<abstract xmlns="http://www.w3.org/1999/xhtml">

<bold>Objective</bold>: The objective of the present study is to clarify the value of clinic, endoscopic, and histologic variables that may predict anemia in patients performing esophagogastroduodenoscopy for gastrointestinal complaints in the absence of bleeding signs or lower digestive disease.
<bold>Methods</bold>: This study included 654 patients referred for endoscopy that were divided based on biological parameters performed in the same day in the study group (306 patients diagnosed with anemia) and the control group (348 patients without anemia).
<bold>Results</bold>: Anemia is frequent in elderly patients, especially in the presence of premalignant gastric lesions, and it is associated with multiple comorbidities. In two multivariate regression models antivitamin K oral anticoagulants were found to be independently associated with anemia (p = 0.01), but not with antiplatelet therapy, or with non-antivitamin K anticoagulants. Multiple regression models support that epigastric pain and heartburn are inversely associated with anemia, while weight loss remained an independent predictor for simultaneous anemia and premalignant lesions. Non-infectious chronic gastritis (p&lt;0.001) is an independent predictor for anemia and premalignant gastric lesions, increasing the odds of anemia by 2.2 times, while reactive gastropathy is inversely associated. Gastric erosions and ulcer remained independent predictors for concomitant anemia and premalignant lesions.
<bold>Conclusions</bold>: Chronic inactive gastritis and premalignant gastric histologic lesions are predictors for anemia in endoscopic population, while active H. pylori infection is not. Dyspeptic symptoms, epigastric pain (p&lt;0.001,OR 0.2-0.5) and heartburn (p&lt;0.001,OR 0.07-0.3) are inversely associated with anemia alone or associated with premalignant gastric lesions.
</abstract>

Objective: The objective of the present study is to clarify the value of clinic, endoscopic, and histologic variables that may predict anemia in patients performing esophagogastroduodenoscopy for gastrointestinal complaints in the absence of bleeding signs or lower digestive disease.
Methods: This study included 654 patients referred for endoscopy that were divided based on biological parameters performed in the same day in the study group (306 patients diagnosed with anemia) and the control group (348 patients without anemia).
Results: Anemia is frequent in elderly patients, especially in the presence of premalignant gastric lesions, and it is associated with multiple comorbidities. In two multivariate regression models antivitamin K oral anticoagulants were found to be independently associated with anemia (p = 0.01), but not with antiplatelet therapy, or with non-antivitamin K anticoagulants. Multiple regression models support that epigastric pain and heartburn are inversely associated with anemia, while weight loss remained an independent predictor for simultaneous anemia and premalignant lesions. Non-infectious chronic gastritis (p<0.001) is an independent predictor for anemia and premalignant gastric lesions, increasing the odds of anemia by 2.2 times, while reactive gastropathy is inversely associated. Gastric erosions and ulcer remained independent predictors for concomitant anemia and premalignant lesions.
Conclusions: Chronic inactive gastritis and premalignant gastric histologic lesions are predictors for anemia in endoscopic population, while active H. pylori infection is not. Dyspeptic symptoms, epigastric pain (p<0.001,OR 0.2-0.5) and heartburn (p<0.001,OR 0.07-0.3) are inversely associated with anemia alone or associated with premalignant gastric lesions.

Predictors of anemia without active bleeding signs in patients referred for endoscopy

George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures

Department of Clinical Science-Internal Medicine

Acta Marisiensis - Seria Medica

This work is licensed under the Creative Commons Attribution 4.0 International License.

Objective: The objective of the present study is to clarify the value of clinic, endoscopic, and histologic variables that may predict anemia in patients...

Predictors of anemia without active bleeding signs in patients referred for endoscopy

Online veröffentlicht: 28. Sept. 2023

Seitenbereich: 187 - 194

Eingereicht: 29. Aug. 2023

Akzeptiert: 07. Sept. 2023

DOI: https://doi.org/10.2478/amma-2023-0036

Schlüsselwörter
anemia, chronic gastritis, dyspepsia, Helicobacter pylori, premalignant gastric lesions

© 2023 Sabrina Nicoleta Munteanu et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Predictors of anemia without active bleeding signs in patients referred for endoscopy

Online veröffentlicht: 28. Sept. 2023

Seitenbereich: 187 - 194

Eingereicht: 29. Aug. 2023

Akzeptiert: 07. Sept. 2023

DOI: https://doi.org/10.2478/amma-2023-0036

Schlüsselwörteranemia, chronic gastritis, dyspepsia, Helicobacter pylori, premalignant gastric lesions

© 2023 Sabrina Nicoleta Munteanu et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Schlüsselwörter
anemia, chronic gastritis, dyspepsia, Helicobacter pylori, premalignant gastric lesions