Local orthodontic force initiates widespread remodelling of the maxillary alveolar bone
Online veröffentlicht: 20. Juli 2021
Seitenbereich: 107 - 115
Eingereicht: 01. Dez. 2019
Akzeptiert: 01. Sept. 2020
DOI: https://doi.org/10.21307/aoj-2020-020
© 2020 Xinyi Gong et al., published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 International License.
Objectives
To clarify the effects of a local orthodontic force on alveolar bone by analysing bone remodelling in different regions of the maxilla during orthodontic tooth movement (OTM).
Methods
An OTM model was established in rats. Histological changes in the maxilla were analysed using TRAP staining, IHC staining for CTSK and haematoxylin and eosin (H and E) staining. The root bifurcation region of the alveolar bone of the first (M1), second (M2) and third (M3) molars were selected as the regions of interest (ROIs), which were further divided into a cervical and an apical level. Sequential fluorochrome labelling was performed to analyse bone deposition rates.
Results
The maxillary left first molars were moved mesially. TRAP staining and IHC staining for CTSK showed orthodontic force increased osteoclast numbers in all six ROIs at both the cervical and apical levels. H and E staining indicated elevated osteoblast numbers in the OTM group in all induced regions. Sequential fluorochrome labelling exhibited increased bone deposition rates around M1, M2 and M3 in the OTM group.
Conclusions
An orthodontic force applied to the first molar could initiate widespread remodelling of the maxillary alveolar bone, which was not restricted to the tension and pressure sites. This may revise the orthodontic biomechanical theory and provide new insights for clinical work.