bB |
constant source rate of B-CLL produced by bone marrow |
r |
replication rate of the leukemic B cells |
dB |
natural mortality rate of the leukemic B |
dBN |
killing rate of B-CLL cells by N cells |
dBT |
killing rate of B-CLL cells by T cells |
bN |
constant source rate of N cells |
dN |
mortality rate of N cells |
dNB |
deactivation rate of N cells by contact with B-CLL cells |
bT |
constant production rate of T cells |
dT |
natural mortality rate of T cells |
dTB |
T cells activity suppression rate by contact with B-CLL cells |
k |
fraction of TH cell activation that results in T cells recruitment |
aTH |
maximal TH cells activation rate by contact with B-CLL cells |
bTH |
constant production rate of TH cells |
dTH |
natural mortality rate of TH cells |
s |
half saturation constant |
L |
parameter shaping the saturating sigmoid response |