<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_joepi-2016-0011_s_001"><h3>Introduction</h3><p>Medial temporal lobe of epilepsy (MTLE) is considered as local/regional epilepsy. However, as was discussed in Part I of this review (Halász, 2016a) there is more evidence regarding the involvement of both temporal lobes so as to consider MTLE as one of the typical bilateral system epilepsies.</p></sec><sec id="j_joepi-2016-0011_s_002"><h3>Aim</h3><p>To provide contemporary review of MTLE in relation to the declarative memory system and the newly recognized hippocampo-frontal memory consolidation during slow wave sleep.</p></sec><sec id="j_joepi-2016-0011_s_003"><h3>Methods</h3><p>A review of the available literature on experimental and clinical data and also the authors own studies in MTLE patients.</p></sec><sec id="j_joepi-2016-0011_s_004"><h3>Review, discussion and results</h3><p>New experimental and clinical neurophysiological data have shown that MTLE is closely linked to the hippocampal memory system. It is likely that hippocampal spiking is the epileptic variations of the normal sharp wave ripple events mediating the encoding and consolidation of memory engrams by a hippocampo-frontal dialogue during slow wave sleep.</p></sec><sec id="j_joepi-2016-0011_s_005"><h3>Conclusions</h3><p>The source of memory impairment in MTLE patients is not merely the cell loss and synaptic transformation of the hippocampal structure, but the every night interference with memory consolidation due to interictal spiking.</p></sec></abstract>

IntroductionMedial temporal lobe of epilepsy (MTLE) is considered as local/regional epilepsy. However, as was discussed in Part I of this review (Halász, 2016a) there is more evidence regarding the involvement of both temporal lobes so as to consider MTLE as one of the typical bilateral system epilepsies.AimTo provide contemporary review of MTLE in relation to the declarative memory system and the newly recognized hippocampo-frontal memory consolidation during slow wave sleep.MethodsA review of the available literature on experimental and clinical data and also the authors own studies in MTLE patients.Review, discussion and resultsNew experimental and clinical neurophysiological data have shown that MTLE is closely linked to the hippocampal memory system. It is likely that hippocampal spiking is the epileptic variations of the normal sharp wave ripple events mediating the encoding and consolidation of memory engrams by a hippocampo-frontal dialogue during slow wave sleep.ConclusionsThe source of memory impairment in MTLE patients is not merely the cell loss and synaptic transformation of the hippocampal structure, but the every night interference with memory consolidation due to interictal spiking.

The relationship of medial temporal lobe epilepsy with the declarative memory system

Journal of Epileptology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

IntroductionMedial temporal lobe of epilepsy (MTLE) is considered as local/regional epilepsy. However, as was discussed in Part I of this review (Halász,...

The relationship of medial temporal lobe epilepsy with the declarative memory system

Online veröffentlicht: 22. Nov. 2016

Seitenbereich: 157 - 165

Eingereicht: 03. Okt. 2016

Akzeptiert: 10. Nov. 2016

DOI: https://doi.org/10.21307/joepi-2016-0011

Schlüsselwörter
Medial temporal lobe epilepsy, memory consolidation, hippocampal memory, slow wave sleep sharp wave ripple, sleep spiking effect

© 2016 Péter Halász et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

The relationship of medial temporal lobe epilepsy with the declarative memory system

Online veröffentlicht: 22. Nov. 2016

Seitenbereich: 157 - 165

Eingereicht: 03. Okt. 2016

Akzeptiert: 10. Nov. 2016

DOI: https://doi.org/10.21307/joepi-2016-0011

SchlüsselwörterMedial temporal lobe epilepsy, memory consolidation, hippocampal memory, slow wave sleep sharp wave ripple, sleep spiking effect

© 2016 Péter Halász et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Schlüsselwörter
Medial temporal lobe epilepsy, memory consolidation, hippocampal memory, slow wave sleep sharp wave ripple, sleep spiking effect