Chen et al. 201614 | Case report | N =2 (female) | B-ALL (n=2) | Pretreatment Cycl+Flud CAR-T dose 50 mL (1×106/kg) | CRS (n=2) TLS | Monitored changes in temperature and blood pressure Monitored vital signs, renal function, and neurological signs, and recorded output and input | CRS is controlled NA |
Ding et al. 201717 | Case report | N=11 (2 females, 9 males) | Neuroblastoma (n=11) | Pretreatment Cycl or Flud | CRS Fever (n=10) | Physical or drug cooling, and monitored temperature | Body temperature returned to normal |
| | | | CAR-T dose NM | Hypotension (n=4) Exanthema (n=6) TLS Infection (n=3) Pleural effusion (n=1) | Monitored blood pressure and gave dopamine Informs the patient not to scratch the skin and smear calamine lotion Continuous ECG monitoring Saline and chlorhexidine gargle alternate gargling Oxygen inhalation, gave diuretic, and recorded output and input | Blood pressure returned to normal after 3 days After 1 week, the exanthema subsided. NA Absorbed inflammation remission after 7 days and 5 days after the pleural effusion |
Feng et al. | Case | N=1 | B-ALL (n=1) | Pretreatment | Fever | Gave antibiotics and | NM |
201615 | report | (female) | | Cycl+Flud | Hypotension | physical cooling | NM |
| | | | CAR-T dose NM | Pain | Monitored blood pressure, and gave boost medicine Evaluated the nature of pain and gave analgesic drugs | NM |
Li and Wan 201716 | Case report | N=9 (4 females, 5 males) | B-ALL (n=6) Hodgkin lymphoma (n=3) | Pretreatment Cycl+Flud CAR-T dose 2×106/kg | Fever (n=8) Hypotension (n=4) Hypoxemia (n=2) Pressure ulcers (n=1) Low platelets and hemoglobin (n=1) | Cold compress ice bag for physical cooling Monitored blood pressure and gave boost medicine Oxygen inhalation Turn over, massage, and smear skin protectant Infused red blood cells and platelets | After 6 hours, temperature dropped to normal Blood pressure returned to normal SpO2 stable at 95–98% After 2 days, the ulcer healed Hemoglobin and platelets increased significantly |
Yu 201712 | Case report | N=7 (3 females, 4 males) | Neuroblastoma (n=5) Burkitt’s lymphoma (n=1) Primitive neuroectodermal tumor (n=1) | Pretreatment Cycl+Flud CAR-T dose 10–15 mL | CRS (n=5) | Physical or drug cooling, and monitored temperature | Returned to normal after 7–14 days of fever |
Zhang et al. | Case report | N=3 (1 female, | B-ALL (n=3) | Pretreatment NM | CRS (n=3) TLS | Closely monitored vital signs and physical or | Body temperature dropped to normal |
201613 | | 2 males) | | CAR-T total | Hyperuricemia | drug cooling | NM |
| | | | dose 5×108–11×108 | (n=3) Hyperkalemia (n=1) | Closely observed changes in indicators such as output and input and biochemical | NM |