<abstract xmlns="http://www.w3.org/1999/xhtml"><p>The onset of human degenerative diseases in humans, including type 2 diabetes, cardiovascular disease, neurological disorders, neurodevelopmental disease and neurodegenerative disease has been shown to be related to exposures to persistent organic pollutants, including polychlorinated biphenyls, chlorinated pesticides, polybrominated diphenyl ethers and others, as well as to polynuclear aromatic hydrocarbons, phthalates, bisphenol-A and other aromatic lipophilic species. The onset of these diseases has also been related to exposures to transition metal ions. A physiochemical mechanism for the onset of degenerative environmental disease dependent upon exposure to a combination of lipophilic aromatic hydrocarbons and transition metal ions is proposed here. The findings reported here also, for the first time, explain why aromatic hydrocarbons exhibit greater toxicity than aliphatic hydrocarbons of equal carbon numbers.</p></abstract>

The onset of human degenerative diseases in humans, including type 2 diabetes, cardiovascular disease, neurological disorders, neurodevelopmental disease and neurodegenerative disease has been shown to be related to exposures to persistent organic pollutants, including polychlorinated biphenyls, chlorinated pesticides, polybrominated diphenyl ethers and others, as well as to polynuclear aromatic hydrocarbons, phthalates, bisphenol-A and other aromatic lipophilic species. The onset of these diseases has also been related to exposures to transition metal ions. A physiochemical mechanism for the onset of degenerative environmental disease dependent upon exposure to a combination of lipophilic aromatic hydrocarbons and transition metal ions is proposed here. The findings reported here also, for the first time, explain why aromatic hydrocarbons exhibit greater toxicity than aliphatic hydrocarbons of equal carbon numbers.

Physiochemical basis of human degenerative disease

Zeliger Research and Consulting, Cape Elizabeth, Maine, USA

Harvard Medical School, Joslin Diabetes Center, Boston, Massachusetts, USA

Interdisciplinary Toxicology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Physiochemical basis of human degenerative disease"}

The onset of human degenerative diseases in humans, including type 2 diabetes, cardiovascular disease, neurological disorders, neurodevelopmental disease and...

Physiochemical basis of human degenerative disease

Online veröffentlicht: 10. Dez. 2015

Seitenbereich: 15 - 21

Eingereicht: 09. Jan. 2015

Akzeptiert: 17. März 2015

DOI: https://doi.org/10.1515/intox-2015-0003

Schlüsselwörter
Alzheimer's disease, cancer, degenerative environmental disease, diabetes, membrane permeability, toxicity mechanism

© 2015 Interdisciplinary Toxicology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Physiochemical basis of human degenerative disease

Online veröffentlicht: 10. Dez. 2015

Seitenbereich: 15 - 21

Eingereicht: 09. Jan. 2015

Akzeptiert: 17. März 2015

DOI: https://doi.org/10.1515/intox-2015-0003

SchlüsselwörterAlzheimer's disease, cancer, degenerative environmental disease, diabetes, membrane permeability, toxicity mechanism

© 2015 Interdisciplinary Toxicology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Schlüsselwörter
Alzheimer's disease, cancer, degenerative environmental disease, diabetes, membrane permeability, toxicity mechanism