[1. Tomassen P., Van Zele T., Zhang et al. - Pathophysiology of chronic rhinosinusitis. Proc Am Thorac Soc., 2011;8(1):115-20. doi: 10.1513/ pats.201005-036RN.10.1513/pats.201005-036RN]Search in Google Scholar
[2. Hobbs A.J., Ignarro L.J. - The nitric oxide-cyclic GMP signal transduction system. In: Zapol W.M., Bloch K.D., eds. - Nitric oxide and the lung. New York: Marcel Dekker, 1997;pp.1-57.]Search in Google Scholar
[3. Lamas S., Michel T. - Molecular biological features of nitric oxide synthase isoforms. In: Zapol W.M., Bloch K.D., eds. - Nitric oxide and the lung. New York: Marcel Dekker, 1997;pp.59-73.]Search in Google Scholar
[4. Förstermann U., Schmidt H.H., Pollock J.S., et al. - Isoforms of nitric oxide synthase: characterization and purification from different cell types. Biochem Pharmacol., 1991;42:1849-1857.]Search in Google Scholar
[5. Morris S.M., Billiar T.R. - New insights into the regulation of inducible nitric oxide synthesis. Am J Physiol., 1994;266:E829-39.10.1152/ajpendo.1994.266.6.E829]Search in Google Scholar
[6. Radi R., Beckman J.S., Bush K.M., et al. - Peroxynitrite-induced membrane lipid peroxidation: the cytotoxic potential of superoxide and nitric oxide. Arch Biochem Biophys., 1991;288:481-487.]Search in Google Scholar
[7. Takeno S., Taruya T., Ueda T., Noda N., Hirakawa K. - Increased exhaled nitric oxide and its oxidation metabolism in eosinophilic chronic rhinosinusitis. Auris Nasus Larynx., 2013;40(5):458-64. doi: 10.1016/j. anl.2013.02.001.]Search in Google Scholar
[8. Corbelli R., Hammer J. - Measurement of Nasal Nitric Oxide. In: Hammer J., Eber E. (eds) - Paediatric pulmonary function testing. Vol. 33. Prog Respir Res. Basel, Karger, 2005;pp.181-189.10.1159/000083535]Search in Google Scholar
[9. Hibbs J.B., Taintor R.R., Vavrin Z., et al. - Nitric oxide: a cytotoxic activated macrophages effector molecule. Biochem Biophys Res Commun., 1988;157:87-94.]Search in Google Scholar
[10. Denis M. - Interferon-gamma-treated murine macrophages inhibit growth of tubercle bacilli via the generation of reactive nitrogen intermediates.Cell Immunol., 1991;131:150-157.10.1016/0008-8749(91)90014-3]Search in Google Scholar
[11. Kwon N.S., Stuehr D.J., Nathan C.F. - Inhibition of tumor cell ribonucleotide reductase by macrophage derived nitric oxide. J Exp Med., 1991;174:761-768.]Search in Google Scholar
[12. Wink D.A., Kasprzak K.S., Maragos C.M., et al. - DNA deaminating ability and genotoxicity of nitric oxide and its progenitors. Science, 1991;254:1001-1003.10.1126/science.1948068]Search in Google Scholar
[13. Ignarro L.J., Fukuto J.M., Griscavage J.M., et al. - Oxidation of nitric oxide in aqueous solution to nitrite but not nitrate, comparison with enzymatically formed nitric oxide from L-arginine. Proc Natl Acad Sci USA, 1993;90(17):8103-8107.10.1073/pnas.90.17.8103]Search in Google Scholar
[14. Stamler J.S., Simon D.I., Osborne J.A., et al. - S-nitrosylation of proteins with nitric oxide: synthesis and characterization of biologically active compounds. Proc Natl Acad Sci USA ,1992;89:444-448.10.1073/pnas.89.1.444]Search in Google Scholar
[15. Maarsingh H., Zaagsma J., Meurs H. - Arginine homeostasis in allergic asthma. Eur J Pharmacol., 2008;585:375-384.]Search in Google Scholar
[16. Zimmermann N., Rothenberg M.E. - The arginine-arginase balance in asthma and lung inflammation. Eur J Pharmacol., 2006;533:253-262.]Search in Google Scholar
[17. Munder M. - Arginase: an emerging key player in the mammalian immune system. Br J Pharmacol., 2009;158:638-651.10.1111/j.1476-5381.2009.00291.x]Search in Google Scholar
[18. Cho W.S., Kim T.H., Kim K.H., et al. - Increased Expression of Arginase I and II in Allergic Nasal Mucosa. Laryngoscope, 2011;121:236-240.10.1002/lary.21288]Search in Google Scholar
[19. Maarsingh H., Zaagsma J., Meurs H. - Arginase: a key enzyme in the pathophysiology of allergic asthma opening novel therapeutic perspectives. Br J Pharmacol., 2009;158(3):652-664.]Search in Google Scholar
[20. Lundberg J. - Nitric Oxide and the Paranasal Sinuses. Anat Rec., 2008;291:1479-1484.]Search in Google Scholar
[21. Lundberg J., Weitzberg E., Alving K. - Nitric oxide in exhaled air. Eur Respir J., 1996;9(12): 2671-2680.]Search in Google Scholar
[22. Maniscalco M., Sofia M., Pelaia G. - Nitric oxide in upper airways inflammatory diseases. Inflamm Res., 2007;56(2):58-69.]Search in Google Scholar
[23. Kharitonov S., Rajakulasingam K., O’Connor B., Durham S., Barnes P. - Nasal nitric oxide is increased in patients with asthma and allergic rhinitis and may be modulated by nasal glucocorticoids. J Allergy Clin Immunol., 1997;99(1 Pt 1): 58-64.10.1016/S0091-6749(97)81045-7]Search in Google Scholar
[24. Guclu O., Uludağ A., Akcalı A., Tekin K., Erdoğan H., Sılan F., Derekoy F.S. - Does the maxillary sinus have a triggering role in nasal nitric oxide synthesis? Rhinology, 2012;50(4): 402-407. doi: 10.4193/Rhino12.081.10.4193/Rhino12.08123193533]Search in Google Scholar
[25. Chiba Y., Matsuo K., Sakai H., Abe K., Misawa M. - Increased expression of inducible nitric oxide synthase in nasal mucosae of guinea pigs with induced allergic rhinitis. Am J Rhinol., 2006;20(3):336-341.]Search in Google Scholar
[26. Hess A., Bloch W., Rocker J., Addicks K., Stennert E., Michel O. - In vitro expression of inducible nitric oxide synthase in the nasal mucosa of guinea pigs after incubation with lipopolysaccharides or cytokines. Eur Arch Otorhinolaryngol., 1998;255(9):448-453.]Search in Google Scholar
[27. Dowling R.B., Newton R., Robichaud A., Cole P.J., Barnes P.J., Wilson R. - Effect of inhibition of nitric oxide synthase on Pseudomonas aeruginosa infection of respiratory mucosa in vitro. Am J Respir Cell Mol Biol., 1998;19(6):950-958.]Search in Google Scholar
[28. Stark J.M., Khan A.M., Chiappetta C.L., Xue H., Alcorn J.L., Colasurdo G.N. - Immune and functional role of nitric oxide in a mouse model of respiratory syncytial virus infection. J Infect Dis., 2005;191(3):387-395.]Search in Google Scholar
[29. Lundberg J.O.N., Farkas-Szallasi T., Weizberg E., Rinder J., Lindholm J., Anggaard A., et al.. - High nitric oxide production in human paranasal sinuses. Nature Med., 1995;1(4):370-373.]Search in Google Scholar
[30. Green S.J., Meltzer M.S., Hibbs J.B. Jr., Nacy C.A. - Activated macrophages destroy intracellular Leishmania major amastigotes by an L-arginine-dependent killing mechanism. J Immunol., 1990;144(1):278-283.]Search in Google Scholar
[31. Chan J., Xing Y., Magliozzi S., Bloom B.R. - Killing of virulent Mycobacterium tuberculosis by reactive nitrogen intermediates produced by activated murine macrophages. J Exp Med., 1992;175(4):1111-1122.]Search in Google Scholar
[32. Taylor-Robinson A.W., Phillips R.S., Severn A., et al. - The role of TH1 and TH2 cells in a rodent malaria infection. Science, 1993;260(5116):1931-1934.10.1126/science.81003668100366]Search in Google Scholar
[33. Lindberg S., Cervin A., Runner T. - Low levels of nasal nitric oxide (NO) correlate to impaired mucociliary function in the upper airways. Acta Otolaryngol., 1997;117(5):728-734.]Search in Google Scholar
[34. Runner T., Lindberg S. - Effects of nitric oxide on blood flow and mucociliary activity in the human nose. Ann Otol Rhinol Laryngol., 1998;107(1):40-46.]Search in Google Scholar
[35. Runer T., Cervin A., Lindberg S., Uddman R. - Nitric oxide is a regulator of mucociliary activity in the upper respiratory tract. Otolaryngol Head Neck Surg., 1998;119(3):278-287.]Search in Google Scholar
[36. Arnal J.F. , Flores P., Rami J., Murris-Espin M., Bremont F., Pasto I., Aguilla M., Serrano E., Didier A. - Nasal nitric oxide concentration in paranasal sinus inflammatory diseases. Eur Respir J., 1999;13(2):307-312.]Search in Google Scholar
[37. Tornberg D.C., Marteus H., Schedin U., Alving K., Lundberg J.O., Weitzberg E. - Nasal and oral contribution to inhaled and exhaled nitric oxide: a study in tracheotomized patients. Eur Respir J., 2002;19(5):859-864.]Search in Google Scholar
[38. Frieri M. - Asthma linked with rhinosinusitis: An extensive review. Allergy Rhinol. (Providence), 2014;5(1):41-49. doi:10.2500/ar.2014.5.0083.10.2500/ar.2014.5.0083401974524684837]Search in Google Scholar
[39. Michels Dde S., Rodrigues Ada M., Nakanishi M., Sampaio A.L., Venosa A.R. - Nasal Involvement in Obstructive Sleep Apnea Syndrome. Int J Otolaryngol., 2014;2014:717419. doi: 10.1155/2014/717419.10.1155/2014/717419427359725548569]Search in Google Scholar
[40. Citardi M.J., Song W., Batra P.S., et al. - Characterization of oxidative pathways in chronic rhinosinusitis and sinonasal polyposis. Am J Rhinol., 2006;20(3):353-359.]Search in Google Scholar
[41. Bommarito L., Guida G., Heffler E., et al. - Nasal nitric oxide concentration in suspected chronic rhinosinusitis. Ann Allergy Asthma Immunol., 2008;101(4):358-362.]Search in Google Scholar
[42. Colantonio D., Brouillette L., Parikh A., Scadding G.K. - Paradoxical low nasal nitric oxide in nasal polyposis. Clin Exp Allergy, 2002;32(5):698-701.10.1046/j.1365-2222.2002.01379.x11994092]Search in Google Scholar
[43. Ricciardolo F.L. - Multiple roles of nitric oxide in the airways. Thorax, 2003;58(2):175-182.10.1136/thorax.58.2.175174656412554905]Search in Google Scholar
[44. Duszyk M., Radomski M.W. - The role of nitric oxide in the regulation of ion channels in airway epithelium: implications for diseases of the lung. Free Radic Res., 2000;33(5):449-459.]Search in Google Scholar
[45. Duszyk M. - Regulation of anion secretion by nitric oxide in human air way epithelial cells. Am J Physiol Lung Cell Mol Physiol., 2001;281(2):L450-L457.10.1152/ajplung.2001.281.2.L45011435220]Search in Google Scholar
[46. Naraghi M., Deroee A.F., Ebrahimkhani M., Kiani S., Dehpour A. - Nitric oxide: a new concept in chronic sinusitis pathogenesis. Am J Otolaryngol., 2007;28(5):334- 337.]Search in Google Scholar
[47. Dabholkar Y.G., Saberwal A.A., Velankar H.K., Shetty A.K., Chordia N.P., Budhwani S.R. - Correlation of Nasal Nitric Oxide Measurement with Computed Tomography Findings in Chronic Rhinosinusitis. Indian J Otolaryngol Head Neck Surg., 2014;66(1):92-96. doi: 10.1007/s12070-013-0689-8.10.1007/s12070-013-0689-8393870224605309]Search in Google Scholar
[48. Lundberg J.O., Maniscalco M., Sofia M., Lundblad L., Weitzberg E. - Humming, nitric oxide, and paranasal sinus obstruction. JAMA, 2003;289(3):302-303.10.1001/jama.289.3.302-b12525230]Search in Google Scholar
[49. Ragab S.M., Lund V.J., Saleh H.A., Scadding G. - Nasal nitric oxide in objective evaluation of chronic rhinosinusitis therapy. Allergy, 2006;61(6):717-724.10.1111/j.1398-9995.2006.01044.x16677241]Search in Google Scholar
[50. Baraldi E., Azzolin N.M., Biban P., Zacchello F. - Effect of antibiotic therapy on nasal nitric oxide concentration in children with acute sinusitis. Am J Respir Crit Care Med., 1997;155(5):1680-1683.]Search in Google Scholar
[51. Deroee A.F., Naraghi M., Sontou A.F., Ebrahimkhani M.R., Dehpour A.R. - Nitric oxide metabolites as biomarkers for follow-up after chronic rhinosinusitis surgery. Am J Rhinol Allergy, 2009;23(2):159-161. doi: 10.2500/ajra.2009.23.3289.10.2500/ajra.2009.23.328919401041]Search in Google Scholar
[52. Schlosser R.J., Spotnitz W.D., Peters E.J., et al. - Elevated nitric oxide metabolite levels in chronic sinusitis. Otolaryngol Head Neck Surg., 2000;123(4):357-362.]Search in Google Scholar
[53. Deja M., Busch T., Bachmann S., et al. - Reduced nitric oxide in sinus epithelium of patients with radiologic maxillary sinusitis and sepsis. Am J Respir Crit Care Med., 2003;168(3):281- 286.]Search in Google Scholar
[54. Ho L.P., Innes J.A., Greening A.P. - Nitrite levels in breath condensate of patients with cystic fibrosis is elevated in contrast to exhaled nitric oxide. Thorax, 1998;53(8):680- 684.10.1136/thx.53.8.68017452849828856]Search in Google Scholar
[55. Flak T.A., Goldman W.E. - Autotoxicity of nitric oxide in airway disease. Am J Respir Crit Care Med., 1996;154(4 Pt 2):S202-S206.10.1164/ajrccm/154.4_Pt_2.S2028876543]Search in Google Scholar
[56. Feng C.H., Miller M.D., Simon R.A. - The united allergic airway: Connections between allergic rhinitis, asthma, and chronic sinusitis. Am J Rhinol Allergy, 2012;26(3):187-190. doi: 10.2500/ajra.2012.26.3762.10.2500/ajra.2012.26.3762390650922643942]Search in Google Scholar
[57. Caimmi D., Marseglia A., Pieri G., et al. - Nose and lungs: One way, one disease. Ital J Pediatr., 2012;38:60. doi: 10.1186/1824-7288-38-60.10.1186/1824-7288-38-60350767223098057]Search in Google Scholar
[58. Scadding G., Scadding G.K. - Update on the use of nitric oxide as a noninvasive measure of airways inflammation. Rhinology, 2009;47(2):115-120.]Search in Google Scholar
[59. Silkoff P.E., Lent A.M., Busacker A.A., et al. - Exhaled nitric oxide identifies the persistent eosinophilic phenotype in severe refractory asthma. J Allergy Clin Immunol., 2005;116(6):1249-1255.]Search in Google Scholar
[60. Smith A.D., Cowan J.O., Brassett K.P., Herbison G.P., Taylor D.R. - Use of exhaled nitric oxide measurements to guide treatment in chronic asthma. N Engl J Med., 2005;352(21):2163-2173.]Search in Google Scholar
[61. Downie S.R., Andersson M., Rimmer J., et al. - Association between nasal and bronchial symptoms in subjects with persistent allergic rhinitis. Allergy, 2004;59(3):320-326.10.1111/j.1398-9995.2003.00419.x14982515]Search in Google Scholar
[62. Smith A.D., Cowan J.O., Filsell S., et al. - Diagnosing asthma: comparisons between exhaled nitric oxide measurements and conventional tests. Am J Respir Crit Care Med., 2004;169(4):473-478.]Search in Google Scholar
[63. Donohue J.F., Jain N. - Exhaled nitric oxide to predict corticosteroid responsiveness and reduce asthma exacerbation rates. Respir Med., 2013;107(7):943-952. doi: 10.1016/j.rmed.2013.02.018.10.1016/j.rmed.2013.02.01823601567]Search in Google Scholar
[64. Scott M., Raza A., Karmaus W., Mitchell F., Grundy J., Kurukulaaratchy R.J., et al. - Influence of atopy and asthma on exhaled nitric oxide in an unselected birth cohort study. Thorax,. 2010;65(3):258-262. doi: 10.1136/thx.2009.125443.10.1136/thx.2009.125443289007020335297]Search in Google Scholar
[65. Smith A.D., Cowan J.O., Brassett K.P., et al. - Exhaled nitric oxide: a predictor of steroid response. Am J Respir Crit Care Med., 2005;172(4):453-459.]Search in Google Scholar
[66. Jeong J.H., Yoo H.S., Lee S.H., Kim K.R., Yoon H.J., Kim S.H. - Nasal and exhaled nitric oxide in chronic rhinosinusitis with polyps. Am J Rhinol Allergy, 2014;28(1):e11-e16. doi: 10.2500/ajra.2014.28.3984.10.2500/ajra.2014.28.398424717870]Search in Google Scholar
[67. Wodehouse T., Kharitonov S.A., Mackay I.S., Barnes P.J., Wilson R., Cole P.J. - Nasal nitric oxide measurements for the screening of primary ciliary dyskinesia. Eur Respir J., 2003;21(1):43-47.]Search in Google Scholar
[68. Lee K.J., Cho S.H., Lee S.H., Tae K., Yoon H.J., Kim S.H., Jeong J.H. - Nasal and Exhaled Nitric Oxide in Allergic Rhinitis. Clin Exp Otorhinolaryngol., 2012;5(4):228-233. doi: 10.3342/ceo.2012.5.4.228.10.3342/ceo.2012.5.4.228350677523205229]Search in Google Scholar
[69. Santamaria F., De Stefano S., Montella S., et al. - Nasal nitric oxide assessment in primary ciliary dyskinesia using aspiration, exhalation, and humming. Med Sci Monit., 2008;14(2):CR80-85.]Search in Google Scholar
[70. Struben V.M., Sewbalak W.V., Wieringa M.H., et al. - Nasal nitric oxide in cystic fibrosis with and without humming. Eur J Clin Invest., 2007;37(2):140-144.]Search in Google Scholar
[71. Maniscalco M., Sofia M., Weitzberg E., et al. - Humming-induced release of nasal nitric oxide for assessment of sinus obstruction in allergic rhinitis: pilot study. Eur J Clin Invest., 2004;34(8):555-560. ]Search in Google Scholar
