<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Hesperidin (HE), chrysin (CH) and naringenin (NA) are flavonoids, being the most important group of polyphenols, and show anti-inflammatory properties which have been demonstrated on various models. Polyphenols have a lot of biological properties, such as antioxidative, antiviral, immunomodulatory and anticancer activities. However, the effect on mastitis has not been yet described. This research aimed to analyse the tolerability of selected polyphenols after multiple intramammary administrations (IMM) as well as to investigate their potential impact on somatic cell count (SCC) in mastitis dairy cows. The study was performed on 12 Polish Holstein Blackand- White cows in their 4th to 6th lactation. Only animals with inflammation in one-quarter of the udder were selected. The selection was based on SCC and clinical assessment. The experiment was performed with multiple intramammary administrations with each of these polyphenols in dairy cows affected with mastitis. Polyphenols were administered at a dose of 30 mg/quarter/day. Milk samples for SCC, blood plasma samples for pharmacokinetics and blood haematology and biochemistry (selected blood parameters were tested) were collected at baseline, treatment period and within the recovery period. Positive effects concerning the SCC in milk of mastitic cows were confirmed for all tested polyphenols.</p></abstract>

Hesperidin (HE), chrysin (CH) and naringenin (NA) are flavonoids, being the most important group of polyphenols, and show anti-inflammatory properties which have been demonstrated on various models. Polyphenols have a lot of biological properties, such as antioxidative, antiviral, immunomodulatory and anticancer activities. However, the effect on mastitis has not been yet described. This research aimed to analyse the tolerability of selected polyphenols after multiple intramammary administrations (IMM) as well as to investigate their potential impact on somatic cell count (SCC) in mastitis dairy cows. The study was performed on 12 Polish Holstein Blackand- White cows in their 4th to 6th lactation. Only animals with inflammation in one-quarter of the udder were selected. The selection was based on SCC and clinical assessment. The experiment was performed with multiple intramammary administrations with each of these polyphenols in dairy cows affected with mastitis. Polyphenols were administered at a dose of 30 mg/quarter/day. Milk samples for SCC, blood plasma samples for pharmacokinetics and blood haematology and biochemistry (selected blood parameters were tested) were collected at baseline, treatment period and within the recovery period. Positive effects concerning the SCC in milk of mastitic cows were confirmed for all tested polyphenols.

The Effect of Hesperidin, Chrysin, and Naringenin on Somatic Cell Count in Mastitis Dairy Cows After Multiple Intramammary Administration

Department of Pharmacology, Faculty of Veterinary Medicine

Department of Pharmacology and Toxicology

Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine

Department of Animal Nutrition and Feed Science

Annals of Animal Science

This work is licensed under the Creative Commons Attribution 4.0 International License.

Hesperidin (HE), chrysin (CH) and naringenin (NA) are flavonoids, being the most important group of polyphenols, and show anti-inflammatory properties which...

The Effect of Hesperidin, Chrysin, and Naringenin on Somatic Cell Count in Mastitis Dairy Cows After Multiple Intramammary Administration

Online veröffentlicht: 04. Feb. 2022

Seitenbereich: 155 - 172

Eingereicht: 17. März 2021

Akzeptiert: 29. Juli 2021

DOI: https://doi.org/10.2478/aoas-2021-0060

Schlüsselwörter
dairy cows, inflammation, immunomodulator, mastitis, flavonoids

© 2022 Artur Burmańczuk et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

The Effect of Hesperidin, Chrysin, and Naringenin on Somatic Cell Count in Mastitis Dairy Cows After Multiple Intramammary Administration

Online veröffentlicht: 04. Feb. 2022

Seitenbereich: 155 - 172

Eingereicht: 17. März 2021

Akzeptiert: 29. Juli 2021

DOI: https://doi.org/10.2478/aoas-2021-0060

Schlüsselwörterdairy cows, inflammation, immunomodulator, mastitis, flavonoids

© 2022 Artur Burmańczuk et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Schlüsselwörter
dairy cows, inflammation, immunomodulator, mastitis, flavonoids