Cromer-related blood group antigens and the glycosyl phosphatidylinositol-linked protein, decay-accelerating factor DAF (CD55)

Cromer-related blood group antigens are located on the complement regulatory glycoprotein, decay-accelerating factor (DAF). DAF is not detectable on red cells from individuals with a Cromer_null phenotype (termed Inab), which is probably an inherited condition. DAF is also absent from a subpopulation of red cells (PNH) III) from patients with paroxysmal nocturnal hemoglobinuria (PNH), an acquired hematological defect. PNH III red cells, like Inab cells, lack all the Cromer-related antigens described to date.