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Formulation and Evaluation of Gastroretentive In Situ Gelling System of Ketoprofen

AR. Shabaraya
AR. Shabaraya
, 
T. T Ashwini
T. T Ashwini
 und 
K. Vineetha
K. Vineetha
   | 07. Okt. 2023
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Article Category: Original Paper
Online veröffentlicht: 07. Okt. 2023
Seitenbereich: 10 - 19
Eingereicht: 24. Mai 2022
Akzeptiert: 28. Aug. 2023
DOI: https://doi.org/10.2478/afpuc-2023-0018
Schlüsselwörter
© 2023 AR. Shabaraya et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Figure 1.

In vitro buoyancy study of formulation F7.
In vitro buoyancy study of formulation F7.

Figure 2.

In vitro release profile of ketoprofen in situ gel formulations.
In vitro release profile of ketoprofen in situ gel formulations.

Composition of ketoprofen floating in situ gel.

Formulation code Ketoprofen (g) Sodium alginate (%) Gellan gum (%) HPMC K100M (%) Trisodium citrate (%) CaCl2 (%) CaCO3 paraben (%) Methyl (%) Propyl paraben saccharine (%) Sodium (%) Distilled water (q. s) (ml)
F1 2 0.5 - - 0.25 0.16 0.750 0.18 0.02 0.2 100
F2 2 1 - - 0.25 0.16 0.750 0.18 0.02 0.2 100
F3 2 1.5 - - 0.25 0.16 0.750 0.18 0.02 0.2 100
F4 2 - 0.150 - 0.25 0.16 0.750 0.18 0.02 0.2 100
F5 2 - 0.175 - 0.25 0.16 0.750 0.18 0.02 0.2 100
F6 2 - 0.150 0.2 0.25 0.16 0.750 0.18 0.02 0.2 100
F7 2 - 0.175 0.2 0.25 0.16 0.750 0.18 0.02 0.2 100

In vitro buoyancy study of prepared in situ gel of ketoprofen.

Formulation code Floating lag time (s) Total floating time (h)
F1 45 >24
F2 30 >24
F3 24 >24
F4 69 >24
F5 64 >24
F6 37 >24
F7 22 >24

Physical appearance, pH, and gelling capacity of prepared in situ gel.

Formulation code Physical appearance pH* Gelling capacity
F1 Light yellow 7.61 ± 0.03 ++
F2 Light yellow 6.98 ± 0.01 ++
F3 Light yellow 6.94 ± 0.04 +++
F4 Milky white 6.95 ± 0.05 ++
F5 Milky white 7.32 ± 0.02 +++
F6 Milky white 6.89 ± 0.03 +++
F7 Milky white 7.34 ± 0.01 +++

Drug content, gel strength, density of prepared in situ gel of ketoprofen.

Formulation code Drug content (%)* Gel strength (s)* Density (g/cm3)*
F1 83.45 ± 0.03 30.1 ± 0.22 0.575 ± 0.0102
F2 90.50 ± 0.53 36.14 ± 0.03 0.615 ± 0.0021
F3 92.42 ± 0.02 45.21 ± 0.51 0.632 ± 0.0062
F4 86.71 ± 0.31 21.21 ± 0.04 0.522 ± 0.0028
F5 93.65 ± 0.31 27.54 ± 0.02 0.550 ± 0.0025
F6 90.09 ± 0.72 73.65 ± 0.31 0.613 ± 0.0166
F7 95.53 ± 0.01 78.65 ± 0.01 0.616 ± 0.0025

Viscosity of prepared in situ gel of ketoprofen.

Formulation code Viscosity (cps)*
F1 209.0 ± 0.2
F2 225.9 ± 0.03
F3 239.7 ± 0.32
F4 133.8 ± 0.07
F5 138.9 ± 0.51
F6 153.7 ± 0.03
F7 155.3 ± 0.06
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