1. bookVolume 1 (2017): Issue s1 (October 2017)
    EBTNA Utility Gene Test on Ophthalmology
30 Jan 2017
4 Hefte pro Jahr
access type Open Access

Pharmacologically active fractions of Sideritis spp. and their use in inherited eye diseases

Online veröffentlicht: 27 Oct 2017
Seitenbereich: 6 - 10
30 Jan 2017
4 Hefte pro Jahr

The main constituents of the genus Sideritis are various terpenoids, sterols, coumarins, flavonoid aglycones and glycosides. Sideritis species have been traditionally used as infusions or flavoring agents and in medicine as anti-inflammatory, antiulcer, antimicrobial, antioxidant, antispasmodic and analgesic agents. This paper includes the following sections: Introduction, Description and distribution of Sideritis spp, Pharmacological effects, Toxicity tests, Rationale for use of Sideritis spp. in ophthalmology and Conclusions. The aim is to provide a comprehensive overview on the botanical, phytochemical and pharmacological aspects of the genus Sideritis, and to establish the scientific basis of its pharmacological use. New approaches to using officinal plants have recently yielded significant results. The paper also reviews this information and provides a critical view on the options for exploiting the potential of Sideritis spp. in ophthalmology.

1. Charles B. Spainhour; Drug Discovery Handbook;Shane Cox Gad 2005 John Wiley.Search in Google Scholar

2. Gullo VP, McAlpine J, Lam KS, Baker D, Petersen F, Journal of Industrial Microbiology and Biotechnology, 2006; 33, 523-531.10.1007/s10295-006-0107-2Open DOISearch in Google Scholar

3. Rosén J, Gottfries J, Muresan S, Backlund A, Oprea TI, Journal of Medicinal Chemistry, 2009; 52, 1953-1962.Search in Google Scholar

4. Log˘og˘lu E, Arslan S, Oktemer AS¸ Akiyan I. Biological activities of some natural compounds from Sideritis sipylea Boiss. Phytotherapy Research 2006; 20, 294-297.10.1002/ptr.1855Open DOISearch in Google Scholar

5. Davis PH, Mill RR, Flora of Turkey and the East Aegean Islands. Edinburgh University Press, Edinburgh, 1988; p. 10.Search in Google Scholar

6. “Sideritis (Genus)”. Zipcodezoo.com. 2013-10-04. Retrieved 2013- 11-30 La-Serna Ramos IE, Negrin Sosa L, Perez de Paz PL. A palynological study of the genus Sideritis subgenus Marrubiastum (Lamiaceae): Macaronesian endemism. Grana 1994; 33, 21-37Search in Google Scholar

7. Goliaris A. 1995. [Genetic study of the Greek mountain tea (Sideritis L.)]. PhD Thesis, Aristotle University of Thessaloniki, Greece. Vol. 30, No. 3. 131pp.Search in Google Scholar

8. Report on Sideritis spp. EMA/HMPC/39455/2015, Assessment report on Sideritis scardica Griseb.; Sideritis clandestina (Bory & Chaub.) Hayek; Sideritis raeseri Boiss. & Heldr.; Sideritis syriaca L., herba, 7 July 2015.Search in Google Scholar

9. Piozzi F, Bruno M, Rosselli S, Maggio A. The diterpenoids from the genus Sideritis. Studies in Natural Products Chemistry, 2006; 33, 493-540.Search in Google Scholar

10. Kilic T. Isolation and biological activity of new and known diterpenoids from Sideritis stricta Boiss & Heldr. Molecules, 2006; 11, 257-262.Search in Google Scholar

11. Pessoa C, Silveira ER, Lemos TE, Wetmore LA, Moraes MO, Leyva A, Antiproliferative effects of compounds derived from plants of Northeast Brazil. Phytother Res, 2000; 14(3):187-91.10.1002/(SICI)1099-1573(200005)14:3<187::AID-PTR572>3.0.CO;2-IOpen DOISearch in Google Scholar

12. Má˜nez S, Jimenez A, Villar A. Seasonal variation of hypolaetin 8-glucoside in Sideritis mugronensis borja. Phytotherapy Research, 1990; 4, 124-125.Search in Google Scholar

13. Gonzalez-Burgos E, Carretero ME, Gomez-Serranillos MP. Kaurane diterpenes from Sideritis spp. exert a cytoprotective effect against oxidative injury that is associated with modulation of the Nrf2 system. Phytochemistry. 2013; 93:116-23.Search in Google Scholar

14. Ferrandiz ML, Nair AG, Alcaraz MJ. Inhibition of sheep platelet arachidonate metabolism by flavonoids from Spanish and Indian medicinal herbs. Pharmazie 1990; 45 (3), 206-208.Search in Google Scholar

15. Turkmenoglu FP, Baysal I, Ciftci-Yabanoglu S, Yelekci K, Temel H, Paşa S, Ezer N, Calış I and Ucar G. Flavonoids from Sideritis species: human monoamine oxidase (hMAO) inhibitory activities, molecular docking studies and crystal structure of xanthomicrol. Molecules, 2015; 20, 7454-7473Search in Google Scholar

16. Kirimer N, Baser KHC, Demirci B, Duman H. Essential oils of Sideritis species of Turkey belonging to the section Empedoclia. Chemistry of Natural Compounds, 2004; 40, 19-23.10.1023/B:CONC.0000025458.00475.cfOpen DOISearch in Google Scholar

17. Gonzalez-Burgos E, Carretero ME, Gomez-Serranillos MP. Sideritis spp.: uses, chemical composition and pharmacological activities - a review. J Ethnopharmacol. 2011; 17,135(2):209-25.Search in Google Scholar

18. Gonzalez-Burgos E, Gomez-Serranillos MP, Palomino OM, Carretero ME. Aspectos botanicos y farmacologicos del genero Sideritis. Revista de Fitoterapia, 2009; 9, 133-145.Search in Google Scholar

19. Font Quer P. Plantas Medicinales. El Dioscorides Renovado. Ediciones Peninsula, 2000.Search in Google Scholar

20. Alcaraz MJ, Jimenez MJ. Anti-inflammatory compounds from Sideritis javalambrensis n-hexane extract. Journal of Natural Products, 1989; 52, 1088-1091.Search in Google Scholar

21. Moroney MA, Alcaraz MJ, Forder RA, Carey F, Hoult RS. Selectivity of neutrophil 5-lypoxygenase and cyclo-oxygenase inhibition by an antiinflammatory flavonoid glycoside and related aglycone flavonoids. Journal of Pharmacy and Pharmacology, 1988; 40, 787-792. 10.1111/j.2042-7158.1988.tb05173.xOpen DOISearch in Google Scholar

22. Hofrichter J, Krohn M, Schumacher T, Lange C, Feistel B, Walbroel B, Pahnke J. Sideritis spp. Extracts enhance memory and learning in Alzheimer’s β-amyloidosis mouse models and aged C57Bl/6 mice. J Alzheimers Dis, 2016; 31, 53(3):967-80.Search in Google Scholar

23. Sarac N, Ugur A. Antimicrobial activities and usage in folkloric medicine of some Lamiaceae species growing in Mugla, Turkey. EurAsian Journal of Bio-Sciences, 2007; 4, 28-37.Search in Google Scholar

24. Dulger B, Gonuz A, Bican T. Antimicrobial studies on three endemic species of Sideritis from Turkey. Acta Biologica Cracoviensia, 2005; 47,153-156.Search in Google Scholar

25. Dulger B, Gonuz A, Aysel V. Inhibition of clotrimazole-resistant Candida albicans by some endemic Sideritis species from Turkey. Fitoterapia, 2006; 77, 404-405.Search in Google Scholar

26. Rodriguez-Linde ME, Diaz RM, Garcia-Granados A, Quevedo- Sarmiento J, Moreno E, Onorato MR, Parra A, Ramos-Cor menzana A. Antimicrobial activity of natural and semisynthetic diterpenoids from Sideritis spp. Microbios, 1994; 77, 7-13.Search in Google Scholar

27. Tunalier Z, Kosar M, Ozturk N, Baser KHC, Duman H, Kirimer N, Antioxidant properties and phenolic composition of Sideritis species. Chemistry of Natural Compounds, 2004; 40, 206-210.10.1023/B:CONC.0000039124.83109.acOpen DOISearch in Google Scholar

28. Armata M, Gabrieli C, Termentzi A, Zervou M, Kokkalou E. Constituents of Sideritis syriaca. ssp. syriaca (Lamiaceae) and their antioxidant activity. Food Chemistry, 2008; 111, 179-186.Search in Google Scholar

29. Hernandez-Perez M, Sanchez-Mateo CC, Montalbetti-Moreno Y, Rabanal RM. Studies on the analgesic and the anti-inflammatory effects of Sideritis candicans Ait. var. eriocephala Webb aerial part. Journal of Ethnopharmacology, 2004; 93, 279-284.10.1016/j.jep.2004.03.044Open DOISearch in Google Scholar

30. Aboutabl, EA, Nassar MI, Elsakhawy FM, Maklad YA, Osman AF, El-Khrisy EAM. Phytochemical and pharmacological studies on Sideritis tauric Stephan ex Wild. Journal of Ethnopharmacology, 2002; 82, 177-184.10.1016/S0378-8741(02)00172-1Open DOISearch in Google Scholar

31. Alcaraz MJ, Tordera M. Studies on the gastric anti-ulcer activity of hypolaetin-8-glucoside. Phytotherapy Research, 1988; 2, 85-88Search in Google Scholar

32. Gürbüz I, Ozkan AM, Yesilada E, Kutsal O. Anti-ulcerogenic activity of some plants used in folk medicine of Pinarbasi (Kayseri, Turkey). Journal of Ethnopharmacology, 2005; 101, 313-318.Search in Google Scholar

33. Basile A, Senatore F, Gargano R, Sorbo S, Del Pezzo M, Lavitola A, Ritieni A, Bruno M, Spatuzzi D, Rigano D, Vuotto ML. Antibacterial and antioxidant activities in Sideritis italica (Miller) Greuter et Burdet essential oils. Journal of Ethnopharmacology, 2006 107, 240-248.Search in Google Scholar

34. Demirtas I, Sahin A, Ayhan B, Tekin S, Telci I. Antiproliferative effects of the methanolic extracts of Sideritis libanotica Labill. subsp. linearis. Records of Natural Products, 2009; 3, 104-109.Search in Google Scholar

35. Kassi E, Papoutsi Z, Fokialakis N, Messari I, Mitakou S, Paraskevi M. Greek plant extracts exhibit Selective Estrogen Receptor Modulator (SERM)-like properties. Journal of Agriculture and Food Chemistry, 2004 52, 6956-6961.10.1021/jf0400765Open DOISearch in Google Scholar

36. Bruno M, Rosselli S, Pibiri I, Kilgore N, Lee KH. Anti-VIH agents derived from the ent-kaurene diterpenoid linearol. Journal of Natural Products, 2002; 65,1594-1597.Search in Google Scholar

37. Lazari DM, Sylignaki GI, Matta MK, Panagiotidis CA. Evaluation of the antiherpetical activities of Sideritis perfoliata L. subsp perfoliata (Lamiaceae). Planta Medica, 2006; 72, 1010-11010.Search in Google Scholar

38. Pooja VK, Lal AV. A review on ayurvedic medicinal plants for eye disorders from ancient to modern era IJPSR, 2014; Vol. 5(12): 5088-5096.Search in Google Scholar

39. Perry HD, Donnenfeld DE, Acheampong A, Kanel- lopoulos AJ, Sforza PD, D’Aversa G, Wallerstein A, Stern M. Topical Cyclosporine A in the management of postkeratoplasty glaucoma and corticosteroid induced ocular hypertension (CIOH) and the penetration of topical 0.5% cyclosporine A into the cornea and anterior chamber. Clao Journal , 1998; 24 (3), 159-165.Search in Google Scholar

40. Bilgihan K, Gurelik G, Akata F, Hasanreisoglu B. Fluorometholone- induced cataract after photorefractive keratectomy. Ophthalmologica , 1997; 211 (6), 394-396.Search in Google Scholar

41. Villena C, Vivas JM, Villar AM. Suppression of croton oil-induced rabbit corneal edema by sideritis javalambrensis. J Ethnopharmacol. 2000; 71(1-2):301-5.Search in Google Scholar

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