Protective efficacy of various carbonyl compounds and their metabolites, and nutrients against acute toxicity of some cyanogens in rats: biochemical and physiological studies

Abraham P, Lockwood A, Patka J, Rabinovich M, Sutherland J, Chester K. (2015). Sodium nitroprusside in intensive care medicine and issues of cyanide poisoning, cyanide poisoning prophylaxis, and thiocyanate poisoning. In: Toxicology of cyanides and cyanogens experimental, applied and clinical aspects (Alan H Hall, Gary E Isom, Gary A Rockwood eds), Wiley Blackwell, West Sussex, UK, 129–150.10.1002/9781118628966.ch9Search in Google Scholar

Bhattacharya R. (2004). α-Ketoglutarate: a promising antidote to cyanide poisoning. In: Pharmacological Perspectives of Toxic Chemicals and their Antidotes (Flora SJS, Romano JA, Baskin SI, Sekhar K eds), Narosa Publishing House, New Delhi, India, 411–430.Search in Google Scholar

Bhattacharya R. (2015). Recent perspectives on alpha-ketoglutarate. In: Toxicology of cyanides and cyanogens experimental, applied and clinical aspects (Alan H Hall, Gary E Isom, Gary A Rockwood eds), Wiley Blackwell, West Sussex, UK, 317–329.10.1002/9781118628966.ch27Search in Google Scholar

Bhattacharya R, Flora SJS. (2009). Cyanide toxicity and its treatment In: Handbook of Toxicology of Chemical Warfare Agents (Gupta RC ed), New York, Elsevier, 255–270.10.1016/B978-0-12-374484-5.00019-5Search in Google Scholar

Bhattacharya R, Lakshmana Rao PV. (1997). Cyanide induced DNA fragmentation in mammalian cell cultures. Toxicology123: 207–215.Search in Google Scholar

Bhattacharya R, Rao P, Singh P, Yadav SK, Upadhyayay P, Malla S, Gujar NL, Lomash V, Pant SC. (2014). Biochemical, oxidative and histological changes caused by sub-acute oral exposure of some synthetic cyanogens in rats: Ameliorative effect of α-ketoglutarate. Food Chem Toxicol67: 201–211.Search in Google Scholar

Bhattacharya R, Satpute RM, Hariharakrishnan J, Tripathi H, Saxena, PB. (2009). Acute toxicity of some synthetic cyanogens in rats and their response to oral treatment with alpha-ketoglutarate. Food Chem Toxicol47: 2314–2320.10.1016/j.fct.2009.06.02019539683Open DOISearch in Google Scholar

Bhattacharya R, Tulsawani RK. (2008). In vitro and In vivo evaluation of various carbonyl compounds against cyanide toxicity with particular reference to alpha-ketoglutaric acid. Drug Chem Toxicol31: 149–161.10.1080/0148054070168886518161514Open DOISearch in Google Scholar

Bhattacharya R, Vijayaraghavan R. (2002). Promising role of alpha-ketoglutarate in protecting against the lethal effects of cyanide. Hum Exp Toxicol21: 297–303.10.1191/0960327102ht255oa12195933Open DOISearch in Google Scholar

Borron SW. (2015). Cyanogenic aliphatic nitriles. In: Toxicology of cyanides and cyanogens experimental, applied and clinical aspects (Alan H. Hall, Gary E. Isom, Gary A. Rockwood, eds), Wiley Blackwell, West Sussex, UK, 166–180.Search in Google Scholar

Chanas B, Wang H, Ghanayem BI. (2003). Differential metabolism of acrylonitrile to cyanide is responsible for the greater sensitivity of male vs. female mice: role of CYP2E1 and epoxide hydrolases. Toxicol Appl Pharmacol193: 293–302.Search in Google Scholar

Cooperstein SJ, Lazarow A. (1951). A microspectrophotometric method for the determination of cytochrome oxidase. J Biol Chem189: 665–670.Search in Google Scholar

Delhumeau G, Cruz-Mendoza AM, Lojero CG. (1994). Protection of cytochrome C oxidase against cyanide inhibition by pyruvate and α-ketoglutarate. Effect of aeration in vitro. Toxicol Appl Pharmacol126: 345-351.Search in Google Scholar

Dixon WJ. (1965). The up-and-down method for small samples. J Am Stat Assoc60: 967–978.10.1080/01621459.1965.10480843Open DOISearch in Google Scholar

Epstein J. (1947). Estimation of microquantities of cyanide. Anal Chem19: 272–274.10.1021/ac60004a018Open DOISearch in Google Scholar

Feldstein M, Klendshoj NC. (1954). The determination of cyanide in biologic fluids by microdiffusion analysis. J Lab Clin Med44: 166–17.Search in Google Scholar

Hadri L El, Chanas B, Ghanayem BI. (2005). Comparative metabolism of methacrylonitrile and acrylonitrile to cyanide using cytochrome p4502E1 and microsomal epoxide hydrolase-nullmice. Toxicol Appl Pharmacol205: 116–125.Search in Google Scholar

Hall AH, Dart R, Bogdan G. (2007). Sodium thiosulfate or hydroxocobalamin for the empiric treatment of cyanide poisoning? Ann Emerg Med49: 806–813.10.1016/j.annemergmed.2006.09.02117098327Search in Google Scholar

Hall VA, Guest JM. (1992). Sodium nitroprusside-induced cyanide intoxication and prevention with sodium thiosulfate prophylaxis. Am J Crit Care1: 19–27.Search in Google Scholar

Mirkin DB. (2015). The special case of acrylonitrile (CH₂=CH-C≡N) In: Toxicology of cyanides and cyanogens experimental, applied and clinical aspects (Alan H Hall, Gary E Isom, Gary A Rockwood eds), Wiley Blackwell, West Sussex, UK, 181–194.10.1002/9781118628966.ch13Search in Google Scholar

Niknahad H, Khan S, O’Brien P. (1995). Hepatocyte injury resulting from the inhibition of mitochondrial respiration at low oxygen concentrations involves reductive stress and oxygen activation. Chemico-Biol Inter98: 27–44.Search in Google Scholar

Niknahad H, Khan S, Sood C, O’ Brien PJ. (1994). Prevention of cyanide-induced cytotoxicity by nutrients in isolated rat hepatocytes. Toxicol Appl Pharmacol128: 271-79.Search in Google Scholar

Niknahad H, O’Brien PJ. (1996). Antidotal effect of dihydroxyacetone against cyanide toxicity in vivo. Toxicol Appl Pharmacol138: 186–191.Search in Google Scholar

Patnaik P. (2007). A Comprehensive Guide to the Hazardous Properties of Chemical Substances, 3^rd Edn, John Wiley & Sons, Inc, NJ, USA.10.1002/9780470134955Search in Google Scholar

Prabhakaran K, Li L, Borowitz JL, Isom GE. (2006). Inducible nitric oxide synthase up-regulation and mitochondrial glutathione depletion mediate cyanide-induced necrosis in mesencephalic cells. J Neurosci Res84: 1003–1011.10.1002/jnr.20998Open DOISearch in Google Scholar

Rao P, Singh P, Yadav SK, Gujar NL, Bhattacharya R. (2013). Acute toxicity of some synthetic cyanogens in rats: Time-dependent cyanide generation and cytochrome oxidase inhibition in soft tissues after sub-lethal oral intoxication. Food Chem Toxicol59: 595–609.Search in Google Scholar

Saillenfait AM, Sabate JP. (2000). Comparative developmental toxicities of aliphatic nitriles: in vivo and in vitro observations. Toxicol Appl Pharmacol163: 149–163.Search in Google Scholar

Sambrook J, Russell WD. (2000). Protocol: DNA isolation from mammalian tissue. In: Molecular Cloning: A Laboratory Manual (Sambrook J, Russel WD eds), Cold spring Harbor Laboratory Press, NY, 623–627.Search in Google Scholar

Schwartz C, Morgan RL, Way LM, Way JL. (1979). Antagonism of cyanide intoxication with sodium pyruvate. Toxicol Appl Pharmacol50: 437-441.10.1016/0041-008X(79)90396-XOpen DOISearch in Google Scholar

Scolnick B, Hamel D, Woolf AD. (1993). Successful treatment of life-threatening propionitrile exposure with sodium nitrite/sodium thiosulfate followed by hyperbaric oxygen. J Occup Med35: 577–580.10.1097/00043764-199306000-000148331438Open DOISearch in Google Scholar

Their R, Lewalter J, Bolt HM. (2000). Species difference in acrylonitrile metabolism and toxicity between experimental animals and human based on observations in human accidental poisoning. Arch Toxicol74: 184–189.Search in Google Scholar

Tulsawani R, Kumar D, Bhattacharya R. (2007). Effect of pre-treatment of α-ketoglutarate on cyanide-induced toxicity and alterations in various physiological variables in rodents. Biomed Environ Sci20: 56–63.Search in Google Scholar

Vesey CJ, Cole PV. (1985). Blood cyanide and thiocyanate concentrations produced by long-term therapy with sodium nitroprusside. Br J Anaes57: 148–155.Search in Google Scholar

Wu Jong –C, Hseu You –C, Chen Chin –H, Wang Shu –H, Chen Ssu –C. (2009). Comparative investigations of genotoxic activity of five nitriles in the comet assay and the Ames test. J Hazard Mater169: 492–497.Search in Google Scholar

Zhang X, Li L, Prabhakaran K, Zhang L, Leavesley HB, Borowitz JL, Isom GE. (2007). Uncoupling protein-2 up-regulation and enhanced cyanide toxicity are mediated by PPARα activation and oxidative stress. Toxicol Appl Pharmacol223: 10–19.Search in Google Scholar