<abstract xmlns="http://www.w3.org/1999/xhtml"><bold>Introduction</bold>: New designer drugs of the amphetamine class like 4-methoxyamphetamine (PMA) and 4-methoxymethampheta-mine (PMMA) elicit psychoactive effects in the central nervous system (CNS) by enhancing monoaminergic neurotransmission. These substances are substrates for neurotransmitter transporter proteins, and after binding with them they penetrate inside the cells. PMA and PMMA also reverse the transport of endogenic neurotransmitters and stimulate their increased release into the synaptic gap. PMMA has a weaker psychostimulating effect and a stronger hallucinogenic effect than PMA.<bold>Materials and methods</bold>: The article presents the case of fatal PMMA intoxication in a 28-year-old man. The post-mortem forensic toxicological analysis of collected blood samples was performed using the LC/MS/MS technique. The analysis detected 213 ng/mL of amphetamine, 270 ng/mL of 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy), and 4585 ng/mL of PMMA.<bold>Results</bold>: The cause of death was acute multiple organ failure resulting from heavy intoxication with psychoactive substances, particularly with PMMA.</abstract>

Introduction: New designer drugs of the amphetamine class like 4-methoxyamphetamine (PMA) and 4-methoxymethampheta-mine (PMMA) elicit psychoactive effects in the central nervous system (CNS) by enhancing monoaminergic neurotransmission. These substances are substrates for neurotransmitter transporter proteins, and after binding with them they penetrate inside the cells. PMA and PMMA also reverse the transport of endogenic neurotransmitters and stimulate their increased release into the synaptic gap. PMMA has a weaker psychostimulating effect and a stronger hallucinogenic effect than PMA.Materials and methods: The article presents the case of fatal PMMA intoxication in a 28-year-old man. The post-mortem forensic toxicological analysis of collected blood samples was performed using the LC/MS/MS technique. The analysis detected 213 ng/mL of amphetamine, 270 ng/mL of 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy), and 4585 ng/mL of PMMA.Results: The cause of death was acute multiple organ failure resulting from heavy intoxication with psychoactive substances, particularly with PMMA.

Fatal intoxication with PMMA – a novel designer analogue of amphetamine

Pomeranian Medical University in Szczecin

Department of Clinical and Forensic Toxicology

Pomeranian Journal of Life Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Fatal intoxication with PMMA \u2013 a novel designer analogue of amphetamine"}

Introduction: New designer drugs of the amphetamine class like 4-methoxyamphetamine (PMA) and 4-methoxymethampheta-mine (PMMA) elicit psychoactive effects in...

Fatal intoxication with PMMA – a novel designer analogue of amphetamine

Online veröffentlicht: 23. Dez. 2019

Seitenbereich: 94 - 96

DOI: https://doi.org/10.21164/pomjlifesci.641

Schlüsselwörter
PMMA, fatal intoxication, LC/MS/MS

© 2020 Barbara Potocka-Banaś et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Fatal intoxication with PMMA – a novel designer analogue of amphetamine

Online veröffentlicht: 23. Dez. 2019

Seitenbereich: 94 - 96

DOI: https://doi.org/10.21164/pomjlifesci.641

SchlüsselwörterPMMA, fatal intoxication, LC/MS/MS

© 2020 Barbara Potocka-Banaś et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Schlüsselwörter
PMMA, fatal intoxication, LC/MS/MS