Toxicological aspects of increased use of surface and hand disinfectants in Croatia during the COVID-19 pandemic: a preliminary report

1World health Organization. Cleaning and disinfection of environmental surfaces in the context of COVID-19. Interim guidance, 2020 [displayed 9 July 2020]. Available at https://www.who.int/publications/i/item/cleaning-and-disinfection-of-environmental-surfaces-inthe-context-of-covid-19 World health Organization Cleaning and disinfection of environmental surfaces in the context of COVID-19 Interim guidance 2020 [displayed 9 July 2020]. Available at https://www.who.int/publications/i/item/cleaning-and-disinfection-of-environmental-surfaces-inthe-context-of-covid-1910.15557/PiMR.2020.0005Search in Google Scholar

2Centers for Disease Control and Prevention. Cleaning and Disinfection for Households. Interim Recommendations for U.S. Households with Suspected or Confirmed Coronavirus Disease 2019 (COVID-19), 2020 [displayed 9 July 2020]. Available at https://www.cdc.gov/coronavirus/2019-ncov/prevent-getting-sick/cleaning-disinfection.html Centers for Disease Control and Prevention Cleaning and Disinfection for Households Interim Recommendations for U.S. Households with Suspected or Confirmed Coronavirus Disease 2019 (COVID-19) 2020 [displayed 9 July 2020]. Available at https://www.cdc.gov/coronavirus/2019-ncov/prevent-getting-sick/cleaning-disinfection.htmlSearch in Google Scholar

3Regulation (EU) No 528/2012 of the European Parliament and of the Council of 22 May 2012 concerning the making available on the market and use of biocidal products [displayed 9 July 2020]. Available at https://eur-lex.europa.eu/legal-content/EN/TXT/PDF/?uri=CELEX:32012R0528&from=EN Regulation (EU) No 528/2012 of the European Parliament and of the Council of 22 May 2012 concerning the making available on the market and use of biocidal products [displayed 9 July 2020]. Available at https://eur-lex.europa.eu/legal-content/EN/TXT/PDF/?uri=CELEX:32012R0528&from=ENSearch in Google Scholar

4Služba za toksikologiju Hrvatskog zavoda za javno zdravstvo. Registar sigurnosno-tehničkih listova, deklaracija i uputa [Database of Safety Data Sheets, in Croatian] [displayed 7 April 2020]. Available at http://37.48.233.226/registar-sigurnosno-tehnickihlistova-deklaracija-i-uputa Služba za toksikologiju Hrvatskog zavoda za javno zdravstvo Registar sigurnosno-tehničkih listova, deklaracija i uputa [Database of Safety Data Sheets, in Croatian] [displayed 7 April 2020]. Available at http://37.48.233.226/registar-sigurnosno-tehnickihlistova-deklaracija-i-uputaSearch in Google Scholar

5R Studio Team. Integrated Development for R. RStudio, 2019 [displayed 9 July 2020]. Available at http://www.rstudio.com/ R Studio Team Integrated Development for R. RStudio RStudio 2019 [displayed 9 July 2020]. Available at http://www.rstudio.com/Search in Google Scholar

6Chang A, Schnall AH, Law R, Bronstein AC, Marraffa JM, Spiller HA, Hays HL, Funk AR, Mercurio-Zappala M, Calello DP, Aleguas A, Borys DJ, Boehmer T, Svendsen E. Cleaning and disinfectant chemical exposures and temporal associations with COVID-19- National Poison Data System, United States, January 1, 2020-March 31, 2020. MMWR Morb Mortal Wkly Rep 2020;69:496–8. Chang A Schnall AH Law R Bronstein AC Marraffa JM Spiller HA Hays HL Funk AR Mercurio-Zappala M Calello DP Aleguas A Borys DJ Boehmer T Svendsen E Cleaning and disinfectant chemical exposures and temporal associations with COVID-19- National Poison Data System, United States, January 1, 2020-March 31, 2020 MMWR Morb Mortal Wkly Rep 202069496 810.15585/mmwr.mm6916e1718841132324720Search in Google Scholar

7Santos C, Kieszak S, Wang A, Law R, Schier J, Wolkin A. Reported adverse health effects in children from ingestion of alcohol-based hand sanitizers - United States, 2011–2014. MMWR Morb Mortal Wkly Rep 2017;66:223–6. Santos C Kieszak S Wang A Law R Schier J Wolkin A Reported adverse health effects in children from ingestion of alcohol-based hand sanitizers - United States, 2011–2014 MMWR Morb Mortal Wkly Rep 201766223 610.15585/mmwr.mm6608a5565789328253227Search in Google Scholar

8Rayar P, Ratnapalan S. Pediatric ingestions of house hold products containing ethanol: a review. Clin Pediatr (Phila) 2013;52:203–9. doi: 10.1177/0009922812470970 Rayar P Ratnapalan S Pediatric ingestions of house hold products containing ethanol: a review Clin Pediatr (Phila) 201352203 9 10.1177/000992281247097023299839Open DOISearch in Google Scholar

9Hertzog JH, Radwick A. Acute alcohol intoxication in a child following ingestion of an ethyl-alcohol-based hand sanitizer. Int J Clin Pharmacol Ther 2015;53:557–60. doi: 10.5414/CP202362 Hertzog JH Radwick A Acute alcohol intoxication in a child following ingestion of an ethyl-alcohol-based hand sanitizer Int J Clin Pharmacol Ther 201553557 60 10.5414/CP20236225943177Open DOISearch in Google Scholar

10Chan APL, Chan TYK. Methanol as an unlisted ingredient in supposedly alcohol-based hand rub can pose serious health risk. Int J Environ Res Pub Health 2018;15:1440. doi: 10.3390/ijerph15071440 Chan APL Chan TYK Methanol as an unlisted ingredient in supposedly alcohol-based hand rub can pose serious health risk Int J Environ Res Pub Health 2018151440 10.3390/ijerph15071440606914629987197Open DOISearch in Google Scholar

11Babić Ž, Macan J, Turk R. Toksikološke preporuke za primjenu antiseptika i dezinficijensa tijekom borbe protiv širenja koronavirusa [Toxicological guidelines for the use of antiseptics and disinfectants to fight coronavirus spread, in Croatian] [displayed 30 July 2020]. Available at: https://www.imi.hr/hr/2020/24/03/toksikoloskepreporuke-za-primjenu-antiseptika-i-dezinficijensa-tijekom-borbeprotiv-sirenja-koronavirusa/ Babić Ž Macan J Turk R Toksikološke preporuke za primjenu antiseptika i dezinficijensa tijekom borbe protiv širenja koronavirusa [Toxicological guidelines for the use of antiseptics and disinfectants to fight coronavirus spread, in Croatian] [displayed 30 July 2020]. Available at https://www.imi.hr/hr/2020/24/03/toksikoloskepreporuke-za-primjenu-antiseptika-i-dezinficijensa-tijekom-borbeprotiv-sirenja-koronavirusa/Search in Google Scholar