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Bacterial isolates and their antimicrobial susceptibility profile of superficial and deep-seated skin and soft tissue infections

Rao Muhammad Abid Khan
Rao Muhammad Abid Khan
, 
Sunil Kumar Dodani
Sunil Kumar Dodani
, 
Ali Nadeem
Ali Nadeem
, 
Sana Jamil
Sana Jamil
 und 
Mirza Naqi Zafar
Mirza Naqi Zafar
   | 17. Sept. 2023
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Article Category: Original article
Online veröffentlicht: 17. Sept. 2023
Seitenbereich: 55 - 63
DOI: https://doi.org/10.2478/abm-2023-0045
Schlüsselwörter
© 2023 Rao Muhammad Abid Khan et al., published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 International License.

Figure 1.

Prevalence of bacteria causing superficial and deep-seated SSTIs among patients attending the SIUT Hospital from November 2020 to May 2021.Others = Proteus spp., Acinetobacter spp., Morganella morganii, Aeromonas hydrophila, CoNS, Enterococcus spp., Streptococcus spp., and Streptococcus pneumoniae. CoNS, coagulase-negative Staphylococcus.
Prevalence of bacteria causing superficial and deep-seated SSTIs among patients attending the SIUT Hospital from November 2020 to May 2021.Others = Proteus spp., Acinetobacter spp., Morganella morganii, Aeromonas hydrophila, CoNS, Enterococcus spp., Streptococcus spp., and Streptococcus pneumoniae. CoNS, coagulase-negative Staphylococcus.

Antimicrobial resistance pattern of common bacteria isolated from sSSTIs and dSSTIs against oral, injectable, and carbapenem antibiotics

Bacterial isolate SSTIs Number of resistance pathogens to antimicrobial agents, n (%)
P.O. Injectable Carbapenem
SXT CIP AMC E DA AK TZP SCF CRO IPM
E. coli (n = 126) sSSTI (n = 57) 43 (75.4) 42 (73.6) 22 (38.5) - - 2 (3.5) 14 (24.5) 13 (22.8) 38 (66.7) 9 (15.7)
dSSTI (n = 69) 48 (70) 56 (81) 40 (58) - - 9 (13) 23 (33) 25 (36) 61 (88) 14 (20)
Klebsiella spp. (n = 76) sSSTI (n = 27) 16 (59) 21 (77.8) 17 (63) - - 9 (33.3) 9 (33.3) 10 (37) 22 (81.4) 7 (25.9)
dSSTI (n= 49) 38 (78) 40 (82) 30 (61) - - 20 (41) 24 (49) 27 (55) 43 (88) 17 (35)
P. aeruginosa (n = 38) sSSTI (n = 9) 9 (100) 6 (66.6) - - - 4 (44.4) 4 (44.4) 5 (55.5) - 6 (66.6)
dSSTI (n = 29) 26 (90) 20 (69) - - - 11 (38) 9 (31) 11 (38) - 14 (48)
S. aureus (n = 57) sSSTI (n = 14) 8 (57.1) 13 (92.8) 11 (78.5) 10 (71.4) 3 (21.4) - - - - -
dSSTI (n= 43) 16 (37) 39 (91) 35 (81) 29 (67) 5 (12) - - - - -

Demographic characteristics and distribution of cases among inpatients and outpatients suffering from sSSTIs and dSSTIs

sSSTI n = 124 (36%) dSSTI n = 223 (64%) Total n = 347
Frequency % Frequency % Frequency %
Patient setting
  Inpatient 63 30 148 70 211 61
  Outpatient 61 45 75 55 136 39
Gender
  Male 88 38 144 62 232 67
  Female 36 31 79 69 115 33
Age (years)
  ≤20 23 38 38 62 61 18
  21–50 56 36 101 64 157 45
  ≥51 35 38 56 62 91 26
Underlying medical condition
  Chronic kidney disease 47 37 80 63 127 37
  Diabetes mellitus 36 39 56 61 92 27
  Malignancy 13 28 33 72 46 13
  Immunosuppression 16 42 22 58 38 11
  Chronic liver disease 9 28 23 72 32 9
  Heart failure 3 25 9 75 12 3
SSTIs
  Wound infection 82 66 - - - -
  Diabetic foot ulcer 15 12 - - - -
  Impetigo 15 12 - - - -
  Cellulitis 12 10 - - - -
  Abscess - - 138 62 - -
  Surgical site infection - - 72 32 - -
  Necrotizing fasciitis - - 13 6 - -
Organisms
  E. coli 57 45 69 55 126 36
  Klebsiella spp. 27 35 49 65 76 22
  S. aureus 14 24 43 76 57 16
  Pseudomonasaeruginosa 9 24 29 76 38 11
  Proteus spp. 7 58 5 42 12 3
  Acinetobacter spp. 5 45 6 55 11 3
  Morganella morganii 3 30 7 70 10 3
  CoNS - - 6 100 6 2
  Enterococcus spp. 2 40 3 60 5 1.4
  Streptococcus spp. - - 4 100 4 01
  Aeromonas hydrophila - - 1 100 1 0.2
  Streptococcuspneumoniae - - 1 100 1 0.2

MDR pattern of bacteria isolated from sSSTIs and dSSTIs

Bacterial isolate SSTIs Antimicrobial classes related to number (%)
R1 R2 R3 R4 ≥R5 MDR, n (%)
E. coli sSSTI (n = 57) 8 (14) 8 (14) 14 (25) 6 (11) 14 (25) 34 (60)
dSSTI (n = 69) 4 (6) 8 (12) 21 (30) 10 (14) 23 (33) 54 (78)
Klebsiella spp. sSSTI (n = 27) 2 (7) 4 (15) 5 (19) 4 (15) 9 (33) 18 (67)
dSSTI (n = 49) 2 (4) 4 (8) 9 (18) 5 (10) 25 (51) 39 (80)
P. aeruginosa sSSTI (n = 9) 3 (33) 0 (0) 1 (11) 0 (0) 5 (56) 6 (66.6)
dSSTI (n= 29) 4 (14) 5 (17) 5 (17) 2 (7) 9 (31) 16 (55)
S. aureus sSSTI (n = 14) 0 (0) 1 (7) 7 (50) 3 (21) 2 (14) 12 (86)
dSSTI (n = 43) 2 (5) 9 (21) 21 (49) 4 (9) 5 (12) 30 (70)
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