Experimental Study of the Laser-Induced Oxyhemoglobin Photodissociation in Cutaneous Blood Vessels

A new optical method for reduction of local tissue hypoxia is proposed. It is shown that this method of phototherapy allows the control of a local oxygen concentration in tissue. Different aspects of biomedical application of this phenomenon are discussed. The results of in vivo experimental investigation of the laser-induced photodissociation of oxyhemoglobin in cutaneous blood vessels and its role in tissue oxygenation are presented. The rates of oxygen saturation SpO₂ in blood and their dependence on the wavelength of the transcutaneous laser irradiation have been experimentally measured.