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Mesenchymal stem cells and their secretome - candidates for safe and effective therapy for systemic lupus erythematosus

Małgorzata Popis

Małgorzata Popis

Department of Anatomy, Poznań University of Medical SciencesPoznań, Poland
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Popis, Małgorzata
, 
Aneta Konwerska

Aneta Konwerska

Department of Histology and Embryology, Poznań University of Medical SciencesPoznań, Poland
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Konwerska, Aneta
, 
Małgorzata Partyka

Małgorzata Partyka

Department of Histology and Embryology, Poznań University of Medical SciencesPoznań, Poland
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Partyka, Małgorzata
, 
Maria Wieczorkiewicz

Maria Wieczorkiewicz

Department of Basic and Preclinical Sciences, Institute of Veterinary Medicine, Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University in ToruńToruń, Poland
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Wieczorkiewicz, Maria
, 
Sylwia Ciesiółka

Sylwia Ciesiółka

Department of Histology and Embryology, Poznań University of Medical SciencesPoznań, Poland
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Ciesiółka, Sylwia
, 
Katarzyna Stefańska

Katarzyna Stefańska

Department of Histology and Embryology, Poznań University of Medical SciencesPoznań, Poland
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Stefańska, Katarzyna
, 
Julia Spaczyńska

Julia Spaczyńska

Department of Anatomy, Poznań University of Medical SciencesPoznań, Poland
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Spaczyńska, Julia
, 
Afsaneh Golkar-Narenji

Afsaneh Golkar-Narenji

Prestage Department of Poultry Science, North Carolina State UniversityRaleigh, USA
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Golkar-Narenji, Afsaneh
, 
Michal Jeseta

Michal Jeseta

  • Department of Obstetrics and Gynecology, University Hospital and Masaryk UniversityBrno, Czech Republic
  • Department of Veterinary Sciences, Czech University of Life Sciences in PraguePrague, Czech Republic
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Jeseta, Michal
, 
Dorota Bukowska

Dorota Bukowska

Department of Clinical Sciences and Diagnostics, Institute of Veterinary Medicine, Nicolaus Copernicus University in ToruńToruń, Poland
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Bukowska, Dorota
, 
Paul Mozdziak

Paul Mozdziak

  • Prestage Department of Poultry Science, North Carolina State UniversityRaleigh, USA
  • Physiology Graduate Program, North Carolina State UniversityRaleigh, USA
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Mozdziak, Paul
 und 
Marta Dyszkiewicz-Konwińska

Marta Dyszkiewicz-Konwińska

  • Department of Anatomy, Poznań University of Medical SciencesPoznań, Poland
  • Department of Biomaterials and Experimental Dentistry, Poznań University of Medical SciencesPoznań, Poland
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Dyszkiewicz-Konwińska, Marta
  
27. Sept. 2021
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Online veröffentlicht: 27. Sept. 2021
Seitenbereich: 110 - 122
Eingereicht: 02. Aug. 2021
Akzeptiert: 05. Sept. 2021
DOI: https://doi.org/10.2478/acb-2021-0016
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© 2021 Małgorzata Popis et al., published by Sciendo
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FIGURE 1

Identification of MSCs is based on following criteria, proposed and recommended by International Society for Cellular Therapy: a) cells must be plastic adherent during culture in standard conditions b) cells must exhibit presence of following markers: CD105, CD73, CD90 and reveal lack expression of following markers: CD45, CD34, HLA-DR, CD14 or CD11b, CD79a or CD19 c) cells must demonstrate the ability toward differentiation to adipocytes, chondroblasts, osteocytes upon culture in standard in vitro differentiating conditions. Created with BioRender.com
Identification of MSCs is based on following criteria, proposed and recommended by International Society for Cellular Therapy: a) cells must be plastic adherent during culture in standard conditions b) cells must exhibit presence of following markers: CD105, CD73, CD90 and reveal lack expression of following markers: CD45, CD34, HLA-DR, CD14 or CD11b, CD79a or CD19 c) cells must demonstrate the ability toward differentiation to adipocytes, chondroblasts, osteocytes upon culture in standard in vitro differentiating conditions. Created with BioRender.com

FIGURE 2

Mesenchymal stem cell sources can be split into adult tissues like adipose tissue, peripheral blood, ligamentum flavum, annulus fibrosus, bone marrow, or dental pulp, and perinatal tissues including amniotic membrane, amniotic fluid, placenta, umbilical cord Wharton's jelly and umbilical blood. Created with BioRender.com
Mesenchymal stem cell sources can be split into adult tissues like adipose tissue, peripheral blood, ligamentum flavum, annulus fibrosus, bone marrow, or dental pulp, and perinatal tissues including amniotic membrane, amniotic fluid, placenta, umbilical cord Wharton's jelly and umbilical blood. Created with BioRender.com

FIGURE 3

Schematic representation of exosome biogenesis. Process of exosome formation begins with endocytosis, leading to formation of early endosome. Then molecules such as nucleic acids, proteins and lipids, of both intra and extra-cellular origin, invaginate into the lumen of late endosome, giving rise to intraluminal vesicles. Late endosome transform into multivesicular body, which is capable to undergo fusion with cell membrane and release of exosomes to the extracellular space. Created with BioRender.com
Schematic representation of exosome biogenesis. Process of exosome formation begins with endocytosis, leading to formation of early endosome. Then molecules such as nucleic acids, proteins and lipids, of both intra and extra-cellular origin, invaginate into the lumen of late endosome, giving rise to intraluminal vesicles. Late endosome transform into multivesicular body, which is capable to undergo fusion with cell membrane and release of exosomes to the extracellular space. Created with BioRender.com
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