[1. Chung HT, Samlowski WE, Daynes RA. Modification of the murine immune system by glucocorticoids: alterations of the tissue localization properties of circulating lymphocytes. Cellular immunology. 1986; 101: 571-585.10.1016/0008-8749(86)90167-X]Search in Google Scholar
[2. Van Vliet E, Melis M, van Evijk W. The influence of dexamethasone treatment on the lymphoid and stromal composition of the mouse thymus: a flowcytometric and immunohistological analysis. Cellular Immunology. 1986; 103: 229-240.10.1016/0008-8749(86)90086-9]Search in Google Scholar
[3. Wyllie AH, Morris RG. Hormone-induced cell death. Purification and properties of thymocytes undergoing apoptosis after glucocorticoid treatment. Am J Pathol. 1982; 109: 78-87.]Search in Google Scholar
[4. Mitevska E, Kostovska N, Vasilevska K, Trajkov D. Stereological study of thymus after dexamethasone application. Maced Pharm Bull. 2004; 50(2): 25-28.]Search in Google Scholar
[5. Mitevska E, Spiroski M. Qualitative histological analysis of adrenal cortex following application of medroxyprogesterone acetate. Maced J Med Sci. 2010; 3(2): 123-131.10.3889/MJMS.1857-5773.2010.0100]Search in Google Scholar
[6. Mitevska E, Spiroski M. Quantitative analysis of adrenal cortical histological alterations after application of medroxyprogesterone acetate. Maced J Med Sci. 2010; 3(4): 352-357.10.3889/MJMS.1857-5773.2010.0122]Search in Google Scholar
[7. Staples LD, Binns RM, Heap RB. Influence of certain steroids on lymphocyte transformation in sheep and goats studied in vitro. J Endocrinol. 1983; 98(1): 55-69.10.1677/joe.0.0980055]Search in Google Scholar
[8. Golikov PP, Bobkova AS. Effect of steroid hormones on DNA matrix activity and glucocorticoidreceptor interaction. Probl Endocrinol. 1981; 27(3): 52-6.]Search in Google Scholar
[9. Maule AG, Schreck CB. Glucocorticoid receptors in leukocytes and gill of juvenile coho salmon (Oncorhynchus kisutch). Gen Comp Endocrinol. 1990; 77(3): 448-55.10.1016/0016-6480(90)90236-F]Search in Google Scholar
[10. Jeklova E, Leva L, Jaglic Z, Faldyna M. Dexamethasone- induced immunosuppression: a rabbit model. Veterinary Immunology and Immunopathology. 2008; 122(3-4): 231-240.10.1016/j.vetimm.2007.11.011]Search in Google Scholar
[11. Marchetti MC, Di Marco B, Cifone G, Migliorati G, Riccardi C. Dexamethasone-induced apoptosis of thymocytes: role of glucocorticoid receptor-associated Src kinase and caspase-8 activation. Blood. 2003; 101(2): 585-93.10.1182/blood-2002-06-1779]Search in Google Scholar
[12. Marchetti MC, Marco BD, Santini MC, Bartoli A, Delfino DV, Riccardi C. Dexamethasone-induced thymocytes apoptosis requires glucocorticoid recaptor nuclear translocation but not mitochondrial membrane potential transition. Toxicology letters. 2003; 139: 175-180.10.1016/S0378-4274(02)00431-9]Search in Google Scholar
[13. Cifone MG, Migliorati G, Parroni R, Marchetti C, Millimaggi D, Santoni A, Riccardi C. Dexamethasone- induced thymocyte apoptosis: apoptotic signal involves the sequential activation of phosphorinositide- specific phospholipase C, acidic sphingomyelinase, and caspases. Blood. 1999; 93(7): 2282-96.10.1182/blood.V93.7.2282]Search in Google Scholar
[14. Selman PJ, van Garderen E, Mol JA, van den Ingh TS. Comparison of the histological changes in the dog after treatment with the progestins medroxyprogesterone acetate and proligestone. Vet Q. 1995; 17(4): 128-33.10.1080/01652176.1995.9694551]Search in Google Scholar
[15. Kosaka A, Yamashita A. Experimental study of combination medical endocrine therapy on DMBAinduced mammary tumor, with special reference to the effect of drug-dose on various factors. Gan To Kagaku Ryoho. 1992; 19(1): 75-81.]Search in Google Scholar
[16. Mitevska SE, Gerasimovska AZ, Kakaseva SL, Trajkov KD, Jurhar RM, Stojoska EP, Spiroski ZM. Histophisiology of the spleen after application of medroxyprogesterone acetate. Zbornik matice srpske za prirodne nauke / Proceedings for Natural Sciences, Matica Srpska. 1998; 95: 25-32.]Search in Google Scholar
[17. Mitevska E, Spiroski M. Histological characteristics of mesenteric lymph nodes after application of medroxyprogesterone acetate. Makedonski medicinski pregled. 1998; 52(1-2): 3-7.]Search in Google Scholar
[18. Mitevska E. Histological characteristics of thymus assessed with stereological parameters after medroxyprogesterone acetate application. Maced J Med Sci. 2011; 4(4): 367-371.10.3889/MJMS.1857-5773.2011.0197]Search in Google Scholar
[19. Kleynhans L, Du Plessis N, Allie N, Jacobs M, Kidd M, Van Helden P, et al. The Contraceptive Depot Medroxyprogesterone Acetate Impairs Mycobacterial Control and Inhibits Cytokine Secretion in Mice Infected with Mycobacterium tuberculosis. Infect Immun. 2013; 81(4): 1234-1244.10.1128/IAI.01189-12]Search in Google Scholar
[20. Baker HJ, Lindsey JR, WeisbrothSH, The Laboratory Rat. Research Applications, Academic Press 1980; USA.]Search in Google Scholar
[21. Hebel R, Stromberg MW. Anatomy and Embryology of the Laboratory Rat, BioMed Verlag 1986; Germany.]Search in Google Scholar
[22. Muss HB, Case LD, Atkins JN, Bearden JD 3rd, Cooper MR, Cruz JM, et al. Tamoxifen versus highdose oral medroxyprogesterone acetate as initial endocrine therapy for patients with metastatic breast cancer. Journal of Clinical Oncology. 1994; 12(8): 1630-1638.10.1200/JCO.1994.12.8.1630]Search in Google Scholar
[23. Pronin VN, Pukhlikov AV. Characteristics of the surgical stage in the combined treatment of poorly differentiated cancer of the corpus uteri. Vopr Oncol. 1988; 34(9): 1102-1105.]Search in Google Scholar
[24. Senga O, Miyakawa M, Hikita H, Horigome N, Kouzu S, Kuwae K, et al. A case of complete response of breast cancer with pulmonary metastases to combination therapy of 5 DFUR and MPA. Gan To Kagaku Ryoho. 1994; 21(15): 2655-2658.]Search in Google Scholar
[25. Gudovic R, Matavulj M, Stefanovic N, Lozanov- Cvetkovic Z. Osnovi stereologije. Folia anatomica. 1994; 21/22(2): 13.]Search in Google Scholar
[26. Kalisnik M Temelji stereologije. Acta Stereologica 1985; 4(1): 1-148.]Search in Google Scholar
[27. Bianchini R, Nocentini G, Krausz LT, Fettucciari K, Coaccioli S, Ronchetti S, Riccardi C. Modulation of Pro- and Antiapoptotic Molecules in Double-Positive (CD4+CD8+) Thymocytes following Dexamethasone Treatment. JPET. 2006; 319(2): 887-897.10.1124/jpet.106.108480]Search in Google Scholar
[28. Catalano G, Altomare D, Laurentaci G. Immunodepressive action and effects of medroxyprogesterone acetate on the lymphatic tissue of the spleen of rabbits. Arch Sci Med. 1982; 139(3): 269-278.]Search in Google Scholar
[29. Rondinone CM, Schillaci R, Castillo MB, roldan A. Inhibitory effect of 11 β-hydroxypregna-1,4-diene-3,20-dione (delta HOP) on lymphocyte proliferation. Clin Exp Imunol. 1991; 86(2): 311-314.10.1111/j.1365-2249.1991.tb05815.x]Search in Google Scholar
[30. Corsini G, Puppo F. Effect of medroxyprogesterone acetate upon PHA, Con A and PWM stimulated lymphocytes and on E-rosette function. J Immunopharmacol. 1982-1983; 4(3):247-253.10.3109/08923978209026438]Search in Google Scholar
[31. Staples LD, Heap RB, Brown D, Marrs RW. Structural requirements for steroid inhibition of sheep lymphocyte mitogenesis in vitro. Steroids. 1984; 44(5): 419-433.10.1016/S0039-128X(84)80002-1]Search in Google Scholar
[32. Malarkey WB, Burleson Cacioppo JT, Poehlmann K, Glaser R, Kiecolt-Glaser JK. Differential effects of estrogen and medroxyprogesterone on basal and stress-induced growth hormone release, IGF-1 levels, and cellular immunity in postmenopausal women. Endocrine. 1997; 7(2): 227-233.10.1007/BF02778145]Search in Google Scholar
[33. Mantovani G, Maccio A, Esu S, Lai P, Santona MC, Massa E, et al. Medroxyprogesterone acetate reduces the in vitro production of cytokines and serotonin involved in anorexia/cachexia and emesis by peripheral blood mononuclear cells of cancer patients. Eur J Cancer. 1997; 33(4): 602-607.10.1016/S0959-8049(96)00486-8]Search in Google Scholar
[34. Scambia G, Panici PB, Maccio A, Castelli P, Serri F, Mantovani G, et al. Effects of antiestrogen and progestin on immune functions in breast cancer patients. Cancer. 1988; 61(11): 2214-2218.10.1002/1097-0142(19880601)61:11<2214::AID-CNCR2820611115>3.0.CO;2-V]Search in Google Scholar
[35. Huber H, Huslein P, Muchalica W, Wagenbichler P. radiosensitising effect of medroxyprogesterone acetate on endometrial cancer cells in vitro. Cancer. 1984; 54: 999-1001.10.1002/1097-0142(19840915)54:6<999::AID-CNCR2820540610>3.0.CO;2-Q]Search in Google Scholar
[36. Al-Sumidaie AM. The effect of tamoxifen and medroxyprogesterone on giant cell formation by monocytes from patients with breast cancer. J Cancer Res Clin Oncol. 1988; 114(4): 399-404.10.1007/BF02128185]Search in Google Scholar
[37. Coldham NG, Lai LC, Ghilchik MW, Walker MM, James VH, Reed MJ. The effect of treatment with 4- hydroxyandrostenedione or medroxyprogesterone acetate on human breast tumour regression. Anticancer Research. 1993; 13(3): 753-758.]Search in Google Scholar
[38. King KL, Cidlovski JA. Cell cycle regulation and apoptosis. Annu Rev Physiol. 1998; 60: 601-617.10.1146/annurev.physiol.60.1.601]Search in Google Scholar
[39. Zieger G, Zieger W, Kubatsch B. Effect and duration of gestagen influence on adrenal cortex and ovary. A morphological study in the Syrian golden hamster. Pathol Res Pract. 1982; 173(3): 202-217.10.1016/S0344-0338(82)80084-8]Search in Google Scholar
[40. Vicent GP, Pecci A, Ghini AA, Piwien-Pilipuk G, Valeiro AS, Burton G, et al. The glucocorticoid properties of the synthetic steroid pregna-1,4-diene-11beta-ol-3,20-dione (delta-HOP) are not entirely correlated with the steroid binding to the glucocorticoid receptor. Mol Cell Endocrinol. 1999; 149(1-2): 207-219.10.1016/S0303-7207(98)00205-6]Search in Google Scholar
[41. Henson PM, Bratton DL. Antiinflamatory effects of apoptotic cells. J Clin Invest. 2013; 123(7): 2773-2774.10.1172/JCI69344]Search in Google Scholar
[42. Freire-de-Lima CG, Yi Qun Xiao, Gardai SJ, Bratton DL, Schiemann WP, Henson PM. Apoptotic cells, through transforming growth factor-β, co-ordinately induce anti-inflammatory and suppress pro-inflammatory eicosanoid and NO synthesis in murine macrophages. Journal of Biological Chemistry. 2006; 281: 38376-38384.10.1074/jbc.M605146200]Search in Google Scholar
[43. Gao Y, Herndon JM, Zhang H, Griffith TS, Ferguson TA. Antiinflammatory effects of CD95 ligand (FasL)-induced apoptosis. JEM. 1998; 188(5): 887.10.1084/jem.188.5.887]Search in Google Scholar
[44. Beijerink NJ, Bhatti SFM, Okkens AC, et al. Adenohypophiseal function in bitches treated with medroxyprogesterone acetate. Dom Anim Endocrinol. 2007; 32: 63-78.10.1016/j.domaniend.2005.12.008]Search in Google Scholar
[45. Kleynhans L, Du Plessis N, Black GF, Loxton AG, Kidd M, Van Helden PD, et al. Medroxyprogesterone Acetate Alters Mycobacterium Bovis BCGInduced Cytokine Production in Peripheral Blood Mononuclear Cells of Contraceptive Users. PLoS One 2011; 6(9): e24639. doi:10.1371/journal.pone.0024639.10.1371/journal.pone.0024639316962021931790]Search in Google Scholar
[46. Hughes GC, Martin D, Zhang K, Hudkins KL, Alpers CE, Clark EA, Elkon KB. Decrease in glomerulonephritis and Th1-associated autoantibody production after progesterone treatment in NZB/NZW Mice. Arthritis & Rheumatism. 2009; 60(6): 1775-1784.10.1002/art.2454819479860]Search in Google Scholar
[47. Selman PJ, Mol JA, Rutteman GR, Rijnberk A. Progestin treatment in the dog. II. Effects on the hypothalamic-pituitary-adrenocortical axis. European Journal of Endocrinology. 1994; 131(4): 422-430.10.1530/eje.0.13104227921232]Search in Google Scholar
[48. Fenton SL, Luong QT, Sarafeim A, Mustard KJ, Pound J, Desmond JC, et al. Fibrates and medroxyprogesterone acetate induce apoptosis of primary Burkitt’s lymphoma cells and cell lines: potential for applying old drugs to a new disease. Leukemia. 2003; 17(3): 568-575.10.1038/sj.leu.240284312646946]Search in Google Scholar
[49. Tomasicchio M, Avenant C, Du Toit A, Ray RM, Hapgood JP. The progestin-only contraceptive medroxyprogesterone acetate, but not norethisterone acetate, enhances HIV-1 Vpr-mediated apoptosis in human CD4+ T cells through the glucocorticoid receptor. PLoS One 2013; 8(5):e62895. doi: 10.1371/journal pone.0062895.]Search in Google Scholar
[50. Bakry S, Ahmed HA, Al-OtaibiPrenatal ML. Exposure to medroxyprogesterone acetate. American- Eurasian Journal of Toxicological Sciences. 2010; 2(1): 01-12.]Search in Google Scholar
[51. Vermeulen M, Pazos P, Lanari C, Molinolo A, Gamberale R, Geffner JR, Giordano M. Medroxypro gesterone acetate enhances in vivo and in vitro antibody production. Immunology. 2001; 104(1): 80-86.10.1046/j.0019-2805.2001.01281.x178328111576224]Search in Google Scholar
[52. Ory K, Lebeau J, Levalous C, Bishay, Fouchet P, Allemand I, et al. Apoptosis inhibition mediated by medroxyprogesterone acetate treatment of breast cancer cell lines. Breast cancer Res Treat. 2001; 68(3): 187-198.10.1023/A:1012288510743]Search in Google Scholar