<abstract xmlns="http://www.w3.org/1999/xhtml">

Glyceryl laurate (GL) is a natural or synthetic surfactant with antiviral and antimicrobial activity and is not only effective in common colds or flu, but also against swine flu, herpes simplex, shingles, or chronic fatigue. The study aimed to formulate the GL granules as a semi-product for the compression of tablets and evaluate the influence of the substitution of sucrose laurate (Ryoto®) with sucrose ester (Sisterna®) in the composition of the granules and the effect of granule size on the quality of the compressed tablets. Four types of granules, varying in grain size and the type of additional surfactant, were prepared by melt granulation. The traditional pharmacopoeia tests were used to assess tablets’ quality. The granule size significantly affected all evaluated parameters: hardness, uniformity of mass, friability, and disintegration. The replacement of sucrose laurate with sucrose ester caused a slight decrease in tablet strength and a shortening of disintegration. However, it did not significantly impact friability and uniformity of mass. For this reason, the excipient, sucrose ester, can be evaluated as an adequate replacement in the composition of GL tablets.
</abstract>

Glyceryl laurate (GL) is a natural or synthetic surfactant with antiviral and antimicrobial activity and is not only effective in common colds or flu, but also against swine flu, herpes simplex, shingles, or chronic fatigue. The study aimed to formulate the GL granules as a semi-product for the compression of tablets and evaluate the influence of the substitution of sucrose laurate (Ryoto®) with sucrose ester (Sisterna®) in the composition of the granules and the effect of granule size on the quality of the compressed tablets. Four types of granules, varying in grain size and the type of additional surfactant, were prepared by melt granulation. The traditional pharmacopoeia tests were used to assess tablets’ quality. The granule size significantly affected all evaluated parameters: hardness, uniformity of mass, friability, and disintegration. The replacement of sucrose laurate with sucrose ester caused a slight decrease in tablet strength and a shortening of disintegration. However, it did not significantly impact friability and uniformity of mass. For this reason, the excipient, sucrose ester, can be evaluated as an adequate replacement in the composition of GL tablets.

Glyceryl Laurate Tablets: Effect of the Excipients and Granule Size on the Tablet Quality

Faculty of Pharmacy, Department of Galenic Pharmacy

European Pharmaceutical Journal

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Glyceryl laurate (GL) is a natural or synthetic surfactant with antiviral and antimicrobial activity and is not only effective in common colds or flu, but also...

Glyceryl Laurate Tablets: Effect of the Excipients and Granule Size on the Tablet Quality

Article Category: Special Issue Article

Online veröffentlicht: 24. Aug. 2023

Seitenbereich: 62 - 66

Eingereicht: 16. Juni 2023

Akzeptiert: 21. Juni 2023

DOI: https://doi.org/10.2478/afpuc-2023-0007

Schlüsselwörter
glyceryl laurate, monolaurin, melt granulation, granules, quality tests

© 2023 M. Špaglová et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Glyceryl Laurate Tablets: Effect of the Excipients and Granule Size on the Tablet Quality

Article Category: Special Issue Article

Online veröffentlicht: 24. Aug. 2023

Seitenbereich: 62 - 66

Eingereicht: 16. Juni 2023

Akzeptiert: 21. Juni 2023

DOI: https://doi.org/10.2478/afpuc-2023-0007

Schlüsselwörterglyceryl laurate, monolaurin, melt granulation, granules, quality tests

© 2023 M. Špaglová et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Schlüsselwörter
glyceryl laurate, monolaurin, melt granulation, granules, quality tests