1 | rs145786768 | C/A | V507F | Deleterious (0.004) | Probably damaging (0.990) | Probably damaging | Disease (9) | Deleterious (−3.744) | Disease (6) | Decrease (−2.49) |
2 | rs193922716 | G/A | R335W | Deleterious (0) | Probably damaging (0.996) | Probably damaging | Disease (3) | Deleterious (−5.816) | Neutral (1) | Decrease (−0.36) |
3 | rs193922717 | C/T | E415K | Deleterious (0.003) | Probably damaging (0.955) | Probably damaging | Disease (5) | Deleterious (−3.097) | Neutral (0) | Decrease (−1.00) |
4 | rs193922719 | T/A | K591M | Deleterious (0.002) | Possibly damaging (0.751) | Probably damaging | Disease (8) | Deleterious (−4.949) | Disease (6) | Decrease (−0.13) |
5 | rs1803125 | G/T | Q32K | Deleterious (0.025) | Possibly damaging (0.868) | Probably damaging | Disease (0) | Neutral (−1.975) | Disease (3) | Decrease (−0.41) |
6 | rs11547455 | G/A | S629F | Deleterious (0.001) | Possibly damaging (0.481) | Probably damaging | Disease (5) | Deleterious (−3.097) | Disease (1) | Increase (0.64) |
7 | rs11547455 | G/A | S727F | Deleterious (0.002) | Probably damaging (0.974) | Probably damaging | Neutral (0) | Deleterious (−3.858) | Neutral (1) | Decrease (−0.20) |
8 | rs374063766 | C/G | Q198H | Deleterious (0.035) | Probably damaging (0.965) | Probably damaging | Neutral (3) | Neutral (−1.942) | Neutral (3) | Decrease (−0.82) |
9 | rs11547455 | G/A | S727F | Deleterious (0.002) | Probably damaging (0.974) | Probably damaging | Neutral (0) | Deleterious (−3.858) | Neutral (1) | Decrease (−0.20) |
V507F | 8 | Buried | - |
R335W | 9 | Exposed | Functional |
E415K | 8 | Exposed | - |
K591M | 9 | Exposed | Functional |
F561Y | 8 | Exposed | Functional |
Q32K | 7 | Exposed | - |
Q32K | 0.087 (Stabilizing) | −0.009 kcal/mol (Destabilizing) | −0.453 (Destabilizing) | 0.030 (Stabilizing) | −0.019 (Destabilizing) | 0.012 | Increase of molecule flexibility |
F561Y | −0.705 (Destabilizing) | −0.089 (Destabilizing) | −0.673 (Destabilizing) | −1.030 (Destabilizing) | −0.560 (Destabilizing) | 0.111 | Increase of molecule flexibility |
K591M | 0.057 (Stabilizing) | 0.016 (Destabilizing) | 0.335 (Stabilizing) | 0.130 (Stabilizing) | 0.485 (Stabilizing) | −0.019 | Decrease of molecule flexibility |
E415K | 0.107 (Stabilizing) | 0.023 (Destabilizing) | −0.461 (Destabilizing) | −0.150 (Destabilizing) | −0.062 (Destabilizing) | −0.029 | Decrease of molecule flexibility |
V507F | 0.627 (Stabilizing) | 0.195 (Destabilizing) | −1.244 (Destabilizing) | −1.190 (Destabilizing) | 1.458 (Destabilizing) | −0.244 | Decrease of molecule flexibility |
R335W | 0.050 (Stabilizing) | −0.172 (Destabilizing) | −0.198 (Destabilizing) | −0.010 (Destabilizing) | −0.447 (Destabilizing) | 0.215 | Increase of molecule flexibility |
V507F | Buried | 13% | 20 Å | α helix | −64° | −44° |
R335W | Exposed | 44% | 101 Å | Coil | −110° | 137° |
E415K | Exposed | 52% | 90 Å | Strand/β sheet | −108° | 137° |
K591M | Exposed | 37% | 77 Å | α helix | −57° | −41° |
E594K | Buried | 6% | 10 Å | α helix | −66° | −41° |
F561Y | Buried | 4% | 8 Å | α helix | −60° | −38° |
R609S | Buried | 9% | 22 Å | Strand/β sheet | −112° | 132° |