Successful treatment of epilepsia partialis continua due to Rassmussen encephalitis with perampanel
Online veröffentlicht: 31. März 2016
Seitenbereich: 67 - 70
Eingereicht: 14. Dez. 2015
Akzeptiert: 18. März 2016
DOI: https://doi.org/10.21307/joepi-2016-0003
Schlüsselwörter
© 2016 Katja Göde et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Background
Epilepsia partialis continua (EPC) is a difficult to treat condition, which tends to be refractory to antiepileptic drugs (AEDs). We previously published two other treatment episodes of EPC due to stroke and vascular dementia with a possible effect of perampanel (PER).
Aim
With the publication of a third treatment episode of EPC terminated by the administration of PER we would like to suggest that PER may be an effective treatment option in this condition.
Material and Methods
We present a case where PER was the last AED introduced in the treatment of a patient with EPC and individual seizures due to Rasmussen encephalitis before his seizure frequency could be reduced significantly.
Results
A 44 years old male patient, who had been on a combination therapy of at least 4 AEDs since the age of 24, was admitted to our hospital presenting with an EPC. After the introduction of PER in the therapy EPC stopped and he remained seizure free for more than a year. Two of his other AEDs could be tapered of.
Conclusion
PER might be especially effective in EPC.