<abstract xmlns="http://www.w3.org/1999/xhtml">

<bold>Introduction:</bold> Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity, mortality, and healthcare costs worldwide. Lung cancer is the second most common cancer and is the leading cause of cancer mortality, accounting for almost 25% of all cancer deaths. This study aims to investigate the prevalence of COPD in patients with lung cancer (LC).
<bold>Materials and Methods:</bold> This is a cross-sectional observational study. Consecutive patients with suspected LC in a respiratory clinic were studied. The method of verification of the lung abnormalities (fibrobronchoscopy and/or transthoracic biopsy) was performed. Postbronchodilator spirometry was performed. An FEV1/FVC ratio &lt; 0.7 was diagnostic for the presence of COPD. The association between the presence of COPD and LC with other routine tests (laboratory tests, blood gas analysis, CT) was also analyzed.
<bold>Results:</bold> A total of 65 patients with verified LC were included. 48.4% of the LC patients in this study had COPD. There was no significant difference in the prevalence of COPD in the different subgroups of non-small cell cancer: unspecified non-small cell cancer – 62.5%, squamous cell cancer – 50%, adenocarcinoma – 45.8% (p = 0.33). Patients with COPD and LC had lower FEV1 (56.9 vs. 70.5%, p = 0.01) but not FVC (71.6 vs. 74.6%, p = 0.67). The presence of COPD in LC patients was associated with lower leukocytes (8.8 vs. 11.3 x109, p = 0.018). Squamous cell cancer was associated with a higher number of leukocytes compared to adenocarcinoma (11.0 vs. 8.4 x109, p = 0.026), although smoking showed no clear association with histology.
<bold>Conclusion:</bold> Nearly half (48.4%) of the patients with LC also had COPD.
</abstract>

Introduction: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity, mortality, and healthcare costs worldwide. Lung cancer is the second most common cancer and is the leading cause of cancer mortality, accounting for almost 25% of all cancer deaths. This study aims to investigate the prevalence of COPD in patients with lung cancer (LC).
Materials and Methods: This is a cross-sectional observational study. Consecutive patients with suspected LC in a respiratory clinic were studied. The method of verification of the lung abnormalities (fibrobronchoscopy and/or transthoracic biopsy) was performed. Postbronchodilator spirometry was performed. An FEV1/FVC ratio < 0.7 was diagnostic for the presence of COPD. The association between the presence of COPD and LC with other routine tests (laboratory tests, blood gas analysis, CT) was also analyzed.
Results: A total of 65 patients with verified LC were included. 48.4% of the LC patients in this study had COPD. There was no significant difference in the prevalence of COPD in the different subgroups of non-small cell cancer: unspecified non-small cell cancer – 62.5%, squamous cell cancer – 50%, adenocarcinoma – 45.8% (p = 0.33). Patients with COPD and LC had lower FEV1 (56.9 vs. 70.5%, p = 0.01) but not FVC (71.6 vs. 74.6%, p = 0.67). The presence of COPD in LC patients was associated with lower leukocytes (8.8 vs. 11.3 x109, p = 0.018). Squamous cell cancer was associated with a higher number of leukocytes compared to adenocarcinoma (11.0 vs. 8.4 x109, p = 0.026), although smoking showed no clear association with histology.
Conclusion: Nearly half (48.4%) of the patients with LC also had COPD.

Prevalence of COPD in Patients with Lung Cancer

Department of Occupational Diseases, Faculty of Medicine

Department of Respiratory Diseases, Faculty of Medicine

Department of Anaesthesia, Resuscitation and Intensive Care

Acta Medica Bulgarica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"Prevalence of COPD in Patients with Lung Cancer"}

Introduction: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity, mortality, and healthcare costs worldwide. Lung cancer is the...

Prevalence of COPD in Patients with Lung Cancer

Online veröffentlicht: 10. Feb. 2023

Seitenbereich: 18 - 20

Eingereicht: 30. Sept. 2022

Akzeptiert: 25. Okt. 2022

DOI: https://doi.org/10.2478/amb-2022-0036

Schlüsselwörter
COPD, lung cancer, prevalence, spirometry, histology

© 2022 E. Mekov et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Prevalence of COPD in Patients with Lung Cancer

Online veröffentlicht: 10. Feb. 2023

Seitenbereich: 18 - 20

Eingereicht: 30. Sept. 2022

Akzeptiert: 25. Okt. 2022

DOI: https://doi.org/10.2478/amb-2022-0036

SchlüsselwörterCOPD, lung cancer, prevalence, spirometry, histology

© 2022 E. Mekov et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Schlüsselwörter
COPD, lung cancer, prevalence, spirometry, histology