Following an apparent increase in the number of patients with anti- V and/or anti-Jsa who required V– and/or Js(a–) red cell units, red cells from African American blood donors negative for C, E, S, K, Fya, Fyb, and Jkb were typed for V and Jsa over a 2-year period. Of the 438 donors typed for V and Jsa, 168 (38.36%) were V+ and 71 (16.44%) were Js(a+). The incidence of V (Rh10) was higher than that reported in previous studies, but no change was seen in the incidence of Jsa (K6).