Uneingeschränkter Zugang

Experimental evaluation of the nonselective and selective TMEM16 family calcium-activated chloride channel blockers in the airways


Zitieren

Ferrera L, Caputo A, Galietta LJ. TMEM16A protein: a new identity for Ca(2+)-dependent Cl channels. Physiology (Bethesda). 2010; 25(6):357–63. DOI: 10.1152/physiol.00030.2010. FerreraL CaputoA GaliettaLJ TMEM16A protein: a new identity for Ca(2+)-dependent Cl channels Physiology (Bethesda) 2010 25 6 357 63 10.1152/physiol.00030.2010 Open DOISearch in Google Scholar

Wang H, Zou L, Ma K, Yu J, Wu H, Wei M, Xiao Q. Cell-specific mechanisms of TMEM16A Ca2+-activated chloride channel in cancer. Mol Cancer. 2017; 16(1):152. doi: 10.1186/s12943-017-0720-x. WangH ZouL MaK YuJ WuH WeiM XiaoQ Cell-specific mechanisms of TMEM16A Ca2+-activated chloride channel in cancer Mol Cancer 2017 16 1 152 10.1186/s12943-017-0720-x Open DOISearch in Google Scholar

Huang F, Zhang H, Wu M, Yang H, Kudo M, Peters CJ, Woodruff PG, Solberg OD, Donne ML, Huang X, Sheppard D, Fahy JV, Wolters PJ, Hogan BL, Finkbeiner WE, Li M, Jan YN, Jan LY, Rock JR. Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction. Proc Natl Acad Sci U S A. 2012; 109(40):16354–9. doi: 10.1073/pnas.1214596109. HuangF ZhangH WuM YangH KudoM PetersCJ WoodruffPG SolbergOD DonneML HuangX SheppardD FahyJV WoltersPJ HoganBL FinkbeinerWE LiM JanYN JanLY RockJR Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction Proc Natl Acad Sci U S A 2012 109 40 16354 9 10.1073/pnas.1214596109 Open DOISearch in Google Scholar

Danielsson J, Kuforiji AS, Yocum GT, Zhang Y, Xu D, Gallos G, Emala CW Sr. Agonism of the TMEM16A calcium-activated chloride channel modulates airway smooth muscle tone. Am J Physiol Lung Cell Mol Physiol. 2020; 318(2):L287–L295. DOI: 10.1152/ajplung.00552.2018. DanielssonJ KuforijiAS YocumGT ZhangY XuD GallosG EmalaCWSr Agonism of the TMEM16A calcium-activated chloride channel modulates airway smooth muscle tone Am J Physiol Lung Cell Mol Physiol 2020 318 2 L287 L295 10.1152/ajplung.00552.2018 Open DOISearch in Google Scholar

Bulley S, Jaggar JH. Cl channels in smooth muscle cells. Pflugers Arch. 2014 May;466(5):861–72. DOI: 10.1007/s00424-013-1357-2. BulleyS JaggarJH Cl channels in smooth muscle cells Pflugers Arch 2014 May 466 5 861 72 10.1007/s00424-013-1357-2 Open DOISearch in Google Scholar

Danielsson J, Perez-Zoghbi J, Bernstein K, Barajas MB, Zhang Y, Kumar S, Sharma PK, Gallos G, Emala CW. Antagonists of the TMEM16A calcium-activated chloride channel modulate airway smooth muscle tone and intracellular calcium. Anesthesiology. 2015; 123(3):569–81. doi: 10.1097/ALN.0000000000000769. DanielssonJ Perez-ZoghbiJ BernsteinK BarajasMB ZhangY KumarS SharmaPK GallosG EmalaCW Antagonists of the TMEM16A calcium-activated chloride channel modulate airway smooth muscle tone and intracellular calcium Anesthesiology 2015 123 3 569 81 10.1097/ALN.0000000000000769 Open DOISearch in Google Scholar

Namkung W, Phuan PW, Verkman AS. TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells. J Biol Chem. 2011; 286(3):2365–74. doi: 10.1074/jbc.M110.175109. NamkungW PhuanPW VerkmanAS TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells J Biol Chem 2011 286 3 2365 74 10.1074/jbc.M110.175109 Open DOISearch in Google Scholar

Franova S, Joskova M, Sadlonova V, Pavelcikova D, Mesarosova L, Novakova E, Sutovska M. Experimental model of allergic asthma. Adv Exp Med Biol. 2013;756:49–55. doi: 10.1007/978-94-007-4549-0_7. FranovaS JoskovaM SadlonovaV PavelcikovaD MesarosovaL NovakovaE SutovskaM Experimental model of allergic asthma Adv Exp Med Biol 2013 756 49 55 10.1007/978-94-007-4549-0_7 Open DOISearch in Google Scholar

Sutovska M, Nosalova G, Franova S. The role of potassium ion channels in cough and other reflexes of the airways. J Physiol Pharmacol. 2007; 58 Suppl 5(Pt 2):673–83. SutovskaM NosalovaG FranovaS The role of potassium ion channels in cough and other reflexes of the airways J Physiol Pharmacol 2007 58 Suppl 5(Pt 2) 673 83 Search in Google Scholar

Kocmalova M, Oravec M, Adamkov M, Sadlonova V, Kazimierova I, Medvedova I, Joskova M, Franova S, Sutovska M. Potassium ion channels and allergic asthma. Adv Exp Med Biol. 2015;838:35–45. doi: 10.1007/5584_2014_76. KocmalovaM OravecM AdamkovM SadlonovaV KazimierovaI MedvedovaI JoskovaM FranovaS SutovskaM Potassium ion channels and allergic asthma Adv Exp Med Biol 2015 838 35 45 10.1007/5584_2014_76 Open DOISearch in Google Scholar

Pennock BE, Cox CP, Rogers RM, Cain WA, Wells JH. A noninvasive technique for measurement of changes in specific airway resistance. J Appl Physiol Respir Environ Exerc Physiol. 1979 Feb;46(2):399–406. doi: 10.1152/jappl.1979.46.2.399. PennockBE CoxCP RogersRM CainWA WellsJH A noninvasive technique for measurement of changes in specific airway resistance J Appl Physiol Respir Environ Exerc Physiol 1979 Feb 46 2 399 406 10.1152/jappl.1979.46.2.399 Open DOISearch in Google Scholar

Šutovská M, Kocmálová M, Kazimierová I, Forsberg CIN, Jošková M, Adamkov M, Fraňová S. Effects of Inhalation of STIM-Orai Antagonist SKF 96365 on Ovalbumin-Induced Airway Remodeling in Guinea Pigs. Adv Exp Med Biol. 2021;1335:87–101. doi: 10.1007/5584_2021_633. ŠutovskáM KocmálováM KazimierováI ForsbergCIN JoškováM AdamkovM FraňováS Effects of Inhalation of STIM-Orai Antagonist SKF 96365 on Ovalbumin-Induced Airway Remodeling in Guinea Pigs Adv Exp Med Biol 2021 1335 87 101 10.1007/5584_2021_633 Open DOISearch in Google Scholar

Sutovska M, Kocmalova M, Franova S, Vakkalanka S, Viswanadha S. Pharmacodynamic evaluation of RP3128, a novel and potent CRAC channel inhibitor in guinea pig models of allergic asthma. Eur J Pharmacol. 2016;772:62–70. doi: 10.1016/j.ejphar.2015.12.047. SutovskaM KocmalovaM FranovaS VakkalankaS ViswanadhaS Pharmacodynamic evaluation of RP3128, a novel and potent CRAC channel inhibitor in guinea pig models of allergic asthma Eur J Pharmacol 2016 772 62 70 10.1016/j.ejphar.2015.12.047 Open DOISearch in Google Scholar

Šutovská M, Capek P, Kočmalová M, Pawlaczyk I, Zaczyńska E, Czarny A, Uhliariková I, Gancarz R, Fraňová S. Characterization and pharmacodynamic properties of Arnica montana complex. Int J Biol Macromol. 2014; 69:214–21. doi: 10.1016/j.ijbiomac.2014.05.051. ŠutovskáM CapekP KočmalováM PawlaczykI ZaczyńskaE CzarnyA UhliarikováI GancarzR FraňováS Characterization and pharmacodynamic properties of Arnica montana complex Int J Biol Macromol 2014 69 214 21 10.1016/j.ijbiomac.2014.05.051 Open DOISearch in Google Scholar

Nosál’ová G, Kardosová A, Franová S. Antitussive activity of a glucuronoxylan from Rudbeckia fulgida compared to the potency of two polysaccharide complexes from the same herb. Pharmazie. 2000 Jan;55(1):65–8. Nosál’ováG KardosováA FranováS Antitussive activity of a glucuronoxylan from Rudbeckia fulgida compared to the potency of two polysaccharide complexes from the same herb Pharmazie 2000 Jan 55 1 65 8 Search in Google Scholar

Search in Google Scholar

Bai W, Liu M, Xiao Q. The diverse roles of TMEM16A Ca2+-activated Cl channels in inflammation. J Adv Res. 2021; 33:53–68. doi: 10.1016/j.jare.2021.01.013. BaiW LiuM XiaoQ The diverse roles of TMEM16A Ca2+-activated Cl channels in inflammation J Adv Res 2021 33 53 68 10.1016/j.jare.2021.01.013 Open DOISearch in Google Scholar

Teixeira MC, Coelho RR, Leal-Cardoso JH, Criddle DN. Comparative effects of niflumic acid and nifedipine on 5-hydroxytryptamine- and acetylcholine-induced contraction of the rat trachea. Eur J Pharmacol. 2000; 394:117–122. TeixeiraMC CoelhoRR Leal-CardosoJH CriddleDN Comparative effects of niflumic acid and nifedipine on 5-hydroxytryptamine- and acetylcholine-induced contraction of the rat trachea Eur J Pharmacol 2000 394 117 122 Search in Google Scholar

Huang F, Zhang H, Wu M, Yang H, Kudo M, Peters CJ, Woodruff PG, Solberg OD, Donne ML, Huang X, Sheppard D, Fahy JV, Wolters PJ, Hogan BL, Finkbeiner WE, Li M, Jan YN, Jan LY, Rock JR. Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction. Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16354–9. doi: 10.1073/pnas.1214596109. HuangF ZhangH WuM YangH KudoM PetersCJ WoodruffPG SolbergOD DonneML HuangX SheppardD FahyJV WoltersPJ HoganBL FinkbeinerWE LiM JanYN JanLY RockJR Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction Proc Natl Acad Sci U S A 2012 Oct 2 109 40 16354 9 10.1073/pnas.1214596109 Open DOISearch in Google Scholar

Adner M, Canning BJ, Meurs H, Ford W, Ramos Ramírez P, van den Berg MPM, Birrell MA, Stoffels E, Lundblad LKA, Nilsson GP, Olsson HK, Belvisi MG, Dahlén SE. Back to the future: reestablishing guinea pig in vivo asthma models. Clin Sci (Lond). 2020; 134(11):1219–1242. doi: 10.1042/CS20200394. AdnerM CanningBJ MeursH FordW Ramos RamírezP van den BergMPM BirrellMA StoffelsE LundbladLKA NilssonGP OlssonHK BelvisiMG DahlénSE Back to the future: reestablishing guinea pig in vivo asthma models Clin Sci (Lond) 2020 134 11 1219 1242 10.1042/CS20200394 Open DOISearch in Google Scholar

Canning BJ, Chou Y. Using guinea pigs in studies relevant to asthma and COPD. Pulm Pharmacol Ther. 2008; 21(5):702–20. doi: 10.1016/j.pupt.2008.01.004. CanningBJ ChouY Using guinea pigs in studies relevant to asthma and COPD Pulm Pharmacol Ther 2008 21 5 702 20 10.1016/j.pupt.2008.01.004 Open DOISearch in Google Scholar

Canning BJ. Afferent nerves regulating the cough reflex: mechanisms and mediators of cough in disease. Otolaryngol Clin North Am. 2010; 43(1):15–25, vii. doi: 10.1016/j.otc.2009.11.012. CanningBJ Afferent nerves regulating the cough reflex: mechanisms and mediators of cough in disease Otolaryngol Clin North Am 2010 43 1 15 25 vii 10.1016/j.otc.2009.11.012 Open DOISearch in Google Scholar

Lee MG, Macglashan DW Jr, Undem BJ. Role of chloride channels in bradykinin-induced guinea pig airway vagal C-fibre activation. J Physiol. 2005; 566(Pt 1):205–12. doi: 10.1113/jphysiol.2005.087577. LeeMG MacglashanDWJr UndemBJ Role of chloride channels in bradykinin-induced guinea pig airway vagal C-fibre activation J Physiol 2005 566 Pt 1 205 12 10.1113/jphysiol.2005.087577 Open DOISearch in Google Scholar

Mazzone SB, McGovern AE. Na+-K+-2Cl cotransporters and Cl channels regulate citric acid cough in guinea pigs. J Appl Physiol (1985)101: 635–643, 2006. doi:10.1152/japplphysiol.00106.2006. MazzoneSB McGovernAE Na+-K+-2Cl cotransporters and Cl channels regulate citric acid cough in guinea pigs J Appl Physiol 1985 101 635 643 2006 10.1152/japplphysiol.00106.2006 Open DOISearch in Google Scholar

Jin X, Shah S, Liu Y, Zhang H, Lees M, Fu Z, Lippiat JD, Beech DJ, Sivaprasadarao A, Baldwin SA, Zhang H, Gamper N. Activation of the Cl–channel ANO1 by localized calcium signals in nociceptive sensory neurons requires coupling with the IP3 receptor. Sci Signal6: ra73, 2013. doi:10.1126/scisignal.2004184. JinX ShahS LiuY ZhangH LeesM FuZ LippiatJD BeechDJ SivaprasadaraoA BaldwinSA ZhangH GamperN Activation of the Cl–channel ANO1 by localized calcium signals in nociceptive sensory neurons requires coupling with the IP3 receptor Sci Signal 6 ra73 2013 10.1126/scisignal.2004184 Open DOISearch in Google Scholar

Undem BJ, Sun H. Molecular/Ionic Basis of Vagal Bronchopulmonary C-Fiber Activation by Inflammatory Mediators. Physiology (Bethesda). 2020; 35(1):57–68. doi: 10.1152/physiol.00014.2019. UndemBJ SunH Molecular/Ionic Basis of Vagal Bronchopulmonary C-Fiber Activation by Inflammatory Mediators Physiology (Bethesda) 2020 35 1 57 68 10.1152/physiol.00014.2019 Open DOISearch in Google Scholar

Choi SI, Hwang SW. Depolarizing Effectors of Bradykinin Signaling in Nociceptor Excitation in Pain Perception. Biomol Ther (Seoul). 2018; 26(3):255–267. doi: 10.4062/biomolther.2017.127. ChoiSI HwangSW Depolarizing Effectors of Bradykinin Signaling in Nociceptor Excitation in Pain Perception Biomol Ther (Seoul) 2018 26 3 255 267 10.4062/biomolther.2017.127 Open DOISearch in Google Scholar

Ousingsawat J, Martins JR, Schreiber R, Rock JR, Harfe BD, Kunzelmann K. Loss of TMEM16A causes a defect in epithelial Ca2+-dependent chloride transport. J Biol Chem. 2009; 284(42):28698–703. doi: 10.1074/jbc.M109.012120. OusingsawatJ MartinsJR SchreiberR RockJR HarfeBD KunzelmannK Loss of TMEM16A causes a defect in epithelial Ca2+-dependent chloride transport J Biol Chem 2009 284 42 28698 703 10.1074/jbc.M109.012120 Open DOISearch in Google Scholar

Rock JR, Futtner CR, Harfe BD. The transmembrane protein TMEM16A is required for normal development of the murine trachea. Dev Biol. 2008; 321(1):141–9. doi: 10.1016/j.ydbio.2008.06.009. RockJR FuttnerCR HarfeBD The transmembrane protein TMEM16A is required for normal development of the murine trachea Dev Biol 2008 321 1 141 9 10.1016/j.ydbio.2008.06.009 Open DOISearch in Google Scholar

Huang F, Rock JR, Harfe BD, Cheng T, Huang X, Jan YN, Jan LY. Studies on expression and function of the TMEM16A calcium-activated chloride channel. Proc Natl Acad Sci U S A. 2009; 106(50):21413–8. doi: 10.1073/pnas.0911935106. HuangF RockJR HarfeBD ChengT HuangX JanYN JanLY Studies on expression and function of the TMEM16A calcium-activated chloride channel Proc Natl Acad Sci U S A 2009 106 50 21413 8 10.1073/pnas.0911935106 Open DOISearch in Google Scholar

Centeio R, Ousingsawat J, Cabrita I, Schreiber R, Talbi K, Benedetto R, Doušová T, Verbeken EK, De Boeck K, Cohen I, Kunzelmann K. Mucus Release and Airway Constriction by TMEM16A May Worsen Pathology in Inflammatory Lung Disease. Int J Mol Sci. 2021; 22(15):7852. doi: 10.3390/ijms22157852. CenteioR OusingsawatJ CabritaI SchreiberR TalbiK BenedettoR DoušováT VerbekenEK De BoeckK CohenI KunzelmannK Mucus Release and Airway Constriction by TMEM16A May Worsen Pathology in Inflammatory Lung Disease Int J Mol Sci 2021 22 15 7852 10.3390/ijms22157852 Open DOISearch in Google Scholar

Scudieri P, Caci E, Bruno S, Ferrera L, Schiavon M, Sondo E, Tomati V, Gianotti A, Zegarra-Moran O, Pedemonte N, Rea F, Ravazzolo R, Galietta LJ. Association of TMEM16A chloride channel overexpression with airway goblet cell metaplasia. J Physiol. 2012; 590(23):6141–55. doi: 10.1113/jphysiol.2012.240838. ScudieriP CaciE BrunoS FerreraL SchiavonM SondoE TomatiV GianottiA Zegarra-MoranO PedemonteN ReaF RavazzoloR GaliettaLJ Association of TMEM16A chloride channel overexpression with airway goblet cell metaplasia J Physiol 2012 590 23 6141 55 10.1113/jphysiol.2012.240838 Open DOISearch in Google Scholar

Gao J, Yin H, Dong Y, Wang X, Liu Y, Wang K. A Novel Role of Uricosuric Agent Benzbromarone in BK Channel Activation and Reduction of Airway Smooth Muscle Contraction. Mol Pharmacol. 2023; 103(4):241–254. doi: 10.1124/molpharm.122.000638. GaoJ YinH DongY WangX LiuY WangK A Novel Role of Uricosuric Agent Benzbromarone in BK Channel Activation and Reduction of Airway Smooth Muscle Contraction Mol Pharmacol 2023 103 4 241 254 10.1124/molpharm.122.000638 Open DOISearch in Google Scholar

Zaidman NA, Panoskaltsis-Mortari A, O’Grady SM. Large-conductance Ca2+-activated K+ channel activation by apical P2Y receptor agonists requires hydrocortisone in differentiated airway epithelium. J Physiol. 2017; 595(14):4631–4645. doi: 10.1113/JP274200. ZaidmanNA Panoskaltsis-MortariA O’GradySM Large-conductance Ca2+-activated K+ channel activation by apical P2Y receptor agonists requires hydrocortisone in differentiated airway epithelium J Physiol 2017 595 14 4631 4645 10.1113/JP274200 Open DOISearch in Google Scholar

eISSN:
2453-6725
Sprache:
Englisch
Zeitrahmen der Veröffentlichung:
2 Hefte pro Jahr
Fachgebiete der Zeitschrift:
Pharmazie, andere