How improvements in monitoring and safety practices lowered airborne formaldehyde concentrations at an Italian university hospital: a summary of 20 years of experience
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Musiał A, Gryglewski RW, Kielczewski S, Loukas M, Wajda J. Formalin use in anatomical and histological science in the 19th and 20th centuries. Folia Med Cracov 2016;56:31–40. PMID: 28275269MusiałAGryglewskiRWKielczewskiSLoukasMWajdaJFormalin use in anatomical and histological science in the 19th and 20th centuriesFolia Med Cracov2016563140PMID: 28275269Search in Google Scholar
Dimenstein IB. A pragmatic approach to formalin safety in anatomical pathology. Lab Med 2009;40:740–6. doi: 10.1309/LMQ1HJFD4UN0WWBPDimensteinIBA pragmatic approach to formalin safety in anatomical pathologyLab Med200940740610.1309/LMQ1HJFD4UN0WWBPOpen DOISearch in Google Scholar
Onyije FM, Avwioro OG. Excruciating effect of formaldehyde exposure to students in gross anatomy dissection laboratory. Int J Occup Environ Med 2012;3:92–5. PMID: 23022856OnyijeFMAvwioroOGExcruciating effect of formaldehyde exposure to students in gross anatomy dissection laboratoryInt J Occup Environ Med20123925PMID: 23022856Search in Google Scholar
Vimercati L, Carrus A, Martino T, Galise I, Minunni V, Caputo F, Dell’Erba A, Assennato G. Formaldehyde exposure and irritative effects on medical examiners, pathologic anatomy post-graduate students and technicians. Iran J Public Health 2010;39:26–34. PMCID: PMC3481685VimercatiLCarrusAMartinoTGaliseIMinunniVCaputoFDell’ErbaAAssennatoGFormaldehyde exposure and irritative effects on medical examiners, pathologic anatomy post-graduate students and techniciansIran J Public Health2010392634PMCID: PMC3481685Search in Google Scholar
Flyvholm MA, Menné T. Allergic contact dermatitis from FA. A case study focusing on sources of formaldehyde exposure. Contact Derm 1992;27:27–36. doi: 10.1111/j.1600-0536.1992.tb05194.xFlyvholmMAMennéTAllergic contact dermatitis from FA. A case study focusing on sources of formaldehyde exposureContact Derm199227273610.1111/j.1600-0536.1992.tb05194.xOpen DOISearch in Google Scholar
Nielsen GD, Larsen ST, Wolkoff P. Re-evaluation of the WHO (2010) formaldehyde indoor air quality guideline for cancer risk assessment. Arch Toxicol 2017;91:35–61. doi: 10.1007/s00204-016-1733-8NielsenGDLarsenSTWolkoffPRe-evaluation of the WHO (2010) formaldehyde indoor air quality guideline for cancer risk assessmentArch Toxicol201791356110.1007/s00204-016-1733-8Open DOISearch in Google Scholar
Friis UF, Dahlin J, Bruze M, Menné T, Johansen JD. Hidden exposure to formaldehyde in a swab caused allergic contact dermatitis. Contact Derm 2014;70:258–60. doi: 10.1111/cod.12172FriisUFDahlinJBruzeMMennéTJohansenJDHidden exposure to formaldehyde in a swab caused allergic contact dermatitisContact Derm2014702586010.1111/cod.12172Open DOISearch in Google Scholar
Dapson JC, Dapson RW. Hazardous Materials in the Histopathology Laboratory: Regulation, Risks, Handling and Disposal. 4th ed. Battle Creek: Anatech LTD; 2005.DapsonJCDapsonRWHazardous Materials in the Histopathology Laboratory: Regulation, Risks, Handling and Disposal4th edBattle CreekAnatech LTD2005Search in Google Scholar
Council on Scientific Affairs, American Medical Association. Formaldehyde. JAMA 1989;261:1183–7.Council on Scientific Affairs, American Medical AssociationFormaldehyde. JAMA19892611183710.1001/jama.1989.03420080103042Search in Google Scholar
Chemical Industry Institute of Toxicology (CIIT). Formaldehyde: Hazard Characterization and Dose-Response Assessment for Carcinogenicity by the Route of Inhalation. Corrected and republished. Research Triangle Park (NC): CIIT; 1999.Chemical Industry Institute of Toxicology (CIIT). Formaldehyde: Hazard Characterization and Dose-Response Assessment for Carcinogenicity by the Route of InhalationCorrected and republished. Research Triangle Park (NC): CIIT1999Search in Google Scholar
Agency for Toxic Substances and Disease Registry (ATSDR). Toxicological Profile for Formaldehyde. Atlanta (GA): US Department of Health and Human Services; 1999.Agency for Toxic Substances and Disease Registry (ATSDR). Toxicological Profile for Formaldehyde. Atlanta (GA): US Department of Health and Human Services1999Search in Google Scholar
Hazardous Substances Data Bank (HSDB, online database) US National Library of Medicine, National Toxicology Information Program, Bethesda, MD, 1999 March.Hazardous Substances Data Bank (HSDB, online database) US National Library of Medicine, National Toxicology Information ProgramBethesda, MD1999MarchSearch in Google Scholar
Viegas S, Ladeira C, Costa-Veiga A, Perelman J, Gajski G. Forgotten public health impacts of cancer - an overview. Arh Hig Rada Toksikol 2017;68:287–97. doi: 10.1515/aiht-2017-68-3005ViegasSLadeiraCCosta-VeigaAPerelmanJGajskiGForgotten public health impacts of cancer - an overviewArh Hig Rada Toksikol2017682879710.1515/aiht-2017-68-3005Open DOISearch in Google Scholar
International Agency for Research on Cancer (IARC). IARC Classifies Formaldehyde as Carcinogenic to Humans [displayed 27 December 2019]. Available at http://www.iarc.fr/pageroot/PRELEASES/pr153a.htmlInternational Agency for Research on Cancer (IARC). IARC Classifies Formaldehyde as Carcinogenic to Humansdisplayed 27 December2019Available athttp://www.iarc.fr/pageroot/PRELEASES/pr153a.htmlSearch in Google Scholar
International Agency for Research on Cancer (IARC). Formaldehyde, 2-Butoxyethanol and 1-tert-Butoxypropan-2-ol. Monographs on the Evaluation Carcinogenic Risks on Humans. Vol. 88, 2006 [displayed 11 August 2020]. Available at https://publications.iarc.fr/Book-And-Report-Series/Iarc-Monographs-On-The-Identification-Of-Carcinogenic-Hazards-To-Humans/Formaldehyde-2-Butoxyethanol-And-1-Em-Tert-Em-Butoxypropan-2-ol-2006International Agency for Research on Cancer (IARC). Formaldehyde, 2-Butoxyethanol and 1-tert-Butoxypropan-2-olMonographs on the Evaluation Carcinogenic Risks on HumansVol. 882006[displayed 11 August 2020]. Available athttps://publications.iarc.fr/Book-And-Report-Series/Iarc-Monographs-On-The-Identification-Of-Carcinogenic-Hazards-To-Humans/Formaldehyde-2-Butoxyethanol-And-1-Em-Tert-Em-Butoxypropan-2-ol-2006Search in Google Scholar
International Agency for Research on Cancer (IARC). Chemical agents and related occupations volume 100 F A review of human carcinogens; 2012 [displayed 28 August 2020]. Available at https://publications.iarc.fr/Book-And-Report-Series/Iarc-Monographs-On-The-Identification-Of-Carcinogenic-Hazards-To-Humans/Chemical-Agents-And-Related-Occupations-2012International Agency for Research on Cancer (IARC). Chemical agents and related occupations volume 100 F A review of human carcinogens2012[displayed 28 August 2020]. Available athttps://publications.iarc.fr/Book-And-Report-Series/Iarc-Monographs-On-The-Identification-Of-Carcinogenic-Hazards-To-Humans/Chemical-Agents-And-Related-Occupations-2012Search in Google Scholar
Szarvas T, Szatloczky E, Volford J, Trezl L, Tyihak E, Rusznak I. Determination of endogenous formaldehyde level in human blood and urine by dimedone-14C radiometric method. J Radioanal Nucl Chem 1986;106:357–67. doi: 10.1007/BF02163668SzarvasTSzatloczkyEVolfordJTrezlLTyihakERusznakIDetermination of endogenous formaldehyde level in human blood and urine by dimedone-14C radiometric methodJ Radioanal Nucl Chem19861063576710.1007/BF02163668Open DOISearch in Google Scholar
Heck HD, Casanova-Shmitz M, Dodd PB, Schachter EN, Witec TJ, Tosun T. Formaldehyde (CH2O) concentration in the blood of humans and Ficher-344 rats exposed to CH2O under controlled conditions. Am Ind Hyg Assoc J 1985;46:1–3. doi: 10.1080/15298668591394275HeckHDCasanova-ShmitzMDoddPBSchachterENWitecTJTosunTFormaldehyde (CH2O) concentration in the blood of humans and Ficher-344 rats exposed to CH2O under controlled conditionsAm Ind Hyg Assoc J1985461310.1080/15298668591394275Open DOISearch in Google Scholar
Spanel P, Smith D, Holland TA, Al Singary W, Elder JB. Analysis of formaldehyde in the headspace of urine from bladder and prostate cancer patients using selected ion flow tube mass spectrometry. Rapid Commun Mass Spectrom 1999;13:1354–9. doi: 10.1002/(SICI)1097-0231(19990730)13:14<1354::AID-RCM641>3.0.CO;2-JSpanelPSmithDHollandTAAl SingaryWElderJBAnalysis of formaldehyde in the headspace of urine from bladder and prostate cancer patients using selected ion flow tube mass spectrometryRapid Commun Mass Spectrom1999131354910.1002/(SICI)1097-0231(19990730)13:14<1354::AID-RCM641>3.0.CO;2-JOpen DOISearch in Google Scholar
Dugheri S, Bonari A, Pompilio I, Colpo M, Mucci N, Arcangeli G. An integrated air monitoring approach for assessment of formaldehyde in the workplace. Saf Health Work 2018;9:479–485. doi: 10.1016/j.shaw.2018.05.002DugheriSBonariAPompilioIColpoMMucciNArcangeliGAn integrated air monitoring approach for assessment of formaldehyde in the workplaceSaf Health Work2018947948510.1016/j.shaw.2018.05.002Open DOISearch in Google Scholar
Scarselli A, Corfiati M, Di Marzio D, Iavicoli S. National estimates of exposure to formaldehyde in Italian workplaces. Ann Work Expo Health 2017;61:33–43. doi: 10.1093/annweh/wxw004ScarselliACorfiatiMDi MarzioDIavicoliSNational estimates of exposure to formaldehyde in Italian workplacesAnn Work Expo Health201761334310.1093/annweh/wxw004Open DOISearch in Google Scholar
American Chemistry Council’s (ACC). ACGIH decision to lower formaldehyde TLVs lacks transparency and scientific basis [displayed 20 December 2020]. Available at https://www.americanchemistry.com/Media/PressReleasesTranscripts/ACC-news-releases/ACGIH-Decision-to-Lower-Formaldehyde-TLVs-Lacks-Transparency-and-Scientific-Basis.htmlAmerican Chemistry Council’s (ACC). ACGIH decision to lower formaldehyde TLVs lacks transparency and scientific basis[displayed 20 December 2020]. Available athttps://www.americanchemistry.com/Media/PressReleasesTranscripts/ACC-news-releases/ACGIH-Decision-to-Lower-Formaldehyde-TLVs-Lacks-Transparency-and-Scientific-Basis.htmlSearch in Google Scholar
Directive (EU) 2019/983 of the European Parliament and of the Council of 5 June 2019 amending Directive 2004/37/EC on the protection of workers from the risks related to exposure to carcinogens or mutagens at work [displayed 28 August 2020]. Available at https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=uriserv:OJ.L_.2019.164.01.0023.01.ENGDirective (EU) 2019/983 of the European Parliament and of the Council of 5 June 2019 amending Directive 2004/37/EC on the protection of workers from the risks related to exposure to carcinogens or mutagens at work [displayed 28 August 2020]Available athttps://eur-lex.europa.eu/legal-content/EN/TXT/?uri=uriserv:OJ.L_.2019.164.01.0023.01.ENGSearch in Google Scholar
Szulejko JE, Kim KH. Derivatization techniques for determination of carbonyls in air. TrAC Trends Anal Chem 2015;64:29–41. doi: 10.1016/j.trac.2014.08.010SzulejkoJEKimKHDerivatization techniques for determination of carbonyls in airTrAC Trends Anal Chem201564294110.1016/j.trac.2014.08.010Open DOISearch in Google Scholar
Dugheri S, Bonari A, Pompilio I, Colpo M, Mucci N, Montalti M, Arcangeli G. Development of an innovative gas chromatography-mass spectrometry method for assessment of formaldehyde in the workplace atmosphere. Acta Chromatogr 2017;29:511–4. doi: 10.1556/1326.2016.00102DugheriSBonariAPompilioIColpoMMucciNMontaltiMArcangeliGDevelopment of an innovative gas chromatography-mass spectrometry method for assessment of formaldehyde in the workplace atmosphereActa Chromatogr201729511410.1556/1326.2016.00102Open DOISearch in Google Scholar
Mucci N, Dugheri S, Rapisarda V, Campagna M, Garzaro G, Farioli A, Cappelli G, Arcangeli G. Occupational exposure to airborne formaldehyde in hospital: setting an automatic sampling system, comparing different monitoring methods and applying them to assess exposure. Med Lav 2019;110:446–58. doi: 10.23749/mdl.v110i6.8038MucciNDugheriSRapisardaVCampagnaMGarzaroGFarioliACappelliGArcangeliGOccupational exposure to airborne formaldehyde in hospital: setting an automatic sampling system, comparing different monitoring methods and applying them to assess exposureMed Lav20191104465810.23749/mdl.v110i6.8038Open DOISearch in Google Scholar
Dugheri S, Mucci N, Cappelli G, Bonari A, Garzaro G, Marrubini G, Bartolucci G, Campagna M, Arcangeli G. Monitoring of air-dispersed formaldehyde and carbonyl compounds as vapors and adsorbed on particulate matter by denuder-filter sampling and gas chromatographic analysis. Int J Environ Res Public Health 2019;16:1969. doi: 10.3390/ijerph16111969DugheriSMucciNCappelliGBonariAGarzaroGMarrubiniGBartolucciGCampagnaMArcangeliGMonitoring of air-dispersed formaldehyde and carbonyl compounds as vapors and adsorbed on particulate matter by denuder-filter sampling and gas chromatographic analysisInt J Environ Res Public Health201916196910.3390/ijerph16111969Open DOISearch in Google Scholar
Čavlović AO, Lučić RB, Jug M, Radmanović K, Bešlić I. Side-by-side determination of workers’ exposure to wood dust with IOM and openfaced samplers. Arh Hig Rada Toksikol 2013;64:379–84. doi: 10.2478/10004-1254-64-2013-2316ČavlovićAOLučićRBJugMRadmanovićKBešlićISide-by-side determination of workers’ exposure to wood dust with IOM and openfaced samplersArh Hig Rada Toksikol2013643798410.2478/10004-1254-64-2013-2316Open DOISearch in Google Scholar
Carrier D. Analysis of Formaldehyde and Acetaldehyde using automated DNPH derivatisation. Chromatography Technical Note No AS109 [displayed 11 August 2020]. Available at https://www.anatune.co.uk/wp-content/uploads/2015/06/as109.pdfCarrierDAnalysis of Formaldehyde and Acetaldehyde using automated DNPH derivatisationChromatography Technical Note No AS109 [displayed 11 August2020Available athttps://www.anatune.co.uk/wp-content/uploads/2015/06/as109.pdfSearch in Google Scholar
Dalene M, Persson P, Skarping G. Determination of formaldehyde in air by chemisorption on glass filters impregnated with 2,4-dinitrophenylhydrazine using gas chromatography with thermionic specific detection. J Chromatogr A 1992;626:284–8. doi: 10.1016/0021-9673(92)85422-PDaleneMPerssonPSkarpingGDetermination of formaldehyde in air by chemisorption on glass filters impregnated with 2,4-dinitrophenylhydrazine using gas chromatography with thermionic specific detectionJ Chromatogr A1992626284810.1016/0021-9673(92)85422-POpen DOISearch in Google Scholar
Martos PA, Pawliszyn J. Sampling and determination of formaldehyde using solid-phase microextraction with on-fiber derivatization. Anal Chem 1998;70:2311–20. doi: 10.1021/ac9711394MartosPAPawliszynJSampling and determination of formaldehyde using solid-phase microextraction with on-fiber derivatizationAnal Chem19987023112010.1021/ac971139421644641Open DOISearch in Google Scholar
Bourdin D, Desauziers V. Development of SPME on-fiber derivatization for the sampling of formaldehyde and other carbonyl compounds in indoor air. Anal Bioanal Chem 2014;406:317–28. doi: 10.1007/s00216-013-7460-6BourdinDDesauziersVDevelopment of SPME on-fiber derivatization for the sampling of formaldehyde and other carbonyl compounds in indoor airAnal Bioanal Chem20144063172810.1007/s00216-013-7460-624253409Open DOISearch in Google Scholar
Associazione per l’Unificazione nel Settore dell’Industria Chimica (Unichim). [Metodo Ufficiale n. 2237:09: Ambienti di Lavoro-Determinazione delle aldeidi aerodisperse. Metodo per microestrazione in fase solida (SPME), in Italian]. In: Analisi mediante gascromatografia accoppiata alla spettrometria di massa (GC-MS), 2009.Associazione per l’Unificazione nel Settore dell’Industria Chimica (Unichim). [Metodo Ufficiale n. 2237:09: Ambienti di Lavoro-Determinazione delle aldeidi aerodisperse. Metodo per microestrazione in fase solida (SPME), in Italian]InAnalisi mediante gascromatografia accoppiata alla spettrometria di massa (GC-MS)2009Search in Google Scholar
Dugheri S, Mucci N, Pompilio I, Cappelli G, Bossi C, Bonari A, Arcangeli G. Determination of airborne formaldehyde and ten other carbonyl pollutants using programmed temperature vaporization-large volume injection-gas chromatography. Chinese J Chrom 2018;36:1311–22. doi: 10.3724/SP.J.1123.2018.08050DugheriSMucciNPompilioICappelliGBossiCBonariAArcangeliGDetermination of airborne formaldehyde and ten other carbonyl pollutants using programmed temperature vaporization-large volume injection-gas chromatographyChinese J Chrom20183613112210.3724/SP.J.1123.2018.0805030574711Open DOISearch in Google Scholar
UNI - Ente Italiano di Normazione. UNI/TS 11710:2018 -Fume cupboards for chemical handling – Limit values for containment, face velocity and air exchange efficiency; 2018 [displayed 28 August 2020]. Available at http://store.uni.com/catalogo/uni-ts-11710-2018?___store=en&josso_back_to=http%3A%2F%2Fstore.uni.com%2Fjosso-security-check.php&josso_cmd=login_optional&josso_partnerapp_host=store.uni.com&___from_store=itUNI - Ente Italiano di Normazione. UNI/TS 11710:2018 - Fume cupboards for chemical handling – Limit values for containment, face velocity and air exchange efficiency ; 2018 [displayed 28 August 2020]Available athttp://store.uni.com/catalogo/uni-ts-11710-2018?___store=en&josso_back_to=http%3A%2F%2Fstore.uni.com%2Fjosso-security-check.php&josso_cmd=login_optional&josso_partnerapp_host=store.uni.com&___from_store=itSearch in Google Scholar
Ministry of Health, Higher Health Council, Italy. Section I. Guidelines tracking, collection, transport, preservation and storage of cells and tissues for diagnostic investigations of pathological anatomy; 2016 [displayed 11 August 2019]. Available at http://www.salute.gov.it/imgs/C_17_pubblicazioni_2504_allegato.pdfMinistry of Health, Higher Health Council, Italy. Section I. Guidelines tracking, collection, transport, preservation and storage of cells and tissues for diagnostic investigations of pathological anatomy2016[displayed 11 August 2019]. Available athttp://www.salute.gov.it/imgs/C_17_pubblicazioni_2504_allegato.pdfSearch in Google Scholar
Fiocca R, Marchetti A, Massi D, Truini M, Zanin T. [Note relative all’utilizzo della formalina, ri-classificata “cancerogena”, in Italian]. Linee di indirizzo SIAPEC-IAP Divisione Italiana 2016FioccaRMarchettiAMassiDTruiniMZaninT[Note relative all’utilizzo della formalina, ri-classificata “cancerogena”, in Italian]Linee di indirizzo SIAPEC-IAP Divisione Italiana2016Search in Google Scholar
UNI - Ente Italiano di Normazione. UNI EN 689:2018 – Workplace exposure – Measurement of exposure by inhalation to chemical agents - Strategy for testing compliance with occupational exposure limit values; 2018 [displayed 28 August 2020]. Available at http://store.uni.com/catalogo/uni-en-689-2018?___store=en&josso_back_to=http%3A%2F%2Fstore.uni.com%2Fjosso-security-check.php&josso_cmd=login_optional&josso_partnerapp_host=store.uni.com&___from_store=itUNI - Ente Italiano di Normazione. UNI EN 689:2018 – Workplace exposure – Measurement of exposure by inhalation to chemical agents - Strategy for testing compliance with occupational exposure limit values ; 2018 [displayed 28 August 2020]Available athttp://store.uni.com/catalogo/uni-en-689-2018?___store=en&josso_back_to=http%3A%2F%2Fstore.uni.com%2Fjosso-security-check.php&josso_cmd=login_optional&josso_partnerapp_host=store.uni.com&___from_store=itSearch in Google Scholar
Ochs SD M, Grotz LD O, Factorine LS, Rodrigues MR, Netto AD P. Occupational exposure to formaldehyde in an institute of morphology in Brazil: a comparison of area and personal sampling. Environ Sci Pollut Res Int 2011;19:2813–9. doi: 10.1007/s11356-012-0786-3OchsSD MGrotzLD OFactorineLSRodriguesMRNettoAD POccupational exposure to formaldehyde in an institute of morphology in Brazil: a comparison of area and personal samplingEnviron Sci Pollut Res Int2011192813910.1007/s11356-012-0786-322322292Open DOISearch in Google Scholar
Costa S, Coelho P, Costa C, Silva S, Mayana O, Santos LS, Gaspar J, Teixeira JP. Genotoxic damage in pathology anatomy laboratory workers exposed to formaldehyde. Toxicology 2008;252:40–8. doi: 10.1016/j.tox.2008.07.056CostaSCoelhoPCostaCSilvaSMayanaOSantosLSGasparJTeixeiraJPGenotoxic damage in pathology anatomy laboratory workers exposed to formaldehydeToxicology200825240810.1016/j.tox.2008.07.05618721846Open DOISearch in Google Scholar
Orsière T, Sari-Minodier I, Iarmarcovai G, Botta A. Genotoxic risk assessment of pathology and anatomy laboratory workers exposed to formaldehyde by use of personal air sampling and analysis of DNA damage in peripheral lymphocytes. Mutat Res Genet Toxicol Environ Mutagen 2006;605:30–41. doi: 10.1016/j.mrgentox.2006.01.006OrsièreTSari-MinodierIIarmarcovaiGBottaAGenotoxic risk assessment of pathology and anatomy laboratory workers exposed to formaldehyde by use of personal air sampling and analysis of DNA damage in peripheral lymphocytesMutat Res Genet Toxicol Environ Mutagen2006605304110.1016/j.mrgentox.2006.01.00616584911Open DOISearch in Google Scholar