<abstract xmlns="http://www.w3.org/1999/xhtml"><p> Metals are essential components in indispensable biochemical processes for living organisms. This review article highlights the metals zinc and gold in the development and treatment of breast cancer. Metal compounds off er many advantages as therapeutics due to their ability to coordinate ligands in a three-dimensional configuration. In aqueous solution, they form positively charged ions that can bind to negatively charged biological molecules. Metal complexes that contain metal ions such as zinc(II) and gold have received considerable attention as potential anticancer agents. Zinc is an essential trace element that plays a critical role in a wide range of cellular processes that include structural, signalling, catalytic and regulatory functions. Zinc acts as a key structural component in many proteins and enzymes, including transcription factors, cellular signalling proteins, and DNA repair enzymes, and perturbed levels of zinc in tissues may play a role in cancer aetiology and outcome. Unlike zinc, gold is feasible as a component of compounds for effective anticancer therapy. Some progress in anticancer therapy may include interactions between zinc and gold. </p></abstract>

Metals are essential components in indispensable biochemical processes for living organisms. This review article highlights the metals zinc and gold in the development and treatment of breast cancer. Metal compounds off er many advantages as therapeutics due to their ability to coordinate ligands in a three-dimensional configuration. In aqueous solution, they form positively charged ions that can bind to negatively charged biological molecules. Metal complexes that contain metal ions such as zinc(II) and gold have received considerable attention as potential anticancer agents. Zinc is an essential trace element that plays a critical role in a wide range of cellular processes that include structural, signalling, catalytic and regulatory functions. Zinc acts as a key structural component in many proteins and enzymes, including transcription factors, cellular signalling proteins, and DNA repair enzymes, and perturbed levels of zinc in tissues may play a role in cancer aetiology and outcome. Unlike zinc, gold is feasible as a component of compounds for effective anticancer therapy. Some progress in anticancer therapy may include interactions between zinc and gold.

Zinc and Gold Complexes in the Treatment of Breast Cancer / Kompleksi Cinka I Zlata U Lecenju Karcinoma Dojke

Department of Transfusiology, Pula General Hospital, Croatia

Department of Clinical Cytology, Pula General Hospital, Croatia

Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, Serbia / Department for Histology, Faculty of Medical Sciences, University of Kragujevac, Serbia

Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, Serbia

Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, Serbia / Department for Pathophysiology, Faculty of Medical Sciences, University of Kragujevac, Serbia

Department for Preventive and Pediatric Dentistry, Faculty of Medical Sciences, University of Kragujevac, Serbia, Svetozara Markovica 69, 34000 Kragujevac, Serbia; Tel +38134306800, Fax +38134306800112

Experimental and Applied Biomedical Research (EABR)

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Metals are essential components in indispensable biochemical processes for living organisms. This review article highlights the metals zinc and gold in the...

Zinc and Gold Complexes in the Treatment of Breast Cancer / Kompleksi Cinka I Zlata U Lecenju Karcinoma Dojke

Online veröffentlicht: 14. Apr. 2016

Seitenbereich: 55 - 60

Eingereicht: 22. Juli 2015

Akzeptiert: 22. Juli 2015

DOI: https://doi.org/10.1515/sjecr-2015-0044

Schlüsselwörter
Zinc, gold complexes, breast cancer, anticancer therapy

© 2016

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Zinc and Gold Complexes in the Treatment of Breast Cancer / Kompleksi Cinka I Zlata U Lecenju Karcinoma Dojke

Online veröffentlicht: 14. Apr. 2016

Seitenbereich: 55 - 60

Eingereicht: 22. Juli 2015

Akzeptiert: 22. Juli 2015

DOI: https://doi.org/10.1515/sjecr-2015-0044

SchlüsselwörterZinc, gold complexes, breast cancer, anticancer therapy

© 2016

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Schlüsselwörter
Zinc, gold complexes, breast cancer, anticancer therapy