Papillary thyroid cancer (PTC) is the most common histology of thyroid cancer.[1, 2] Nowadays, PTC represents about 70–85% of thyroid carcinomas.[3] Patients with PTC have an excellent prognosis with appropriate surgical resection, with or without postoperative radioactive iodine therapy (RAI).[4]
In the past, almost every patient with a diagnosis of PTC has received postoperative RAI. Currently, the selection of patient for postoperative RAI depends on the risk-group. The risk indicators depend on some indicators obtained at surgery, postoperative neck ultrasonography and postoperative Tg measurements.[3, 5] The American Thyroid Association (ATA) has classified PTC according to recurrence, mortality risks, and the postoperative RAI advantage into three groups: low, intermediate, and high risk.[3]
Patients with intermediate-risk may have: microscopic tumour invasion into the perithyroidal soft tissues; vascular invasion; clinical N1 or > 5 pathologic N1 (lymph nodes < 3 cm in largest dimension); multifocal microcarcinoma; aggressive histology (e.g., tall cell, hobnail variant, columnar cell carcinoma; BRAFV600E mutation; and RAI-avid metastatic foci in the neck on the first post-treatment WBS.[3]
Postoperative RAI may act as adjuvant therapy by eradicating cancer microscopic foci, as PTC is frequently multifocal, and by eradicating microscopic lymph node metastases. In addition, aend tail whole body scan (WBS) can be done after postoperative RAI; the results of this scan may identify previously undiagnosed disease, and may change the initial staging and facilitate early recurrence detection that is based on serum thyroglobulin (Tg) measurement and/or WBS.[6, 7]
Although I-131 is widely used, RAI therapy is not without adverse consequences. RAI can impact quality of life due to side effects such as acute or chronic xerostomia, acute or chronic sialoadentitis, and dental caries.[8, 9] Reports of a slightly increased risk of developing secondary primary malignancies after RAI therapy have called for a more selective use of RAI.[10, 11]
The ATA currently recommends adjuvant RAI therapy for high-risk patients and select intermediate-risk cases but not for low-risk patients.[3] Adjuvant RAI therapy has been debated for intermediate-risk patients because of the long-term prognosis of patients in this risk group.
In this study, we examined whether postoperative RAI was associated with a survival advantage among patients with intermediate-risk PTC
This study is a retrospective study of patients with papillary thyroid cancer that was treated at the Clinical Oncology & Nuclear Medicine Department, Mansoura University Hospital during the period from 1st January 2002 till 1stJanuary 2012.
Patients aged 18 years or older, who had undergone total, near-total, or subtotal thyroidectomy were included. The intermediate risk group was selected for inclusion in our analyses which was defined according to the ATA risk criteria and American Joint Commission on Cancer (AJCC) staging. Patients have: tumour with microscopic tumour invasion into the perithyroidal soft tissues; vascular invasion; clinical N1 or > 5 pathologic N1 (lymph nodes < 3 cm in largest dimension); multifocal microcarcinoma; and aggressive histology (e.g., tall cell, hobnail variant, columnar cell carcinoma were selected for inclusion in our analyses. They were divided into two groups: those who received postoperative RAI therapy and those who did not.
Follicular, Hürthle cell medullary and anaplastic thyroid cancers were excluded. Additional cases were excluded due to missing data for some variables. Patients with more than one primary cancer were also excluded.
The demographic variables included for the patients were age and gender. Pathological and clinical characteristics included in our analyses were tumour size, lymph node status, margin status, minimal extrathyroidal extension (yes/no), multifocality (yes/no), aggressive variants of PTC, such as poorly differentiated, tall cell, columnar and sclerosing insular variants (yes/no), vascular invasion (yes/no) and RAI administration (yes/no).
Patient characteristics were reported as frequencies and proportions for categorical variables and SD for continuous variables. Differences between patients who underwent RAI and those who did not were examined using X2 tests and Student’s
A total of 100 (43.1%) of the PTC patients (n = 232) met the defi nition of intermediate risk. Of those, 70 (70%) received RAI and 30 (30%) did not. Patients who received RAI versus those who did not had a higher proportion of tumour, 2 cm or more (85.8% vs. 40%, respectively), lymph node involvement (85.8% vs. 26.7%), multifocal tumours (49.9% vs. 33.3%), aggressive histology (28.7% vs. 13.3%), vascular invasion (21.4% vs. 13.3%), positive surgical margin status (21.4% vs. 16.7%) and minimal extrathyroidal extension (21.4%% vs. 13.3%), (all P < .001) (Table 1).
Characteristics of Patients and Tumors.Characteristics NO RAI RAI P % n % n Value <0.001 < 17 56.7 40 57.1% ≥ 13 43.3 30 42.9% <0.001 21 70 50 71.4% 9 30 20 28.6% <0.001 18 60 10 14.2% 6 20 20 28.7% 6 20 40 57.1% <0.001 22 73.3 10 14.2% 8 26.7 10 14.2% 0 0 20 28.7% 0 0 30 42.9% <0.001 10 33.3 36 49.1% 20 66.6 34 51.9% <0.001 4 13.3 20 28.7% 26 86.7 50 71.3% <0.001 4 13.3 15 21.4% 26 86.7 55 78.6% <0.001 5 16.7 15 21.4% 25 83.3 55 78.6% <0.001 4 13.3 15 21,4% 26 86,7 55 78.6%
The mean follow-up time was 7.1 years (4.8-15.1 years), and a median survival time could not be estimated. There were 4 deaths (5.7%) in the RAI group vs. 3 (10%) in the no RAI group (P < .001). Most patients were alive as of 2012, and a median survival time could not be estimated. Overall survival at 10 years was 96% in the RAI group vs. 93% in the no RAI group (P < .001). RAI administration was associated with improved OS in all patients as demonstrated by Kaplan-Meier survival curves (log-rank P < .001) (Figure 1).
After multivariate adjustment for patient demographic and clinical factors, RAI was associated with a 27% reduced risk of death [hazard risk (HR) 0.73 {confidence interval (CI) 0.64–0.84}, P < .001]. Patient factors associated with compromised OS included: ‘older patient age and male gender’. The pathological and clinical factors associated with compromised OS included; ‘larger tumour size, presence of lymph node metastases, multifocal tumours, aggressive histology, vascular invasion, positive surgical margin, minimal extrathyroidal extension and lack of RAI therapy’ (all P ≤ .001) (Table 2).
Multivariate analysis of 100 patients with intermediate-risk papillary thyroid carcinoma.HR (95% Cl) P Value Age < 45 1.00 ≥ 45 1.36(0.94-1.92) <0.001 Gender Male 0.73(0.65-0.82) <0.001 Female 1.00 1.00 <0.001 0.62(0.49-0.78) <0.001 0.74(0.56-0.97) lymph nodes N0 1.00 N1 1.45(1.05-2.12) <0.001 Multifocality Yes 0.83(0.75-0.92) <0.001 No 1.00 Aggressive histology Yes 0.94(0.58-1.66) <0.001 No 1.00 0.98(0.68-1.56) <0.001 1.00 Positive margins Yes 1.55(1.15-2.22) <0.001 No 1.00 Extrathyroidal extension Yes 0.62(0.49-0.78) <0.001 No 1.00 RAI use No 1.00 Yes 0.72(0.59-0.88) <0.001
Due to the indolent nature of differentiated thyroid cancer and long-term survival, there is a lack of randomized clinical trials studying PTC management because a large number of patients would be needed, with extended follow-up and associated high cost.[6] As a result, there is no consensus in the literature regarding the potential benefit of RAI for intermediate-risk patients. As outlined by the ATA, the decision to treat is therefore based on clinical judgment, with particular weight placed on patient’s age, histology, tumour size, and lymph node metastases status in combination with other potential risk factors, such as the presence of tumour multifocality and vascular invasion.[3]
Currently, the intermediate-risk group has not been analyzed because other studies used alternate risk and staging definitions instead of the ATA definitions, or studies were designed lacking stratifying patients into an intermediate risk category.[12, 13, 14]
This representative study addresses the association between RAI and the survival for patients with intermediate-risk PTC. Although mortality from PTC is low and the disease is generally associated with an excellent prognosis, we observed a 27% reduced risk of death [hazard risk (HR) 0.73 (CI 0.64–0.84), P < .001] in our multivariate analyses when RAI was administered in the postoperative setting. Our results suggest that RAI is associated with improved OS in intermediate-risk patients with papillary thyroid cancer. Our findings support previous studies suggesting that RAI survival benefit in older patients.[12, 13]
Our finding of a reduced risk of death associated with RAI administration is in contrast to the results of two other large studies: ‘using the Surveillance, Epidemiology, and End Results (SEER) database, and a single-institution study from the Mayo Clinic that provided extended patient follow-up’.[12, 14] Although neither study examined the intermediate-risk group specifically, both studies failed to show a survival benefit for RAI therapy among the patients, overall.[12, 14]
Podnos et al.[12] (12) failed to show an overall survival benefit associated with RAI on multivariate analysis (median follow-up of 95 months) among 12 661 PTC patients using the SEER database (P = .9176). However, this study identified improved survival with RAI only among patients who had all of the following risks: patient’s age older than 45 years, tumour size greater than 2 cm, positive lymph nodes, and distant metastases.
In a large, single-institution, a retrospective study conducted at the Mayo Clinic, Hay et al.[14] found no disease specific survival or recurrence benefit when RAI therapy was used among patients with papillary thyroid cancers, deemed to be low risk or high risk. In this study, a MACIS prognostic score: ‘distant metastasis, patient’s age, completeness of resection, local invasion, and tumour size’ with a score of less than 6 was deemed to be low risk, and a score of 6 or greater was assessed as high risk.[14] Due to a difference in risk definitions, the Mayo Clinic study examined low and high risks and did not directly evaluate patients at intermediate risk.
As part of the National Thyroid Cancer Treatment Cooperative Study Group (NTCTCSG), a prospective multi-institution registry of 11 North American institutions, Jonklaas et al.[13] found a survival benefit for adjuvant RAI used in a subset of intermediate-risk patients. Using multivariate regression and propensity score analyses, they found that RAI administration was associated with improved overall survival in NTCTSG stages II, III, and IV papillary thyroid cancers. They also found improved disease-specific survival and reduced recurrence rates with RAI use among patients with NTCTSG stages III and IV, but not stage II, disease. In contrast to our study, Jonklaas et al. used an alternative NTCTCSG staging system and did not specifically analyze the ATA intermediate-risk patients. Depending on the patient’s age, intermediate-risk patients can fall into NTCTSG stages I-III. Although Jonklaas et al. found benefit with RAI among a subset of intermediate-risk patients, no benefit was seen in NTCTCSG stage I patients, which includes some intermediate-risk patients younger than 45 years. In contrast, our study found RAI administration was associated with OS benefit in all intermediate-risk patients, as defined by ATA criteria, regardless of patient’s age..
Our finding of a reduced risk of death associated with RAI administration is in agreement to results of one large study[15] in which, Ewa Ruel et al. observed a 29% reduced risk of death hazard ratio of 0.71 in intermediate-risk PTC patients. Overall survival in patients younger than 45 years ‘36 % reduction in risk of death with a hazard ratio of 0.64’ was improved by using RAI.[15] However, the unavailability of the number and dimension of lymph node metastases were an important limitation of this study.[16]
Recent studies reported that increasing number of lymph node metastases and macroscopic lymph node metastases were associated with decreasing overall survival,[17, 18] these finding are in agreement with our results.
The limitations of this study include: small number, retrospective, and single institution. Additionally, some variables of interest were incomplete, for example, patient preference, patient comorbidities, information on post-RAI therapy whole-body scans and disease recurrence. An important limitation of our study is that it does not provide disease specific survival information; therefore, we could analyze only overall survival.
A large prospective randomized controlled trial is warranted; however, the indolent nature of thyroid cancer and the high costs of conducting such study have made this difficult in the past.
This representative study addresses the survival benefit of RAI for patients with intermediate-risk PTC, but conducting of large prospective randomized controlled trial is still warranted.