<abstract xmlns="http://www.w3.org/1999/xhtml">Periodontal disease is an inflammatory disease of multifactorial etiology. In order for it to appear there must come to an imbalance between the effects of pathogens and host defense mechanisms. As a result of its course the destruction of structures supporting the teeth appears (periodontium, cement, bone), and consequently leads to teeth loosening and loss. In recent years, the participation of RANKL/RANK/OPG in bone remodeling process was highligted.At the molecular level the bone resorption is regulated through the interaction of the ligand receptor activator of nuclear NF-kappa B (RANKL) and osteoprotegerin (OPG), which is a system of two proteins belonging to the protein tumor necrosis factor (TNF). Recent findings about the RANKL protein and OPG have shed new light on the previously unexplained phenomenon of the basis of bone resorption.Research has shown that both protein OPG and RANKL can be detected in gingival crevicular fluid, which has become a window of opportunity in the analysis of non-invasive markers of periodontal tissues, confirming elevated levels of RANKL protein in periodontal disease, and decreased levels of OPG protein. Bone resorption is initiated by the binding of the RANKL protein to receptors RANK present on the surface of mature osteoclasts, and their precursors, which leads to the differentiation and activation of osteoclasts. OPG, being RANKL’s inhibitor, has, in turn, opposite characteristics to RANKL, resulting in the reduction of osteoclastogenesis process. Despite all this, the exact mechanism of bone resorption has not yet been elucidated.</abstract>

Periodontal disease is an inflammatory disease of multifactorial etiology. In order for it to appear there must come to an imbalance between the effects of pathogens and host defense mechanisms. As a result of its course the destruction of structures supporting the teeth appears (periodontium, cement, bone), and consequently leads to teeth loosening and loss. In recent years, the participation of RANKL/RANK/OPG in bone remodeling process was highligted.At the molecular level the bone resorption is regulated through the interaction of the ligand receptor activator of nuclear NF-kappa B (RANKL) and osteoprotegerin (OPG), which is a system of two proteins belonging to the protein tumor necrosis factor (TNF). Recent findings about the RANKL protein and OPG have shed new light on the previously unexplained phenomenon of the basis of bone resorption.Research has shown that both protein OPG and RANKL can be detected in gingival crevicular fluid, which has become a window of opportunity in the analysis of non-invasive markers of periodontal tissues, confirming elevated levels of RANKL protein in periodontal disease, and decreased levels of OPG protein. Bone resorption is initiated by the binding of the RANKL protein to receptors RANK present on the surface of mature osteoclasts, and their precursors, which leads to the differentiation and activation of osteoclasts. OPG, being RANKL’s inhibitor, has, in turn, opposite characteristics to RANKL, resulting in the reduction of osteoclastogenesis process. Despite all this, the exact mechanism of bone resorption has not yet been elucidated.

Bone metabolism and RANKL/RANK/OPG trail in periodontal disease

Chair and Department of Oral Surgery, Medical University of Lublin,

Current Issues in Pharmacy and Medical Sciences

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{"article-title":"Bone metabolism and RANKL/RANK/OPG trail in periodontal disease"}

Periodontal disease is an inflammatory disease of multifactorial etiology. In order for it to appear there must come to an imbalance between the effects of...

Bone metabolism and RANKL/RANK/OPG trail in periodontal disease

Online veröffentlicht: 23. Jan. 2017

Seitenbereich: 171 - 175

Eingereicht: 21. März 2016

Akzeptiert: 14. Juli 2016

DOI: https://doi.org/10.1515/cipms-2016-0036

Schlüsselwörter
bone metabolism, periodontitis, RANKL/RANK/OPG, cytokins

© 2016 Lukasz Czupkallo et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Bone metabolism and RANKL/RANK/OPG trail in periodontal disease

Online veröffentlicht: 23. Jan. 2017

Seitenbereich: 171 - 175

Eingereicht: 21. März 2016

Akzeptiert: 14. Juli 2016

DOI: https://doi.org/10.1515/cipms-2016-0036

Schlüsselwörterbone metabolism, periodontitis, RANKL/RANK/OPG, cytokins

© 2016 Lukasz Czupkallo et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Schlüsselwörter
bone metabolism, periodontitis, RANKL/RANK/OPG, cytokins