<abstract xmlns="http://www.w3.org/1999/xhtml">Holoprosencephaly is a congenital structural abnormality of brain resulting from incomplete cleavage of prosencephalon into two cerebral hemispheres. It is classified as a disorder of organogenesis and brain histogenesis and is typically associated with facial anomalies.Holoprosencephaly is relatively rare – the incidence in live births varies between 1:10,000 – 1:15,000 but is described in 1 out of 250 spontaneously aborted embryos.There are four major varieties of holoprosencephaly according to the degree of separation of the brain hemispheres; this division is crucial for the patient’s prognosis. Three classic subtypes are alobar, semilobar, and lobar holoprosencephaly and there is also a fourth subtype called middle interhemispheric variant.We present a case study of a term newborn with prenatally diagnosed holoprosencephaly with severe facial dys-morphism and associated health complications.</abstract>

Holoprosencephaly is a congenital structural abnormality of brain resulting from incomplete cleavage of prosencephalon into two cerebral hemispheres. It is classified as a disorder of organogenesis and brain histogenesis and is typically associated with facial anomalies.Holoprosencephaly is relatively rare – the incidence in live births varies between 1:10,000 – 1:15,000 but is described in 1 out of 250 spontaneously aborted embryos.There are four major varieties of holoprosencephaly according to the degree of separation of the brain hemispheres; this division is crucial for the patient’s prognosis. Three classic subtypes are alobar, semilobar, and lobar holoprosencephaly and there is also a fourth subtype called middle interhemispheric variant.We present a case study of a term newborn with prenatally diagnosed holoprosencephaly with severe facial dys-morphism and associated health complications.

Case Report of a Term Newborn with Prenatally Diagnosed Alobar Holoprosencephaly

Acta Medica Martiniana

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"Case Report of a Term Newborn with Prenatally Diagnosed Alobar Holoprosencephaly"}

Holoprosencephaly is a congenital structural abnormality of brain resulting from incomplete cleavage of prosencephalon into two cerebral hemispheres. It is...

Case Report of a Term Newborn with Prenatally Diagnosed Alobar Holoprosencephaly

Online veröffentlicht: 21. Dez. 2020

Seitenbereich: 138 - 142

Eingereicht: 07. Sept. 2020

Akzeptiert: 09. Okt. 2020

DOI: https://doi.org/10.2478/acm-2020-0016

Schlüsselwörter
holoprosencephaly, newborn, facial abnormalities, cleft lip and palate

© 2020 E Malchova et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Case Report of a Term Newborn with Prenatally Diagnosed Alobar Holoprosencephaly

Online veröffentlicht: 21. Dez. 2020

Seitenbereich: 138 - 142

Eingereicht: 07. Sept. 2020

Akzeptiert: 09. Okt. 2020

DOI: https://doi.org/10.2478/acm-2020-0016

Schlüsselwörterholoprosencephaly, newborn, facial abnormalities, cleft lip and palate

© 2020 E Malchova et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Schlüsselwörter
holoprosencephaly, newborn, facial abnormalities, cleft lip and palate