<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Yersiniosis is a zoonosis caused by the <italic>Yersinia</italic> bacterium. The route of infection is most commonly oral and is caused by consumption of <italic>Yersinia</italic>-contaminated food. The clinical presentations of chronic yersiniosis are abdominal pain, diarrhea, relapsing arthritis, and skin lesions, that is, nodular erythema. The diagnosis is based on culture-dependent identification of <italic>Yersinia</italic> in stool, positive serologic test results, or molecular techniques. The treatment of choice is combination antibiotic therapy. Mild forms of the disease do not usually require treatment. Yersiniosis frequently mimics or confounds other chronic intestinal and extraintestinal inflammatory conditions, particularly Crohn’s disease. Therefore, diagnosis of yersiniosis may be a challenge for medical practitioners. Not including <italic>Yersinia</italic> infection in the differential diagnosis of abdominal symptoms can lead to an incorrect diagnosis and inappropriate treatment. This review summarises the current knowledge of <italic>Yersinia enterocolitica</italic> and <italic>pseudotuberculosis</italic> infection, with special focus on differential diagnosis between this infection and Crohn’s disease.</p>
</abstract>

Yersiniosis is a zoonosis caused by the Yersinia bacterium. The route of infection is most commonly oral and is caused by consumption of Yersinia-contaminated food. The clinical presentations of chronic yersiniosis are abdominal pain, diarrhea, relapsing arthritis, and skin lesions, that is, nodular erythema. The diagnosis is based on culture-dependent identification of Yersinia in stool, positive serologic test results, or molecular techniques. The treatment of choice is combination antibiotic therapy. Mild forms of the disease do not usually require treatment. Yersiniosis frequently mimics or confounds other chronic intestinal and extraintestinal inflammatory conditions, particularly Crohn’s disease. Therefore, diagnosis of yersiniosis may be a challenge for medical practitioners. Not including Yersinia infection in the differential diagnosis of abdominal symptoms can lead to an incorrect diagnosis and inappropriate treatment. This review summarises the current knowledge of Yersinia enterocolitica and pseudotuberculosis infection, with special focus on differential diagnosis between this infection and Crohn’s disease.

Yersiniosis: a forgotten mimicker and confounder of Crohn’s disease

Postępy Higieny i Medycyny Doświadczalnej

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"Yersiniosis: a forgotten mimicker and confounder of Crohn\u2019s disease"}

Yersiniosis is a zoonosis caused by the Yersinia bacterium. The route of infection is most commonly oral and is caused by consumption of Yersinia-contaminated...

	Yersinia enterocolitica	Crohn’s disease
Clinical symptoms	Fever (+++)Abdominal pain (++)Diarrhea (++/+++)Weight loss (−)	Abdominal pain (+++)Diarrhea (++)Weight loss (++)Fever (+)
Cause	Infectious	Multifactorial: genetic, environmental, immune
Course	Acute or subacute (few days/weeks)	Lifelong with periods of aggravation and/or remissions
Location	Terminal ileum, appendix, rarely colon	Terminal ileum, colon, whole gastrointestinal tract
Extraintestinal involvement	Lymph nodes, liver, spleen, joints, skin, cerebrospinal fluid	Liver, joints, skin, eyes
Endoscopy	Round or oval mucosal elevations, small ulcers	Serpiginous and longitudinal ulcers forming a cobblestone pattern, fistula, perianal lesions, intestinal stricture
Histopathology	Nonspecific infiltration with dominance of mononuclear cells	Multiple granulomas with abscesses present in bowel wall and follicles
Treatment	Antibiotics	Steroid/immunosuppressive

Yersiniosis: a forgotten mimicker and confounder of Crohn’s disease

Article Category: Review

Online veröffentlicht: 10. Mai 2022

Seitenbereich: 104 - 110

Eingereicht: 19. Feb. 2021

Akzeptiert: 17. Nov. 2021

DOI: https://doi.org/10.2478/ahem-2022-0002

Schlüsselwörter
Yersiniosis, Crohn’s disease, inflammatory bowel disease, diarrhea,

© 2022 Iwona Zawada et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Fig. 1

Fig. 2

Fig. 3

Fig. 4

Differential diagnosis of Yersinia enterocolitica and Crohn’s disease

Yersiniosis: a forgotten mimicker and confounder of Crohn’s disease

Article Category: Review

Online veröffentlicht: 10. Mai 2022

Seitenbereich: 104 - 110

Eingereicht: 19. Feb. 2021

Akzeptiert: 17. Nov. 2021

DOI: https://doi.org/10.2478/ahem-2022-0002

SchlüsselwörterYersiniosis, Crohn’s disease, inflammatory bowel disease, diarrhea,

© 2022 Iwona Zawada et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Fig. 1

Fig. 2

Fig. 3

Fig. 4

Differential diagnosis of Yersinia enterocolitica and Crohn’s disease

Schlüsselwörter
Yersiniosis, Crohn’s disease, inflammatory bowel disease, diarrhea,