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Molecular and immunohistochemical characteristics of complete hydatidiform moles

KB Kubelka-Sabit

KB Kubelka-Sabit

Department of Histopathology and Cytology, Clinical Hospital “Acibadem-Sistina”Skopje, Republic of Macedonia
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Kubelka-Sabit, KB
, 
I Prodanova

I Prodanova

Diagnostic Laboratory “Histolab”Skopje, Republic of Macedonia
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Prodanova, I
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D Jasar

D Jasar

Department of Histopathology and Cytology, Clinical Hospital “Acibadem-Sistina”Skopje, Republic of Macedonia
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Jasar, D
, 
G Bozinovski

G Bozinovski

Macedonian Academy of Sciences and Arts, Research Centre for Genetic Engineering and Biotechnology “Georgi D. Efremov”Skopje, Republic of Macedonia
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Bozinovski, G
, 
V Filipovski

V Filipovski

Department of Histopathology and Cytology, Clinical Hospital “Acibadem-Sistina”Skopje, Republic of Macedonia
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Filipovski, V
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S Drakulevski

S Drakulevski

Department of Histopathology and Cytology, Clinical Hospital “Acibadem-Sistina”Skopje, Republic of Macedonia
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Drakulevski, S
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D Plaseska-Karanfilska

D Plaseska-Karanfilska

Macedonian Academy of Sciences and Arts, Research Centre for Genetic Engineering and Biotechnology “Georgi D. Efremov”Skopje, Republic of Macedonia
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Plaseska-Karanfilska, D
  
30. Juni 2017
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Artikel-Kategorie: Original Article
Online veröffentlicht: 30. Juni 2017
Seitenbereich: 27 - 34
DOI: https://doi.org/10.1515/bjmg-2017-0009
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© 2017 Kubelka-Sabit KB, Prodanova I, Jasar D, Bozinovski G, Filipovski V, Drakulevski S, Plaseska-Karanfilska D
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Figure 1

Microscopic appearance of the chorionic villi in complete hydatidiform mole with a pronounced stromal edema and trophoblastic proliferation (hematoxylin and eosin, ×100).
Microscopic appearance of the chorionic villi in complete hydatidiform mole with a pronounced stromal edema and trophoblastic proliferation (hematoxylin and eosin, ×100).

Figure 2

Mucoid stromal degeneration and irregular villous contours in complete hydatidiform mole (hematoxylin and eosin, ×200).
Mucoid stromal degeneration and irregular villous contours in complete hydatidiform mole (hematoxylin and eosin, ×200).

Figure 3

Ki-67 proliferation index >50.0% in villous cytotrophoblasts (×200).
Ki-67 proliferation index >50.0% in villous cytotrophoblasts (×200).

Figure 4

Absence of p57 staining In the villous cytotrophoblasts and villous stromal cells (×200).
Absence of p57 staining In the villous cytotrophoblasts and villous stromal cells (×200).

Figure 5

p63 staining in >50.0% of the villous cytotrophoblasts (×200).
p63 staining in >50.0% of the villous cytotrophoblasts (×200).

Histopathological characteristics of complete mole_

Complete MoleCharacteristics Absent orPresent CompleteMole Casesn = 8 (%)
Heterogenous population of villi absentpresent 0 (0.0)8 (100.0)
Circumferential trophoblastic proliferation absentpresent 1 (12.5)7 (87.5)
Cytotrophoblastic proliferation absentpresent 3 (37.5)5 (62.5)
Nuclear atypia absentpresent 0 (0.0)8 (100.0)
Karyorrhectic stromal debris absentpresent 6 (75 0)2 (25.0)

Immunohistochemical characteristics of complete moles_

Positive Cells (%) Ki-67Antibodyn = 8 p63Antibodyn = 8 p57Antibodyn = 8
n (%) n (%) n (%)
0 0 (0.0) 0 (0.0) 8 (100)
10 0 (0.0) 0 (0.0) 0 (0.0)
20 0 (0.0) 0 (0.0) 0 (0.0)
30 0 (0.0) 0 (0.0) 0 (0.0)
40 0 (0.0) 0 (0.0) 0 (0.0)
50 0 (0.0) 0 (0.0) 0 (0.0)
60 0 (0.0) 3 (37.5) 0 (0.0)
70 4 (50.0) 2 (25.0) 0 (0.0)
80 3 (37.5) 3 (37.5) 0 (0.0)
90 1 (12.5) 0(0.0) 0 (0.0)
100 0 (0.0) 0(0.0) 0 (0.0)

Primary antibodies with clones and dilutions_

Primary Antibody (producer) Clone Dilution
Monoclonal mouse anti-humanKi-67 antigen (Ventana) MIB-1 RTU
Monoclonal mouse primaryantibody anti-p63 (Ventana) 4A4 RTU
Monoclonal mouse Primaryantibody anti-p57 (Vector Laboratories) Kip2 1:50

Histopathological characteristics of partial mole_

Partial Mole Characteristics Absent orPresent CompleteMole Casesn = 8 (%)
Two types of villi absentpresent 8 (100.0)0(0.0)
Irregular villus contours absentpresent 0(0.0)8 (100.0)
Trophoblastic stromal inclusions absentpresent 7(87.5)1 (12.5)
Focal trophoblastic proliferation absentpresent 7(87.5)1 (12.5)
Presence of fetal erythrocytes absentpresent 8 (100.0)0 (0.0)
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