<abstract xmlns="http://www.w3.org/1999/xhtml"><p>We studied the presence of drug-dependent antibodies (D-DAbs) in 53 patients with AIDS who developed immune hemolytic anemia (IHA). We examined sera and eluates for the presence of D-DAbs. Drug antibodies were detected in 43.4 percent (23/53) of the patients with IHA. Antibodies to more than one drug were detected in 60.8 percent (14/23) of patients with drug-induced IHA (D-IHA). The DAT was positive by RBC-bound IgG in eight patients, RBC-bound IgG/C3d in nine, IgG/IgA in three, IgG/IgA/C3d in two, and one patient had RBC-bound C3d only. No drug-independent antibodies were detected. Our study demonstrates that patients with AIDS commonly develop D-DAbs. D-IHA should be included in the differential diagnosis of a falling Hb in AIDS patients receiving drugs. <bold><italic>Immunohematology</italic> 2003;19:10–15.</bold></p></abstract>

We studied the presence of drug-dependent antibodies (D-DAbs) in 53 patients with AIDS who developed immune hemolytic anemia (IHA). We examined sera and eluates for the presence of D-DAbs. Drug antibodies were detected in 43.4 percent (23/53) of the patients with IHA. Antibodies to more than one drug were detected in 60.8 percent (14/23) of patients with drug-induced IHA (D-IHA). The DAT was positive by RBC-bound IgG in eight patients, RBC-bound IgG/C3d in nine, IgG/IgA in three, IgG/IgA/C3d in two, and one patient had RBC-bound C3d only. No drug-independent antibodies were detected. Our study demonstrates that patients with AIDS commonly develop D-DAbs. D-IHA should be included in the differential diagnosis of a falling Hb in AIDS patients receiving drugs. Immunohematology 2003;19:10–15.

Drug-dependent antibodies with immune hemolytic anemia in AIDS patients

Immunohematology

{"article-title":"Drug-dependent antibodies with immune hemolytic anemia in AIDS patients"}

We studied the presence of drug-dependent antibodies (D-DAbs) in 53 patients with AIDS who developed immune hemolytic anemia (IHA). We examined sera and...

Drug-dependent antibodies with immune hemolytic anemia in AIDS patients

Online veröffentlicht: 14. Okt. 2020

Seitenbereich: 10 - 15

DOI: https://doi.org/10.21307/immunohematology-2019-467

Schlüsselwörter
drug-induced hemolytic anemia, drugdependent antibodies, AIDS, immune hemolytic anemia

© 2003 C. A. González et al., published by Sciendo

Drug-dependent antibodies with immune hemolytic anemia in AIDS patients

Online veröffentlicht: 14. Okt. 2020

Seitenbereich: 10 - 15

DOI: https://doi.org/10.21307/immunohematology-2019-467

Schlüsselwörterdrug-induced hemolytic anemia, drugdependent antibodies, AIDS, immune hemolytic anemia

© 2003 C. A. González et al., published by Sciendo

Schlüsselwörter
drug-induced hemolytic anemia, drugdependent antibodies, AIDS, immune hemolytic anemia