<abstract xmlns="http://www.w3.org/1999/xhtml"><p> Objective: The aim of the study is to assess 24-hour blood pressure variability, circadian blood pressure profile and its relation to 24-hour blood pressure and cardiovascular risk factors in primary hypertension without any associated disease versus associated with a disease such as diabetes or chronic kidney disease. Methods: This observational study included 90 hypertensive patients, 49 with primary hypertension without associated disease and 41 patients with primary hypertension and diabetes or chronic kidney disease. Circadian blood pressure profile and 24-hour variability were assessed using ambulatory monitoring. Laboratory data regarding cardiovascular risk factors and demographic data were collected in a questionnaire. Results: The number of dipper patients was higher in the group without associated disease, but the difference was not statistically significant (p=0.27). In both groups a positive correlation was found between 24-hour systolic blood pressure variability and 24-hour systolic blood pressure (p=0.029) and was related to age (p=0.031). In the second group, systolic variability showed a positive correlation with serum triglycerides (p=0.006, r=0.416, CI: 0.1252 to 0.6422). Conclusion: Our findings suggest that systolic blood pressure variability is related to age, systolic blood pressure values and serum lipid levels. To prevent end organ damage in hypertension, the assessment of ambulatory monitoring derived 24-hour systolic blood pressure variability and its reduction may be at least as important as blood pressure lowering.</p></abstract>

Objective: The aim of the study is to assess 24-hour blood pressure variability, circadian blood pressure profile and its relation to 24-hour blood pressure and cardiovascular risk factors in primary hypertension without any associated disease versus associated with a disease such as diabetes or chronic kidney disease. Methods: This observational study included 90 hypertensive patients, 49 with primary hypertension without associated disease and 41 patients with primary hypertension and diabetes or chronic kidney disease. Circadian blood pressure profile and 24-hour variability were assessed using ambulatory monitoring. Laboratory data regarding cardiovascular risk factors and demographic data were collected in a questionnaire. Results: The number of dipper patients was higher in the group without associated disease, but the difference was not statistically significant (p=0.27). In both groups a positive correlation was found between 24-hour systolic blood pressure variability and 24-hour systolic blood pressure (p=0.029) and was related to age (p=0.031). In the second group, systolic variability showed a positive correlation with serum triglycerides (p=0.006, r=0.416, CI: 0.1252 to 0.6422). Conclusion: Our findings suggest that systolic blood pressure variability is related to age, systolic blood pressure values and serum lipid levels. To prevent end organ damage in hypertension, the assessment of ambulatory monitoring derived 24-hour systolic blood pressure variability and its reduction may be at least as important as blood pressure lowering.

The relationship between blood pressure variability and cardiovascular risk factors in patients with primary hypertension

University of Medicine and Pharmacy Tîrgu Mureş - Doctoral School, Department of Internal Medicine IV

County Clinical Emergency Hospital Tîrgu Mures, Clinic of Hematology

University of Medicine and Pharmacy Tîrgu Mureş, Department of Internal Medicine I

University of Medicine and Pharmacy Tîrgu Mureş, Department for Forensics Medicine

County Clinical Hospital, Department for Gastroenterology

Acta Marisiensis - Seria Medica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Objective: The aim of the study is to assess 24-hour blood pressure variability, circadian blood pressure profile and its relation to 24-hour blood pressure...

The relationship between blood pressure variability and cardiovascular risk factors in patients with primary hypertension

Online veröffentlicht: 16. Juni 2015

Seitenbereich: 31 - 33

Eingereicht: 27. Okt. 2014

Akzeptiert: 20. Jan. 2015

DOI: https://doi.org/10.1515/amma-2015-0022

Schlüsselwörter
blood pressure variability, cardiovascular risk factors, ambulatory monitoring

© by I. Benedek

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The relationship between blood pressure variability and cardiovascular risk factors in patients with primary hypertension

Online veröffentlicht: 16. Juni 2015

Seitenbereich: 31 - 33

Eingereicht: 27. Okt. 2014

Akzeptiert: 20. Jan. 2015

DOI: https://doi.org/10.1515/amma-2015-0022

Schlüsselwörterblood pressure variability, cardiovascular risk factors, ambulatory monitoring

© by I. Benedek

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Schlüsselwörter
blood pressure variability, cardiovascular risk factors, ambulatory monitoring