<abstract xmlns="http://www.w3.org/1999/xhtml"><p><italic>Streblus asper</italic> Lour (Moraceae), commonly known as Siamee Rough Brush in English is widely distributed in subtropical Asia and traditionally used for several medicinal purposes. In the present study, the ethyl acetate fraction of the methanol extract from <italic>Streblus asper</italic> bark (EASA) was evaluated for antitumor effect against Dalton’s ascitic lymphoma (DAL) in Swiss albino mice. Twenty-four hours after intraperitoneal inoculation of DAL cells in mice, EASA was administered intraperitoneally at 200 and 400 mg/kg body weight for 9 consecutive days. On the 10th day, half of the mice were sacrificed to determine the tumor growth parameters, and the rest were kept alive for survival assessment. Hematological, serum biochemical and tissue (liver, kidney) antioxidant profiles were also determined. EASA exhibited significant and dose dependent decrease in tumor growth parameters and increased survival of DAL bearing animals. EASA significantly and dose-dependently normalized the altered hematological, serum biochemical and tissue antioxidant parameters as compared with the DAL control mice. From the present study it may be concluded that <italic>S. asper</italic> bark possesses remarkable antitumor efficacy mediated by amelioration of oxidative stress by multiple mechanisms.</p></abstract>

Streblus asper Lour (Moraceae), commonly known as Siamee Rough Brush in English is widely distributed in subtropical Asia and traditionally used for several medicinal purposes. In the present study, the ethyl acetate fraction of the methanol extract from Streblus asper bark (EASA) was evaluated for antitumor effect against Dalton’s ascitic lymphoma (DAL) in Swiss albino mice. Twenty-four hours after intraperitoneal inoculation of DAL cells in mice, EASA was administered intraperitoneally at 200 and 400 mg/kg body weight for 9 consecutive days. On the 10th day, half of the mice were sacrificed to determine the tumor growth parameters, and the rest were kept alive for survival assessment. Hematological, serum biochemical and tissue (liver, kidney) antioxidant profiles were also determined. EASA exhibited significant and dose dependent decrease in tumor growth parameters and increased survival of DAL bearing animals. EASA significantly and dose-dependently normalized the altered hematological, serum biochemical and tissue antioxidant parameters as compared with the DAL control mice. From the present study it may be concluded that S. asper bark possesses remarkable antitumor efficacy mediated by amelioration of oxidative stress by multiple mechanisms.

Antitumor activity and antioxidant status of <italic>Streblus asper</italic> bark against Dalton's ascitic lymphoma in mice

Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, West Bengal India

Faculty of Pharmaceutical Sciences, PCTE Group of Institutes, Ludhiana 142021, Punjab, India

Interdisciplinary Toxicology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Antitumor activity and antioxidant status of  bark against Dalton's ascitic lymphoma in mice

Streblus asper Lour (Moraceae), commonly known as Siamee Rough Brush in English is widely distributed in subtropical Asia and traditionally used for several...

Antitumor activity and antioxidant status of Streblus asper bark against Dalton's ascitic lymphoma in mice

Online veröffentlicht: 07. März 2016

Seitenbereich: 125 - 130

Eingereicht: 14. Juni 2014

Akzeptiert: 18. Juni 2015

DOI: https://doi.org/10.1515/intox-2015-0019

Schlüsselwörter
Dalton’s ascitic lymphoma (DAL), antitumor, antioxidant

© 2015 Interdisciplinary Toxicology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Antitumor activity and antioxidant status of Streblus asper bark against Dalton's ascitic lymphoma in mice

Online veröffentlicht: 07. März 2016

Seitenbereich: 125 - 130

Eingereicht: 14. Juni 2014

Akzeptiert: 18. Juni 2015

DOI: https://doi.org/10.1515/intox-2015-0019

SchlüsselwörterDalton’s ascitic lymphoma (DAL), antitumor, antioxidant

© 2015 Interdisciplinary Toxicology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Schlüsselwörter
Dalton’s ascitic lymphoma (DAL), antitumor, antioxidant