Unusual aetiology of a type 2 myocardial infarction: a case-based review

1Thygesen K, Alpert JS, Jaffe AS, Chaitman BR, Bax JJ, Morrow DA, White HD; the Executive Group on behalf of the Joint European Society of Cardiology (ESC)/American College of Cardiology (ACC)/American Heart Association (AHA)/World Heart Federation (WHF) Task Force for the Universal Definition of Myocardial Infarction. Fourth universal definition of myocardial infarction (2018). Circulation 2018;138: e618–51. doi: 10.1161/ CIR.0000000000000617Thygesen K Alpert JS Jaffe AS Chaitman BR Bax JJ Morrow DA White HD the Executive Group on behalf of the Joint European Society of Cardiology (ESC)/American College of Cardiology (ACC)/American Heart Association (AHA)/World Heart Federation (WHF) Task Force for the Universal Definition of Myocardial Infarction Fourth universal definition of myocardial infarction (2018) Circulation 2018138 e618 51 10.1161/CIR.0000000000000617Open DOISearch in Google Scholar

2Kim S, Lim JH, Kim Y, Oh S, Choi WG. A case of acute carbon monoxide poisoning resulting in an ST elevation myocardial infarction. Korean Circ J 2012;42:133–5. doi: 10.4070/kcj.2012.42.2.133Kim S Lim JH Kim Y Oh S Choi WG A case of acute carbon monoxide poisoning resulting in an ST elevation myocardial infarction Korean Circ J 201242133 5 10.4070/kcj.2012.42.2.133Open DOISearch in Google Scholar

3Kidiyoor Y, Nayak VC, Devi V, Bakkannavar SM, Kumar GP, Menezes RG. A rare case of myocardial infarction due to parathion poisoning. J Forensic Leg Med 2009;16:472–4. doi: 10.1016/j.jflm.2009.05.003Kidiyoor Y Nayak VC Devi V Bakkannavar SM Kumar GP Menezes RG A rare case of myocardial infarction due to parathion poisoning J Forensic Leg Med 200916472 4 10.1016/j.jflm.2009.05.003Open DOISearch in Google Scholar

4Lionte C, Sorodoc L, Petris O, Sorodoc V. [Electrocardiographic changes in acute organophosphate poisoning, in Romainan]. Rev Med Chir Soc Med Nat Iasi 2007;111:906–11. PMID: 18389778Lionte C Sorodoc L Petris O Sorodoc V [Electrocardiographic changes in acute organophosphate poisoning, in Romainan] Rev Med Chir Soc Med Nat Iasi 2007111906 11 PMID: 18389778Search in Google Scholar

5Kiss Z, Fazekas T. Arrhythmias in organophosphate poisonings. Acta Cardiol 1979;34:303–23. PMID: 317206Kiss Z Fazekas T Arrhythmias in organophosphate poisonings Acta Cardiol 197934303 23 PMID: 317206Search in Google Scholar

6Karasu-Minareci E, Gunay N, Minareci K, Sadan G, Ozbey G. What may be happen after an organophosphate exposure: Acute myocardial infarction? J Forensic Leg Med 2012;19:94–6. doi: 10.1016/j.jflm.2011.07.011Karasu-Minareci E Gunay N Minareci K Sadan G Ozbey G What may be happen after an organophosphate exposure: Acute myocardial infarction? J Forensic Leg Med 20121994 6 10.1016/j.jflm.2011.07.011Open DOISearch in Google Scholar

7Chharba ML, Sepaha GC, Jain SR, Bhagwat RR, Khandekar JD. ECG and necropsy changes in organophosphorus compound (malathion) poisoning. Indian J Med Sci 1970;24:424–9. PMID: 5523187Chharba ML Sepaha GC Jain SR Bhagwat RR Khandekar JD ECG and necropsy changes in organophosphorus compound (malathion) poisoning Indian J Med Sci 197024424 9 PMID: 5523187Search in Google Scholar

8Georgidalis N, Konstantinos T, Tsitsimpikou C, Vardavas A, Ramin R, Germanakis I, Tsatsakis A, Stagos D, Kouretas D. Pesticides and cardiotoxicity. Where do we stand? Toxicol Appl Pharmacol 2018;353:1–14. doi: 10.1016/j. taap.2018.06.004Georgidalis N Konstantinos T Tsitsimpikou C Vardavas A Ramin R Germanakis I Tsatsakis A Stagos D Kouretas D Pesticides and cardiotoxicity Where do we stand? Toxicol Appl Pharmacol 20183531 14 10.1016/j.taap.2018.06.004Open DOISearch in Google Scholar

9Sandoval Y, Thygesen K, Jaffe AS. The universal definition of myocardial infarction: present and future. Circulation 2 0 2 0 ; 1 4 1 : 1 4 3 4 – 6 . do i : 1 0 . 1 1 6 1 / CIRCULATIONAHA.120.045708Sandoval Y Thygesen K Jaffe AS The universal definition of myocardial infarction: present and future Circulation 2020 141 1434 6 10.1161/CIRCULATIONAHA.120.045708Open DOISearch in Google Scholar

10Ibanez B, James S, Agewall S, Antunes MJ, Bucciarelli-Ducci C, Bueno H, Caforio ALP, Crea F, Goudevenos JA, Halvorsen S, Hindricks G, Kastrati A, Lenzen MJ, Prescott E, Roffi M, Valgimigli M, Varenhorst C, Vranckx P, Widimský P; ESC Scientific Document Group. 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J 2018;39:119–77. doi: 10.1093/eurheartj/ehx393Ibanez B James S Agewall S Antunes MJ Bucciarelli-Ducci C Bueno H Caforio ALP Crea F Goudevenos JA Halvorsen S Hindricks G Kastrati A Lenzen MJ Prescott E Roffi M Valgimigli M Varenhorst C Vranckx P Widimský P; ESC Scientific Document Group. 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC) Eur Heart J 201839119 77 10.1093/eurheartj/ehx393Open DOISearch in Google Scholar

11Antman EM, Anbe DT, Armstrong PW, Bates ER, Green LA, Hand M, Hochman JS, Krumholz HM, Kushner FG, Lamas GA, Mullany CJ, Ornato JP, Pearle DL, Sloan MA, Smith SC Jr; American College of Cardiology; American Heart Association; Canadian Cardiovascular Society. ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to revise the 1999 guidelines for the management of patients with acute myocardial infarction). Circulation 2004;110:e82-e293.Antman EM Anbe DT Armstrong PW Bates ER Green LA Hand M Hochman JS Krumholz HM Kushner FG Lamas GA Mullany CJ Ornato JP Pearle DL Sloan MA Smith SCJr American College of Cardiology; American Heart Association; Canadian Cardiovascular Society. ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to revise the 1999 guidelines for the management of patients with acute myocardial infarction) Circulation 2004110e82 e29310.1161/01.CIR.0000134791.68010.FASearch in Google Scholar

12Karki P, Ansari JA, Bhandary S, Koirala S. Cardiac and electrocardiographical manifestations of acute organophosphate poisoning. Singapore Med J 2004;45:385– 9. PMID: 15284933Karki P Ansari JA Bhandary S Koirala S Cardiac and electrocardiographical manifestations of acute organophosphate poisoning Singapore Med J 200445385 9 PMID: 15284933Search in Google Scholar

13Lionte C, Bologa C, Sorodoc L. Toxic and drug-induced changes of the electrocardiogram. In: Millis R, editor. Advances in electrocardiograms - clinical applications. Rijeka: InTech; 2012. p. 286–8.Lionte C Bologa C Sorodoc L Toxic and drug-induced changes of the electrocardiogram Millis R Advances in electrocardiograms - clinical applications Rijeka InTech 2012 286810.5772/22891Search in Google Scholar

14Ludomirsky A, Klein HO, Sarelli P, Becker B, Hoffman S, Taitelman U, Barzilai J, Lang R, David D, DiSegni E, Kaplinsky E. Q-T prolongation and polymorphous (“torsade de pointes”) ventricular arrhythmias associated with organophosphorus insecticide poisoning. Am J Cardiol 1982;49:1654–8. doi: 10.1016/0002-9149(82)90242-9Ludomirsky A Klein HO Sarelli P Becker B Hoffman S Taitelman U Barzilai J Lang R David D DiSegni E Kaplinsky E Q-T prolongation and polymorphous (“torsade de pointes”) ventricular arrhythmias associated with organophosphorus insecticide poisoning Am J Cardiol 1982491654 8 10.1016/0002-9149(82)90242-9Open DOISearch in Google Scholar

15Kapka- Skrzypczak L, Cyranka M, Skrzypczak M, Kruszewski M. Biomonitoring and biomarkers of organophosphate pesticides exposure - state of the art. Ann Agric Environ Med 2011;18:294–303. PMID: 22216802Kapka- Skrzypczak L Cyranka M Skrzypczak M Kruszewski M Biomonitoring and biomarkers of organophosphate pesticides exposure - state of the art Ann Agric Environ Med 201118294 303 PMID: 22216802Search in Google Scholar

16Kumar S, Kumar Divan S, Dubey S. Myocardial infarction in organophosphorus poisoning: Association or just chance? J Emerg Trauma Shock 2014;7:131–2. doi: 10.4103/09742700.130885Kumar S Kumar Divan S Dubey S Myocardial infarction in organophosphorus poisoning: Association or just chance? J Emerg Trauma Shock 20147131 2 10.4103/09742700.130885Open DOISearch in Google Scholar

17Tamis-Holland JE, Jneid H, Reynolds HR, Agewall S, Brilakis ES, Brown TM, Cushman M, Kumbhani DJ, Arslanian-Engoren C, Bolger AF, Beltrame JF; American Heart Association Interventional Cardiovascular Care Committee of the Council on Clinical Cardiology; Council on Cardiovascular and Stroke Nursing; Council on Epidemiology and Prevention; and Council on Quality of Care and Outcomes Research. Contemporary diagnosis and management of patients with myocardial infarction in the absence of obstructive coronary artery disease: A scientific statement from the American Heart Association. Circulation 2019;139:e891-e908. doi: 10.1161/CIR.0000000000000670Tamis-Holland JE Jneid H Reynolds HR Agewall S Brilakis ES Brown TM Cushman M Kumbhani DJ Arslanian-Engoren C Bolger AF Beltrame JF American Heart Association Interventional Cardiovascular Care Committee of the Council on Clinical Cardiology; Council on Cardiovascular and Stroke Nursing; Council on Epidemiology and Prevention; and Council on Quality of Care and Outcomes Research. Contemporary diagnosis and management of patients with myocardial infarction in the absence of obstructive coronary artery disease: A scientific statement from the American Heart Association Circulation 2019139e891 e908 10.1161/CIR.000000000000067030913893Open DOISearch in Google Scholar

18Scarlone G, Niccoli G, Crea F. Editor’s choice - Pathophysiology, diagnosis and management of MINOCA: an update. Eur Heart J Acute Cardiovasc Care 2019;8:54–62. doi: 10.1177/2048872618782414Scarlone G Niccoli G Crea F Editor’s choice - Pathophysiology, diagnosis and management of MINOCA: an update Eur Heart J Acute Cardiovasc Care 2019854 62 10.1177/204887261878241429952633Open DOISearch in Google Scholar

19Sundagaragiri S, Tandur S. Electrocardiographic profile of cardiotoxic plants and animals. Int J Med Res Health Sci 2016;11:719–25.Sundagaragiri S Tandur S Electrocardiographic profile of cardiotoxic plants and animals Int J Med Res Health Sci 201611719 25Search in Google Scholar

20Waiskopf N, Shenhar-Tsarfaty S, Soreq H. Serum cholinesterase activities as biomarkers of cardiac malfunctioning. In: Patel V, Preedy V, editors. Biomarkers in cardiovascular disease. Biomarkers in disease: methods, discoveries and applications. Dordrecht: Springer; 2016. p. 197–218.Waiskopf N Shenhar-Tsarfaty S Soreq H Serum cholinesterase activities as biomarkers of cardiac malfunctioning Patel V Preedy V Biomarkers in cardiovascular disease. Biomarkers in disease: methods, discoveries and applications Dordrecht Springer 2016 197 21810.1007/978-94-007-7678-4_10Search in Google Scholar

21Mdaghri YA, Mossadeq A, Faroudy M, Sbihi A. Complications cardiaques au cours de l’intoxication aux organophosphorés [Cardiac complications associated with organophosphate poisoning, in French]. Ann Cardiol Angeiol (Paris) 2010;59:114–7. doi: 10.1016/j.ancard.2009.07.005Mdaghri YA Mossadeq A Faroudy M Sbihi A Complications cardiaques au cours de l’intoxication aux organophosphorés [Cardiac complications associated with organophosphate poisoning, in French] Ann Cardiol Angeiol (Paris) 201059114 7 10.1016/j.ancard.2009.07.00519963204Open DOISearch in Google Scholar

22Aydın NB, Küçüktepe Z. Organophosphate intoxication emerging young a case of respiratory failure and myocardial infarction. Selcuk Med J 2014;30:41–3.Aydın NB Küçüktepe Z Organophosphate intoxication emerging young a case of respiratory failure and myocardial infarction Selcuk Med J 20143041 3Search in Google Scholar

23Joshi P, Manoria P, Joseph D, Gandhi Z. Acute myocardial infarction: can it be a complication of acute organophosphorus compound poisoning? J Postgrad Med 2013;59:142–4. doi: 10.4103/0022-3859.113843Joshi P Manoria P Joseph D Gandhi Z Acute myocardial infarction: can it be a complication of acute organophosphorus compound poisoning? J Postgrad Med 201359142 4 10.4103/0022-3859.11384323793318Open DOISearch in Google Scholar

24Pankaj M, Krishna K. Acute organophosphorus poisoning complicated by acute coronary syndrome. J Assoc Physicians India 2014;62:614–6. PMID: 25672037Pankaj M Krishna K Acute organophosphorus poisoning complicated by acute coronary syndrome J Assoc Physicians India 201462614 6 PMID: 25672037Search in Google Scholar

25Tkaczyk J, Brożyna K, Ciechański K, Radzka A, Tchórz M. Fatal pesticide intoxication - case report of a 2 patients. J Educ Health Sport 2018;8:169–74. doi: 10.5281/ zenodo. 1246007Tkaczyk J Brożyna K Ciechański K Radzka A Tchórz M Fatal pesticide intoxication - case report of a 2 patients J Educ Health Sport 20188169 74 10.5281/zenodo.1246007Open DOISearch in Google Scholar

26Kuo HS, Yen CC, Wu CI, Li YH, Chen JY. Organophosphate poisoning presenting as out-of-hospital cardiac arrest: A clinical challenge. J Cardiol Cases 2017;16:18–21. doi: 10.1016/j.jccase.2017.03.006Kuo HS Yen CC Wu CI Li YH Chen JY Organophosphate poisoning presenting as out-of-hospital cardiac arrest: A clinical challenge J Cardiol Cases 20171618 21 10.1016/j.jccase.2017.03.006614925930279788Open DOISearch in Google Scholar

27Höfler M. The Bradford Hill considerations on causality: a counterfactual perspective. Emerg Themes Epidemiol 2005;2:11. doi: 10.1186/1742-7622-2-11.Höfler M The Bradford Hill considerations on causality: a counterfactual perspective Emerg Themes Epidemiol 2005211 10.1186/1742-7622-2-11129138216269083Open DOISearch in Google Scholar

28Ayyadurai P, Subbiah G, Selvaraj V. Myocardial infarction following organophosphorus compound poisoning. J Assoc Physicians India 2018; 66:88–9. PMID: 31315337Ayyadurai P Subbiah G Selvaraj V Myocardial infarction following organophosphorus compound poisoning J Assoc Physicians India 2018 6688 9 PMID: 31315337Search in Google Scholar

29Peter JV, Sudarsan TI, Moran JL. Clinical features of organophosphate poisoning: a review of different classification systems and approaches. Indian J Crit Care Med 2014;18:735–45. doi: 10.4103/0972-5229.144017Peter JV Sudarsan TI Moran JL Clinical features of organophosphate poisoning: a review of different classification systems and approaches Indian J Crit Care Med 201418735 45 10.4103/0972-5229.144017423809125425841Open DOISearch in Google Scholar

30Cha YS, Kim H, Go J, Kim TH, Kim OH, Cha KC, Lee KH, Hwang SO. Features of myocardial injury in severe organophosphate poisoning. Clin Toxicol (Phila) 2014;52:873–9. doi: 10.3109/15563650.2014.944976Cha YS Kim H Go J Kim TH Kim OH Cha KC Lee KH Hwang SO Features of myocardial injury in severe organophosphate poisoning Clin Toxicol (Phila) 201452873 9 10.3109/15563650.2014.94497625116419Open DOISearch in Google Scholar

31Dayton SB, Sandler DP, Blair A, Alavanja M, Beane Freeman LE, Hoppin JA. Pesticide use and myocardial infarction incidence among farm women in the agricultural health study. J Occup Environ Med 2010;52:693–7. doi: 10.1097/ JOM.0b013e3181e66d25Dayton SB Sandler DP Blair A Alavanja M Beane Freeman LE, Hoppin JA. Pesticide use and myocardial infarction incidence among farm women in the agricultural health study J Occup Environ Med 201052693 7 10.1097/JOM.0b013e3181e66d25292722520595914Open DOISearch in Google Scholar

32DeFilippis AP, Chapman AR, Millis NL, De Lemos JA, Arbab-Zadeh A, Newby LK, Morrow DA. Assessment and treatment of patients with type 2 myocardial infarction and acute nonischemic myocardial injury. Circulation 2 0 1 9 ; 1 4 0 : 1 6 6 1 – 7 8 . do i : 1 0 . 1 1 6 1 / CIRCULATIONAHA.119.040631DeFilippis AP Chapman AR Millis NL De Lemos JA Arbab-Zadeh A Newby LK Morrow DA Assessment and treatment of patients with type 2 myocardial infarction and acute nonischemic myocardial injury Circulation 2019 140 1661 78 10.1161/CIRCULATIONAHA.119.040631685532931416350Open DOISearch in Google Scholar

33Putot A, Derrida SB, Zeller M, Avondo A, Ray P, Manckoundia P, Cottin Y. Short-term prognosis of myocardial injury, type 1, and type 2 myocardial infarction in the emergency unit. Am J Med 2018;131:1209–19. doi: 10.1016/j. amjmed.2018.04.032Putot A Derrida SB Zeller M Avondo A Ray P Manckoundia P Cottin Y Short-term prognosis of myocardial injury, type 1, and type 2 myocardial infarction in the emergency unit Am J Med 20181311209 19 10.1016/j.amjmed.2018.04.03229753793Open DOISearch in Google Scholar

34Padney AK, Duong T, Swiatkiewicz I, Daniels LB. A comparison of biomarker rise in type 1 and type 2 myocardial infarction. Am J Med 2020;133:1203–8. doi: 10.1016/j. amjmed.2020.02.024Padney AK Duong T Swiatkiewicz I Daniels LB A comparison of biomarker rise in type 1 and type 2 myocardial infarction Am J Med 20201331203 8 10.1016/j.amjmed.2020.02.02432234496Open DOISearch in Google Scholar

35Villar J, Short JH, Lighthall G. Lactate predicts both short-and long-term mortality in patients with and without sepsis. Infect Dis (Auckl) 2019;12:1178633719862776. doi: 10.1177/1178633719862776Villar J Short JH Lighthall G Lactate predicts both short-and long-term mortality in patients with and without sepsis Infect Dis (Auckl) 2019121178633719862776 10.1177/1178633719862776668632331431799Open DOISearch in Google Scholar

36Lazzeri C, Valente S, Chiostri M, Gensini GF. Clinical significance of lactate in acute cardiac patients. World J Cardiol 2015;7:483–9. doi: 10.4330/wjc.v7.i8.483Lazzeri C Valente S Chiostri M Gensini GF Clinical significance of lactate in acute cardiac patients World J Cardiol 20157483 9 10.4330/wjc.v7.i8.483454978226322188Open DOISearch in Google Scholar