Uneingeschränkter Zugang

The Cromer blood group system: an update

J.R. Storry
J.R. Storry
 und 
C. Lomas-Francis
C. Lomas-Francis
   | 30. Sept. 2021
Immunohematology's Cover Image
Über diesen Artikel
Vorheriger Artikel
Nächster Artikel
Zitieren
Article Category: review-article
Online veröffentlicht: 30. Sept. 2021
Seitenbereich: 118 - 121
DOI: https://doi.org/10.21307/immunohematology-2021-017
© 2021 J.R. Storry et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Antithetical antigens in the Cromer blood group system: molecular basis and distribution of the low-prevalence antigen

High-prevalence antigen number Name Low-prevalence antigen number Name Nucleotide change Exon Amino acid change Reference rs number* Low-prevalence antigen identified in gnomAD † frequency of the low-prevalence allele (>0.01%)
CROM2 Tc a CROM3 Tcb c.155G>T 2 p.Arg52Leu 2 rs28371588 African Americans African 2.6%Latin American 0.1%
CROM4 Tcc c.155G>C p.Arg52Pro 4 Europeans European 0.03%
CROM9 WESb CROM8 WESa c.245T>G 2 p.Leu82Arg 4 rs147474393 African Americans, Finns African 0.3%Finn 0.4%

Molecular bases for the new CD55null (IFC-, Inab phenotype) alleles

ISBT allele name Nucleotide change Exon Amino acid change Reference rs number † Null phenotype identified in Occurrence in gnomAD ‡
CROM*01N.04 c.366 367insA 3 p.Thr123Asnfs*6 819 No rs Moroccans
CROM*01N.05 c.148G>T 2 p.Glu50Ter 13 rs773074921 Pakistanis 3/30,616 alleles in South Asian population only
CROM*01N.06 c.639G>A 5 p.Trp213Ter 9 rs1391706310 Thais 3/18,392 alleles in East Asian population only
Not assigned c.149_150delAAinsCCTT 2 p.Glu50Alafs*12 19 rs1135402916 Turks No data
c.109delG 2 p.Gly37Alafs*24 rs1135402915 Turks, Syrians No data
c.800G>C 6 p.Cys267Ser rs1135402917 Turks No data
c.287-1G>A 3 Exon skipping rs1135402918 Turks No data

High-prevalence antigens of the Cromer blood group system: molecular basis and distribution of the antigen-negative phenotype

Number Name Nucleotide change Exon Amino acid change Reference rs number* Negative phenotype identified in gnomAD † frequency of the variant allele (≥0.01%)
CROM1 Cra c.679G>C 6 p.Ala227Pro 2 rs60822373 African Americans African 2%
CROM5 Dra c.596C>T 5 p.Ser199Leu 3 rs1135402914 Uzbekistani Jewish, Japanese None
CROM6 Esa c.239T>A 2 p.Ile80Asn 4 rs776347919 Mexicans, African Americans None
CROM10 UMC c.749C>T 6 p.Thr250Met 5 rs566298946 Japanese East Asian 0.1%
CROM11 GUTI c.719G>A 6 p.Arg240His 6 rs199705465 Native Chileans(5.3%) Finn 0.02%
CROM12 SERF c.647C>T 5 p.Pro216Leu 7 rs144692928 Thais South Asian 0.1%East Asian 0.02%African 0.018%
CROM13 ZENA c.726T>G 6 p.His242Gln 7 rs769586650 Turkish Syrians None
CROM14 CROV c.466G>A 3 p.Glu156Lys 7 No rs Croatians Data not available
CROM15 CRAM c.740A>G 6 p.Gln247Arg 7 No rs Somalians Data not available
CROM16 CROZ c.389G>A 3 p.Arg130His 8 rs756646491 Australians None
CROM17 CRUE c.650T>G 5 p.Leu217Trp 9 rs567156112 Thais East Asian 0.1%(Vietnamese 1%)
CROM18 CRAG c.173A>G 2 p.Asp58Gly 10 No rs Greeks Data not available
CROM19 CROK c. 245T>C 2 p.Leu82Pro 11 No rs Israeli Druze Data not available
CROM20 CORS c.713G>A 6 p.Gly238Glu 12 No rs French Corsicans Data not available
eISSN:
1930-3955
Sprache:
Englisch
Zeitrahmen der Veröffentlichung:
4 Hefte pro Jahr
Fachgebiete der Zeitschrift:
Medizin, Klinische Medizin, Laboratoriumsmedizin
Zeitschrift RSS Feed