<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Ewing sarcoma with renal localization is one of the rarest members of the Ewing sarcoma family with less than 200 cases reported in the Medline database. Considering the fact that the majority of data published on the Ewing sarcoma with neuroectodermal differentiation is obtained through a few case reports and case series, it becomes understandable why we currently have no universally accepted treatment regimens.</p>
<p><bold>Case summary</bold>: A 33-year-old patient presented to the Emergency Department with right lumbar pain following a mild trauma and an episode of macroscopic hematuria. Physical examination confirmed hematuria and flank pain and a palpable flank mass was identified. MRI showed a cystic lesion of the upper pole of the right kidney of 127/110/123 mm. After prior agreement of the multidisciplinary team, a 3D laparoscopic right radical nephrectomy was done. The histopathological diagnosis revealed an Ewing sarcoma with extensive neuroectodermal differentiation staged as pT3N1M0L1V2R0. Despite swift implementation of the chemotherapy protocol, the progression of the disease was quickly noted. Currently, one year after diagnosis, the disease is still progressing despite the chemotherapy treatment, the patient being a third line chemotherapy candidate. As renal localization of Ewing sarcoma with extensive neuroectodermal differentiation is extremely rare, multimodal treatment strategies must be established by a multidisciplinary team. Despite its aggressive biological behavior, a proper therapeutic management might increase patient life expectancy.</p>
</abstract>

Ewing sarcoma with renal localization is one of the rarest members of the Ewing sarcoma family with less than 200 cases reported in the Medline database. Considering the fact that the majority of data published on the Ewing sarcoma with neuroectodermal differentiation is obtained through a few case reports and case series, it becomes understandable why we currently have no universally accepted treatment regimens.
Case summary: A 33-year-old patient presented to the Emergency Department with right lumbar pain following a mild trauma and an episode of macroscopic hematuria. Physical examination confirmed hematuria and flank pain and a palpable flank mass was identified. MRI showed a cystic lesion of the upper pole of the right kidney of 127/110/123 mm. After prior agreement of the multidisciplinary team, a 3D laparoscopic right radical nephrectomy was done. The histopathological diagnosis revealed an Ewing sarcoma with extensive neuroectodermal differentiation staged as pT3N1M0L1V2R0. Despite swift implementation of the chemotherapy protocol, the progression of the disease was quickly noted. Currently, one year after diagnosis, the disease is still progressing despite the chemotherapy treatment, the patient being a third line chemotherapy candidate. As renal localization of Ewing sarcoma with extensive neuroectodermal differentiation is extremely rare, multimodal treatment strategies must be established by a multidisciplinary team. Despite its aggressive biological behavior, a proper therapeutic management might increase patient life expectancy.

Renal Ewing sarcoma with extensive neuroectodermal differentiation: Case report and literature review

George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures

George Emil Palade University of Medicine, Pharmacy, Science and Technology

Acta Marisiensis - Seria Medica

This work is licensed under the Creative Commons Attribution 4.0 International License.

Ewing sarcoma with renal localization is one of the rarest members of the Ewing sarcoma family with less than 200 cases reported in the Medline database....

Renal Ewing sarcoma with extensive neuroectodermal differentiation: Case report and literature review

Online veröffentlicht: 28. Sept. 2023

Seitenbereich: 226 - 231

Eingereicht: 30. Aug. 2023

Akzeptiert: 06. Sept. 2023

DOI: https://doi.org/10.2478/amma-2023-0034

Schlüsselwörter
Ewing sarcoma, neuroectodermal, kidney, diagnosis, chemotherapy

© 2023 Alexandra Daniela Sava et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Renal Ewing sarcoma with extensive neuroectodermal differentiation: Case report and literature review

Online veröffentlicht: 28. Sept. 2023

Seitenbereich: 226 - 231

Eingereicht: 30. Aug. 2023

Akzeptiert: 06. Sept. 2023

DOI: https://doi.org/10.2478/amma-2023-0034

SchlüsselwörterEwing sarcoma, neuroectodermal, kidney, diagnosis, chemotherapy

© 2023 Alexandra Daniela Sava et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Schlüsselwörter
Ewing sarcoma, neuroectodermal, kidney, diagnosis, chemotherapy