induced oxidative damage in rabbit–purification and characterization of glutathione peroxidase. Biomed. Pharmacother., 89: 711-718. Search in Google Scholar

El-Far A.H., Oyinloye B.E., Sepehrimanesh M., Allah M.A.G., Abu-Reidah I., Shaheen H. M., Razeghian-Jahromi I., Alsenosy A.A., Noreldin A.E., Al Jaouni S.K, Mousa S.A. (2019). Date palm (Phoenix dactylifera): novel findings and future directions for food and drug discovery. Curr. Drug Discov. Technol., 16(1): 2-10. Search in Google Scholar

El-Far H.A. (2015). Thymoquinone anticancer discovery: possible mechanisms. Curr. Drug Discov. Technol., 12(2): 80-89. Search in Google Scholar

El-Far H.A., Badria A.F., Shaheen M.H. (2016). Possible anticancer mechanisms of some Costus speciosus active ingredients concerning drug discovery. Curr. Drug Discov.Technol., 13(3): 123-143. Search in Google Scholar

El-Hallouty S.M., Fayad W., Meky N.H., EL-Menshawi B.S., Wassel G.M., Hasabo A.A. (2015). In vitro anticancer activity of some Egyptian plant extracts against different human cancer cell lines. Int. J. Pharm. Tech. Res., 8: 267-272. Search in Google Scholar

El-Najjar N., Chatila M., Moukadem H., Vuorela H., Ocker M., Gandesiri M., Schneider-Stock R., Gali-Muhtasib H. (2010). Reactive oxygen species mediate thymoquinone-induced apoptosis and activate ERK and JNK signaling. Apoptosis, 15(2): 183-195. Search in Google Scholar

El-Sayed W.M. (2011). Upregulation of chemoprotective enzymes and glutathione by Nigella sativa (black seed) and thymoquinone in CCl4-intoxicated rats. Int. J. Toxicol., 30(6): 707-714. Search in Google Scholar

Ercisli S., Gadze J., Agar G., Yildirim N., Hizarci Y. (2011). Genetic relationships among wild pomegranate (Punica granatum) genotypes from Coruh Valley in Turkey. Genet. Mol. Res., 10(1): 459-464. Search in Google Scholar

Esmaeilbeig M., Kouhpayeh S.A., Amirghofran Z. (2015). An investigation of the growth inhibitory capacity of several medicinal plants from Iran on tumor cell lines. Iran. J. Cancer Prev., 8(5). Search in Google Scholar

Fadavi A., Barzegar M., Azizi M.H., Bayat M. (2005). Note. Physicochemical composition of ten pomegranate cultivars (Punica granatum L.) grown in Iran. Food Sci. Tech. Inter., 11(2): 113-119. Search in Google Scholar

Farah I.O., Begum R.A. (2003). Effect of Nigella sativa (N. sativa L.) and oxidative stress on the survival pattern of MCF-7 breast cancer cells. Biomed. Sci. Instrum., 39: 359-364. Search in Google Scholar

Fattouch S., Caboni P., Coroneo V., Tuberoso C.I., Angioni A., Dessi S., Marzouki N., Cabras P. (2007). Antimicrobial activity of Tunisian quince (Cydonia oblonga Miller) pulp and peel polyphenolic extracts. J. Agric. Food Chem., 55(3): 963-969. Search in Google Scholar

Fukushima S., Takada N., Hori T., Wanibuchi H. (1997). Cancer prevention by organosulfur compounds from garlic and onion. J. Cell Biochem. Suppl. 27:100-5. Search in Google Scholar

Galeone C., Pelucchi C., Levi F., Negri E., Franceschi S., Talamini R., Giacosa A., La Vecchia C. (2006). Onion and garlic use and human cancer. Am. J. Clin. Nutr., 84(5):1027-32. Search in Google Scholar

Gali-Muhtasib H., Diab-Assaf M., Boltze C., Al-Hmaira J., Hartig R., Roessner A., Schneider-Stock R. (2004). Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via a p53-dependent mechanism. Int. J. Oncol., 25(4) : 857-866. Search in Google Scholar

Gali-Muhtasib H., Kuester D., Mawrin C., Bajbouj K., Diestel A., Ocker M., Habold C., Foltzer-Jourdainne C., Schoenfeld P., Peters B., Diab-Assaf M., Pommrich U., Itani W., Lippert H., Roessner A., Schneider-Stock R. (2008). Thymoquinone triggers inactivation of the stress response pathway sensor CHEK1 and contributes to apoptosis in colorectal cancer cells. Cancer Res., 68(14): 5609-5618. Search in Google Scholar

Gan F.F., Nagle A.A., Ang X., Ho O.H., Tan S.H., Yang H., Chew E.H. (2011). Shogaols at proapoptotic concentrations induce G2/M arrest and aberrant mitotic cell death associated with tubulin aggregation. Apoptosis, 16(8): 856-867. Search in Google Scholar

Gebriel W. (2011). International Institute for Science, Technology and Education (IISTE). Available at: https://www.iiste.org/Journals/index.php/JBAH/article/view/15162 (Accessed: 28 November 2018). Search in Google Scholar

Grayer R.J., Kite G.C., Veitch N.C., Eckert M.R., Marin P.D., Senanayake P., Paton A.J. (2002). Leaf flavonoid glycosides as chemosystematic characters in Ocimum. Biochem. Syst. Ecol., 30(4): 327-342. Search in Google Scholar

Gurung R.L., Lim S.N., Khaw A.K., Soon J.F.F., Shenoy K., Mohamed A.S., Jayapal M., Sethu S., Baskar R., Hande M.P. (2010). Thymoquinone induces telomere shortening, DNA damage and apoptosis in human glioblastoma cells. PloS one, 5(8): e12124. Search in Google Scholar

Hajhashemi V., Ghannadi A., Jafarabadi H. (2004). Black cumin seed essential oil, as a potent analgesic and antiinflammatory drug. Phytoth. Res., 18(3): 195-199. Search in Google Scholar

Han R. (1994). Highlight on the studies of anticancer drugs derived from plants in China. Stem cells, 12(1): 53-63. Search in Google Scholar

Hanahan D.,Weinberg R.A. (2000). The Hallmarks of Cancer, Cell, 100(1): 57–70.10.1016/S0092-8674(00)81683-9 Search in Google Scholar

Heo B.G., Jang H.G., Cho J.Y., Namiesnik J., Jastrzebski Z., Vearasilp K., González-Águilar G. A., Martinez-Ayala A.L., Suhaj M., Gorinstein S. (2013). Partial characterization of indigo (Polygonum tinctorium Ait.) plant seeds and leaves. Ind. Crops Prod., 42 :429-439. Search in Google Scholar

Heo B.G., Park Y.J., Lee S.J., Kim K.S., Cho J.Y., Boo H.O. (2012). Antioxidant enzyme activity and antimicrobial activity of Isatis tinctoria extract. Korean J. Plant Res., 25(5): 543-549. Search in Google Scholar

Heo B.G., Park Y.J., Park Y.S., Bae J.H., Cho J.Y., Park K., Jastrzěbski Z., Gorinstein S. (2014). Anticancer and antioxidant effects of extracts from different parts of indigo plant. Ind. Crops Prod., 56: 9-16. Search in Google Scholar

Herre E.A., Jandér K.C., Machado C.A. (2008). Evolutionary ecology of figs and their associates: recent progress and outstanding puzzles. Annu. Rev. Ecol. Evol., 439-458.10.1146/annurev.ecolsys.37.091305.110232 Search in Google Scholar

Hsing A.W., Chokkalingam A.P., Gao Y.T., Madigan M.P., Deng J., Gridley G., Fraumeni Jr J.F. (2002). Allium vegetables and risk of prostate cancer: a population-based study. J. Natl. Cancer Inst., 94(21): 1648-1651. Search in Google Scholar

Huang H.C., Ho Y.C., Lim J.M., Chang T.Y., Ho C.L., Chang T.M. (2015). Investigation of the anti-melanogenic and antioxidant characteristics of Eucalyptus camaldulensis flower essential oil and determination of its chemical composition. Int. J. Mol. Sci.,16(5): 10470-10490. Search in Google Scholar

Husari A., Hashem Y., Zaatari G., El Sabban M. (2017). Pomegranate juice prevents the formation of lung nodules secondary to chronic cigarette smoke exposure in an animal model. Oxid. Med. Cell. Longev., 2017 :6063201. Search in Google Scholar

Iddamaldeniya S.S., Wickramasinghe N., Thabrew I., Ratnatunge N., Thammitiyagodage M.G. (2003). Protection against diethylnitrosoamine-induced hepatocarcinogenesis by an indigenous medicine comprised of Nigella sativa, Hemidesmus indicus and Smilax glabra: a preliminary study. J. Carcinog., 2(1): 6. Search in Google Scholar

Ismaili H., Sosa S., Brkic D., Fkih-Tetouani S., Ilidrissi A., Touati D., Aquino R.P., Tubaro A. (2002). Topical anti-inflammatory activity of extracts and compounds from Thymus broussonettii. J. Pharm. Pharmacol., 54(8): 1137-1140. Search in Google Scholar

Jafri S.H., Glass J., Shi R., Zhang S., Prince M., Kleiner-Hancock H. (2010). Thymoquinone and cisplatin as a therapeutic combination in lung cancer: In vitro and in vivo. J. Exp. Clin. Cancer Res., 29(1): 1-11. Search in Google Scholar

Jang H.G., Heo B.G., Park Y.S., Namiesnik J., Barasch D., Katrich E., Vearasilp K., Trakhtenberg S., Gorinstein S. (2012). Chemical composition, antioxidant and anticancer effects of the seeds and leaves of indigo (Polygonum tinctorium Ait.) plant. Appl. Biochem, Biotechnol., 167(7): 1986-2004. Search in Google Scholar

Jasmine, R., Manikandan, K., Karthikeyan, K. (2015). Evaluating the antioxidant and anticancer property of Ficus carica fruits. Afr. J. Biotechnol., 14(7), 634-641.10.5897/AJB2014.13742 Search in Google Scholar

Jeune M.A., Kumi-Diaka J., Brown J. (2005). Anticancer activities of pomegranate extracts and genistein in human breast cancer cells. J. Med. Food, 8(4): 469–475. Search in Google Scholar

Jiang H., Xie Z., Koo H.J., McLaughlin S.P., Timmermann B.N., Gang D.R. (2006). Metabolic profiling and phylogenetic analysis of medicinal Zingiber species: Tools for authentication of ginger (Zingiber officinale Rosc.). Phytochem., 67(15): 1673-1685. Search in Google Scholar

Jing L., Zhang Y.M., Luo J.G., Kong L.Y. (2015). Tirucallane-type triterpenoids from the fruit of Ficus carica and their cytotoxic activity. Chem. Pharm. Bull., 63(3): 237-243. Search in Google Scholar

Jolad S.D., Lantz R.C., Solyom A.M., Chen G.J., Bates R.B., Timmermann B.N. (2004). Fresh organically grown ginger (Zingiber officinale): composition and effects on LPS-induced PGE2 production. Phytochem., 65(13): 1937-1954. Search in Google Scholar

Joseph M.M., Aravind S.R., Varghese S., Mini S., Sreelekha T.T. (2012). Evaluation of antioxidant, antitumor and immunomodulatory properties of polysaccharide isolated from fruit rind of Punica granatum. Mol. Med. Rep., 5(2): 489-496. Search in Google Scholar

Jrah-Harzallah H., Ben-Hadj-Khalifa S., Maloul A., El-Ghali R., Mahjoub T. (2013). Thymoquinone effects on DMH-induced erythrocyte oxidative stress and haematological alterations during colon cancer promotion in rats. J. Funct. Foods, 5(3):10.1016/j.jff.2013.04.017 Search in Google Scholar

Jurenka J. (2008). Therapeutic applications of pomegranate (Punica granatum L.): a review. Altern. Med. Rev., 13(2): 128–144. Search in Google Scholar

Kameswaran T.R., Ramanibai R. (2008). The antiproliferative activity of flavanoidal fraction of Indigofera tinctoria is through cell cycle arrest and apoptotic pathway in A-549 cells. J. Biol. Sci., 3(3): 584. Search in Google Scholar

Kaplan M., Hayek T., Raz A., Coleman R., Dornfeld L., Vaya J., Aviram M. (2001). Pomegranate juice supplementation to atherosclerotic mice reduces macrophage lipid peroxidation, cellular cholesterol accumulation and development of atherosclerosis. J. Nutr., 131(8): 2082-2089. Search in Google Scholar

Karthikeyan, K., Gunasekaran, P., Ramamurthy, N., Govindasamy, S. (1999). Anticancer activity of Ocimum sanctum. Pharm. Biol., 37(4): 285-290. Search in Google Scholar

Khafaga A.F., Abd El-Hack M.E., Taha A.E., Elnesr S.S., Alagawan, M. (2019). The potential modulatory role of herbal additives against Cd toxicity in human, animal, and poultry: a review. Environ. Sci. Pollut. Res., 26(5): 4588-4604. Search in Google Scholar

Khan A.W., Farooq M., Haseeb M., Choi S. (2022). Role of plant-derived active constituents in cancer treatment and their mechanisms of action. Cells, 11(8), 1326.10.3390/cells11081326903106835456005 Search in Google Scholar

Khan N., Afaq F., Mukhtar H. (2008). Cancer chemoprevention through dietary antioxidants: progress and promise. Antioxid. Redox Signal., 10(3): 475-510. Search in Google Scholar

Khan N., Hadi N., Afaq F., Syed D.N., Kweon M.H., Mukhtar H. (2007). Pomegranate fruit extract inhibits prosurvival pathways in human A549 lung carcinoma cells and tumor growth in athymic nude mice. Carcinogen., 28(1): 163-173. Search in Google Scholar

Khare C.P. (2004). Encyclopedia of Indian medicinal plants. NewYork: Springes-Verlag Berlin Heidelberg. Search in Google Scholar

Khodarahmi G.A., Ghasemi N., Hassanzadeh F., Safaie M. (2011). Cytotoxic effects of different extracts and latex of Ficus carica L. on HeLa cell line. ran. J. Pharm. Sci., 10(2): 273. Search in Google Scholar

Kim M.O., Lee M.H., Oi N., Kim S.H., Bae K.B., Huang Z., Kim D.J., Reddy K., Lee S.Y., Park S.J., Kim J.Y., Xie H., Kundu J.K., Ryoo Z.Y., Bode A.M., Surh Y.J., Dong Z. (2014). [6]-Shogaol inhibits growth and induces apoptosis of non-small cell lung cancer cells by directly regulating Akt1/2. Carcinogen., 35(3): 683-691. Search in Google Scholar

Kim Y.H., Choi E.M. (2009). Stimulation of osteoblastic differentiation and inhibition of interleukin-6 and nitric oxide in MC3T3-E1 cells by pomegranate ethanol extract. Phytother. Res., 23(5): 737-739. Search in Google Scholar

Kluth D., Banning A., Paur I., Blomhoff R., Brigelius-Flohé R. (2007). Modulation of pregnane X receptor-and electrophile responsive element-mediated gene expression by dietary polyphenolic compounds. Free Radic. Biol. Med., 42(3): 315-325. Search in Google Scholar

Koeduka T., Fridman E., Gang D.R., Vassão D.G., Jackson B.L., Kish C.M., Orlova I., Spassova S.M., Lewis N.G., Noel J.P., Baiga T.J., Dudareva N., Pichersky E. (2006). Eugenol and isoeugenol, characteristic aromatic constituents of spices, are biosynthesized via reduction of a coniferyl alcohol ester. Proc. Nat. Acad. Sci., 103(26): 10128-10133. Search in Google Scholar

Kohno H., Suzuki R., Yasui Y., Hosokawa M., Miyashita K., Tanaka T. (2004). Pomegranate seed oil rich in conjugated linolenic acid suppresses chemically induced colon carcinogenesis in rats. Cancer Sci., 95(6): 481-486. Search in Google Scholar

Kolli-Bouhafs, K., Boukhari, A., Abusnina, A., Velot, E., Gies, J. P., Lugnier, C., Rondé, P. (2012). Thymoquinone reduces migration and invasion of human glioblastoma cells associated with FAK, MMP-2 and MMP-9 down-regulation. Clin. Drug Investig., 30(6), 2121-2131.10.1007/s10637-011-9777-322170088 Search in Google Scholar

Kundu J., Kim D.H., Kundu J.K., Chun K.S. (2014). Thymoquinone induces heme oxygenase-1 expression in HaCaT cells via Nrf2/ARE activation: Akt and AMPKα as upstream targets. Food Chem. Toxicol., 65: 18-26. Search in Google Scholar

Kurt Y., Kaya N., IŞik K. (2008). Isozyme variation in four natural populations of Cedrus libani A. Rich. in Turkey. Turk. J. Agric. For., 32(2): 137-145. Search in Google Scholar

Kwak T.K., Sohn E.J., Kim S., Won G., Choi J.U., Jeong K., Kwon O.S., Kim S.H. (2014). Inhibitory effect of ethanol extract of Ocimum sanctum on osteopontin mediated metastasis of NCI-H460 non-small cell lung cancer cells. BMC Complement. Altern. Med., 14(1): 1-10. Search in Google Scholar

Kweon S., Park K.A., Choi H. (2003). Chemopreventive effect of garlic powder diet in diethylnitrosamine-induced rat hepatocarcinogenesis. Life Sci., 73(19): 2515-2526. Search in Google Scholar

Lansky E.P., Newman R.A. (2007). Punica granatum (pomegranate) and its potential for prevention and treatment of inflammation and cancer. J. Ethnopharmacol., 109(2): 177-206. Search in Google Scholar

Lanzotti V., Barile E., Antignani V., Bonanomi G., Scala F. (2012). Antifungal saponins from bulbs of garlic, Allium sativum L. var. Voghiera. Phytochem., 78: 126-134. Search in Google Scholar

Lei X., Lv X., Liu M., Yang Z., Ji M., Guo X., Dong W. (2012). Thymoquinone inhibits growth and augments 5-fluorouracil-induced apoptosis in gastric cancer cells both in vitro and in vivo. Biochem. Biophys. Res. Commun., 417(2): 864-868. Search in Google Scholar

Li F., Rajendran P., Sethi G. (2010). Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells through suppression of signal transducer and activator of transcription 3 activation pathway. Br. J. Pharmacol., 161(3): 541-554. Search in Google Scholar

Liu K., Chen Q., Liu Y., Zhou X., Wang X. (2012). Isolation and biological activities of decanal, linalool, valencene, and octanal from sweet orange oil. J. Food Sci., 77(11): C1156-C1161. Search in Google Scholar

Magesh V., Lee J.C., Ahn K.S., Lee H.J., Lee H.J., Lee E.O., Shim B.S., Jung H.J., Kim J.S., Kim D.K., Choi S.H., Ahn K.S., Kim S.H. (2009). Ocimum sanctum induces apoptosis in A549 lung cancer cells and suppresses the in vivo growth of Lewis lung carcinoma cells. Phytother. Res., 23(10): 1385-1391. Search in Google Scholar

Mahmoud G.I. (2013). Biological effects, antioxidant and anticancer activities of marigold and basil essential oils. J. Med. Plant Res., 7(10): 561-572. Search in Google Scholar

Mahmoud S.S., Torchilin V.P. (2013). Hormetic/cytotoxic effects of Nigella sativa seed alcoholic and aqueous extracts on MCF-7 breast cancer cells alone or in combination with doxorubicin. Cell Biochem. Biophys., 66(3): 451-460. Search in Google Scholar

Martino L.D., Bruno M., Formisano C., Feo V.D., Napolitano F., Rosselli S., Senatore F. (2009). Chemical composition and antimicrobial activity of the essential oils from two species of Thymus growing wild in southern Italy. Molecules, 14(11): 4614-4624. Search in Google Scholar

Mat M.C., Mohamed A.S., Hamid S.S. (2011). Primary human monocyte differentiation regulated by Nigella sativa pressed oil. Lipids Health Dis., 10(1): 1-11. Search in Google Scholar

Mehana E.S.E., Khafaga A.F., Elblehi S.S., Abd El-Hack M.E., Naiel M.A., Bin-Jumah M., Othman S.I., Allam A.A. (2020). Biomonitoring of heavy metal pollution using acanthocephalans parasite in ecosystem: An updated overview. Animals, 10(5): 811. Search in Google Scholar

Mehta R., Lansky E.P. (2004). Breast cancer chemopreventive properties of pomegranate (Punica granatum) fruit extracts in a mouse mammary organ culture. Eur. J. Cancer Prev., 13(4): 345-348. Search in Google Scholar

Menichini G., Alfano C., Provenzano E., Marrelli M., A Statti G., Somma F., Menichini F., Conforti F. (2012). Fig latex (Ficus carica L. cultivar Dottato) in combination with UV irradiation decreases the viability of A375 melanoma cells in vitro. Anticancer Agents Med. Chem., 12(8): 959-965. Search in Google Scholar

Millen A.E., Subar A.F., Graubard B.I., Peters U., Hayes R.B, Weissfeld J.L., Yokochi L. A., Ziegler R.G. (2007). PLCO Cancer Screening Trial Project Team. Fruit and vegetable intake and prevalence of colorectal adenoma in a cancer screening trial. Am. J. Clin. Nutr., 86(6):1754-64. Search in Google Scholar

Mohammadi M., Majd A., Nejadsattari T., Hashemi M. (2014). Antioxidant and Anticancer Activities of Ocimum basilicum L. cv. Dark Opal (Lamiaceae). Phcog. Commn., 4(4). Search in Google Scholar

Motaghed M., Al-Hassan F.M., Hamid S.S. (2014). Thymoquinone regulates gene expression levels in the estrogen metabolic and interferon pathways in MCF7 breast cancer cells. Int. J. Mol. Med., 33(1): 8-16. Search in Google Scholar

Muhammad N., Usmani D., Tarique M., Naz H., Ashraf M., Raliya R.,Tabrez S., Zughaibi T. A., Alsaieedi A., Hakeem I.J., Suhail M. (2022). The role of natural products and their multitargeted approach to treat solid cancer. Cells, 11(14): 2209. Search in Google Scholar

Nagi M.N., Almakki H.A. (2009). Thymoquinone supplementation induces quinone reductase and glutathione transferase in mice liver: possible role in protection against chemical carcinogenesis and toxicity. Phytother. Res., 23(9): 1295-1298. Search in Google Scholar

Nuutila A.M., Puupponen-Pimiä R., Aarni M., Oksman-Caldentey K.M. (2003). Comparison of antioxidant activities of onion and garlic extracts by inhibition of lipid peroxidation and radical scavenging activity. Food Chem., 81(4): 485-493. Search in Google Scholar

O’Brien M.A., Kirby R. (2008). Apoptosis: A review of pro-apoptotic and anti-apoptotic pathways and dysregulation in disease. J. Vet. Emerg. Crit. Care, 18(6): 572-585. Search in Google Scholar

Oliveira A.P., Pereira J.A., Andrade P.B., Valentão P., Seabra R.M., Silva B.M. (2007). Phenolic profile of Cydonia oblonga Miller leaves. J. Agric. Food Chem., 55(19): 7926-7930. Search in Google Scholar

Oliviero M., Romilde I., Beatrice M.M., Matteo V., Giovanna N., Consuelo A., Claudio C., Giorgio S., Filippo M., Massimo N. (2016). Evaluations of thyme extract effects in human normal bronchial and tracheal epithelial cell lines and in human lung cancer cell line. Chem. Biol. Interact., 256: 125-133. Search in Google Scholar

Pacheco-Palencia L.A., Noratto G., Hingorani L., Talcott S.T., Mertens-Talcott S.U. (2008). Protective effects of standardized pomegranate (Punica granatum L.) polyphenolic extract in ultraviolet-irradiated human skin fibroblasts. J. Agric. Food Chem., 56(18): 8434-8441. Search in Google Scholar

Pacifico S., Gallicchio M., Fiorentino A., Fischer A., Meyer U., Stintzing F.C. (2012). Antioxidant properties and cytotoxic effects on human cancer cell lines of aqueous fermented and lipophilic quince (Cydonia oblonga Mill.) preparations. Food Chem. Toxicol., 50(11): 4130-4135. Search in Google Scholar

Paramasivam A., Sambantham S., Shabnam J., Raghunandhakumar S., Anandan B., Rajiv R., Vijayashree P.J., Jayaraman G. (2012). Anti-cancer effects of thymoquinone in mouse neuroblastoma (Neuro-2a) cells through caspase-3 activation with down-regulation of XIAP. Toxicol. Lett., 213(2), 151-159.10.1016/j.toxlet.2012.06.01122732633 Search in Google Scholar

Park J.E., Pezzuto J.M. (2002). Botanicals in cancer chemoprevention. Cancer Metastasis Rev., 21(3): 231-255. Search in Google Scholar

Patel A., Hafez E., Elsaid F., Amanullah M. (2014). Anti-cancer action of a new recombinant lectin produced from Acacia species. Int. J. Med. Sci., 5: 1. Search in Google Scholar

Patel B.P., Shah S.V., Shukla S.N., Shah P.M., Patel P.S. (2007). Clinical significance of MMP-2 and MMP-9 in patients with oral cancer. Head Neck. 29(6): 564-572. Search in Google Scholar

Pawar V.A., Pawar P.R. (2014). Costus speciosus: an important medicinal plant. Int. J. Sci. Res., 3(7): 28-33. Search in Google Scholar

Peng L., Liu A., Shen Y., Xu H.Z., Yang S.Z., Ying X.Z., Liao W., Liu H.X., Lin Z.Q., Chen Q.Y., Cheng S.W., Shen W.D. (2013). Antitumor and anti-angiogenesis effects of thymoquinone on osteosarcoma through the NF-κB pathway. Oncol. Rep., 29(2): 571-578. Search in Google Scholar

Pieroni A., Quave C.L., Villanelli M.L., Mangino P., Sabbatini G., Santini L., Tomasi M. (2004). Ethnopharmacognostic survey on the natural ingredients used in folk cosmetics, cosmeceuticals and remedies for healing skin diseases in the inland Marches, Central-Eastern Italy. J. Ethnopharmacol., 91(2-3): 331-344. Search in Google Scholar

Pitchai D., Roy A., Banu S. (2014). In Vitro and In Silico evaluation of NF-κB targeted costunolide action on estrogen receptor-negative breast cancer cells—a comparison with normal breast cells. Phytother. Res., 28(10): 1499-1505. Search in Google Scholar

Prashanth G.K., Prashanth P.A., Nagabhushana B.M., Ananda S., Krishnaiah G.M., Nagendra H.G., Tejabhiram Y. (2018). Comparison of anticancer activity of biocompatible ZnO nanoparticles prepared by solution combustion synthesis using aqueous leaf extracts of Abutilon indicum, Melia azedarach and Indigofera tinctoria as biofuels. Artif. Cells Nanomed. Biotechnol., 46(5): 968-979. Search in Google Scholar

Raghunandhakumar S., Paramasivam A., Senthilraja S., Naveenkumar C., Asokkumar S., Binuclara J., Devaki T. (2013). Thymoquinone inhibits cell proliferation through regulation of G1/S phase cell cycle transition in N-nitrosodiethylamine-induced experimental rat hepatocellular carcinoma. Toxicol. Lett., 223(1): 60-72. Search in Google Scholar

Rajput S., Kumar B.P., Dey K.K., Pal I., Parekh A., Mandal M. (2013). Molecular targeting of Akt by thymoquinone promotes G1 arrest through translation inhibition of cyclin D1 and induces apoptosis in breast cancer cells. Life Sci., 93(21): 783-790. Search in Google Scholar

Rana A., Anand J., Tyagi M., Rai N. (2021). Forest-Based Medicinal Plants for Cancer Cure. In Non-Timber Forest Products (pp. 255-280). Springer, Cham.10.1007/978-3-030-73077-2_11 Search in Google Scholar

Reddy S.E., Kirti Dolma S., Koundal R., Singh B. (2016). Chemical composition and insecticidal activities of essential oils against diamondback moth, Plutella xylostella (L.)(Lepidoptera: Yponomeutidae). Nat. Prod. Res., 30(16): 1834-1838. Search in Google Scholar

Reindl W., Yuan J., Krämer A., Strebhardt K., Berg T. (2008). Inhibition of polo-like kinase 1 by blocking polo-box domain-dependent protein-protein interactions. Chem. Bio., 15(5):459-466. Search in Google Scholar

Renukadevi K.P., Sultana S.S. (2011). Determination of antibacterial, antioxidant and cytotoxicity effect of Indigofera tinctoria on lung cancer cell line NCI-h69. Int. J. Pharmacol., 7(3): 356-362. Search in Google Scholar

Riahi-Chebbi I., Haoues M., Essafi M., Zakraoui O., Fattouch S., Karoui H., Essafi-Benkhadir K. (2015). Quince peel polyphenolic extract blocks human colon adenocarcinoma LS174 cell growth and potentiates 5-fluorouracil efficacy. Cancer cell Int., 16(1): 1-15. Search in Google Scholar

Ronald Steriti N.D. (2002). Nutritional support for chronic myelogenous and other leukemias: a review of the scientific literature. Altern. Med. Rev., 7(5): 404-409. Search in Google Scholar

Roothaert R.L., Franzel S. (2001). Farmers’ preferences and use of local fodder trees and shrubs in Kenya. Agrofor. Syst., 52(3): 239-252. Search in Google Scholar

Roy A., Manikkam R. (2015). Cytotoxic impact of costunolide isolated from Costus speciosus on breast cancer via differential regulation of cell cycle—an in-vitro and in-silico approach. Phytother. Res., 29(10): 1532-1539. Search in Google Scholar

Roy F., Boye J.I., Simpson B.K. (2010). Bioactive proteins and peptides in pulse crops: Pea, chickpea and lentil. Food Res. Int., 43(2): 432-442. Search in Google Scholar

Rubnov S., Kashman Y., Rabinowitz R., Schlesinger M., Mechoulam R. (2001). Suppressors of cancer cell proliferation from fig (Ficus c arica) resin: isolation and structure elucidation. Nat. Prod. Res., 64(7): 993-996. Search in Google Scholar

Saab A.M., Guerrini A., Sacchetti G., Maietti S., Zeino M., Arend J., Efferth T. (2012). Phytochemical analysis and cytotoxicity towards multidrug-resistant leukemia cells of essential oils derived from Lebanese medicinal plants. Planta Med., 78(18): 1927-1931. Search in Google Scholar

Saab A.M., Lampronti I., Grandini A., Borgatti M., Finotti A., Sacchetti G., Guerrini A. (2011). Antiproliferative and erythroid differentiation activities of Cedrus libani seed extracts against K562 human chronic myelogenus leukemia cells. Int. J. Pharm. Biol. Arch, 2(6):1744-1748. Search in Google Scholar

Saeed M., Abd El-Hack M.E., Alagawany M., Arain M.A., Arif M., Mirza M.A., Dhama K. (2017). Chicory (cichorium intybus) herb: Chemical composition, pharmacology, nutritional and healthical applications. Int. J. Pharmacol., 13(4), 351-360.10.3923/ijp.2017.351.360 Search in Google Scholar

Saeed M., Yatao X., Hassan F.U., Arain M.A., Abd El-Hack M.E., Noreldin A.E., Sun C. (2018). Influence of graded levels of l-theanine dietary supplementation on growth performance, carcass traits, meat quality, organs histomorphometry, blood chemistry and immune response of broiler chickens. Int. J. Mol. Sci., 19(2): 462. Search in Google Scholar

Sakalar C., Yuruk M., Kaya T., Aytekin M., Kuk S., Canatan H. (2013). Pronounced transcriptional regulation of apoptotic and TNF–NF-kappa-B signaling genes during the course of thymoquinone mediated apoptosis in HeLa cells. Mol. Cell. Biochem., 383(1):243-251. Search in Google Scholar

Salim E.I., Fukushima S. (2003). Chemopreventive potential of volatile oil from black cumin (Nigella sativa L.) seeds against rat colon carcinogenesis. Nutr. Cancer., 45(2): 195-202. Search in Google Scholar

Sayed-Ahmed M.M., Aleisa A.M., Al-Rejaie S.S., Al-Yahya A.A., Al-Shabanah O.A., Hafez M.M., Nagi M.N. (2010). Thymoquinone attenuates diethylnitrosamine induction of hepatic carcinogenesis through antioxidant signaling. Oxid. Med. Cell. Longev., 3(4): 254-261. Search in Google Scholar

Seeram N.P., Adams L.S., Henning S.M., Niu Y., Zhang Y., Nair M.G., Heber D. (2005). In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice. J. Nutr. Biochem., 16(6): 360-367. Search in Google Scholar

Selim S., Al Jaouni, S. (2015). Anticancer and apoptotic effects on cell proliferation of diosgenin isolated from Costus speciosus (Koen.) Sm. BMC Complement. Altern. Med., 15(1): 1-7. Search in Google Scholar

Selim S., Al Jaouni S. (2016). Anti-inflammatory, antioxidant and antiangiogenic activities of diosgenin isolated from traditional medicinal plant, Costus speciosus (Koen ex. Retz.) Sm. Nat. Prod. Res., 30(16): 1830-1833. Search in Google Scholar

Sertel S., Eichhorn T., Plinkert P.K., Efferth T. (2011). Cytotoxicity of Thymus vulgaris essential oil towards human oral cavity squamous cell carcinoma. Anticancer Res., 31(1): 81-87. Search in Google Scholar

Sethi G., Ahn K.S., Aggarwal B.B. (2008). Targeting nuclear factor-κB activation pathway by thymoquinone: role in suppression of antiapoptotic gene products and enhancement of apoptosis. Mol. Cancer Res., 6(6): 1059-1070. Search in Google Scholar

Setiawan V.W., Yu G.P., Lu Q.Y., Lu M.L., Yu S.Z., Mu L., Zhang Z.F. (2005). Allium vegetables and stomach cancer risk in China. Asian Pac. J. Cancer Prev., 6(3): 387. Search in Google Scholar

Sezik E., Yeşilada E., Honda G., Takaishi Y., Takeda Y., Tanaka T. (2001). Traditional medicine in Turkey X. Folk medicine in central Anatolia. J. Ethnopharmacol. 75(2-3): 95-115. Search in Google Scholar

Shahraki S., Khajavirad A., Shafei M.N., Mahmoudi M., Tabasi N.S. (2016). Effect of total hydroalcholic extract of Nigella sativa and its n-hexane and ethyl acetate fractions on ACHN and GP-293 cell lines. J. Tradit. Complement. Med., 6(1): 89-96. Search in Google Scholar

Sharma P., McClees S.F., Afaq F. (2017). Pomegranate for prevention and treatment of cancer: an update. Molecules, 22(1): 177. Search in Google Scholar

Shoieb A.M., Elgayyar M., Dudrick P.S., Bell J.L., Tithof P.K. (2003). In vitro inhibition of growth and induction of apoptosis in cancer cell lines by thymoquinone. Int. J. Oncol., 22(1): 107-113. Search in Google Scholar

Singh B., Saxena A.K., Chandan B.K., Bhardwaj V., Gupta V.N., Suri O.P., Handa S.S. (2001). Hepatoprotective activity of indigtone—a bioactive fraction from Indigofera tinctoria Linn. Phytother. Res., 15(4): 294-297. Search in Google Scholar

Singh G., Kapoor I.P.S., Singh P., de Heluani C.S., de Lampasona M.P., Catalan C.A. (2008). Chemistry, antioxidant and antimicrobial investigations on essential oil and oleoresins of Zingiber officinale. Food Chem. Toxicol., 46(10): 3295-3302. Search in Google Scholar

Singh G., Passsari A.K., Leo V.V., Mishra V.K., Subbarayan S., Singh B.P., Nachimuthu S.K. (2016). Evaluation of phenolic content variability along with antioxidant, antimicrobial, and cytotoxic potential of selected traditional medicinal plants from India. Front. Plant Sci., 7: 407. Search in Google Scholar

Specht C.D., Stevenson D.W. (2006). A new phylogeny-based generic classification of Costaceae (Zingiberales). Taxon, 55(1): 153-163. Search in Google Scholar

Sreepriya M., Devaki T., Nayeem M. (2001). Protective effects of Indigofera tinctoria L. against D-Galactosamine and carbon tetrachloride challenge on ‘in situ’ perfused rat liver. Indian J. Physiol. Pharmacol., 45(4):428-34. Search in Google Scholar

Sridevi M., Bright J.O.H.N., Yamini K. (2016). Anti-cancer effect of ocimum-sanctum ethanolic extract in non-small cell lung carcinoma cell line. Int. J. Pharm. Pharm. Sci., 8: 8-20. Search in Google Scholar

Taie H.A.A., Radwan S. (2010). Potential activity of basil plants as a source of antioxidants and anticancer agents as affected by organic and bio-organic fertilization. Not. Bot. Horti. Agrobot., 38(1): 119-127. Search in Google Scholar

Taleb R., El Hakim J., Elias A., Mroueh M., Daher C. (2014). Anti-cancer activity of 2-himachalen-7-ol isolated from Cedrus libani. Planta Med., 80(16): P1L27. Search in Google Scholar

Tan W., Pan T., Wang S., Li P., Men Y., Tan R., Wang Y. (2021). Immunometabolism modulation, a new trick of edible and medicinal plants in cancer treatment. Food Chem., 131860. Search in Google Scholar

Taylor R.C., Cullen S.P., Martin S.J. (2008). Apoptosis: controlled demolition at the cellular level. Nat. Rev. Mol., 9(3): 231-241. Search in Google Scholar

Tezcan G., Tunca B., Bekar A., Yalcin M., Sahin S., Budak F., Bilir A. (2015). Ficus carica latex prevents invasion through induction of let-7d expression in GBM cell lines. Cell. Mol. Neurobiol., 35(2): 175-187. Search in Google Scholar

Thabrew M.I., Mitry R.R., Morsy M.A., Hughes R.D. (2005). Cytotoxic effects of a decoction of Nigella sativa, Hemidesmus indicus and Smilax glabra on human hepatoma HepG2 cells. Life Sci., 77(12): 1319-1330. Search in Google Scholar

Torres M.P., Ponnusamy M.P., Chakraborty S., Smith L.M., Das S., Arafat H.A., Batra S.K. (2010). Effects of thymoquinone in the expression of mucin 4 in pancreatic cancer cells: implications for the development of novel cancer therapies. Mol. Cancer therap., 9(5): 1419-1431. Search in Google Scholar

Tuntiwechapikul W., Taka T., Songsomboon C., Kaewtunjai N., Imsumran A., Makonkawkeyoon L., Pompimon W., Lee T.R. (2010). Ginger extract inhibits human telomerase reverse transcriptase and c-Myc expression in A549 lung cancer cells. J. Med. Food, 13(6): 1347-1354. Search in Google Scholar

Turati F., Pelucchi C., Guercio V., Vecchia C.L., Galeone C. (2015). Allium vegetable intake and gastric cancer: A case–control study and meta-analysis. Mol. Nutr. Food Res., 59(1): 171-179. Search in Google Scholar

Vidyavati H.G., Manjunatha H., Hemavathy J., Srinivasan K. (2010). Hypolipidemic and antioxidant efficacy of dehydrated onion in experimental rats. Food. Sci. Technol., 47(1): 55-60. Search in Google Scholar

Vijayababu M.R., Arunkumar A., Kanagaraj P., Venkataraman P., Krishnamoorthy G., Arunakaran J. (2006). Quercetin downregulates matrix metalloproteinases 2 and 9 proteins expression in prostate cancer cells (PC-3). Mol. Cell. Biochem., 287(1): 109-116. Search in Google Scholar

Vijayan R., Joseph S., Mathew B. (2018). Indigofera tinctoria leaf extract mediated green synthesis of silver and gold nanoparticles and assessment of their anticancer, antimicrobial, antioxidant and catalytic properties. Artif. Cells Nanomed. Biotechnol., 46(4): 861-871. Search in Google Scholar

Viry E., Anwar A., Kirsch G., Jacob C., Diederich M., Bagrel D. (2011). Antiproliferative effect of natural tetrasulfides in human breast cancer cells is mediated through the inhibition of the cell division cycle 25 phosphatases. Int. J. Oncol., 38(4): 1103-1111. Search in Google Scholar

Viuda-Martos M., Fernández-López J., Pérez-Álvarez J.A. (2010). Pomegranate and its many functional components as related to human health: a review. Compr. Rev. Food Sci. Food Saf., 9(6): 635-654. Search in Google Scholar

Walid E., Hedia H., Nizar T., Yassine Y., Nizar N., Ali F. (2012). Total phenolic contents and antioxidant activities of pomegranate peel, seed, leaf and flower. J. Med. Plant Res., 6(32): 4724-4730. Search in Google Scholar

Wang X., Bai H., Zhang X., Liu J., Cao P., Liao N., Zhang W., Wang Z., Hai C. (2013). Inhibitory effect of oleanolic acid on hepatocellular carcinoma via ERK–p53-mediated cell cycle arrest and mitochondrial-dependent apoptosis. Carcinogen., 34(6): 1323-1330. Search in Google Scholar

WHO (World Health Organization) (2000). General guidelines for methodologies on research and evaluation of traditional medicine (No. WHO/EDM/TRM/2000.1). World Health Organization. Search in Google Scholar

Woo C.C., Hsu A., Kumar A.P., Sethi G., Tan K.H.B. (2013). Thymoquinone inhibits tumor growth and induces apoptosis in a breast cancer xenograft mouse model: the role of p38 /MAPK and ROS. PloS one, 8(10): e75356. Search in Google Scholar

Woo C.C., Loo S.Y., Gee V., Yap C.W., Sethi G., Kumar A.P., Tan K.H.B. (2011). Anticancer activity of thymoquinone in breast cancer cells: possible involvement of PPAR-γ pathway. Biochem. Pharmacol., 82(5): 464-475. Search in Google Scholar

World Health Organization. (2019). WHO global report on traditional and complementary medicine 2019. World Health Organization. Search in Google Scholar

Worthen D.R., Ghosheh O.A., Crooks P.A. (1998). The in vitro anti-tumor activity of some crude and purified components of blackseed, Nigella sativa L. Anticancer Res., 18(3A): 1527-1532. Search in Google Scholar

Wu C., Wang M., Dong Y., Cheng Z., Meng H. (2015). Growth, bolting and yield of garlic (Allium sativum L.) in response to clove chilling treatment. Sci. Hortic., 194: 43-52. Search in Google Scholar

Yang G., Wang S., Zhong L., Dong X., Zhang W., Jiang L., Geng C., Sun X., Liu X., Chen M., Ma Y. (2012). 6-Gingerol induces apoptosis through lysosomal-mitochondrial axis in human hepatoma G2 cells. Phytother. Res., 26(11): 1667-1673. Search in Google Scholar

Yeşilada E., Gürbüz İ., Shibata H. (1999). Screening of Turkish anti-ulcerogenic folk remedies for anti-Helicobacter pylori activity. J. Ethnopharmacol., 66(3): 289-293. Search in Google Scholar

Zarlaha A., Kourkoumelis N., Stanojkovic T.P., Kovala-Demertzi D. (2014). Cytotoxic activity of essential oil and extracts of ocimum basilicum against human carcinoma cells. Molecular docking study of isoeugenol as a potent cox and lox inhibitor. Dig. J. Nanomater. Biostructures., 9(3). Search in Google Scholar

Zeggwagh N.A., Sulpice T., Eddouks M. (2007). Anti-hyperglycaemic and hypolipidemic effects of Ocimum basilicum aqueous extract in diabetic rats. Am. J. Pharmacol. Toxicol., 2: 123-129. Search in Google Scholar

Zeng Y.W., Du J., Pu X.Y., Yang J.Z., Yang T., Yang S.M., Yang X.M. (2015). Coevolution between human’s anticancer activities and functional foods from crop origin center in the world. Asian. Pac. J. Cancer Prev., 16(6): 2119-2128. Search in Google Scholar

Zhang Y., Wan Y., Huo B., Li B., Jin Y., Hu X. (2018). Extracts and components of Ficus carica leaves suppress survival, cell cycle, and migration of triple-negative breast cancer MDA-MB-231 cells. OncoTargets Ther., 11: 4377. Search in Google Scholar

Zhou B., Yi H., Tan J., Wu Y., Liu G., Qiu Z. (2015). Anti-proliferative effects of polyphenols from pomegranate rind (Punica granatum L.) on EJ bladder cancer cells via regulation of p53/miR-34a Axis. Phytother. Res., 29(3): 415-422. Search in Google Scholar

Zingue S., Njuh A.N., Tueche A.B., Tamsa J., Tchoupang E.N., Kakene S.D., Njamen D. (2018). In vitro cytotoxicity and in vivo antimammary tumor effects of the hydroethanolic extract of Acacia seyal (Mimosaceae) stem bark. BioMed Research International, 1–13.10.1155/2018/2024602588990329770327 Search in Google Scholar

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