<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec><h3>Introduction</h3>
<p>The aim of this study was to examine retinal vessels in autosomal dominant polycystic kidney disease (ADPKD) patients with normal kidney function and without diabetes mellitus.</p>
</sec>
<sec><h3>Materials and Methods</h3>
<p>We enrolled 39 adult individuals with ADPKD and 45 gender- and age-matched individuals as controls. A full ophthalmologic examination, including retinal vessel caliber and reactions to flicker stimulation analysis and grading of hypertensive retinopathy according to the Keith-Wagener classification, was performed.</p>
</sec>
<sec><h3>Results</h3>
<p>Multivariable analysis of ADPKD patients and controls, adjusted for age, gender, estimated glomerular filtration rate (e-GFR) and the presence of hypertension, revealed that ADPKD was an independent factor associated with lower arteriovenous ratio (AVR) values (by 0.069 on average, β = −0.50, p &lt; 0.0001). The severity of hypertensive retinopathy according to the Keith-Wagener classification appeared to be more advanced in the ADPKD group than in the controls, despite the lack of vascular abnormalities, such as retinal hemorrhages, exudates, cotton wool spots or papilledema, as well as microaneurysms, which are very characteristic signs of ADPKD in other vascular beds.</p>
</sec>
<sec><h3>Conclusions</h3>
<p>Lower AVR values could be a specific pathophysiological ocular manifestation of systemic vasculopathy in the course of ADPKD.</p>
</sec>
</abstract>

Introduction
The aim of this study was to examine retinal vessels in autosomal dominant polycystic kidney disease (ADPKD) patients with normal kidney function and without diabetes mellitus.

Materials and Methods
We enrolled 39 adult individuals with ADPKD and 45 gender- and age-matched individuals as controls. A full ophthalmologic examination, including retinal vessel caliber and reactions to flicker stimulation analysis and grading of hypertensive retinopathy according to the Keith-Wagener classification, was performed.

Results
Multivariable analysis of ADPKD patients and controls, adjusted for age, gender, estimated glomerular filtration rate (e-GFR) and the presence of hypertension, revealed that ADPKD was an independent factor associated with lower arteriovenous ratio (AVR) values (by 0.069 on average, β = −0.50, p < 0.0001). The severity of hypertensive retinopathy according to the Keith-Wagener classification appeared to be more advanced in the ADPKD group than in the controls, despite the lack of vascular abnormalities, such as retinal hemorrhages, exudates, cotton wool spots or papilledema, as well as microaneurysms, which are very characteristic signs of ADPKD in other vascular beds.

Conclusions
Lower AVR values could be a specific pathophysiological ocular manifestation of systemic vasculopathy in the course of ADPKD.

Evidence of retinal arteriolar narrowing in patients with autosomal-dominant polycystic kidney disease

Department of Nephrology, Transplantology and Internal Medicine

Department of Biochemistry and Medical Chemistry

Postępy Higieny i Medycyny Doświadczalnej

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Introduction
The aim of this study was to examine retinal vessels in autosomal dominant polycystic kidney disease (ADPKD) patients with normal kidney function...

Evidence of retinal arteriolar narrowing in patients with autosomal-dominant polycystic kidney disease

Article Category: Original Study

Online veröffentlicht: 09. März 2022

Seitenbereich: 82 - 90

Eingereicht: 03. März 2021

Akzeptiert: 17. Nov. 2021

DOI: https://doi.org/10.2478/ahem-2022-0001

Schlüsselwörter
autosomal dominant polycystic kidney disease (ADPKD), arteriolar narrowing, arteriovenous ratio, retinal vessel analysis (RVA)

© 2022 Maria Pietrzak-Nowacka et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Evidence of retinal arteriolar narrowing in patients with autosomal-dominant polycystic kidney disease

Article Category: Original Study

Online veröffentlicht: 09. März 2022

Seitenbereich: 82 - 90

Eingereicht: 03. März 2021

Akzeptiert: 17. Nov. 2021

DOI: https://doi.org/10.2478/ahem-2022-0001

Schlüsselwörterautosomal dominant polycystic kidney disease (ADPKD), arteriolar narrowing, arteriovenous ratio, retinal vessel analysis (RVA)

© 2022 Maria Pietrzak-Nowacka et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Schlüsselwörter
autosomal dominant polycystic kidney disease (ADPKD), arteriolar narrowing, arteriovenous ratio, retinal vessel analysis (RVA)