Analgesic effects of oxycodone hydrochloride injection after laparoscopic cholecystectomy and influence on substance P, 5-hydroxytryptamine, and patient-controlled intravenous analgesia
, , , , , und | 23. Juli 2023
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Article Category: Original Study
Online veröffentlicht: 23. Juli 2023
Seitenbereich: 42 - 48
Eingereicht: 29. Juli 2022
Akzeptiert: 03. Feb. 2023
DOI: https://doi.org/10.2478/ahem-2023-0006
Schlüsselwörter
© 2023 Lei Tan et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Recovery time of spontaneous breathing and awakening time
| Group | n | Recovery time of spontaneous breathing (min) | Awakening time (min) |
|---|---|---|---|
| Control | 60 | 11.3±1.4 | 16.3±1.7 |
| Observation | 60 | 10.9±1.1 | 15.8±1.4 |
| t | 1.740 | 1.759 | |
| P | 0.084 | 0.081 |
Substance P and 5-HT levels
| Index | Group | T0 | T1 | T2 | T3 |
|---|---|---|---|---|---|
| Substance P (ng/L) | Control | 124.5±5.6 | 168.2±7.2 |
188.2±5.4 |
226.3±5.9 |
| Observation | 124.3±5.5 | 151.8±5.8 |
174.9±5.9 |
199.2±6.2 |
|
| Time difference | F=236.281, P<0.001 | ||||
| Intergroup difference | F=458.992, P<0.001 | ||||
| Intergroup × time difference | F=312.093, P<0.001 | ||||
| 5-HT (ng/mL) | Control | 461.5±10.9 | 614.8±14.5 |
685.7±10.2 |
774.3±8.3 |
| Observation | 462.8±10.3 | 548.9±15.1 |
609.7±9.4 |
683.2±7.4 |
|
| Time difference | F=673.225, P<0.001 | ||||
| Intergroup difference | F=1139.034, P<0.001 | ||||
| Intergroup × time difference | F=899.326, P<0.001 | ||||
Incidence rates of adverse reactions after PCIA
| Group | n | Nausea and vomiting (n, %) | Constipation (n, %) | Dizziness (n, %) |
|---|---|---|---|---|
| Control | 60 | 15 (25.00) | 14 (23.33) | 10 (16.67) |
| Observation | 60 | 6 (10.00) | 5 (8.33) | 3 (5.00) |
| χ2 | 4.675 | 5.065 | 4.227 | |
| P | 0.031 | 0.024 | 0.040 |
VAS and Ramsay scores
| Index | Group | T0 | T1 | T2 | T3 | T4 | T5 | T6 |
|---|---|---|---|---|---|---|---|---|
| VAS score | Control | 1.13±0.19 | 2.43±0.23 | 2.66±0.43 | 4.04±0.26 |
4.58±0.43 |
3.88±0.41 |
3.68±0.34 |
| Observation | 1.11±0.20 | 2.32±0.22 | 2.32±0.34 | 3.28±0.31 |
3.26±0.36 |
3.91±0.39 |
3.70±0.35 |
|
| Time difference | F=0.734, P=0.873 | |||||||
| Intergroup difference | F=1.124, P=0.456 | |||||||
| Intergroup × time difference | F=0.917, P=0.671 | |||||||
| Ramsay score | Control | 1.28±0.24 | 3.78±0.43 | 3.61±0.28 | 3.34±0.31 |
3.28±0.34 |
1.26±0.32 |
1.18±0.21 |
| Observation | 1.27±0.25 | 3.51±0.37 | 3.34±0.27 | 3.16±0.29 |
3.25±0.35 |
1.21±0.29 |
1.16±0.19 |
|
| Time difference | F=0.956, P=0.902 | |||||||
| Intergroup difference | F=1.732, P=0.239 | |||||||
| Intergroup × time difference | F=1.263, P=0.526 | |||||||
Baseline clinical data
| Control group (n=60) | Observation group (n=60) | t/χ2 | P | |
|---|---|---|---|---|
| Gender | χ2=0.034 | 0.853 | ||
| Male | 34 (56.67%) | 35 (58.33%) | ||
| Female | 26 (43.34%) | 25 (41.67%) | ||
| Age (year) | 45.91±2.41 | 45.87±2.43 | t=0.091 | 0.928 |
| Mean body weight (kg) | 62.84±3.36 | 62.78±3.41 | t=0.097 | 0.922 |
| Pathological type | χ2=0.034 | 0.854 | ||
| Gallbladder polyps | 33 (55.00%) | 34 (56.67%) | ||
| Gallbladder stones | 27 (45.00%) | 26 (43.33%) |
HR, MAP and SpO2 at different time points
| Index | Group | T0 | T1 | T2 |
|---|---|---|---|---|
| HR (beats/min) | Control | 74.0±5.4 | 90.8±7.2 |
87.9±5.4 |
| Observation | 74.5±5.6 | 89.2±6.4 |
80.3±6.3 |
|
| Time difference | F=116.784, P<0.001 | |||
| Intergroup difference | F=127.383, P<0.001 | |||
| Intergroup × time difference | F=121.095, P<0.001 | |||
| MAP (mmHg) | Control | 84.7±5.3 | 95.5±6.8 |
92.5±5.8 |
| Observation | 83.5±5.6 | 90.5±8.3 |
87.5±5.4 |
|
| Time difference | F=67.983, P<0.001 | |||
| Intergroup difference | F=127.886, P<0.001 | |||
| Intergroup × time difference | F=89.043, P<0.001 | |||
| SpO2(%) | Control | 98.3±6.7 | 94.3±7.1 |
98.4±6.2 |
| Observation | 98.4±6.3 | 96.4±7.3 | 98.5±6.3 | |
| Time difference | F=73.294, P<0.001 | |||
| Intergroup difference | F=109.675, P<0.001 | |||
| Intergroup × time difference | F=98.042, P<0.001 | |||
Classification of agitation during anesthesia recovery (n, %)
| Group | n | Mild | Moderate | Severe | Total |
|---|---|---|---|---|---|
| Control | 60 | 6 (10.00) | 7 (11.67) | 0 | 13 (21.67) |
| Observation | 60 | 3 (5.00) | 2 (3.33) | 0 | 5 (8.33) |
| Fisher's probability | - | ||||
| P | 0.036 |