The Pathogenesis of Foot-and-Mouth Disease Virus Infection: How the Virus Escapes from Immune Recognition and Elimination

Abdullah SW, Wu J, Wang X et al (2023) Advances and breakthroughs in IRES-directed translation and replication of picornaviruses. mBio 14:e0035823. https://doi.org/10.1128/mbio.00358-23 AbdullahSW WuJ WangX 2023 Advances and breakthroughs in IRES-directed translation and replication of picornaviruses mBio 14 e0035823 https://doi.org/10.1128/mbio.00358-23 Search in Google Scholar

Agudo Torres R (2009) Caracterización de las proteínas del virus de la fiebre aftosa implicadas en respuesta a mutagénesis letal por análogos de nucleótido. Tesis Doctoral, Universidad Autónoma de Madrid. Agudo TorresR 2009 Caracterización de las proteínas del virus de la fiebre aftosa implicadas en respuesta a mutagénesis letal por análogos de nucleótido Tesis Doctoral Universidad Autónoma de Madrid Search in Google Scholar

Ahmed B, Megersa L, Mulatu G et al (2020) Seroprevalence and associated risk factors of foot and mouth disease in cattle in West Shewa Zone, Ethiopia. Vet Med Int 2020:6821809. https://doi.org/10.1155/2020/6821809 AhmedB MegersaL MulatuG 2020 Seroprevalence and associated risk factors of foot and mouth disease in cattle in West Shewa Zone, Ethiopia Vet Med Int 2020 6821809. https://doi.org/10.1155/2020/6821809 Search in Google Scholar

Aiewsakun P, Pamornchainavakul N, Inchaisri C (2020) Early origin and global colonization of foot-and-mouth disease virus. Sci Rep 10:15268. https://doi.org/10.1038/s41598-020-72246-6 AiewsakunP PamornchainavakulN InchaisriC 2020 Early origin and global colonization of foot-and-mouth disease virus Sci Rep 10 15268 https://doi.org/10.1038/s41598-020-72246-6 Search in Google Scholar

Arzt J, Pacheco JM, Smoliga GR et al (2014) Foot-and-mouth disease virus virulence in cattle is co-determined by viral replication dynamics and route of infection. Virology 452:12–22. https://doi.org/10.1016/j.virol.2014.01.001 ArztJ PachecoJM SmoligaGR 2014 Foot-and-mouth disease virus virulence in cattle is co-determined by viral replication dynamics and route of infection Virology 452 12 22 https://doi.org/10.1016/j.virol.2014.01.001 Search in Google Scholar

Bauer K (1997) Foot-and-mouth disease as zoonosis. Arch Virol Suppl 13:95–97. https://doi.org/10.1007/978-3-7091-6534-8_9 BauerK 1997 Foot-and-mouth disease as zoonosis Arch Virol Suppl 13 95 97 https://doi.org/10.1007/978-3-7091-6534-8_9 Search in Google Scholar

Belsham GJ, Martinez-Salas E (2019) Genome organization, translation and replication of foot-and-mouth disease virus RNA. In: Sobrino F, Domingo E (eds) Foot and mouth disease: Current perspective. Caister Academic Press, Boca Raton, Florida, United States, pp 19–52. https://doi.org/10.1201/9780429125614-2 BelshamGJ Martinez-SalasE 2019 Genome organization, translation and replication of foot-and-mouth disease virus RNA In: Sobrino F Domingo E (eds) Foot and mouth disease: Current perspective Caister Academic Press Boca Raton, Florida, United States 19 52 https://doi.org/10.1201/9780429125614-2 Search in Google Scholar

Biswal JK, Mohapatra JK, Bisht P et al (2015) A positively charged lysine residue at VP2 131 position allows for the enhanced adaptability of foot-and-mouth disease virus serotype A in BHK-21 cells. Biologicals 43:71–78. https://doi.org/10.1016/j.biologicals.2014.07.001 BiswalJK MohapatraJK BishtP 2015 A positively charged lysine residue at VP2 131 position allows for the enhanced adaptability of foot-and-mouth disease virus serotype A in BHK-21 cells Biologicals 43 71 78 https://doi.org/10.1016/j.biologicals.2014.07.001 Search in Google Scholar

Brito BP, Rodriguez LL, Hammond JM et al (2017) Review of the global distribution of foot-and-mouth disease virus from 2007 to 2014. Transbound Emerg Dis 64:316–332. https://doi.org/10.1111/tbed.12373 BritoBP RodriguezLL HammondJM 2017 Review of the global distribution of foot-and-mouth disease virus from 2007 to 2014 Transbound Emerg Dis 64 316 332 https://doi.org/10.1111/tbed.12373 Search in Google Scholar

Burman A, Clark S, Abrescia NG et al (2006) Specificity of the VP1 GH loop of foot-and-mouth disease virus for αv integrins. J Virol 80:9798–9810. https://doi.org/10.1128/JVI.00577-06 BurmanA ClarkS AbresciaNG 2006 Specificity of the VP1 GH loop of foot-and-mouth disease virus for αv integrins J Virol 80 9798 9810 https://doi.org/10.1128/JVI.00577-06 Search in Google Scholar

Cacciabue M, Currá A, Carrillo E et al (2020) A beginner’s guide for FMDV quasispecies analysis: Sub-consensus variant detection and haplotype reconstruction using next-generation sequencing. Brief Bioinform 21:1766–1775. https://doi.org/10.1093/bib/bbz086 CacciabueM CurráA CarrilloE 2020 A beginner’s guide for FMDV quasispecies analysis: Sub-consensus variant detection and haplotype reconstruction using next-generation sequencing Brief Bioinform 21 1766 1775 https://doi.org/10.1093/bib/bbz086 Search in Google Scholar

Diaz-San Segundo F, Moraes MP, de Los Santos T et al (2010) Interferon-induced protection against foot-and-mouth disease virus infection correlates with enhanced tissue-specific, innate immune cell infiltration and interferon-stimulated gene expression. J Virol 84:2063–2077. https://doi.org/10.1128/JVI.01874-09 Diaz-San SegundoF MoraesMP de Los SantosT 2010 Interferon-induced protection against foot-and-mouth disease virus infection correlates with enhanced tissue-specific, innate immune cell infiltration and interferon-stimulated gene expression J Virol 84 2063 2077 https://doi.org/10.1128/JVI.01874-09 Search in Google Scholar

Domingo E, Baranowski E, Escarmís C et al (2012) Foot-and-mouth disease virus. In: King AMQ, Adams MJ, Carstens EB, Lefkowitz EJ (eds) Virus taxonomy: Ninth report of the International Committee on taxonomy of viruses. Elsevier Academic Press, Amsterdam, The Netherlands, pp 855–880. DomingoE BaranowskiE EscarmísC 2012 Foot-and-mouth disease virus In: King AMQ Adams MJ Carstens EB Lefkowitz EJ (eds) Virus taxonomy: Ninth report of the International Committee on taxonomy of viruses Elsevier Academic Press Amsterdam, The Netherlands 855 880 Search in Google Scholar

Ferretti L, Di Nardo A, Singer B et al (2018) Within-host recombination in the foot-and-mouth disease virus genome. Viruses 10:221. https://doi.org/10.3390/v10050221 FerrettiL Di NardoA SingerB 2018 Within-host recombination in the foot-and-mouth disease virus genome Viruses 10 221 https://doi.org/10.3390/v10050221 Search in Google Scholar

Golde WT, Pacheco JM, Duque H et al (2005) Vaccination against foot-and-mouth disease virus confers complete clinical protection in 7 days and partial protection in 4 days: Use in emergency outbreak response. Vaccine 23:5775–5782. https://doi.org/10.1016/j.vaccine.2005.07.043 GoldeWT PachecoJM DuqueH 2005 Vaccination against foot-and-mouth disease virus confers complete clinical protection in 7 days and partial protection in 4 days: Use in emergency outbreak response Vaccine 23 5775 5782 https://doi.org/10.1016/j.vaccine.2005.07.043 Search in Google Scholar

Grubman MJ, Baxt B (2004) Foot-and-mouth disease. Clin Microbiol Rev 17:465–493. https://doi.org/10.1128/CMR.17.2.465-493.2004 GrubmanMJ BaxtB 2004 Foot-and-mouth disease Clin Microbiol Rev 17 465 493 https://doi.org/10.1128/CMR.17.2.465-493.2004 Search in Google Scholar

Grubman MJ, Moraes MP, Diaz-San Segundo F et al (2008) Evading the host immune response: How foot-and-mouth disease virus has become an effective pathogen. FEMS Immunol Med Microbiol 53:8–17. https://doi.org/10.1111/j.1574-695X.2008.00409.x GrubmanMJ MoraesMP Diaz-San SegundoF 2008 Evading the host immune response: How foot-and-mouth disease virus has become an effective pathogen FEMS Immunol Med Microbiol 53 8 17 https://doi.org/10.1111/j.1574-695X.2008.00409.x Search in Google Scholar

Han SC, Guo HC, Sun SQ et al (2016) Productive entry of the foot-and-mouth disease virus via macropinocytosis, independent of phosphatidylinositol 3-kinase. Sci Rep 6:19294. https://doi.org/10.1038/srep19294 HanSC GuoHC SunSQ 2016 Productive entry of the foot-and-mouth disease virus via macropinocytosis, independent of phosphatidylinositol 3-kinase Sci Rep 6 19294 https://doi.org/10.1038/srep19294 Search in Google Scholar

Hardham JM, Krug P, Pacheco JM et al (2020) Novel foot-and-mouth disease vaccine platform: Formulations for safe and DIVA-compatible FMD vaccines with improved potency. Front Vet Sci 7:554305. https://doi.org/10.3389/fvets.2020.554305 HardhamJM KrugP PachecoJM 2020 Novel foot-and-mouth disease vaccine platform: Formulations for safe and DIVA-compatible FMD vaccines with improved potency Front Vet Sci 7 554305 https://doi.org/10.3389/fvets.2020.554305 Search in Google Scholar

Haseeb M, Anwar MA, Choi S (2018) Molecular interactions between innate and adaptive immune cells in chronic lymphocytic leukemia and their therapeutic implications. Front Immunol 9:2720. https://doi.org/10.3389/fimmu.2018.02720 HaseebM AnwarMA ChoiS 2018 Molecular interactions between innate and adaptive immune cells in chronic lymphocytic leukemia and their therapeutic implications Front Immunol 9 2720 https://doi.org/10.3389/fimmu.2018.02720 Search in Google Scholar

Haydon DT, Samuel AR, Knowles NJ (2001) The generation and persistence of genetic variation in the foot-and-mouth disease virus. Prev Vet Med 51:111–124. https://doi.org/10.1016/s0167-5877(01)00210-0 HaydonDT SamuelAR KnowlesNJ 2001 The generation and persistence of genetic variation in the foot-and-mouth disease virus Prev Vet Med 51 111 124 https://doi.org/10.1016/s0167-5877(01)00210-0 Search in Google Scholar

He Y, Li K, Cao Y et al (2021a) Structures of the foot-and-mouth disease virus with neutralizing antibodies derived from recovered natural host reveal a mechanism for cross-serotype neutralization. PLoS Pathog 17:e1009507. https://doi.org/10.1371/journal.ppat.1009507 HeY LiK CaoY 2021a Structures of the foot-and-mouth disease virus with neutralizing antibodies derived from recovered natural host reveal a mechanism for cross-serotype neutralization PLoS Pathog 17 e1009507 https://doi.org/10.1371/journal.ppat.1009507 Search in Google Scholar

He Y, Li K, Wang L et al (2021b) Structures of the foot-and-mouth disease virus with bovine neutralizing antibodies reveal the determinant of intraserotype cross-neutralization. J Virol 95:e0130821. https://doi.org/10.1128/JVI.01308-21 HeY LiK WangL 2021b Structures of the foot-and-mouth disease virus with bovine neutralizing antibodies reveal the determinant of intraserotype cross-neutralization J Virol 95 e0130821 https://doi.org/10.1128/JVI.01308-21 Search in Google Scholar

Heath L, van der Walt E, Varsani A et al (2006) Recombination patterns in Aphthoviruses mirror those found in other Picornaviruses. J Virol 80:11827–11832. https://doi.org/10.1128/JVI.01100-06 HeathL van der WaltE VarsaniA 2006 Recombination patterns in Aphthoviruses mirror those found in other Picornaviruses J Virol 80 11827 11832 https://doi.org/10.1128/JVI.01100-06 Search in Google Scholar

Howes EL (2018) Investigating the foot-and-mouth disease virus 3A protein. Doctoral dissertation, University of St Andrews. Available from the University of St Andrews Research Repository HowesEL 2018 Investigating the foot-and-mouth disease virus 3A protein Doctoral dissertation University of St Andrews Available from the University of St Andrews Research Repository Search in Google Scholar

Jamal SM, Belsham GJ (2013) Foot-and-mouth disease: Past, present, and future. Vet Res 44:116. https://doi.org/10.1186/1297-9716-44-116 JamalSM BelshamGJ 2013 Foot-and-mouth disease: Past, present, and future Vet Res 44 116 https://doi.org/10.1186/1297-9716-44-116 Search in Google Scholar

Knight-Jones TJ, Rushton J (2013) The economic impacts of foot-and-mouth disease - what are they, how big are they, and where do they occur? Prev Vet Med 112:161–173. https://doi.org/10.1016/j.prevetmed.2013.07.013 Knight-JonesTJ RushtonJ 2013 The economic impacts of foot-and-mouth disease - what are they, how big are they, and where do they occur? Prev Vet Med 112 161 173 https://doi.org/10.1016/j.prevetmed.2013.07.013 Search in Google Scholar

Knox C, Moffat K, Ali S et al (2005) Foot-and-mouth disease virus replication sites form next to the nucleus and close to the Golgi apparatus, but exclude marker proteins associated with host membrane compartments. J Gen Virol 86:687–696. https://doi.org/10.1099/vir.0.80208-0 KnoxC MoffatK AliS 2005 Foot-and-mouth disease virus replication sites form next to the nucleus and close to the Golgi apparatus, but exclude marker proteins associated with host membrane compartments J Gen Virol 86 687 696 https://doi.org/10.1099/vir.0.80208-0 Search in Google Scholar

Kotecha A, Perez-Martin E, Harvey Y et al (2018) Chimeric O1K foot-and-mouth disease virus with SAT2 outer capsid as an FMD vaccine candidate. Sci Rep 8:13654. https://doi.org/10.1038/s41598-018-31856-x KotechaA Perez-MartinE HarveyY 2018 Chimeric O1K foot-and-mouth disease virus with SAT2 outer capsid as an FMD vaccine candidate Sci Rep 8 13654 https://doi.org/10.1038/s41598-018-31856-x Search in Google Scholar

Kotecha A, Wang Q, Dong X et al (2017) Rules of engagement between αvβ6 integrin and the foot-and-mouth disease virus. Nat Commun 8:15408. https://doi.org/10.1038/ncomms15408 KotechaA WangQ DongX 2017 Rules of engagement between αvβ6 integrin and the foot-and-mouth disease virus Nat Commun 8 15408 https://doi.org/10.1038/ncomms15408 Search in Google Scholar

Lawrence P, Rai D, Conderino JS et al (2016) Role of the Jumonji C-domain containing protein 6 (JMJD6) in infectivity of foot-and-mouth disease virus. Virology 492:38–52. https://doi.org/10.1016/j-virol.2016.02.005 LawrenceP RaiD ConderinoJS 2016 Role of the Jumonji C-domain containing protein 6 (JMJD6) in infectivity of foot-and-mouth disease virus Virology 492 38 52 https://doi.org/10.1016/j-virol.2016.02.005 Search in Google Scholar

Lefebvre DJ, Neyts J, De Clercq K (2010) Development of a foot-and-mouth disease infection model in severe combined immunodeficient mice for the preliminary evaluation of antiviral drugs. Transbound Emerg Dis 57:430–433. https://doi.org/10.1111/j.1865-1682.2010.01169.x LefebvreDJ NeytsJ De ClercqK 2010 Development of a foot-and-mouth disease infection model in severe combined immunodeficient mice for the preliminary evaluation of antiviral drugs Transbound Emerg Dis 57 430 433 https://doi.org/10.1111/j.1865-1682.2010.01169.x Search in Google Scholar

Lei X, Cui S, Zhao Z et al (2015) Etiology, pathogenesis, antivirals, and vaccines of hand, foot, and mouth disease. Nat Sci Rev 2:268–284. https://doi.org/10.1093/nsr/nwv038 LeiX CuiS ZhaoZ 2015 Etiology, pathogenesis, antivirals, and vaccines of hand, foot, and mouth disease Nat Sci Rev 2 268 284 https://doi.org/10.1093/nsr/nwv038 Search in Google Scholar

Li F, Li Y, Ma J et al (2023) Molecular evolution, diversity, and adaptation of foot-and-mouth disease virus serotype O in Asia. Front Microbiol 14:1147652. https://doi.org/10.3389/fmicb.2023.1147652 LiF LiY MaJ 2023 Molecular evolution, diversity, and adaptation of foot-and-mouth disease virus serotype O in Asia Front Microbiol 14 1147652. https://doi.org/10.3389/fmicb.2023.1147652 Search in Google Scholar

Li JP, Kusche-Gullberg M (2016) Heparan sulfate: Biosynthesis, structure, and function. Int Rev Cell Mol Biol 325:215–273. https://doi.org/10.1016/bs.ircmb.2016.02.009 LiJP Kusche-GullbergM 2016 Heparan sulfate: Biosynthesis, structure, and function Int Rev Cell Mol Biol 325 215 273 https://doi.org/10.1016/bs.ircmb.2016.02.009 Search in Google Scholar

Li K, Wang C, Yang F et al (2021) Virus–host interactions in foot-and-mouth disease virus infection. Front Immunol 12:571509. https://doi.org/10.3389/fimmu.2021.571509 LiK WangC YangF 2021 Virus–host interactions in foot-and-mouth disease virus infection Front Immunol 12 571509. https://doi.org/10.3389/fimmu.2021.571509 Search in Google Scholar

Lin JY, Li ML, Shih SR (2009) Far upstream element binding protein 2 interacts with enterovirus 71 internal ribosomal entry site and negatively regulates viral translation. Nucleic Acids Res 37: 47–59. https://doi.org/10.1093/nar/gkn901 LinJY LiML ShihSR 2009 Far upstream element binding protein 2 interacts with enterovirus 71 internal ribosomal entry site and negatively regulates viral translation Nucleic Acids Res 37 47 59 https://doi.org/10.1093/nar/gkn901 Search in Google Scholar

Loundras EA (2017) The foot-and-mouth disease virus replication complex: Dissecting the role of the viral polymerase (3Dpol) and investigating interactions with phosphatidylinositol-4-kinase (PI4K). Doctoral dissertation, University of Leeds. LoundrasEA 2017 The foot-and-mouth disease virus replication complex: Dissecting the role of the viral polymerase (3Dpol) and investigating interactions with phosphatidylinositol-4-kinase (PI4K) Doctoral dissertation University of Leeds Search in Google Scholar

Madi M, Mioulet V, King DP et al (2015) Development of a non-infectious, encapsidated positive control RNA for molecular assays to detect foot-and-mouth disease virus. J Virol Methods 220:27–34. https://doi.org/10.1016/j.jviromet.2015.04.002 MadiM MiouletV KingDP 2015 Development of a non-infectious, encapsidated positive control RNA for molecular assays to detect foot-and-mouth disease virus J Virol Methods 220 27 34 https://doi.org/10.1016/j.jviromet.2015.04.002 Search in Google Scholar

Mahapatra M, Statham B, Li Y et al (2016) Emergence of antigenic variants within serotype A FMDV in the Middle East with antigenically critical amino acid substitutions. Vaccine 34:3199–3206. https://doi.org/10.1016/j.vaccine.2016.02.057 MahapatraM StathamB LiY 2016 Emergence of antigenic variants within serotype A FMDV in the Middle East with antigenically critical amino acid substitutions Vaccine 34 3199 3206 https://doi.org/10.1016/j.vaccine.2016.02.057 Search in Google Scholar

Martín-Acebes MA, González-Magaldi M, Sandvig K et al (2007) Productive entry of type C foot-and-mouth disease virus into susceptible cultured cells requires clathrin and is dependent on the presence of plasma membrane cholesterol. Virology 369:105–118. https://doi.org/10.1016/j.virol.2007.07.021 Martín-AcebesMA González-MagaldiM SandvigK 2007 Productive entry of type C foot-and-mouth disease virus into susceptible cultured cells requires clathrin and is dependent on the presence of plasma membrane cholesterol Virology 369 105 118 https://doi.org/10.1016/j.virol.2007.07.021 Search in Google Scholar

Martinez-Salas E, Saiz M, Sobrino F (2008) Foot-and-mouth disease virus. In: Thomas C, Mettenleiter TC, Sobrino F (eds) Animal viruses: Molecular biology. Caister Academic Press, Norfolk, United Kingdom, pp 1–47. Martinez-SalasE SaizM SobrinoF 2008 Foot-and-mouth disease virus In: ThomasC MettenleiterTC SobrinoF (eds) Animal viruses: Molecular biology Caister Academic Press Norfolk, United Kingdom 1 47 Search in Google Scholar

Mason PW, Bezborodova SV, Henry TM (2002) Identification and characterization of a cis-acting replication element (cre) adjacent to the internal ribosome entry site of foot-and-mouth disease virus. J Virol 76:9686–9694. https://doi.org/10.1128/jvi.76.19.9686-9694.2002 MasonPW BezborodovaSV HenryTM 2002 Identification and characterization of a cis-acting replication element (cre) adjacent to the internal ribosome entry site of foot-and-mouth disease virus J Virol 76 9686 9694 https://doi.org/10.1128/jvi.76.19.9686-9694.2002 Search in Google Scholar

Mason PW, Rieder E, Baxt B (1994) RGD sequence of foot-and-mouth disease virus is essential for infecting cells via the natural receptor, but can be bypassed by an antibody-dependent enhancement pathway. Proc Natl Acad Sci U S A 91:1932–1936. https://doi.org/10.1073/pnas.91.5.1932 MasonPW RiederE BaxtB 1994 RGD sequence of foot-and-mouth disease virus is essential for infecting cells via the natural receptor, but can be bypassed by an antibody-dependent enhancement pathway Proc Natl Acad Sci U S A 91 1932 1936 https://doi.org/10.1073/pnas.91.5.1932 Search in Google Scholar

Medina GN, Segundo FDS, Stenfeldt C et al (2018) The different tactics of foot-and-mouth disease virus to evade innate immunity. Front Microbiol 9:2644. https://doi.org/10.3389/fmicb.2018.02644 MedinaGN SegundoFDS StenfeldtC 2018 The different tactics of foot-and-mouth disease virus to evade innate immunity Front Microbiol 9 2644 https://doi.org/10.3389/fmicb.2018.02644 Search in Google Scholar

Midgley R, Moffat K, Berryman S et al (2013) A role for endoplasmic reticulum exit sites in foot-and-mouth disease virus infection. J Gen Virol 94:2636. https://doi.org/10.1099/vir.0.055442-0 MidgleyR MoffatK BerrymanS 2013 A role for endoplasmic reticulum exit sites in foot-and-mouth disease virus infection J Gen Virol 94 2636 https://doi.org/10.1099/vir.0.055442-0 Search in Google Scholar

Mwiine FN, Velazquez-Salinas L, Ahmed Z et al (2019) Serological and phylogenetic characterization of foot-and-mouth disease viruses from Uganda during a cross-sectional surveillance study in cattle between 2014 and 2017. Transbound Emerg Dis 66:2011–2024. https://doi.org/10.1111/tbed.13249 MwiineFN Velazquez-SalinasL AhmedZ 2019 Serological and phylogenetic characterization of foot-and-mouth disease viruses from Uganda during a cross-sectional surveillance study in cattle between 2014 and 2017 Transbound Emerg Dis 66 2011 2024 https://doi.org/10.1111/tbed.13249 Search in Google Scholar

Naghavi MH, Walsh D (2017) Microtubule regulation and function during virus infection. J Virol 91:e00538–17. https://doi.org/10.1128/JVI.00538-17 NaghaviMH WalshD 2017 Microtubule regulation and function during virus infection J Virol 91 e00538 17 https://doi.org/10.1128/JVI.00538-17 Search in Google Scholar

Naqvi SS, Bostan N, Fukai K et al (2022) Evolutionary dynamics of foot-and-mouth disease virus serotype A and its endemic sub-lineage A/ASIA/Iran-05/SIS-13 in Pakistan. Viruses 14:1634. https://doi.org/10.3390/v14081634 NaqviSS BostanN FukaiK 2022 Evolutionary dynamics of foot-and-mouth disease virus serotype A and its endemic sub-lineage A/ASIA/Iran-05/SIS-13 in Pakistan Viruses 14 1634 https://doi.org/10.3390/v14081634 Search in Google Scholar

O’Donnell V, LaRocco M, Baxt B (2008) Heparan sulfate-binding foot-and-mouth disease virus enters cells via caveola-mediated endocytosis. J Virol 82:9075–9085. https://doi.org/10.1128/JVI.00732-08 O’DonnellV LaRoccoM BaxtB 2008 Heparan sulfate-binding foot-and-mouth disease virus enters cells via caveola-mediated endocytosis J Virol 82 9075 9085 https://doi.org/10.1128/JVI.00732-08 Search in Google Scholar

Orton RJ, Wright CF, King DP et al (2020) Estimating viral bottleneck sizes for FMDV transmission within and between hosts, and implications for the rate of viral evolution. Interface Focus 10:20190066. https://doi.org/10.1098/rsfs.2019.0066 OrtonRJ WrightCF KingDP 2020 Estimating viral bottleneck sizes for FMDV transmission within and between hosts, and implications for the rate of viral evolution Interface Focus 10 20190066. https://doi.org/10.1098/rsfs.2019.0066 Search in Google Scholar

Pacheco JM, Smoliga GR, O’Donnell V et al (2015) Persistent foot-and-mouth disease virus infection in the nasopharynx of cattle: Tissue-specific distribution and local cytokine expression. PLoS One 10:e0125698. https://doi.org/10.1371/journal.pone.0125698 PachecoJM SmoligaGR O’DonnellV 2015 Persistent foot-and-mouth disease virus infection in the nasopharynx of cattle: Tissue-specific distribution and local cytokine expression PLoS One 10 e0125698 https://doi.org/10.1371/journal.pone.0125698 Search in Google Scholar

Paton DJ, Di Nardo A, Knowles NJ et al (2021) The history of foot-and-mouth disease virus serotype C: The first known extinct serotype? Virus Evol 7:veab009. https://doi.org/10.1093/ve/veab009 PatonDJ Di NardoA KnowlesNJ 2021 The history of foot-and-mouth disease virus serotype C: The first known extinct serotype? Virus Evol 7 veab009 https://doi.org/10.1093/ve/veab009 Search in Google Scholar

Perry BD, Rich KM (2007) Poverty impacts of foot-and-mouth disease and the poverty reduction implications of its control. Vet Rec 160:238–241. https://doi.org/10.1136/vr.160.7.238 PerryBD RichKM 2007 Poverty impacts of foot-and-mouth disease and the poverty reduction implications of its control Vet Rec 160 238 241 https://doi.org/10.1136/vr.160.7.238 Search in Google Scholar

Prempeh H, Smith R, Müller B (2001) Foot-and-mouth disease: The human consequences; the health consequences are slight, the economic ones huge. BMJ 322:565–566. https://doi.org/10.1136/bmj.322.7286.565 PrempehH SmithR MüllerB 2001 Foot-and-mouth disease: The human consequences; the health consequences are slight, the economic ones huge BMJ 322 565 566 https://doi.org/10.1136/bmj.322.7286.565 Search in Google Scholar

Rweyemamu M, Roeder P, Mackay D et al (2008) Epidemiological patterns of foot-and-mouth disease worldwide. Transbound Emerg Dis 55:57–72. https://doi.org/10.1111/j.1865-1682.2007.01013.x RweyemamuM RoederP MackayD 2008 Epidemiological patterns of foot-and-mouth disease worldwide Transbound Emerg Dis 55 57 72 https://doi.org/10.1111/j.1865-1682.2007.01013.x Search in Google Scholar

Sanjuán R (2012) From molecular genetics to phylodynamics: Evolutionary relevance of mutation rates across viruses. PLoS Pathog 8:e1002685. https://doi.org/10.1371/journal.ppat.1002685 SanjuánR 2012 From molecular genetics to phylodynamics: Evolutionary relevance of mutation rates across viruses PLoS Pathog 8 e1002685 https://doi.org/10.1371/journal.ppat.1002685 Search in Google Scholar

Sonenberg N, Hinnebusch AG (2009) Regulation of translation initiation in eukaryotes: Mechanisms and biological targets. Cell 136:731–745. https://doi.org/10.1016/j.cell.2009.01.042 SonenbergN HinnebuschAG 2009 Regulation of translation initiation in eukaryotes: Mechanisms and biological targets Cell 136 731 745 https://doi.org/10.1016/j.cell.2009.01.042 Search in Google Scholar

Stassinopoulos IA, Belsham GJ (2001) A novel protein–RNA binding assay: Functional interactions of the foot-and-mouth disease virus internal ribosome entry site with cellular proteins. RNA 7:114–122. https://doi.org/10.1017/s1355838201001170 StassinopoulosIA BelshamGJ 2001 A novel protein–RNA binding assay: Functional interactions of the foot-and-mouth disease virus internal ribosome entry site with cellular proteins RNA 7 114 122 https://doi.org/10.1017/s1355838201001170 Search in Google Scholar

Stenfeldt C, Pacheco JM, Smoliga GR et al (2016) Detection of foot-and-mouth disease virus RNA and capsid protein in lymphoid tissues of convalescent pigs does not indicate existence of a carrier state. Transbound Emerg Dis 63:152–164. https://doi.org/10.1111/tbed.12235 StenfeldtC PachecoJM SmoligaGR 2016 Detection of foot-and-mouth disease virus RNA and capsid protein in lymphoid tissues of convalescent pigs does not indicate existence of a carrier state Transbound Emerg Dis 63 152 164 https://doi.org/10.1111/tbed.12235 Search in Google Scholar

Tekleghiorghis T, Moormann RJ, Weerdmeester K et al (2016) Foot-and-mouth disease transmission in Africa: Implications for control. A review. Transbound Emerg Dis 63:136–151. https://doi.org/10.1111/tbed.12248 TekleghiorghisT MoormannRJ WeerdmeesterK 2016 Foot-and-mouth disease transmission in Africa: Implications for control. A review Transbound Emerg Dis 63 136 151 https://doi.org/10.1111/tbed.12248 Search in Google Scholar

Wang Y, Das A, Zheng W et al (2020) Development and evaluation of multiplex, real-time RT-PCR assays for the detection and differentiation of foot-and-mouth disease virus and Seneca Valley virus 1. Transbound Emerg Dis 67:604–616. https://doi.org/10.1111/tbed.13373 WangY DasA ZhengW 2020 Development and evaluation of multiplex, real-time RT-PCR assays for the detection and differentiation of foot-and-mouth disease virus and Seneca Valley virus 1 Transbound Emerg Dis 67 604 616 https://doi.org/10.1111/tbed.13373 Search in Google Scholar

World Organization for Animal Health (2023) Terrestrial Animal Health Code. Available at: https://www.woah.org/en/what-we-do/standards/codes-and-manuals/terrestrial-code-online-access World Organization for Animal Health 2023 Terrestrial Animal Health Code Available at: https://www.woah.org/en/what-we-do/standards/codes-and-manuals/terrestrial-code-online-access Search in Google Scholar

Wu P, Rodríguez YY, Hershey BJ et al (2021) Validation of a binary ethylenimine (BEI) inactivation procedure for biosafety treatment of foot-and-mouth disease viruses (FMDVs), vesicular stomatitis viruses (VSVs), and swine vesicular disease viruses (SVDVs). Vet Microbiol 252:108928. https://doi.org/10.1016/j.vetmic.2020.108928 WuP RodríguezYY HersheyBJ 2021 Validation of a binary ethylenimine (BEI) inactivation procedure for biosafety treatment of foot-and-mouth disease viruses (FMDVs), vesicular stomatitis viruses (VSVs), and swine vesicular disease viruses (SVDVs) Vet Microbiol 252 108928 https://doi.org/10.1016/j.vetmic.2020.108928 Search in Google Scholar

Wu X, Hu Y, Sui C et al (2022) Multiple-site SUMOylation of FMDV 3C protease and its negative role in viral replication. J Virol 96:e0061222. https://doi.org/10.1128/jvi.00612-22 WuX HuY SuiC 2022 Multiple-site SUMOylation of FMDV 3C protease and its negative role in viral replication J Virol 96 e0061222 https://doi.org/10.1128/jvi.00612-22 Search in Google Scholar

Xiao Y, Zhang S, Yan H et al (2021) The high immunity induced by the virus-like particles of foot-and-mouth disease virus serotype O. Front Vet Sci 8:633706. https://doi.org/10.3389/fvets.2021.633706 XiaoY ZhangS YanH 2021 The high immunity induced by the virus-like particles of foot-and-mouth disease virus serotype O Front Vet Sci 8 633706 https://doi.org/10.3389/fvets.2021.633706 Search in Google Scholar

Xin X, Wang H, Han L et al (2018) Single-cell analysis of the impact of host cell heterogeneity on infection with the foot-and-mouth disease virus. J Virol 92:e00179–18. https://doi.org/10.1128/JVI.00179-18 XinX WangH HanL 2018 Single-cell analysis of the impact of host cell heterogeneity on infection with the foot-and-mouth disease virus J Virol 92 e00179 18 https://doi.org/10.1128/JVI.00179-18 Search in Google Scholar

Xu W, Yang M (2021) Genetic variation and evolution of foot–and–mouth disease virus serotype A in relation to vaccine matching. Vaccine 39:1420–1427. https://doi.org/10.1016/j.vaccine.2021.01.042 XuW YangM 2021 Genetic variation and evolution of foot–and–mouth disease virus serotype A in relation to vaccine matching Vaccine 39 1420 1427 https://doi.org/10.1016/j.vaccine.2021.01.042 Search in Google Scholar

Yang F, Zhu Z, Cao W et al (2020) Genetic determinants of altered virulence of type O foot-and-mouth disease virus. J Virol 94:e01657–19. https://doi.org/10.1128/JVI.01657-19 YangF ZhuZ CaoW 2020 Genetic determinants of altered virulence of type O foot-and-mouth disease virus J Virol 94 e01657 19 https://doi.org/10.1128/JVI.01657-19 Search in Google Scholar

Ye X, Pan T, Wang D et al (2018) Foot-and-mouth disease virus counteracts on internal ribosome entry site suppression by G3BP1 and inhibits G3BP1-mediated stress granule assembly via post-translational mechanisms. Front Immunol 9:1142. https://doi.org/10.3389/fimmu.2018.01142 YeX PanT WangD 2018 Foot-and-mouth disease virus counteracts on internal ribosome entry site suppression by G3BP1 and inhibits G3BP1-mediated stress granule assembly via post-translational mechanisms Front Immunol 9 1142 https://doi.org/10.3389/fimmu.2018.01142 Search in Google Scholar

Zhang X, Zhu Z, Wang C et al (2020) Foot-and-mouth disease virus 3B protein interacts with pattern recognition receptor RIG-I to block RIG-I–mediated immune signaling and inhibit host antiviral response. J Immunol 205:2207–2221. https://doi.org/10.4049/jimmunol.1901333 ZhangX ZhuZ WangC 2020 Foot-and-mouth disease virus 3B protein interacts with pattern recognition receptor RIG-I to block RIG-I–mediated immune signaling and inhibit host antiviral response J Immunol 205 2207 2221 https://doi.org/10.4049/jimmunol.1901333 Search in Google Scholar

Zhang Z, Murphy C, Quan M et al (2004) Extent of reduction of foot-and-mouth disease virus RNA load in oesophageal–pharyngeal fluid after peak levels may be a critical determinant of virus persistence in infected cattle. J Gen Virol 85:415–421. https://doi.org/10.1099/vir.0.19538-0 ZhangZ MurphyC QuanM 2004 Extent of reduction of foot-and-mouth disease virus RNA load in oesophageal–pharyngeal fluid after peak levels may be a critical determinant of virus persistence in infected cattle J Gen Virol 85 415 421 https://doi.org/10.1099/vir.0.19538-0 Search in Google Scholar

Zhu Z, Li W, Zhang X et al (2020) Foot-and-mouth disease virus capsid protein VP1 interacts with host ribosomal protein SA to maintain activation of the MAPK signal pathway and promote virus replication. J Virol 94:e01350–19. https://doi.org/10.1128/JVI.01350-19 ZhuZ LiW ZhangX 2020 Foot-and-mouth disease virus capsid protein VP1 interacts with host ribosomal protein SA to maintain activation of the MAPK signal pathway and promote virus replication J Virol 94 e01350 19 https://doi.org/10.1128/JVI.01350-19 Search in Google Scholar