The technological scope of a firm’s patents, as expressed by the number and nature of the classes to which these patents are assigned, is an important element to describe the relation between a company’s technological diversity and its profits (Chen, Jang, & Wen, 2010; Chiu, et al., 2010; Olivo et al., 2011). Indeed, research suggests that the scope of patents owned by a firm has a strong impact on performance and is, as such, an economically significant variable (Lerner, 1994; Reitzig, 2003).
As we want to take an international point of view we use the International Patent Classification (IPC) codes, but not American or European patent codes. Moreover, IPC codes have already been used in several other investigations (Chen, Jang, & Wen, 2010; Chiu et al., 2010; Lerner, 1994; Sapsalis, van Pottelsberghe de la Potterie, & Navon, 2006). Following these colleagues we use the number of 3- or 4-digit IPC codes assigned to a patent as a proxy of its technological breadth. Besides, the depth of a patent is also a structural element involved in a patent portfolio. Consider, for example, an IPC code such as “A61K-037”: the head 3 to 4 digits refer to a technological class and subclass (A61K), and the tail digits reflect the technological depth of the patent involved (037). This suggests that at the structural level, the breadth of patent is the primary structure, and the depth of a patent is the secondary one.
The ratio between the total number of codes (7- or 8-digit codes) used to describe patent
Generally, the broader the scope of a patent, the larger the number of competing products and processes that might infringe on the patent (Merges & Nelson, 1990). In this context, these authors pointed out that excessively broad patents may lead to use by other parties. Yet, Gilbert and Shapiro (1990) claimed that broader patents provide inventors with a greater ability to earn profits. As the competitive strength of a firm’s patents is an aspect of their market value, technological value, and social value, finding the optimal depth and breadth of a patent is a complex as well as a controversial topic (Guan & Gao, 2009; Hu & Rousseau, 2015; Hu, Rousseau, & Chen, 2012; Klemperer, 1990; Lee, 2009; Palokangas, 2011; Reitzig, 2003). We recall that, according to Gilbert and Shapiro (1990), the breadth of a patent is related to the flow of profits available to the patentee as well as to the minimum improvements that another inventor has to make in order to obtain a non-infringing patent. According to Lerner (1994) the market value of patents, sometimes even of a single patent, can have a major effect on the value of a firm. Exploring the optimal depth and breadth of a patent, researchers have increasingly recognized the importance to focus on the breadth of a patent (Denocolò, 1996; Kanniainen & Stenbacka, 2000; Merges & Nelson, 1990; Palokangas, 2011).
Continuing our research on the characteristics of the
To show, using a large dataset, how the To provide convincing evidence that the To provide a simple way to gauge a firm’s patent performance by jointly taking two h-type indices into account, each reflecting another aspect of the h-core in the lists of technological breadth and citations (reflecting market value and technological value).
As we are aware of the shortcomings of all h-type indices (Bouyssou & Marchant, 2011; Waltman & van Eck, 2012), we nevertheless claim that our approach is a useful addition to the patent toolbox. Moreover, no indicator on its own can provide information from all possible perspectives at the same time. Borrowing the terminology of Valiant (2013), proposed by him in the context of machine learning, the information provided by such an indicator is at best Probably Approximately Correct (PAC).
Hirsch (2005) proposed the h-index as an author-level indicator combining productivity (published articles) and impact (received citations). Soon his idea was applied to other source-items relations such as journal publications and citations (Braun, Glänzel, & Schubert, 2005), a company’s patent assignments and their citations in other patents (Guan & Gao, 2009), publications and citations of topics, restricted to recent years (Banks, 2006) or availability of books and their loans according to a library classification (Liu & Rousseau, 2009). We first recall the basic mechanism for calculating the h-index of an actor (author, company, or a journal). One considers a two-dimensional table of sources and items, where sources, e.g. publications or patents, are ranked according to items, e.g. received citations. Sources with the same number of items are given different rankings, but the exact order does not matter. Then actor A’s h-index is equal to the number h if the first h sources have each at least h items, while the source ranked h+1 has strictly less than h+1 items.
The relation between the breadth and depth of its patents on the one hand, and the health of a firm on the other, has been studied for several decades (Denicolò, 1996; O’Donoghue, Scotchmer, & Thisse, 1998; Palokangas, 2011; Prencipe, 2000; Wang & von Tunzelmann, 2000). Yet, no final answer about the optimal breadth and depth of patents has been found (Ozman, 2007; Zhang, Chen, & Niu, 2012; Lodh & Battaggion, 2014; Breschi, Lissoni, & Malerba, 2003). When using diversity indexes to measure the technological breadth and depth of a firm, it may happen that results are biased downwards for small and medium-sized firms for which the scale of technological activities is small (Chen, Jang, & Wen, 2010; Hu & Rousseau, 2015; Miller, 2006; Palokangas, 2011). Moreover, diversity indices such as the Rao-Stirling index may show cyclical patterns that are not related to a company’s profits but are rather related to the number of inventors (Leydesdorff, 2015). This suggests that if one wants to understand the optimal breadth and depth of patents, an approach different from the “complexity and diversity” might be worth investigating (Lodh & Battaggion, 2014; Wang & von Tunzelmann, 2000).
Traditionally, the breadth and depth of patents of a firm and their citations are considered separately. This approach, however, does not provide an integrated insight in the major characteristics of a firm’s patents. It has been observed that return on investment of a patent depends largely on a firm’s market value and its technological value, while the competitive strength of a firm’s patents bears a close relation to market value, technological value, social value of patents, and healthy management styles (Guan & Gao, 2009; Hu & Rousseau, 2015; Lee, 2009; Palokangas, 2011).
We develop a new approach to gauge a firm’s innovative performance based on the following insights.
We claim that one of the most important elements affecting the potential applications of a patent is its breadth, operationalized by codes, such as the IPC, the U.S. Patent Classification System (USPC), Cooperative Patent Classification (CPC) or the European Patent Office (EPO) codes assigned to it. This set of codes forms a basic aspect to grant its owner either a very limited right to exclusive use or a more general right covering a variety of different realizations of the invention (Reitzig, 2003). This fact implies that patents can differ with respect to the degree of protection afforded to an invention (Gilbert & Shapiro, 1990; Klemperer, 1990). In this context we note that accrediting codes to a patent is an arena in which patent examiners exercise wide discretion. In general, the broader the patent, the higher the chance to be applied in different practical fields and the larger the potential profits to the firm or a purchaser of the firm’s patent (Palokangas, 2011). This leads to the claim that the optimal breadth of patents should focus on a firm’s performance. Excessively broad patent claims increase the patentees’ non-market related risks from rivals and provide them with little flexibility to face unexpected situations (Merges & Nelson, 1990). However, the narrower a patent’s claims, the more the patentee may be victim of imitation as very similar products may lie outside the original patent’s claims (Denicolò, 1996; Kanniainen & Stenbacka, 2000).
A firm which focuses on excessively broad patents would overspend its research and development (R&D) capital by developing or buying an overly large number of patents. And,
It is well known that the received number of patent citations is an important indicator to measure the influence of a patent. Moreover, patent citations have a positive relation with the profits of the patent owner (Hu, Rousseau, & Chen, 2012; Trajtenberg, 1990).
Many investigations point out that, compared to the breadth of a patent (the primary dimension), it is less meaningful to focus on the depth of a patent because the determination of a patent’s depth is just approximate and no positive relation between a patent’s performance and its depth has been found (Gilbert & Shapiro, 1990; Kanniainen & Stenbacka, 2000; Klemperer, 1990; Lodh & Battaggion, 2014; Ozman, 2007; Palokangas, 2011; Reitzig, 2003; Zhang, Chen, & Niu, 2012).
Grönqvist (2009) argues that broader patents are not necessarily more valuable than narrower ones. Concretely, patents described with many codes do not necessarily lead to a larger profit for the firm. Therefore, neither the breath of patents nor the number of received citations on their own are clear-cut indicators for the value of a company’s patent portfolio. If we want to understand the competitive strength of a firm from the perspective of patent performance, the primary structure of patents (patent breadth), the secondary structure (patent depth), and their influence should jointly be taken into account in a multi-layered approach (Denicolò, 1996; Hu, Rousseau, & Chen, 2012; Palokangas, 2011). Abstractly, their relationships can be described with Equation (1):
To reveal the relation between the essential structure of patents and their competitive strength, e.g. profit performance, in the real world, and clarify the controversy on the influence of depth on a patent’s profit, we propose two types of structural h-indices for patents: (1) the structural h-index, a primary one, combining the number of patents with the primary structure (breadth of patent) and with forward, i.e. received, citations; (2) the synthetic structural h-index, using the number of patents, the breadth and depth of these patents, and the number of forward citations.
Hence, we hypothesize that the primary structure of patents (patent breadth) and their influence on a firm can be measured by a structural h-type index, combining different aspects in a dynamic way.
A firm’s innovation activities are operationalized as the number of patents, while their technological breadth is operationalized by the number of 3- or 4-digit IPC codes. Consider a set of patents granted to a firm in a certain year
Next, we define a yearly h-index slightly modified from the original meaning of Hirsch (2005) to map a firm’s innovation activities and influence in the year
Next, we define the yearly h-index of patent depth in the year
We define the structural h-index for patents granted in the year
where
Finally, we define the synthetic structural h-index for patents granted in the year
where
We recall that the pharmaceutical industry is a high-tech industry in which a firm’s performance (and profit) is closely connected to the market value of its patents (Hu, Rousseau, & Chen, 2012; Chen, Shih, & Chang, 2013). Therefore, the pharmaceutical field is a good test bed to study the practical value of the new indicators
The general range of firms acceptable for our purposes contains those pharmaceutical companies listed in Fortune 500 2006–2010 issued by the CNNMoney website
As there are many invisible factors affecting the performance of patents, we try to control for external variables by considering the following criteria for inclusion in our case study.
Firm location: Different countries have different regulations for patents which may influence realized profits (Chen, Shih, & Chang, 2013). For this reason only US companies were selected. Firm internationality: Prior literature has found that there is a significant effect of firm scale on profits (Chen, Jang, & Wen, 2010). Accordingly, only US-based multinational firms included in Fortune 500 qualify. Firm age: It has been shown that, in terms of innovation activities, older firms have a stronger foundation than younger ones. Hence, a firm’s age influences the outcome of its patents’ performance. For this reason we included only firms founded before the year 1990 (Banerjee & Cole, 2010; McMillan & Thomas, 2005). Patent age: As the time between applying for a pharmaceutical patent and its return on investment is generally between 8 and 12 years, with 5 years as a strict minimum (ISTIS, 2003), and the protection period given by a patent is at most 20 years (WIPO, 2000), care must be exerted to take these facts into account (Chen, Jang, & Wen, 2010; Hu, Rousseau, & Chen, 2012). For this reason, we included only patents granted during the period 1990–2005, and considered profits reported by Fortune 500 for the period 2006–2010.
Taking all these requirements into account resulted in eight US-based multinational pharmaceutical companies meeting all the criteria, namely Johnson & Johnson, Pfizer, Merck, Bristol-Myers Squibb, Amgen, Genzyme, Allergan and Biogen Idec.
We extracted from the Derwent Innovations Index (DII) all patents granted to these eight companies during the period 1990 – 2005. For each record we downloaded all fields, including IPC-codes and citations received (so-called forward citations). Data were extracted on 20/05/2014. This led to a total of 19,080 patents for the eight firms. Next, we collected the yearly profits for each company as reported by Fortune 500 2006–2010.
For the dataset of a company’s patents, we first counted the number of 4-digit IPC codes for each record via a simple program written by ourselves, and determined the yearly
To compare results based on 3-digit IPC codes with those based on 4-digit codes, we also collected the number of 3-digit codes for each patent (Appendix Tables A2 and A3), and calculated the corresponding
To observe the relationship between the
We calculated the Spearman rank correlation coefficient between the eight companies, mean A nested case-control (NCC) study. This type of study is an observational study whereby a case-control approach is employed within an established cohort (Bornehag et al., 2004). This is a popular and valid approach in medical studies for small-sample investigations. As such we consider it also suitable to our study. The nested case control model as applied in medical investigations is less expensive, but less efficient than a full-cohort analysis. However, it has been shown that with four controls per case and/or stratified sampling of controls, relatively little efficiency may be lost (Goldstein & Zhang, 2009).
To apply the NCC method, the eight companies are grouped according to their profits: Group H (high profit) consists of the four companies with the highest profit; Group L (low profit) consists of the four companies with the lowest profits. For each group, we re-rank companies by their profits in a descending way and denote them GHR1, GHR2, GHR3, GHR4, GLR1, GLR2, GLR3, and GLR4 (Table 1). In this way, case-control is performed between four control-pairs of companies with the same rank order in the respective groups (such as GHR1
Controlled cases design for companies included in NCC study.Group H Group L Company Code Profits Rank Company Code Profits Rank Johnson & Johnson GHR1 11,451.00 1 Amgen GLR1 3,718.20 1 Pfizer GHR2 10,461.00 2 Biogen Idec GLR2 554.10 2 Merck GHR3 6,610.02 3 Allergan GLR3 395.24 3 Bristol-Myers Squibb GHR4 4,521.80 4 Genzyme GLR4 349.72 4
Then, we compare the yearly
In this section, we present the results obtained from our analysis of the 19,080 patents. We will show that the two types of structural h-indices
Tables 2 and 3 show the resulting yearly
Yearly Year Johnson & Johnson Pfizer Merck Bristol-Myers Squibb Amgen Biogen Idec Allergan Genzyme 1990 192 161 150 85 32 1 44 12 1991 174 144 186 138 72 0 100 12 1992 145 162 224 100 40 1 100 20 1993 224 132 256 125 35 1 76 12 1994 217 150 240 182 78 30 85 35 1995 240 108 240 162 84 4 92 35 1996 328 120 280 156 84 4 84 84 1997 312 140 264 138 128 30 95 70 1998 280 174 280 174 120 66 70 90 1999 240 196 272 192 78 35 56 96 2000 203 240 200 203 98 70 64 90 2001 189 208 208 186 120 60 130 78 2002 273 252 240 208 140 91 115 60 2003 234 175 333 189 136 56 108 60 2004 210 132 296 189 105 66 90 66 2005 288 108 270 114 91 56 102 30 Mean 234.31 162.63 246.19 158.81 90.06 35.69 88.19 53.13 Rank 2 3 1 4 5 8 6 7
Yearly Year Johnson & Johnson Pfizer Merck Bristol-Myers Squibb Amgen Biogen Idec Allergan Genzyme 1990 160 92 100 68 24 1 33 8 1991 145 120 155 92 36 0 80 12 1992 116 108 160 80 30 1 80 15 1993 160 88 192 100 21 1 57 8 1994 155 100 180 104 39 18 51 21 1995 150 54 150 108 56 4 69 21 1996 246 96 175 104 56 4 63 56 1997 234 80 198 92 64 24 57 56 1998 200 116 175 116 75 44 42 60 1999 160 112 204 128 52 21 42 64 2000 145 150 150 116 70 56 48 60 2001 135 104 130 124 60 40 78 52 2002 195 140 180 130 70 52 69 40 2003 156 100 222 135 85 40 72 40 2004 150 88 222 108 60 44 72 44 2005 216 72 210 95 65 40 68 15 Mean 170.19 101.25 175.19 106.25 53.94 24.375 61.31 35.75 Rank 2 4 1 3 6 8 5 7
Table 4 shows the yearly values of the synthetic structural h-indices for eight companies. Note that
Yearly Year Johnson & Johnson Pfizer Merck Bristol-Myers Squibb Amgen Biogen Idec Allergan Genzyme 1990 15.8 11.396 13.4 9.4 5.4 1.0 6.4 3.2 1991 14.8 11.812 15.8 12.4 7.8 0.0 10.8 3.2 1992 14.4 12.740 16.8 10.6 6.4 1.0 10.6 4.2 1993 16.2 10.836 17.2 12.8 5.6 1.0 10.0 3.2 1994 15.8 12.188 17.2 14.0 8.4 4.8 9.4 5.4 1995 16.0 8.804 16.4 14.2 8.6 1.8 11.6 5.4 1996 20.4 11.852 18.4 13.6 8.8 1.8 10.6 8.8 1997 19.6 10.044 17.6 12.8 10.8 5.0 10.4 8.4 1998 20.4 14.004 18.2 14.8 10.4 7.4 8.2 9.4 1999 20.2 13.544 17.8 16.4 8.6 5.2 8.0 10.0 2000 16.2 14.656 14.4 15.6 9.6 8.4 8.6 9.8 2001 15.6 13.364 15.0 16.0 10.4 7.2 13.0 8.8 2002 19.2 14.024 16.6 15.6 11.2 9.0 12.0 7.4 2003 15.0 12.876 20.0 15.0 11.6 6.6 10.4 7.6 2004 16.0 11.344 19.6 15.0 10.2 7.6 10.0 8.0 2005 18.8 9.868 17.2 11.2 9.6 6.8 10.0 5.2 Mean 17.15 12.085 16.975 13.713 8.963 4.663 10 6.75 Rank 1 4 2 3 6 8 5 7
Table 5 shows the rank correlations between yearly
Correlations among yearly Correlation is significant at the 0.01 level (2-tailed); Correlation is significant at the 0.05 level (2-tailed). Correlation is significant at the 0.05 level (2-tailed).Company Profits 2006–2010 millions of US dollars (Average) Rank profits 2006–2010 Yearly Yearly Using Using Yearly Rank Yearly Rank Yearly Rank Johnson & Johnson 11,451.00 1 234.31 2 170.19 2 17.15 1 Pfizer 10,461.00 2 162.63 3 101.25 4 12.09 4 Merck 6,610.02 3 246.19 1 175.19 1 16.98 2 Bristol-Myers Squibb 4,521.80 4 158.81 4 106.25 3 13.71 3 Amgen 3,718.20 5 90.06 6 53.94 6 8.96 6 Biogen Idec 554.10 6 35.69 8 24.36 8 4.66 8 Allergan 395.24 7 88.19 5 61.31 5 10.00 5 Genzyme 349.72 8 53.13 7 35.75 7 6.75 7 Spearman correlation 0.857 0.762 0.810
Tables 6 and 7 present the results of a longitudinal observation combined with a nested case-control design. Obviously, the yearly
Results of paired differences tests of firms’ yearly Paired differences 95% confidence interval of the difference Pairs- Mean Std. Deviation Lower Upper Sig. (2-tailed) GHR1 - GLR1 144.250 45.918 119.782 168.718 12.566 15 0.000 GHR2 - GLR2 126.938 34.555 108.524 145.351 14.694 15 0.000 GHR3 - GLR3 158.000 46.286 133.336 182.664 13.654 15 0.000 GHR4 - GLP4 105.688 26.630 91.497 119.878 15.875 15 0.000
Results of paired differences tests of firms’ yearly Paired differences 95% confidence interval of the difference Pairs- Mean Std. Deviation Lower Upper Sig. (2-tailed) GHR1 - GLR1 8.188 2.331 6.94560 9.429 14.052 15 0.000 GHR2 - GLR2 7.422 2.700 5.98329 8.861 10.996 15 0.000 GHR3 - GLR3 6.975 2.213 5.79602 8.154 12.610 15 0.000 GHR4 - GLR4 6.963 1.570 6.12586 7.799 17.738 15 0.000
Figure 1 shows average profit values as a function of average
Figure 1
Functional relation between the

In many scientific fields, it is difficult to collect large samples to perform an “ideal” real-world investigation. Therefore, special approaches are developed and carefully designed for small samples. In this contribution we included a nested case-control approach, a method often used in the medical sciences, and applied it to improve the methodology used in patent research. By way of discussion we address the following issues.
Compared to the case of
Although
The first
Our work further leads to the suggestion to different sized firms to include policymaking on technological innovation in its management. This is because there is always a limited R&D capital in a company. Indeed, we also found out that the Spearman correlation coefficient between the yearly average number of 4-digit codes of patents and a firm’s profits is even negative (namely –0.310, Appendix Tables A6 and A7), suggesting that a firm’s profits are highly dependent on the first h items of a firm’s patents rather than the “average patent” (Palokangas, 2011; Reitzig, 2003). The fact that a small group of patents essentially determines the competitive strength of a company is yet another example of the law of the vital few, also known as the 80–20 rule. In this sense, we claim that the structural h-index proposed in this study will be beneficial for modelling an optimal patent system.
Patent evaluation is a complicated issue which requires taking a full picture from different perspectives. This preliminary study proposes a new and simple indicator for gauging a company’s patent portfolio. Positive results are backed by evidence based on a large dataset from the pharmaceutical industry. Of course, we are aware that this is just a case study and, moreover, that any R&D indicator is at best PAC, as put forward in the case of citation indicators by Rousseau (2016). We are convinced though that the structural h-index is a useful addition to the field of patentometrics.
Figure 1

Correlations among yearly Sh and yearly SSh on the one hand and a firm’s profits on the other.
Company | Profits 2006–2010 millions of US dollars (Average) | Rank profits 2006–2010 | Yearly | Yearly | ||||
---|---|---|---|---|---|---|---|---|
Using | Using | |||||||
Yearly | Rank | Yearly | Rank | Yearly | Rank | |||
Johnson & Johnson | 11,451.00 | 1 | 234.31 | 2 | 170.19 | 2 | 17.15 | 1 |
Pfizer | 10,461.00 | 2 | 162.63 | 3 | 101.25 | 4 | 12.09 | 4 |
Merck | 6,610.02 | 3 | 246.19 | 1 | 175.19 | 1 | 16.98 | 2 |
Bristol-Myers Squibb | 4,521.80 | 4 | 158.81 | 4 | 106.25 | 3 | 13.71 | 3 |
Amgen | 3,718.20 | 5 | 90.06 | 6 | 53.94 | 6 | 8.96 | 6 |
Biogen Idec | 554.10 | 6 | 35.69 | 8 | 24.36 | 8 | 4.66 | 8 |
Allergan | 395.24 | 7 | 88.19 | 5 | 61.31 | 5 | 10.00 | 5 |
Genzyme | 349.72 | 8 | 53.13 | 7 | 35.75 | 7 | 6.75 | 7 |
Spearman correlation | 0.857 Correlation is significant at the 0.01 level (2-tailed); | 0.762 Correlation is significant at the 0.05 level (2-tailed). | 0.810 Correlation is significant at the 0.05 level (2-tailed). |
Results of paired differences tests of firms’ yearly SSh between Group H and Group L (based on IPCh4).
Paired differences | 95% confidence interval of the difference | ||||||
---|---|---|---|---|---|---|---|
Pairs- | Mean | Std. Deviation | Lower | Upper | Sig. (2-tailed) | ||
GHR1 - GLR1 | 8.188 | 2.331 | 6.94560 | 9.429 | 14.052 | 15 | 0.000 |
GHR2 - GLR2 | 7.422 | 2.700 | 5.98329 | 8.861 | 10.996 | 15 | 0.000 |
GHR3 - GLR3 | 6.975 | 2.213 | 5.79602 | 8.154 | 12.610 | 15 | 0.000 |
GHR4 - GLR4 | 6.963 | 1.570 | 6.12586 | 7.799 | 17.738 | 15 | 0.000 |
Yearly h-indices for eight companies during the period 1990–2005.
Year | Johnson & Johnson | Pfizer | Merck | Bristol-Myers Squibb | Amgen | Biogen Idec | Allergan | Genzyme |
---|---|---|---|---|---|---|---|---|
1990 | 32 | 23 | 25 | 17 | 8 | 1 | 11 | 4 |
1991 | 29 | 24 | 31 | 23 | 12 | 0 | 20 | 4 |
1992 | 29 | 27 | 32 | 20 | 10 | 1 | 20 | 5 |
1993 | 32 | 22 | 32 | 25 | 7 | 1 | 19 | 4 |
1994 | 31 | 25 | 30 | 26 | 13 | 6 | 17 | 7 |
1995 | 30 | 18 | 30 | 27 | 14 | 2 | 23 | 7 |
1996 | 41 | 24 | 35 | 26 | 14 | 2 | 21 | 14 |
1997 | 39 | 20 | 33 | 23 | 16 | 6 | 19 | 14 |
1998 | 40 | 29 | 35 | 29 | 15 | 11 | 14 | 15 |
1999 | 40 | 28 | 34 | 32 | 13 | 7 | 14 | 16 |
2000 | 29 | 30 | 25 | 29 | 14 | 14 | 16 | 15 |
2001 | 27 | 26 | 26 | 31 | 12 | 10 | 26 | 13 |
2002 | 39 | 28 | 30 | 26 | 14 | 13 | 23 | 10 |
2003 | 26 | 25 | 37 | 27 | 17 | 8 | 18 | 10 |
2004 | 30 | 22 | 37 | 27 | 15 | 11 | 18 | 11 |
2005 | 36 | 18 | 30 | 19 | 13 | 8 | 17 | 5 |
Yearly SSh indices of eight companies during the period 1990–2005 (using IPCh4).
Year | Johnson & Johnson | Pfizer | Merck | Bristol-Myers Squibb | Amgen | Biogen Idec | Allergan | Genzyme |
---|---|---|---|---|---|---|---|---|
1990 | 15.8 | 11.396 | 13.4 | 9.4 | 5.4 | 1.0 | 6.4 | 3.2 |
1991 | 14.8 | 11.812 | 15.8 | 12.4 | 7.8 | 0.0 | 10.8 | 3.2 |
1992 | 14.4 | 12.740 | 16.8 | 10.6 | 6.4 | 1.0 | 10.6 | 4.2 |
1993 | 16.2 | 10.836 | 17.2 | 12.8 | 5.6 | 1.0 | 10.0 | 3.2 |
1994 | 15.8 | 12.188 | 17.2 | 14.0 | 8.4 | 4.8 | 9.4 | 5.4 |
1995 | 16.0 | 8.804 | 16.4 | 14.2 | 8.6 | 1.8 | 11.6 | 5.4 |
1996 | 20.4 | 11.852 | 18.4 | 13.6 | 8.8 | 1.8 | 10.6 | 8.8 |
1997 | 19.6 | 10.044 | 17.6 | 12.8 | 10.8 | 5.0 | 10.4 | 8.4 |
1998 | 20.4 | 14.004 | 18.2 | 14.8 | 10.4 | 7.4 | 8.2 | 9.4 |
1999 | 20.2 | 13.544 | 17.8 | 16.4 | 8.6 | 5.2 | 8.0 | 10.0 |
2000 | 16.2 | 14.656 | 14.4 | 15.6 | 9.6 | 8.4 | 8.6 | 9.8 |
2001 | 15.6 | 13.364 | 15.0 | 16.0 | 10.4 | 7.2 | 13.0 | 8.8 |
2002 | 19.2 | 14.024 | 16.6 | 15.6 | 11.2 | 9.0 | 12.0 | 7.4 |
2003 | 15.0 | 12.876 | 20.0 | 15.0 | 11.6 | 6.6 | 10.4 | 7.6 |
2004 | 16.0 | 11.344 | 19.6 | 15.0 | 10.2 | 7.6 | 10.0 | 8.0 |
2005 | 18.8 | 9.868 | 17.2 | 11.2 | 9.6 | 6.8 | 10.0 | 5.2 |
Mean | 17.15 | 12.085 | 16.975 | 13.713 | 8.963 | 4.663 | 10 | 6.75 |
Rank | 1 | 4 | 2 | 3 | 6 | 8 | 5 | 7 |
Yearly average depth of patents (average dad) for eight companies during the period 1990–2005.
Year | Johnson & Johnson | Pfizer | Merck | Bristol-Myers Squibb | Amgen | Biogen Idec | Allergan | Genzyme |
---|---|---|---|---|---|---|---|---|
1990 | 1.50 | 2.49 | 1.79 | 1.77 | 2.04 | 4.22 | 1.44 | 2.29 |
1991 | 1.72 | 2.53 | 1.67 | 1.76 | 2.81 | 0.00 | 1.80 | 2.13 |
1992 | 1.59 | 2.35 | 1.93 | 1.67 | 2.86 | 2.83 | 1.48 | 2.39 |
1993 | 1.63 | 2.59 | 1.86 | 1.79 | 3.94 | 2.28 | 1.79 | 2.52 |
1994 | 1.52 | 2.47 | 2.58 | 1.70 | 3.71 | 2.53 | 1.62 | 2.00 |
1995 | 1.80 | 2.01 | 2.01 | 2.04 | 2.10 | 1.66 | 1.74 | 2.01 |
1996 | 1.78 | 2.63 | 2.01 | 1.75 | 2.29 | 3.63 | 1.66 | 2.85 |
1997 | 1.67 | 2.61 | 1.95 | 1.82 | 2.65 | 2.89 | 2.07 | 2.40 |
1998 | 2.22 | 3.01 | 2.01 | 1.73 | 3.15 | 2.82 | 1.53 | 3.18 |
1999 | 2.24 | 2.86 | 2.08 | 2.12 | 2.89 | 2.41 | 2.17 | 2.72 |
2000 | 2.38 | 3.14 | 2.22 | 2.40 | 2.93 | 3.33 | 1.68 | 3.44 |
2001 | 2.74 | 3.41 | 2.26 | 2.56 | 2.47 | 3.54 | 1.68 | 3.05 |
2002 | 1.69 | 3.06 | 2.33 | 3.34 | 3.65 | 3.18 | 2.03 | 2.30 |
2003 | 1.77 | 3.19 | 2.46 | 2.73 | 3.50 | 2.42 | 1.81 | 2.69 |
2004 | 1.93 | 2.86 | 2.65 | 2.48 | 3.99 | 2.78 | 1.99 | 2.57 |
2005 | 2.016 | 2.67 | 2.64 | 2.31 | 3.96 | 3.01 | 2.00 | 2.01 |
Mean | 1.887 | 2.743 | 2.153 | 2.123 | 3.059 | 2.721 | 1.781 | 2.543 |
Rank | 7 | 2 | 5 | 6 | 1 | 3 | 8 | 4 |
Yearly average number of 4-digit IPC codes (ave IPC-4 codes) of patents for eight companies during the period 1990–2005.
Year | Johnson & Johnson | Pfizer | Merck | Bristol-Myers Squibb | Amgen | Biogen Idec | Allergan | Genzyme |
---|---|---|---|---|---|---|---|---|
1990 | 2.85 | 2.81 | 2.83 | 2.76 | 3.46 | 9.00 | 2.58 | 2.67 |
1991 | 3.14 | 2.92 | 2.95 | 2.86 | 4.47 | 0.00 | 2.51 | 4.00 |
1992 | 2.37 | 2.60 | 3.00 | 2.72 | 3.63 | 6.00 | 2.84 | 3.91 |
1993 | 2.99 | 2.86 | 2.75 | 2.75 | 4.08 | 7.00 | 1.97 | 2.55 |
1994 | 2.98 | 2.75 | 2.72 | 2.97 | 4.17 | 6.00 | 2.54 | 4.07 |
1995 | 3.19 | 2.89 | 3.06 | 3.02 | 4.39 | 7.50 | 2.50 | 3.50 |
1996 | 3.52 | 2.94 | 3.07 | 2.83 | 4.08 | 6.50 | 1.94 | 3.57 |
1997 | 3.43 | 3.50 | 2.94 | 2.74 | 4.92 | 6.60 | 2.50 | 3.67 |
1998 | 2.60 | 3.60 | 3.12 | 2.59 | 4.64 | 5.56 | 2.36 | 3.08 |
1999 | 2.33 | 3.62 | 3.31 | 2.61 | 3.88 | 4.36 | 2.43 | 3.23 |
2000 | 2.96 | 3.78 | 3.47 | 3.14 | 4.08 | 4.57 | 2.18 | 3.49 |
2001 | 3.07 | 3.78 | 3.52 | 3.08 | 5.62 | 4.72 | 2.16 | 3.17 |
2002 | 2.78 | 3.72 | 3.74 | 3.55 | 6.06 | 4.74 | 2.43 | 3.57 |
2003 | 2.26 | 3.42 | 3.67 | 3.33 | 4.99 | 5.91 | 2.71 | 3.12 |
2004 | 2.91 | 2.97 | 3.48 | 3.04 | 4.66 | 4.51 | 2.56 | 3.29 |
2005 | 2.91 | 2.70 | 3.76 | 3.02 | 3.93 | 4.82 | 2.76 | 3.42 |
Mean | 2.89 | 3.18 | 3.21 | 2.94 | 4.44 | 5.49 | 2.44 | 3.39 |
Rank | 7 | 5 | 4 | 6 | 2 | 1 | 8 | 3 |
Yearly Sh indices of eight companies during the period 1990–2005 (using IPCh4).
Year | Johnson & Johnson | Pfizer | Merck | Bristol-Myers Squibb | Amgen | Biogen Idec | Allergan | Genzyme |
---|---|---|---|---|---|---|---|---|
1990 | 192 | 161 | 150 | 85 | 32 | 1 | 44 | 12 |
1991 | 174 | 144 | 186 | 138 | 72 | 0 | 100 | 12 |
1992 | 145 | 162 | 224 | 100 | 40 | 1 | 100 | 20 |
1993 | 224 | 132 | 256 | 125 | 35 | 1 | 76 | 12 |
1994 | 217 | 150 | 240 | 182 | 78 | 30 | 85 | 35 |
1995 | 240 | 108 | 240 | 162 | 84 | 4 | 92 | 35 |
1996 | 328 | 120 | 280 | 156 | 84 | 4 | 84 | 84 |
1997 | 312 | 140 | 264 | 138 | 128 | 30 | 95 | 70 |
1998 | 280 | 174 | 280 | 174 | 120 | 66 | 70 | 90 |
1999 | 240 | 196 | 272 | 192 | 78 | 35 | 56 | 96 |
2000 | 203 | 240 | 200 | 203 | 98 | 70 | 64 | 90 |
2001 | 189 | 208 | 208 | 186 | 120 | 60 | 130 | 78 |
2002 | 273 | 252 | 240 | 208 | 140 | 91 | 115 | 60 |
2003 | 234 | 175 | 333 | 189 | 136 | 56 | 108 | 60 |
2004 | 210 | 132 | 296 | 189 | 105 | 66 | 90 | 66 |
2005 | 288 | 108 | 270 | 114 | 91 | 56 | 102 | 30 |
Mean | 234.31 | 162.63 | 246.19 | 158.81 | 90.06 | 35.69 | 88.19 | 53.13 |
Rank | 2 | 3 | 1 | 4 | 5 | 8 | 6 | 7 |
The yearly h-index of patent depth (Dhy) for eight companies during the period 1990–2005.
Year | Johnson & Johnson | Pfizer | Merck | Bristol-Myers Squibb | Amgen | Biogen Idec | Allergan | Genzyme |
---|---|---|---|---|---|---|---|---|
1990 | 3 | 6 | 5 | 3 | 3 | 1 | 2 | 2 |
1991 | 4 | 6 | 5 | 4 | 3 | 0 | 4 | 2 |
1992 | 4 | 5 | 6 | 3 | 4 | 1 | 3 | 3 |
1993 | 3 | 5 | 6 | 4 | 4 | 1 | 4 | 2 |
1994 | 3 | 6 | 10 | 4 | 4 | 2 | 3 | 3 |
1995 | 4 | 4 | 6 | 5 | 3 | 1 | 4 | 3 |
1996 | 4 | 6 | 6 | 4 | 4 | 1 | 3 | 4 |
1997 | 4 | 5 | 6 | 6 | 6 | 3 | 4 | 4 |
1998 | 8 | 6 | 5 | 4 | 6 | 3 | 3 | 5 |
1999 | 9 | 6 | 5 | 6 | 5 | 2 | 4 | 6 |
2000 | 9 | 7 | 6 | 6 | 6 | 4 | 3 | 7 |
2001 | 10 | 8 | 7 | 6 | 8 | 4 | 3 | 6 |
2002 | 4 | 8 | 7 | 10 | 8 | 5 | 4 | 5 |
2003 | 5 | 8 | 8 | 7 | 8 | 3 | 4 | 6 |
2004 | 6 | 7 | 8 | 7 | 7 | 4 | 4 | 6 |
2005 | 6 | 8 | 8 | 6 | 8 | 4 | 4 | 4 |
Yearly Sh indices of eight companies during the period 1990–2005 (using IPCh3).
Year | Johnson & Johnson | Pfizer | Merck | Bristol-Myers Squibb | Amgen | Biogen Idec | Allergan | Genzyme |
---|---|---|---|---|---|---|---|---|
1990 | 160 | 92 | 100 | 68 | 24 | 1 | 33 | 8 |
1991 | 145 | 120 | 155 | 92 | 36 | 0 | 80 | 12 |
1992 | 116 | 108 | 160 | 80 | 30 | 1 | 80 | 15 |
1993 | 160 | 88 | 192 | 100 | 21 | 1 | 57 | 8 |
1994 | 155 | 100 | 180 | 104 | 39 | 18 | 51 | 21 |
1995 | 150 | 54 | 150 | 108 | 56 | 4 | 69 | 21 |
1996 | 246 | 96 | 175 | 104 | 56 | 4 | 63 | 56 |
1997 | 234 | 80 | 198 | 92 | 64 | 24 | 57 | 56 |
1998 | 200 | 116 | 175 | 116 | 75 | 44 | 42 | 60 |
1999 | 160 | 112 | 204 | 128 | 52 | 21 | 42 | 64 |
2000 | 145 | 150 | 150 | 116 | 70 | 56 | 48 | 60 |
2001 | 135 | 104 | 130 | 124 | 60 | 40 | 78 | 52 |
2002 | 195 | 140 | 180 | 130 | 70 | 52 | 69 | 40 |
2003 | 156 | 100 | 222 | 135 | 85 | 40 | 72 | 40 |
2004 | 150 | 88 | 222 | 108 | 60 | 44 | 72 | 44 |
2005 | 216 | 72 | 210 | 95 | 65 | 40 | 68 | 15 |
Mean | 170.19 | 101.25 | 175.19 | 106.25 | 53.94 | 24.375 | 61.31 | 35.75 |
Rank | 2 | 4 | 1 | 3 | 6 | 8 | 5 | 7 |
Controlled cases design for companies included in NCC study.
Group H | Group L | ||||||
---|---|---|---|---|---|---|---|
Company | Code | Profits | Rank | Company | Code | Profits | Rank |
Johnson & Johnson | GHR1 | 11,451.00 | 1 | Amgen | GLR1 | 3,718.20 | 1 |
Pfizer | GHR2 | 10,461.00 | 2 | Biogen Idec | GLR2 | 554.10 | 2 |
Merck | GHR3 | 6,610.02 | 3 | Allergan | GLR3 | 395.24 | 3 |
Bristol-Myers Squibb | GHR4 | 4,521.80 | 4 | Genzyme | GLR4 | 349.72 | 4 |
Correlations among yearly average IPC-4 codes and yearly average dad of patents and a firm’s profits.
Company | Rank profits 2006–2010 | Yearly average IPC-4 codes | Yearly average | ||
---|---|---|---|---|---|
Mean | Rank | Mean | Rank | ||
Johnson & Johnson | 1 | 2.89 | 7 | 1.887 | 7 |
Pfizer | 2 | 3.18 | 5 | 2.743 | 2 |
Merck | 3 | 3.21 | 4 | 2.153 | 5 |
Bristol-Myers Squibb | 4 | 2.94 | 6 | 2.123 | 6 |
Amgen | 5 | 4.44 | 2 | 3.059 | 1 |
Biogen Idec | 6 | 5.49 | 1 | 2.721 | 3 |
Allergan | 7 | 2.44 | 8 | 1.781 | 8 |
Genzyme | 8 | 3.39 | 3 | 2.543 | 4 |
Spearman correlation | –0.310 | –0.024 | |||
Results of paired differences tests of firms’ yearly Sh between Group H and Group L (based on IPCh4).
Paired differences | 95% confidence interval of the difference | ||||||
---|---|---|---|---|---|---|---|
Pairs- | Mean | Std. Deviation | Lower | Upper | Sig. (2-tailed) | ||
GHR1 - GLR1 | 144.250 | 45.918 | 119.782 | 168.718 | 12.566 | 15 | 0.000 |
GHR2 - GLR2 | 126.938 | 34.555 | 108.524 | 145.351 | 14.694 | 15 | 0.000 |
GHR3 - GLR3 | 158.000 | 46.286 | 133.336 | 182.664 | 13.654 | 15 | 0.000 |
GHR4 - GLP4 | 105.688 | 26.630 | 91.497 | 119.878 | 15.875 | 15 | 0.000 |
Yearly IPCh3 for eight companies during the period 1990–2005.
Year | Johnson & Johnson | Pfizer | Merck | Bristol-Myers Squibb | Amgen | Biogen Idec | Allergan | Genzyme |
---|---|---|---|---|---|---|---|---|
1990 | 5 | 4 | 4 | 4 | 3 | 1 | 3 | 2 |
1991 | 5 | 5 | 5 | 4 | 3 | 0 | 4 | 3 |
1992 | 4 | 4 | 5 | 4 | 3 | 1 | 4 | 3 |
1993 | 5 | 4 | 6 | 4 | 3 | 1 | 3 | 2 |
1994 | 5 | 4 | 6 | 4 | 3 | 3 | 3 | 3 |
1995 | 5 | 3 | 5 | 4 | 4 | 2 | 3 | 3 |
1996 | 6 | 4 | 5 | 4 | 4 | 2 | 3 | 4 |
1997 | 6 | 4 | 6 | 4 | 4 | 4 | 3 | 4 |
1998 | 5 | 4 | 5 | 4 | 5 | 4 | 3 | 4 |
1999 | 4 | 4 | 6 | 4 | 4 | 3 | 3 | 4 |
2000 | 5 | 5 | 6 | 4 | 5 | 4 | 3 | 4 |
2001 | 5 | 4 | 5 | 4 | 5 | 4 | 3 | 4 |
2002 | 5 | 5 | 6 | 5 | 5 | 4 | 3 | 4 |
2003 | 6 | 4 | 6 | 5 | 5 | 5 | 4 | 4 |
2004 | 5 | 4 | 6 | 4 | 4 | 4 | 4 | 4 |
2005 | 6 | 4 | 7 | 5 | 5 | 5 | 4 | 3 |
Yearly IPCh4 for eight companies during the period 1990–2005.
Year | Johnson & Johnson | Pfizer | Merck | Bristol-Myers Squibb | Amgen | Biogen Idec | Allergan | Genzyme |
---|---|---|---|---|---|---|---|---|
1990 | 6 | 7 | 6 | 5 | 4 | 1 | 4 | 3 |
1991 | 6 | 6 | 6 | 6 | 6 | 0 | 5 | 3 |
1992 | 5 | 6 | 7 | 5 | 4 | 1 | 5 | 4 |
1993 | 7 | 6 | 8 | 5 | 5 | 1 | 4 | 3 |
1994 | 7 | 6 | 8 | 7 | 6 | 5 | 5 | 5 |
1995 | 8 | 6 | 8 | 6 | 6 | 2 | 4 | 5 |
1996 | 8 | 5 | 8 | 6 | 6 | 2 | 4 | 6 |
1997 | 8 | 7 | 8 | 6 | 8 | 5 | 5 | 5 |
1998 | 7 | 6 | 8 | 6 | 8 | 6 | 5 | 6 |
1999 | 6 | 7 | 8 | 6 | 6 | 5 | 4 | 6 |
2000 | 7 | 8 | 8 | 7 | 7 | 5 | 4 | 6 |
2001 | 7 | 8 | 8 | 6 | 10 | 6 | 5 | 6 |
2002 | 7 | 9 | 8 | 8 | 10 | 7 | 5 | 6 |
2003 | 9 | 7 | 9 | 7 | 8 | 7 | 6 | 6 |
2004 | 7 | 6 | 8 | 7 | 7 | 6 | 5 | 6 |
2005 | 8 | 6 | 9 | 6 | 7 | 7 | 6 | 6 |